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Toxicology / Carcinogenesis

Biostatistics Branch

The following investigators are involved in Toxicology/Carcinogenesis projects: Gregg Dinse, Grace Kissling, Shyamal Peddada, Keith Shockley.

 

Examples of three general areas of research and various special topics are given below:

 

Rodent Cancer Bioassays

  • Improved statistical analysis of tumor data
  • Incorporation and analysis of historical control data
  • Analysis of multiple tumor types
  • Litter effects in multigenerational perinatal exposure studies

Rodent Toxicity Studies

  • Optimal design of dose range finding studies
  • Nonlinear dose-response models
  • Estimation of toxic equivalency factors (TEFs)
  • Analysis of chemical mixtures
  • Physiologically based pharmacokinetic (PBPK) models
  • Estrous cyclicity analyses

High Throughput Screening (HTS)

  • Dose-response modeling
  • Experimental design
  • Identification of active/inactive compounds
  • Mining of results from multiple assays
  • Identifying and visualizing correlated activity profiles

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