Zongli Xu, Ph.D.


Zongli Xu, Ph.D. Staff Scientist: Tel (919) 541-1677
Fax (919) 541-2511
xuz@niehs.nih.gov
Curriculum Vitae (93KB); P.O. Box 12233
Mail Drop P.O. Box 12233
Research Triangle Park, North Carolina 27709
Delivery Instructions

Studies
Software
Selected Publications

Related Links

SNPinfo Web Server (http://snpinfo.niehs.nih.gov/index.html)

Zongli Xu, Ph.D., is a Staff Scientist, His research involves both application and methodology studies in genetic epidemiology. Xu's overall goal is to study the interaction between genetic factors and environmental exposures in human health and therefore deciphering the mechanisms underlying complex human diseases. Along with colleagues in the Laboratory of Molecular Carcinogenesis and Biostatistics Branch of NIEHS, his applied work is mainly focused on human carcinogenesis, while much of his methodological work is to develop bioinformatics methods and software tools to facilitate genetic epidemiology study. The applied work helps to motivate methodological research, which involves issues surrounding the design and data analysis in genetic epidemiological studies.

Studies

Genetic and Epigenetic studies with Sister Study samples
Epigenetic study with samples from Norway Facial Clefts Study
Genetic studies in NC-LA Prostate Cancer Consortium
LIFE and VALID Lung Study
Developing bioinformatics methods & software tools

Software

SNPinfo (http://www.niehs.nih.gov/snpinfo/)
A web server for SNP selection and functional information. It can comprehensively utilize computational, experimental and epidemiological information together with genome wide association study (GWAS) results and linkage disequilibrium (LD) information to prioritize SNPs for further genetic mapping studies
TAGster ("/Rhythmyx/assembler/render?sys_contentid=35267&sys_revision=3&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="35267" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="35267" sys_siteid="" sys_folderid="")
A software package to select, evaluate and visualize LD tag SNPs for single or multiple populations.
mPopTag
("/Rhythmyx/assembler/render?sys_contentid=35063&sys_revision=6&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="35063" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="35063" sys_siteid="" sys_folderid="") A software tool to select or evaluate linkage disequilibrium (LD) tag SNPs for multiple populations.

Selected Publications

Xu Z, Bensen JT, Smith GJ, Mohler JL, Taylor JA. GWAS SNP Replication among African American and European American men in the North Carolina-Louisiana prostate cancer project (PCaP). Prostate. 2011 Jun 1;71(8):881-891. doi: 10.1002/pros.21304. Epub 2010 Nov 17. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/21456070) ]
Xu Z, Taylor JA. Integrating GWAS and Candidate Gene Information into Functional SNP Selection for Genetic Association Studies. Nucleic Acids Research. 2009. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/19417063) ]
Xu Z, Kaplan NL, Taylor JA. Tagster: Efficient selection of LD tag SNPs in single or multiple populations. Bioinformatics (Oxford, England) 2007 23(23):3254-3255. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17827206) ]
Xu Z, Kaplan NL, Taylor JA. LD tag SNP selection for candidate gene association studies using HapMap and gene resequencing data. Eur J Hum Genet. 2007 Oct;15(10):1063-1070. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/17568388) ]
Xu Z, Zou F, Vision TJ. High resolution QTL mapping in genotypically selected samples from experimental crosses. Genetics. 2005. 170(1):401-408. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/15781710) ]