Toxicology / Carcinogenesis
Biostatistics Branch
The following investigators are involved in Toxicology/Carcinogenesis projects: Gregg Dinse, Grace Kissling, Shyamal Peddada, Keith Shockley.
Examples of three general areas of research and various special topics are given below:
Rodent Cancer Bioassays
- Improved statistical analysis of tumor data
- Incorporation and analysis of historical control data
- Analysis of multiple tumor types
- Litter effects in multigenerational perinatal exposure studies
Rodent Toxicity Studies
- Optimal design of dose range finding studies
- Nonlinear dose-response models
- Estimation of toxic equivalency factors (TEFs)
- Analysis of chemical mixtures
- Physiologically based pharmacokinetic (PBPK) models
- Estrous cyclicity analyses
High Throughput Screening (HTS)
- Dose-response modeling
- Experimental design
- Identification of active/inactive compounds
- Mining of results from multiple assays
- Identifying and visualizing correlated activity profiles
