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Biomolecular Screening Branch

Raymond Tice, Ph.D.
Raymond Tice, Ph. D.
Chief, Biomolecular Screening Branch
Tel (919)541-4482
Fax (919) 541-0295
tice@niehs.nih.gov
P.O. Box 12233
Mail Drop K2-17
Research Triangle Park, North Carolina 27709
Delivery Instructions
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Research Summary

The Biomolecular Screening Branch (BSB), headed by Raymond R. Tice, Ph.D., develops and carries out programs in medium and high throughput screening of environmental substances for rapid detection of biological activities of significance to toxicology.

 

The Branch develops analysis tools and approaches that integrate its assessment with findings from traditional toxicology.

 

The Branch also administers the National Toxicology Program (NTP)    high throughput screening (HTS) program   , a major new initiative within NTP's Roadmap   to achieve its vision for toxicology in the 21st century. The Roadmap places an increased emphasis on the use of alternative assays for targeting the key pathways, molecular events, or processes linked to disease or injury, and attempts to incorporate them into a research and testing framework. In support of this Program, the Biomolecular Screening Branch represents the NTP in the Toxicology in the 21st Century Partnership, referred to as Tox21  .

 

Tox21  is a unique collaboration between several federal agencies to research and test chemicals in a new way. The goals of the Tox 21 partnership are to:

 

  • Identify patterns of compound-induced biological response in order to characterize toxicity/disease pathways, facilitate cross-species extrapolation, and model low-dose extrapolation
  • Prioritize compounds for more extensive toxicological evaluation
  • Develop predictive models for biological response in humans

 

The goals of the Biomolecular Screening Branch are carried out by 4 groups and adjunct staff from the Division of the National Toxicology Program and the Division of Intramural Research:

 

  • Genetic Toxicology Group("/Rhythmyx/assembler/render?sys_contentid=33793&sys_revision=2&sys_variantid=1278&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="1278" sys_dependentid="33793" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="33793" sys_siteid="" sys_folderid="")
  • Host Susceptibility Group("/Rhythmyx/assembler/render?sys_contentid=46862&sys_revision=1&sys_variantid=1278&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="1278" sys_dependentid="46862" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="46862" sys_siteid="" sys_folderid="")
  • Molecular Toxicology and Informatics Group("/Rhythmyx/assembler/render?sys_contentid=33829&sys_revision=2&sys_variantid=1278&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="1278" sys_dependentid="33829" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="33829" sys_siteid="" sys_folderid="")
  • WormTox Group("/Rhythmyx/assembler/render?sys_contentid=46946&sys_revision=1&sys_variantid=1278&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="1278" sys_dependentid="46946" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="46946" sys_siteid="" sys_folderid="")

Raymond R. Tice, Ph.D.

Raymond R. Tice, Ph.D. is Chief of the NTP Biomolecular Screening Branch (BSB). The BSB is responsible for coordinating the NTP High Throughput Screening (HTS) Initiative and plays a key role in the efforts of the Tox21 Community, which is an outgrowth of a 2008 Memorandum of Understanding (87KB) between the NTP, the NIH Chemical Genomics Center, and EPA's National Center for Computational Toxicology to collaborate on the research, development, validation, and translation of new and innovative test methods that characterize key steps in toxicity pathways.

 

Tice has served as President of the Environmental Mutagen Society and as Vice-President of the International Association of Environmental Mutagen Societies. He is the recipient of NIH Director's Group Awards for activities associated with the NIH Molecular Libraries Initiative and with the development of the ICCVAM Five-Year Plan (2008-2012). In late 2008, along with Christopher Austin, Ph.D., of the NIH Chemical Genomics Center and Robert Kavlock, Ph.D., of EPA's National Center for Computational Toxicology, Tice received the North American Alternative Award from the Humane Society of the United States for "outstanding scientific contributions to the advancement of viable alternatives to animal testing."

 

During his career, he has served on over 50 international expert panels and committees that are primarily related genetic toxicology and more recently to validation of alternative test methods. He has published 130 scientific papers and book chapters, edited four symposia proceedings and contributed to 23 electronic review publications, in support of the NTP chemical nomination process, and to 35 NICEATM-ICCVAM publications. Tice is a member of the editorial boards of Mutation Research and Environmental and Molecular Mutagenesis.

 

Tice received his Ph.D. in biology in 1976 from Johns Hopkins University in Baltimore, Maryland. He was employed by the Medical Department at Brookhaven National Laboratory, Upton, New York from 1976 to 1988, and by Integrated Laboratory Sciences, Inc., Durham, North Carolina from 1988 to 2005, where his last position was as Senior Vice-President for Research and Development. He joined NIEHS in 2005 as the Deputy Director of the NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM) (http://iccvam.niehs.nih.gov/) and in 2008 was promoted to Chief of the Biomolecular Screening Branch.

 

Scientific Support Staff

Sharon K. Nichols
Sharon K. Nichols (http://www.niehs.nih.gov/research/atniehs/dntp/assoc/staff/nichols/index.cfm)
Intramural Program Specialist

Tel (919) 541-7992
Fax (919) 541-3647
nicholss2@niehs.nih.gov

Adjuncts

Grace Kissling, Ph.D.
Grace E. Kissling, Ph.D. (http://www.niehs.nih.gov/research/atniehs/labs/bb/staff/kissling/index.cfm)
Staff Scientist

Tel (919) 541-1756
Fax (919) 541-4311
kissling@niehs.nih.gov
Curriculum Vitae (185KB)
Keith R. Shockley, Ph.D.
Keith R. Shockley, Ph.D. (http://www.niehs.nih.gov/research/atniehs/labs/bb/staff/shockley/index.cfm)
Staff Scientist

Tel (919) 541-3033
Fax (919) 541-4311
shockleykr@niehs.nih.gov
Cynthia Smith
Cynthia S. Smith, Ph.D. (http://www.niehs.nih.gov/research/atniehs/labs/pob/staff/cynthia/index.cfm)
Chemist and Chief, Program Operations Branch

Tel (919)541-3473
Fax (919) 541-3687
smith19@niehs.nih.gov

 

 
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Last Reviewed: April 09, 2012