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Your Environment. Your Health.

Dana B. Hancock, Ph.D.

Genetics, Environment & Respiratory Disease Group

Dana B. Hancock, Ph.D.
Dana B. Hancock, Ph.D.
Special Volunteer
Tel (919) 316-4506
Fax (919) 541-2511
hancockd@niehs.nih.gov
P.O. Box 12233
Mail Drop A3-05
Research Triangle Park, North Carolina 27709
Delivery Instructions

Research Summary

Dana Hancock, Ph.D., joined the Epidemiology Branch as an IRTA postdoctoral fellow in May 2008 shortly after completing her doctoral research from Duke University.  As a genetic epidemiologist, Hancock is interested in the interplay of genetic and environmental risk factors leading to common, complex diseases.  Her doctoral training focused on interactions between candidate genes and environmental factors in Parkinson’s disease. Her postdoctoral training with Stephanie London, M.D., Dr.P.H., focuses on genetic risk factors on a genome-wide scale and corresponding gene-environment interactions in respiratory diseases, including asthma and chronic obstructive pulmonary disease. In doing so, well-known environmental factors for respiratory disease, such as cigarette smoking and air pollution, are considered. Hancock is particularly interested in the use of family-based samples to explore gene-environment interactions in such complex diseases.

Studies

  • Mexico Childhood Asthma Study
    The Mexico Childhood Asthma Study is a case-parent triad study of childhood allergic asthma in Mexico City

  • The Atherosclerosis Risk in Communities (ARIC) Study The ARIC Study is a prospective epidemiologic study conducted in four U.S. communities. ARIC is designed to investigate the etiology and natural history of atherosclerosis, the etiology of clinical atherosclerotic diseases and variation in cardiovascular risk factors.

