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Kristine Witt, M.S.

Genetic Toxicology Group

Kristine Witt, M.S.
Kristine L. Witt, M.S.
Group Leader/Toxicologist
Tel (919) 541-2761
Fax (919) 316-4511
P.O. Box 12233
Mail Drop K2-17
Research Triangle Park, NC 27709

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Kristine Witt, M.S., is a toxicologist in the Biomolecular Screening Branch of the National Toxicology Program (NTP). Witt manages the NTP’s genetic toxicology testing contract, and she provides genetic toxicology test data review and evaluation for inclusion in the NTP Technical Reports. She is also involved in assay selection and study design for the NTP’s High Throughput Screening initiative, chairs the NTP’s High-Throughput Screening faculty, and serves as co-chair of the Pathways/Assays subgroup for the Tox21 collaboration("/Rhythmyx/assembler/render?sys_contentid=21816&sys_revision=5&sys_variantid=610&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="610" sys_dependentid="21816" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="21816" sys_siteid="" sys_folderid="").


In addition to her work for the NTP, Witt is a clinical investigator who manages NIEHS research studies on cytogenetic endpoints in study populations exposed to medications with known or suspected genetic toxicity, with an emphasis on exposure risks to children. She has an extensive background in both clinical cytogenetics and genetic toxicology and has made numerous presentations at national meetings and workshops. Witt received a B.S. in zoology and an M.S. in genetics from The Ohio State University.

Selected Publications

  1. Yamamoto KN, Hirota K, Kono K, Takeda S, Sakamuru S, Xia M, Huang R, Austin CP, Witt KL, Tice RR. (2011) Characterization of environmental chemicals with potential for DNA damage using isogenic DNA repair-deficient chicken DT40 cell lines. Environ. Mol. Mutagen. 52(7):547-61.
  2. Xia M, Shahane S, Huang R, Titus SA, Shum E, Zhao Y, Southall N, Zheng W, Witt KL, Tice RR, Austin CP. (2011) Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels. Toxicol. Appl. Pharmacol. 252(3):250-8.
  3. Witt KL, Moorman PG, Kovalchuk O, Holland N, Block G, Andreassen PR. (2010) Genetics and women's health issues - the commitment of EMS to women scientists and gender-associated disease topics. Environmental and molecular mutagenesis. 51(8-9):774-780.[Abstract]  
  4. Recio L, Hobbs C, Caspary W, Witt KL. (2010) Dose-response assessment of four genotoxic chemicals in a combined mouse and rat micronucleus and comet assay protocol. The Journal of toxicological sciences. 35(2):149-162.[Abstract]  
  5. Witt KL, Malarkey DE, Hobbs CA, Davis JP, Kissling GE, Caspary W, Travlos G, Recio L. (2010) No increases in biomarkers of genetic damage or pathological changes in heart and brain tissues in male rats administered methylphenidate hydrochloride (Ritalin) for 28 days. Environmental and molecular mutagenesis. 51(1):80-88.[Abstract]  
  6. Xia M, Huang R, Sun Y, Semenza GL, Aldred SF, Witt KL, Inglese J, Tice RR, Austin CP. (2009) Identification of Chemical Compounds that Induce HIF-1{alpha} Activity. Toxicol Sci 112(1): 153-63.  
  7. Witt KL, Shelby MD, Itchon-Ramos N, Faircloth M, Kissling GE, Chrisman AK, Ravi H, Murli H, Mattison DR, Kollins SH. (2008) Methylphenidate and amphetamine do not induce cytogenetic damage in lymphocytes of children with ADHD. J Am Acad Child Adolesc Psychiatry. 47(12):1375-83.[Abstract]  
  8. Xia M, Huang R, Witt KL, Southall N, Fostel J, Cho MH, Jadhav A, Smith CS, Inglese J, Portier CJ, Tice RR, Austin CP. (2008) Compound cytotoxicity profiling using quantitative high-throughput screening. Environ Health Perspect. 116(3):284-91.[Abstract]  
  9. Witt KL, Livanos E, Kissling GE, Torous DK, Caspary W, Tice RR, Recio L. (2008) Comparison of flow cytometry and microscopy-based methods for measuring micronucleated reticulocyte frequencies in rodents treated with nongenotoxic and genotoxic chemicals. Mutation Res. 649(1-2):101-113.[Abstract]  
  10. Witt KL,Cunningham CK, Patterson KB, Kissling GE, Dertinger SD, Livingston E, Bishop JB. (2007) Elevated frequencies of micronucleated erythrocytes in infants exposed to zidovudine in utero and postpartum to prevent mother-to-child transmission of HIV. Environ Mol Mutagen. 48:322-329.[Abstract]  
  11. Witt KL, Tice RR, Wolfe G, Bishop JB. (2004) Genetic damage detected in CD-1 mouse pups exposed perinatally to 3'-azido-3'-deoxythymidine or dideoxyinosine via maternal dosing, nursing, and direct gavage. II: Effects of the individual agents compared to combination treatment. Environ Mol Mutagen. 44:321-328.[Abstract]  
  12. Robbins WA, Witt KL, Haseman J, Dunson D, Troiani L, Cohen M, Hamilton CD, Darney SP, Beyler S, Raburn D, Tedder S, Shelby MD, Bishop JB. (2001) Effects of antiretroviral therapy on genetic and morphological endpoints in lymphocytes and sperm of people with HIV infection. J Infect Dis. 184(2):127-35.
  13. Witt KL, Knapton A, Wehr CM, Hook GJ, Mirsalis J, Shelby MD, MacGregor JT. (2000) Micronucleated erythrocyte frequency in peripheral blood of B6C3F1 mice from short-term, prechronic and chronic studies of the NTP carcinogenesis bioassay program. Environ Mol Mutagen. 36(3):163-194.[Abstract]

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