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Your Environment. Your Health.

Aimee D’Aloisio, Ph.D.

Chronic Disease Epidemiology Group

Aimee D’Aloisio, Ph.D.
Aimee D'Aloisio, Ph.D.
Special Volunteer
Tel (919) 541-3225
Fax (919) 541-2511
daloisio@niehs.nih.gov
P.O. Box 12233
Mail Drop A3-05
Research Triangle Park, North Carolina 27709
Delivery Instructions

Research Summary

Aimee D'Aloisio's, Ph.D. research interests focus on women’s health, specifically factors related to pathogenesis of uterine fibroids and reproductive cancers. Under the mentorship of Donna Baird, Ph.D., D'Aloisio’s dissertation research involved the relation of insulin-like growth factor-1 (IGF-I) and IGF binding protein-3 (IGFBP-3) single nucleotide polymorphisms (SNPs) and estimated diplotypes with the prevalence of uterine fibroids using data and DNA samples from the NIEHS Uterine Fibroid Study. In addition, she evaluated how IGF-I and IGFBP-3 SNPs and estimated diplotypes predicted circulating IGF-I and IGFBP-3 levels.

 

As a postdoctoral fellow under the mentorship of Dale Sandler, Ph.D., D’Aloisio is using data from The Sister Study to evaluate environmental risk factors for uterine fibroids, including prenatal and early childhood exposures. D’Aloisio will also evaluate genetic polymorphisms in association with risk of breast cancer in the Sister Study.

Studies

  • Uterine Fibroid Study
    ("/Rhythmyx/assembler/render?sys_contentid=36371&sys_revision=1&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="36371" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="36371" sys_siteid="" sys_folderid="")The Uterine Fibroid Study was designed to determine the prevalence of fibroids, identify risk factors for fibroids, identify biological changes in tumor tissue and describe women's experience of symptoms and their change over time.

  • The Sister Study
    ("/Rhythmyx/assembler/render?sys_contentid=36268&sys_revision=2&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="36268" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="36268" sys_siteid="" sys_folderid="")The Sister Study will prospectively examine environmental and familial risk factors for breast cancer and other diseases in a cohort of 50,000 sisters of women who have had breast cancer. The study should enhance researchers' ability to understand the interplay of genes and environment in breast cancer risk and to identify potentially preventable risk factors.

Selected Publications

  1. West SL, D'Aloisio AA, Agans RP, Kalsbeek WD, Borisov NN, Thorp JM. Prevalence of low sexual desire and hypoactive sexual desire disorder in a nationally representative sample of US women. Archives of Internal Medicine 2008; 168(13): 1441-1449.[Abstract ]
  2. Baird DD, Travlos G, Wilson R, Dunson DB, Hill MC, D'Aloisio A, London SJ, Schectman JM. Uterine Leiomyomata in Relation to Insulin-Like Growth Factor-I, Insulin, and Diabetes. Epidemiology (Cambridge, Mass.) 2009; 20(4):604-610.[Abstract ]
  3. D'Aloisio AA, Schroeder JC, North KE, Poole C, West SL, Travlos GS, Baird DD. IGF-I and IGFBP-3 polymorphisms in relation to circulating levels among African American and Caucasian women. Cancer epidemiology, biomarkers & prevention: a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009; 18(3):954-966.[Abstract ]
  4. Baird DD, Travlos G, Wilson R, Dunson DB, Hill MC, D'Aloisio A, London SJ, Schectman JM. Uterine Leiomyomata in Relation to Insulin-Like Growth Factor-I, Insulin, and Diabetes. Epidemiology (Cambridge, Mass.) 2009; 20(4):604-610.[Abstract ]
  5. D'Aloisio AA, Baird DD, DeRoo LA, Sandler DP. Association of intrauterine and early-life exposures with diagnosis of uterine leiomyomata by 35 years of age in the Sister Study. Environmental health perspectives 2010; 118(3):375-381.[Abstract ]
  6. Steiner AZ, D'Aloisio A, DeRoo L, Sandler D, Baird DD. Association of Intrauterine and Early Life Exposures with Age at Menopause in the Sister Study. American Journal of Epidemology 172(2):140-148, 2010.[Abstract ]
  7. D'Aloisio AA, Baird DD, DeRoo LA, Sandler DP. Early-life exposures and early onset uterine leiomyomata in black women in the Sister Study. Environmental health perspectives 120(3):406-412, 2012.[Abstract ]

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