Genetic Toxicology Group
Kristine L. Witt, M.S.
The Genetic Toxicology Group, headed by Kristine Witt, M.S., is responsible for testing chemicals of interest to the National Toxicology Program (NTP) for their ability to induce measurable changes in DNA and chromosomes that may result in human diseases (e.g., cancer) or increase the risk of birth defects.
Exposure conditions that are investigated may be acute, subacute, or long term. A variety of test systems are employed, including bacteria, cultured mammalian cells, and laboratory rodents.
All data generated by the Group are posted on the NTP website for public use.
Current testing capabilities:
- Bacterial mutagenicity testing (Ames assay)
- In vitro and in vivo Micronucleus (MN) testing
- In vitro and in vivo Comet assay
- Combined in vivo MN/Comet assay
- Pig-a mutation assay in vivo in rat and mouse erythrocytes
Kristine Witt, M.S., is a toxicologist in the Biomolecular Screening Branch of the National Toxicology Program (NTP). Witt manages the NTP’s genetic toxicology testing contract, and she provides genetic toxicology test data review and evaluation for inclusion in the NTP Technical Reports. She is also involved in assay selection and study design for the NTP’s High Throughput Screening initiative, chairs the NTP’s High-Throughput Screening faculty, and serves as co-chair of the Assays and Pathways Working Group for the Tox21 collaboration("/Rhythmyx/assembler/render?sys_contentid=21816&sys_revision=5&sys_variantid=610&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="610" sys_dependentid="21816" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="21816" sys_siteid="" sys_folderid="").
In addition to her work for the NTP, Witt is a clinical investigator who manages NIEHS research studies on cytogenetic endpoints in study populations exposed to medications with known or suspected genetic toxicity, with an emphasis on exposure risks to children. She has an extensive background in both clinical cytogenetics and genetic toxicology and has made numerous presentations at national meetings and workshops. Witt received a B.S. in zoology and an M.S. in genetics from The Ohio State University.
Witt is an active member of the Environmental Mutagenesis and Genomics Society and she serves on the Editorial Board of Mutation Research, Environmental and Genetic Toxicology.