Biomolecular Screening Branch
Richard S. Paules, Ph.D.
Acting Chief, Biomolecular Screening Branch
The Biomolecular Screening Branch (BSB), headed by Richard S. Paules, Ph.D., develops and carries out programs in medium and high throughput screening of environmental substances for rapid detection of biological activities of significance to toxicology.
The Branch develops analysis tools and approaches that integrate its assessment with findings from traditional toxicology.
The Branch also administers the National Toxicology Program (NTP) High Throughput Screening (HTS) Initiative called Tox21, a major initiative within NTP's Roadmap to achieve its vision for toxicology in the 21st century. Tox21 places an increased emphasis on the use of alternative assays for targeting the key pathways, molecular events, or processes linked to disease or injury, and attempts to incorporate them into a research and testing framework. In support of this Program, the Biomolecular Screening Branch represents the NTP in the Toxicology in the 21st Century Partnership.
Tox21 is a unique collaboration between several federal agencies to research and test chemicals in a new way. The goals of the Tox21 partnership are to:
- Identify patterns of compound-induced biological response in order to characterize toxicity/disease pathways, facilitate cross-species extrapolation, and model low-dose extrapolation
- Prioritize compounds for more extensive toxicological evaluation
- Develop predictive models for biological response in humans
The goals of the Biomolecular Screening Branch are carried out by 3 groups and adjunct staff from the Division of the National Toxicology Program and the Division of Intramural Research:
- Genetic Toxicology Group("/Rhythmyx/assembler/render?sys_contentid=33793&sys_revision=2&sys_variantid=1278&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="1278" sys_dependentid="33793" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="33793" sys_siteid="" sys_folderid="")
- Molecular Toxicology and Informatics Group("/Rhythmyx/assembler/render?sys_contentid=33829&sys_revision=2&sys_variantid=1278&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="1278" sys_dependentid="33829" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="33829" sys_siteid="" sys_folderid="")
- Toxicogenomics and Genetics Group