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Selected Publications

Genetic Toxicology Group

  1. Chen S, Zhou D, Hsin LY, Kanaya N, Wong C, Yip R, Sakamuru S, Xia M, Yuan YC, Witt K, Teng C. AroER tri-screen is a biologically relevant assay for endocrine disrupting chemicals modulating the activity of aromatase and/or the estrogen receptor. Toxicological sciences: an official journal of the Society of Toxicology 2014 139(1):198-209.[Abstract ]
  2. Witt KL, Stout MD, Herbert RA, Travlos GS, Kissling GE, Collins BJ, Hooth MJ. (2013) Mechanistic Insights from the NTP Studies of Chromium. Toxicologic pathology 41(2):326-342.[Abstract ]
  3. Yauk CL, Lucas Argueso J, Auerbach SS, Awadalla P, Davis SR, Demarini DM, Douglas GR, Dubrova YE, Elespuru RK, Glover TW, Hales BF, Hurles ME, Klein CB, Lupski JR, Manchester DK, Marchetti F, Montpetit A, Mulvihill JJ, Robaire B, Robbins WA, Rouleau GA, Shaughnessy DT, Somers CM, Taylor JG 6th, Trasler J, Waters MD, Wilson TE, Witt KL, Bishop JB. (2012) Harnessing genomics to identify environmental determinants of heritable disease. Mutat Res. Aug 28. [Epub ahead of print] PubMed PMID: 22935230.[Abstract ]
  4. Morris SM, Petibone DM, Lin W-J, Chen JJ, Vitiello B, Witt KL, Mattison DR. (2012) The Genetic Toxicity of Methylphenidate: A Review of the Current Literature. J Appl Toxicol. Oct;32(10):164-171.[Abstract ]
  5. Mercado-Feliciano M, Cora MC, Witt KL, Granville CA, Hejtmancik MR, Fomby L, Knostman KA, Ryan MJ, Newbold R, Smith C, Foster PM, Vallant MK, Stout MD. (2012) An ethanolic extract of black cohosh causes hematological changes but not estrogenic effects in female rodents. Toxicol Appl Pharmacol. Sept;263(2):138-147.[Abstract ]
  6. Recio L, Kissling GE, Hobbs CA, Witt KL. Comparison of Comet assay dose-response for ethyl methanesulfonate using freshly prepared versus cryopreserved tissues. Environmental and molecular mutagenesis 2012 53(2):101-13.[Abstract ]
  7. Hobbs CA, Chhabra RS, Recio L, Streicker M, Witt KL. Genotoxicity of styrene-acrylonitrile trimer in brain, liver, and blood cells of weanling F344 rats. Environmental and molecular mutagenesis 2012 53(3):227-38.[Abstract ]
  8. Shukla SJ, Huang R, Simmons SO, Tice RR, Witt KL, VanLeer D, Ramabhadran R, Austin CP, Xia M. Profiling environmental chemicals for activity in the antioxidant response element signaling pathway using a high-throughput screening approach. Environ Health Perspectives 2012 120(8):1150-1156.[Abstract ][PDF ]
  9. Yamamoto KN, Hirota K, Kono K, Takeda S, Sakamuru S, Xia M, Huang R, Austin CP, Witt KL, Tice RR. (2011) Characterization of environmental chemicals with potential for DNA damage using isogenic DNA repair-deficient chicken DT40 cell lines. Environ. Mol. Mutagen. 52(7):547-61.
    [Abstract ( 0KL) ]  
  10. Xia M, Shahane S, Huang R, Titus SA, Shum E, Zhao Y, Southall N, Zheng W, Witt KL, Tice RR, Austin CP. (2011) Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels. Toxicol. Appl. Pharmacol. 252(3):250-8.
    [Abstract ( ]  
  11. Witt KL, Moorman PG, Kovalchuk O, Holland N, Block G, Andreassen PR. (2010) Genetics and women's health issues - the commitment of EMS to women scientists and gender-associated disease topics. Environmental and molecular mutagenesis. 51(8-9):774-780.[Abstract ]  
  12. Recio L, Hobbs C, Caspary W, Witt KL. (2010) Dose-response assessment of four genotoxic chemicals in a combined mouse and rat micronucleus and comet assay protocol. The Journal of toxicological sciences. 35(2):149-162.[Abstract ]  
  13. Witt KL, Malarkey DE, Hobbs CA, Davis JP, Kissling GE, Caspary W, Travlos G, Recio L. (2010) No increases in biomarkers of genetic damage or pathological changes in heart and brain tissues in male rats administered methylphenidate hydrochloride (Ritalin) for 28 days. Environmental and molecular mutagenesis. 51(1):80-88.[Abstract ]  
  14. Xia M, Huang R, Sun Y, Semenza GL, Aldred SF, Witt KL, Inglese J, Tice RR, Austin CP. (2009) Identification of Chemical Compounds that Induce HIF-1{alpha} Activity. Toxicol Sci 112(1): 153-63.  
  15. Witt KL, Shelby MD, Itchon-Ramos N, Faircloth M, Kissling GE, Chrisman AK, Ravi H, Murli H, Mattison DR, Kollins SH. (2008) Methylphenidate and amphetamine do not induce cytogenetic damage in lymphocytes of children with ADHD. J Am Acad Child Adolesc Psychiatry. 47(12):1375-83.[Abstract ]  
  16. Xia M, Huang R, Witt KL, Southall N, Fostel J, Cho MH, Jadhav A, Smith CS, Inglese J, Portier CJ, Tice RR, Austin CP. (2008) Compound cytotoxicity profiling using quantitative high-throughput screening. Environ Health Perspect. 116(3):284-91.[Abstract ]  
  17. Witt KL, Livanos E, Kissling GE, Torous DK, Caspary W, Tice RR, Recio L. (2008) Comparison of flow cytometry and microscopy-based methods for measuring micronucleated reticulocyte frequencies in rodents treated with nongenotoxic and genotoxic chemicals. Mutation Res. 649(1-2):101-113.[Abstract ]  
  18. Witt KL,Cunningham CK, Patterson KB, Kissling GE, Dertinger SD, Livingston E, Bishop JB. (2007) Elevated frequencies of micronucleated erythrocytes in infants exposed to zidovudine in utero and postpartum to prevent mother-to-child transmission of HIV. Environ Mol Mutagen. 48:322-329.[Abstract ]  
  19. Witt KL, Tice RR, Wolfe G, Bishop JB. (2004) Genetic damage detected in CD-1 mouse pups exposed perinatally to 3'-azido-3'-deoxythymidine or dideoxyinosine via maternal dosing, nursing, and direct gavage. II: Effects of the individual agents compared to combination treatment. Environ Mol Mutagen. 44:321-328.[Abstract ]  
  20. Robbins WA, Witt KL, Haseman J, Dunson D, Troiani L, Cohen M, Hamilton CD, Darney SP, Beyler S, Raburn D, Tedder S, Shelby MD, Bishop JB. (2001) Effects of antiretroviral therapy on genetic and morphological endpoints in lymphocytes and sperm of people with HIV infection. J Infect Dis. 184(2):127-35.
  21. Witt KL, Knapton A, Wehr CM, Hook GJ, Mirsalis J, Shelby MD, MacGregor JT. (2000) Micronucleated erythrocyte frequency in peripheral blood of B6C3F1 mice from short-term, prechronic and chronic studies of the NTP carcinogenesis bioassay program. Environ Mol Mutagen. 36(3):163-194.[Abstract ]

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