Selected Publications

  1. London SJ, Gao W, Gharib SA, Hancock DB, Wilk JB, House JS, Gibbs RA, Muzny DM, Lumley T, Franceschini N, North KE, Psaty BM, Kovar CL, Coresh J, Zhou Y, Heckbert SR, Brody JA, Morrison AC, Dupuis J. ADAM19 and HTR4 Variants and Pulmonary Function: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study. Circulation. Cardiovascular genetics 2014 7(3):350-358.[Abstract ]
  2. Hancock DB, Soler-Artigas M, Et AL, Tobin MD, London SJ. Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. PLoS genetics 2012 8(12):e1003098-.[Abstract ]
  3. Wilk JB, Shrine NR, Loehr LR, Zhao JH, Manichaikul A, Lopez LM, Smith AV, Heckbert SR, Smolonska J, Tang W, Loth DW, Curjuric I, Hui J, Cho MH, Latourelle JC, Henry AP, Aldrich M, Bakke P, Beaty TH, Bentley AR, Borecki IB, Brusselle GG, Burkart KM, Chen TH, Couper D, Crapo JD, Davies G, Dupuis J, Franceschini N, Gulsvik A, Hancock DB, Harris TB, Hofman A, Imboden M, James AL, Khaw KT, Lahousse L, Launer LJ, Litonjua A, Liu Y, Lohman KK, Lomas DA, Lumley T, Marciante KD, McArdle WL, Meibohm B, Morrison AC, Musk AW, Myers RH, North KE, Postma DS, Psaty BM, Rich SS, Rivadeneira F, Rochat T, Rotter JI, Artigas MS, Starr JM, Uitterlinden AG, Wareham NJ, Wijmenga C, Zanen P, Province MA, Silverman EK, Deary IJ, Palmer LJ, Cassano PA, Gudnason V, Barr RG, Loos RJ, Strachan DP, London SJ, Boezen HM, Probst-Hensch N, Gharib SA, Hall IP, O'Connor GT, Tobin MD, Stricker BH. Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction. American journal of respiratory and critical care medicine 2012 186(7):622-632.[Abstract ]
  4. Imboden M, Bouzigon E, Curjuric I, Ramasamy A, Kumar A, Hancock DB, Wilk JB, Vonk JM, Thun GA, Siroux V, Nadif R, Monier F, Gonzalez JR, Wjst M, Heinrich J, Loehr LR, Franceschini N, North KE, Altmüller J, Koppelman GH, Guerra S, Kronenberg F, Lathrop M, Moffatt MF, O'Connor GT, Strachan DP, Postma DS, London SJ, Schindler C, Kogevinas M, Kauffmann F, Jarvis DL, Demenais F, Probst-Hensch NM. Genome wide association study of lung function decline in adults with and without asthma. The Journal of allergy and clinical immunology 129(5):1218-28, 2012.[Abstract ]
  5. Hancock DB, Romieu I, Chiu GY, Sienra-Monge JJ, Li H, Estela del Rio-Navarro B, London SJ. STAT6 and LRP1 polymorphisms are associated with food allergen sensitization in Mexican children. Journal of Allergy and Clinical Immunology 2012;129(6):1673-6.[Abstract ]
  6. Soler Artigas M‡, Loth D‡, Wain LV‡, Gharib SA‡, Obeidat M‡, Tang W‡, Zhai G, Zhao JH, Smith AV, Huffman JE, Albrecht E, Jackson CM, Evans DM, Cadby G, Fornage M, Manichaikul A, Lopez JM, Johnson T, Aldrich MC, Aspelund T, Barroso I, Campbell H, Cassano PA, Couper DJ, Eiriksdottir G, Franceschini N, Garcia M, Gieger C, Gislason GK, Grkovic I, Hammond CJ, Hancock DB, Harris TB, Ramasamy A, Heckbert SR, Heliövaara M, Homuth G, Hysi PG, James AL, Jankovic S, Joubert BR, Karrasch S, Klopp N, Kritchevsky SB, Koch B, Kritchevsky SB, Launer LJ, Liu Y, Loehr LR, Lohman K, Loos RJP, Lumley T, Balushi A, Ang WQ, Barr GR, Beilby J, Beilin LJ, Blakey JD, Boban M, Boraska V, Brisman J, Britton JR, Brusselle GG, Cooper C, Curjuric I, Dahgam S, Deary IJ, Ebrahim S, Eijgelsheim M, Francks C, Gaysina D, Granell R, Gu X, Hankinson JL, Hardy R, Harris SE, Henderson J, Henry A, Hingorani AD, Hofman A, Holt PG, Hui J, Hunter ML, Imboden M, Jameson KA, Kerr SM, Kolcic I, Kronenberg F, Liu JZ, Marchini J, McKeever T, Morris AD, Olin A-C, Porteus D, Postma DS, Rich SS, Ring SM, Rivadeneira F, Rochat T, Sayer AA, Sayers I, Sly PD, Smith GD, Sood A, Starr JM, Uitterlinden AG, Vonk JM, Wannamethee SG, Whincup PH, Wijmenga C, Williams OD, Wong A, Mangino M, Marciante KD, McArdle WL, Meibohm B, Morrison AC, North KE, Omenaas E, Palmer LJ, Pietiläinen KH, Pin I, Polašek O, Pouta A, Psaty BM, Hartikainen A-L, Rantanen T, Ripatti S, Rotter JI, Rudan I, Rudnicka AR, Schulz H, Shin S-Y, Spector TD, Surakka I, Vitart V, Völzke H, Wareham NJ, Warrington NM, Wichmann H-E, Wild SH, Wilk JB, Wjst M, Wright AF, Zgaga L, Zemunik T, Pennell CE, Nyberg F, Kuh D, Holloway JW, Boezen HM, Lawlor DA, Morris RW, Probst-Hensch N, The International Lung Cancer Consortium, GIANT Consortium, Kaprio J, Wilson JF, Hayward C, Kähönen M, Heinrich J, Musk AW, Jarvis DL, Gläser S, Järvelin M-R, Stricker BHC‡, Elliott P‡, O'Connor GT‡, Strachan DP‡, London SJ‡*, Hall IP‡, Gudnason V‡, Tobin MD‡*. [‡ Equal contribution. *Corresponding authors – SJ London for the CHARGE consortium, MD Tobin for the SpiroMeta Consortium]. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.Nature Genet 2011;43:1082-90.[Abstract ]
