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Your Environment. Your Health.

Rachel Goldsmith, Ph.D.

WormTox Group

Rachel Goldsmith, Ph.D.
Rachel Goldsmith, Ph.D.
IRTA Fellow
Tel (919) 541-2522
P.O. Box 12233
Mail Drop E1-05
Research Triangle Park, North Carolina 27709
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Rachel Goldsmith, Ph.D., is an Intramural Research Training Award fellow in the WormTox Group in the Biomolecular Screening Branch of the National Toxicology Program Division at the National Institute of Environmental Health Sciences (NIEHS). She joined the NTP C. elegans Screening Facility in 2011, where she is developing a mechanism-based toxicological assay. The assay is based on measuring the activities of genes in stress-response pathways that share homologies among C. elegans, rodents and humans.


Prior to joining the NTP, Goldsmith received her B.S. degrees in biochemistry and biology from Brandeis University in Waltham, MA and her Ph.D. in molecular and cellular pathology from the University of North Carolina at Chapel Hill. Her Ph.D. work focused on the potential nephrotoxicity of anti-trypanosomal compounds.

Selected Publications

  1. Goldsmith RB, Gray DR, Yan Z, Generaux CN, Tidwell RR, Reisner HM. 2010. Application of monoclonal antibodies to measure metabolism of an anti-trypanosomal compound in vitro and in vivo. J Clin Lab Anal, 24(3):187-94.  
  2. Chai SC, Ju T, Dang M, Goldsmith RB, Maroney MJ, Pochapsky TC. 2008. Characterization of metal binding in the active sites of acireductone dioxygenase isoforms from Klebsiella ATCC 8724. Biochemistry, 47(8):2428-38.  
  3. Ju T, Goldsmith RB, Chai SC, Maroney MJ, Pochapsky SS, Pochapsky TC. 2006. One protein, two enzymes revisited: a structural entropy switch interconverts the two isoforms of acireductone dioxygenase. J Mol Biol, 363(4):823-34.

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