Christina T. Teng, Ph.D.
Molecular Toxicology and Informatics Group
Christina T. Teng, Ph.D.
Christina Teng, Ph.D., is a molecular biologist who joined the NTP Biomolecular Screening Branch (BSB) in 2008. She is a member of the Molecular Toxicology and Informatics Group and a participant in the tripartite collaboration among the NTP — comprised of NIEHS, the NIH Chemical Genomics Center (NCGC) and the Environmental Protection Agency (EPA) — that identifies key signaling pathways for environmental toxicants. Teng is also a member of a group that is involved in assay selection, design of the NTP initiative for High Throughput Screening and data analysis for subsequent recommendations on follow-up screening.
Before joining the branch, Teng was head of the Gene Regulation Group within the Division of Intramural Research’s (DIR) Laboratory of Reproductive and Developmental Toxicology. The group was focused on the elucidation of the molecular events associated with the regulation of gene expression by an estrogen receptor (ER)-mediated mechanism.
With more than 30 years of experience working on nuclear receptor mediated signaling, Teng was the first to clone the lactoferrin gene from mouse uterus and the human Krüppel-Like Factor 5 (IKLF/KLF5) from uterine carcinoma cells using a molecular approach. In addition, she successfully cloned the estrogen-related receptor alpha and demonstrated its involvement in the ER-mediated signaling pathway. In 1999 she received a patent for "Method of screening for risk of cancer using human lactoferrin DNA probe or primer."
Teng received her Ph.D. in 1969 at the University of Texas, Austin and has published 86 peer-reviewed articles in leading biomedical journals as well as 18 book chapters. She served as an Assistant Professor at the Department of Cell Biology, Baylor College of Medicine, Houston before joining NIEHS in 1983.
- Teng CS, Teng CT and Allfrey VG (1971) Studies of nuclear acidic proteins: Evidence for their phosphorylation, tissue specificity and selective binding to the DNA and stimulatory effects of transcription. J. Biol. Chem 246: 3597-3609.
- Teng CT, Chan MD and Hamilton LD (1973) Poly(inosinic acid), Poly(cytidylic acid) inhibition of DNA synthesis in synchronized HeLa cells. Proc. Natl. Acad. Sci. USA 70: 3904-3908. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/4521216) ]
- Teng CS and Teng CT (1985) Decreased ovalbumin-gene response to oestrogen in the prenatally diethylstilbestrol-exposed chick oviduct. Biochem. J. 228: 689-695. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/4026804) ]
- Pentacost BT and Teng CT (1987) Lactotransferrin is the major estrogen inducible protein of mouse uterine secretions. J. Biol. Chem. 262: 10134-10139. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/3611056) ]
- Panella TJ, Liu YH, Huang AT and Teng CT (1991) Polymorphism and altered methylation of the lactoferrin gene in normal leukocytes, leukemia cells and breast cancer. Cancer Res. 51: 3037-3043. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/1674448) ]
- Liu YH, Yang NY and Teng CT (1993) COUP-TF acts as a competitive repressor for estrogen-receptor mediated activation of the mouse lactoferrin gene. Mol. Cell. Bio. 13:1836-1846. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/8441416) ]
- Shi HP and Teng CT (1994) Characterization of a mitogen response unit in the mouse lactoferrin gene promoter. J. Biol. Chem. 269: 12973-12980. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/8175715) ]
- Yang NY, Shigeta H, Shi HP and Teng CT (1996) Estrogen-related receptor, hERR1, modulates estrogen receptor-mediated response of human lactoferrin gene promoter. J. Biol. Chem. 271:5795-5804. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/8621448) ]
- Shigeta H, Zuo W, Yang NY, DiAugustine R and Teng CT (1997) The mouse estrogen receptor-related orphan receptor a1 (mERR a1): molecular cloning and estrogen responsiveness. J. Mol Endo. 19: 299-309. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/9460651) ]
- Shi HP, Zhang ZP, Wang X, Liu SG and Teng CT (1999) Isolation and characterization of a gene encoding human Kruppel-Like Factof 5 (IKLF): Binding to CAAT/GT box of the mouse lactoferrin gene promoter. Nucl. Acid. Res. 27: 4807-4815. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/10572182) ]
- Zhang ZP and Teng CT (2000) Estrogen receptor related receptor alpha 1 interacts with coactivator and constitutively activates the estrogen response elements of the human lactoferrin gene. J. Biol. Chem. 275: 20837-20846. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/10779508) ]
- Hu P, Kinyamu HK, Wang L, Martin J, Archer TK and Teng CT (2008) Estrogen induces estrogen-related receptor alpha gene expression and chromatin structural changes in estrogen receptor (ER)-positive and ER-negative breast cancer cells. J. Biol. Chem. 283: 6752-6763. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/18174157) ]
- Li Y, Birnbaumer L, Teng CT (2010) Regulation of ERRa gene expression by estrogen receptor agonists and antagonists in SKBR3 breast cancer cells: Differential moleuclar mechanisms mediated by G protein-coupled receptor GPR30/GPER-1. Molecular Endocrinology. 24(5):969-980. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/20211987) ]
- Teng CT, Li Y, Stockton P, Foley J. Fasting induces the expression of PGC-1a and ERR isoforms in the outer stripe of the outer medulla (OSOM) of the mouse kidney. PloS one 2011 6(11):e26961-. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/22073226) ]
- Teng CT, Goodwin B, Shockley K, Xia M, Huang R, Norris J, Merrick BA, Jetten AM, Austin CP, Tice RR. Bisphenol A affects androgen receptor function via multiple mechanisms. Chemico-biological interactions 2013; 203(3): 556-564. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/23562765?dopt=Abstract) ]
- Li Y, Luh CJ, Burn KA, Arao Y, Jiang Z, Teng CT, Tice EE, Korach KS. Endocrine-disrupting chemicals (EDCs): in vitro mechanism of estrogenic activation and differential effects on ER target genes. Environ Health Perspect 2013; 121(4): 459-466. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/23384675?dopt=Abstract) ]
- Shen J, Xu L, Fang H, Richard AM, Bray JD, Judson RS, Zhou G, Colatsky TJ, Aungst JL, Teng C, Harris SC, Ge W, Dai SY, Su Z, Jacobs AC, Harrouk W, Perkins R, Tong W, Hong H. EADB: an estrogenic activity database for assessing potential endocrine activity. Toxicological sciences: an official journal of the Society of Toxicology 2013 135(2):277-291. [Abstract (http://www.ncbi.nlm.nih.gov/pubmed/23897986?dopt=Abstract) ]
- Teng CT, Beams B, Alex Merrick B, Martin N, Romeo C, Jetten AM. Development of a stable cell line with an intact PGC-1α/ERRα axis for screening environmental chemicals. Biochemical and biophysical research communications 2014 444(2):177-181. [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=24457025) ]