  7. Torgerson DG, Ampleford EJ, Chiu GY, Gauderman WJ, Gignoux CR, Graves PE, Himes BE, Levin AM, Matthias RA, Hancock DB, Baurley JW, Eng C, Stern DA, Celedon JC, Rafaels N, Capurso D, Conti DV, Roth LA, Soto-Quiros M, Togias A, LI X, MYERS RA, Romieu I, Van Den Berg DJ, Hu D, Hansel NN, Hernandez RD, Israel E, Salam MT, Galanter J, Avila PC, Avila L, Rodriquez-Santana JR, Chapela R, Rodriguez-Cintron W, Diette GB, Adkinson NF, Abel RA, Ross KD, Shi M, Faruque MU, Dunston GM, Watson HR, Mantese VJ, Liang L, Ruczinski I, Ford JG, Huntsman S, Chung KF, Vora H, Li X, Calhoun WJ, Castro M, Sierra-Monge JJ, del Rio-Navarro B, Deichmann KA, Heinzmann A, Wenzel SE, Busse WW, Gern JE, Lemanske RF Jr, Beaty TH, Bleecker ER, Raby BA, Meyers DA, London SJ. Meta-analysis of Genome-wide Association Studies of Asthma in Ethnically Diverse North American Populations. Nature Genetics 43(9):887-892, 2011.[Abstract ]
  8. Hancock DB, Haberg SE, Furu K, Whitworth KW, Nafstad P, Nystad W, London SJ. Oral contraceptive pill use before pregnancy and respiratory outcomes in early childhood. Pediatric allergy and immunology 22(5):528-536, 2011.[Abstract ]
  9. Shi M, London SJ, Chiu GY, Hancock DB, Zaykin D, Weinberg CR. Using imputed genotypes for relative risk estimation in case-parent studies. American journal of epidemiology 173(5):553-559, 2011.[Abstract ]
  10. Hancock DB, London SJ, CHARGE Pulmonary Function Working Group. Determinants of lung function, COPD, and asthma. The New England journal of medicine. 364(1):86-87, 2011.[Abstract ]
  11. Aschard H, Hancock DB, London SJ, Kraft P. Genome wide meta-analysis of joint tests for genetic and gene-environment interaction effects. Human heredity. 70(4):292-300, 2010.[Abstract ]
  12. Hancock DB, Eijgelsheim M, Wilk JB, Gharib SA, Loehr LR, Marciante KD, Franceschini N, van Durme YMTA, Chen T, Barr RG, Schabath MB, Couper DJ, Brusselle GG, Psaty BM, van Duijn CM, Rotter J, Uitterlinden AG, Hofman A, Punjabi NM, Rivadeneira F, Morrison AC, Enright PL, North KE, Heckbert SR, Lumley T, Stricker BHC, O'Connor GT, London SJ. Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. Nature genetics 2010;42:45-52.[Abstract ]
  13. Wu H, Romieu I, Shi M, Hancock DB, Li H, Sienra-Monge JJ, Chiu GY, del Rio-Navarro BE, London SJ. Evaluation of candidate genes in a genome-wide association study of childhood asthma in Mexicans. The Journal of allergy and clinical immunology. 125(2):321-327, 2010.[Abstract ]
  14. Hancock DB, Eijgelsheim M, Wilk JB, Gharib SA, Loehr LR, Marciante KD, Franceschini N, van Durme YMTA, Chen T, Barr RG, Schabath MB, Couper DJ, Brusselle GG, Psaty BM, van Duijn CM, Rotter J, Uitterlinden AG, Hofman A, Punjabi NM, Rivadeneira F, Morrison AC, Enright PL, North KE, Heckbert SR, Lumley T, Stricker BHC, O'Connor GT, London SJ. Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. Nature genetics 2010;42:45-52.[Abstract ]
  15. Wu H, Romieu I, Shi M, Hancock DB, Li H, Sienra-Monge JJ, Chiu GY, del Rio-Navarro BE, London SJ. Evaluation of candidate genes in a genome-wide association study of childhood asthma in Mexicans. The Journal of allergy and clinical immunology. 125(2):321-327, 2010.[Abstract ]
  16. Hancock DB, Romieu I, Shi M, Sienra-Monge JJ, Wu H, Chiu GY, Li H, del Rio-Navarro BE, Eng C, Chapela R, Burchard EG, Tang H, Sullivan PF, London SJ. Genome-wide association study implicates chromosome 9q21.31 as a susceptibility locus for asthma in Mexican children. PLoS genetics 2009;5(8):e1000623.[Abstract ]
  17. Hancock DB, Martin ER, Vance JM, Scott WK (2008). Nitric oxide synthase genes and their interactions with environmental factors in Parkinson's disease. Neurogenetics 9(4):249-262.
  18. Hancock DB, Martin ER, Mayhew GM, Stajich JM, Jewett R, Stacy MA, Scott BL, Vance JM, Scott WK (2008). Pesticide exposure and risk of Parkinson's disease: a family-based case-control study. BioMed Central Neurology 8(6).[Abstract ]
  19. Hancock DB, Martin ER, Li YJ, Scott WK (2007). Methods for interaction analyses using family-based case-control data: conditional logistic regression versus generalized estimating equations. Genetic Epidemiology 31(8):883-893.
  20. Hancock DB, Martin ER, Stajich JM, Jewett R, Stacy MA, Scott BL, Vance JM, Scott WK (2007). Smoking, caffeine, and nonsteroidal anti-inflammatory drugs as protective factors in families with Parkinson disease. Archives of Neurology 64(4):576-580.[Abstract ]
  21. Hancock DB, Martin ER, Fujiwara K, Stacy MA, Scott BL, Stajich JM, Jewett R, Li YJ, Hauser MA, Vance JM, Scott WK (2006). NOS2A and the modulating effect of cigarette smoking in Parkinson’s disease. Annals of Neurology 60(3):366-373.[Abstract ]

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