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Clarice R. Weinberg, Ph.D.

Biostatistics Branch

Clarice R. Weinberg, Ph.D.
Clarice R. Weinberg, Ph.D.
Chief, Biostatistics Branch
Tel (919) 541-4927
Fax (919) 541-4311
weinber2@niehs.nih.gov
P.O. Box 12233
Mail Drop A3-03
Research Triangle Park, North Carolina 27709
Delivery Instructions

Research Summary

Epidemiology is one of the best tools for studying human health effects of environmental exposures. However, this tool is inherently imperfect and prone to imprecision and biases. Clarice Weinberg’s research has focused on the development of improved methods for design and analysis that account for sources of bias, missing data, response heterogeneity and mismeasurement in epidemiologic studies. Methodologic research is most fruitful when it arises in the context of real applications to epidemiology. Her extensive collaborations with epidemiologists at NIEHS have inspired nearly all of this work.

 

Weinberg is also interested in developing improved designs and methods of analysis to elucidate the joint etiologic roles of genetic and environmental susceptibility factors. Complex diseases, such as birth defects, heart diseases, neurodegenerative disease and cancer, are caused by time and the combined action of genetic susceptibility factors and exposures. One understudied area is the relation between the prenatal environment and health. Of particular interest is the interplay between genetic factors—both maternal and fetal—and maternal exposures in influencing fetal survival, embryologic development and postnatal long-term health. Methods being developed in this area will be applied to data from an international study of oral clefting and to a study of osteosarcoma, a bone cancer that occurs in childhood.

 

Weinberg is also collaborating with Dale Sandler, Ph.D., Chief of the Epidemiology Branch, in a major cohort study of breast cancer, called the Sister Study. This Study is recruiting 50,000 women who are sisters of women with breast cancer. The sisters will be followed prospectively for incidence of breast cancer and other diseases. This cohort design takes advantage of the fact that sisters have an increased prevalence of susceptibility genes, and this enrichment will markedly enhance the research team’s statistical power for detecting gene-by-environment interactions, compared to a similarly-sized random cohort of women.

 

Weinberg and colleagues are now undertaking a new study, called the Two Sister Study, with funding from Susan G. Komen for the Cure. This study, which uses a family-based design, builds on the Sister Study  cohort by recruiting some 1,600 families where one sister is already a member of the Sister Study and the sister who had breast cancer was recently diagnosed and was under the age of 50 at diagnosis. DNA, household dust samples, and extensive questionnaire data will allow elucidation of the role of interacting environmental and genetic factors in the development of young-onset disease. Parents will also be asked to contribute DNA via a mail-back saliva collection kit. Follow-up of the affected sisters over the coming years will also allow better characterization of factors that contribute to healthy survival following treatment for cancer.

Software

  • Case Control
    ("/Rhythmyx/assembler/render?sys_contentid=56407&sys_revision=1&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="56407" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="56407" sys_siteid="" sys_folderid="")This archive provides information for fitting log-linear models and carrying out statistical tests for a design that includes two samples from the same population: one sample of affected individuals and their mothers and a second sample of unaffected individuals and their mothers.
  • coMotif ("/Rhythmyx/assembler/render?sys_contentid=34836&sys_revision=3&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="34836" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="34836" sys_siteid="" sys_folderid="")
    A three-component mixture framework to model the joint distribution of two motifs as well as the situation where some sequences contain only one or none of the motifs.
  • Ctrl-mom-hybrid
    ("/Rhythmyx/assembler/render?sys_contentid=56408&sys_revision=1&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="56408" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="56408" sys_siteid="" sys_folderid="")This archive provides information for fitting log-linear models and carrying out statistical tests for a hybrid design that includes a sample of affected individuals and their parents and a sample of unaffected individuals and their mothers (case-parent triad/control-mother dyad design).
  • Extracting Patterns and Identifying co-expressed Genes (EPIG)
    ("/Rhythmyx/assembler/render?sys_contentid=34840&sys_revision=5&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="34840" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="34840" sys_siteid="" sys_folderid="")A method for Extracting microarray gene expression Patterns and Identifying co-expressed Genes.
  • GEI-TRIMM
    ("/Rhythmyx/assembler/render?sys_contentid=56417&sys_revision=1&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="56417" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="56417" sys_siteid="" sys_folderid="")This package includes the program GEI-TRIMM, which implements the method described in the manuscript Shi M, Umbach DM, Weinberg CR 2010 "Testing Haplotype-Environment Interactions Using Case-parent Triads."
  • Hybrid Design
    ("/Rhythmyx/assembler/render?sys_contentid=34981&sys_revision=3&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="34981" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="34981" sys_siteid="" sys_folderid="")Provides information for fitting log-linear models and carrying out statistical tests.
  • LEM scripts
    ("/Rhythmyx/assembler/render?sys_contentid=56421&sys_revision=1&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="56421" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="56421" sys_siteid="" sys_folderid="")This archive provides information for fitting log-linear models and carrying out statistical tests for preterm birth study.
  • Lem Scripts Case-Sibling (http://www.niehs.nih.govhttp://edit:9992/Rhythmyx/assembler/render?sys_authtype=0&sys_variantid=567&sys_revision=1&sys_contentid=75459&sys_context=0)
    This package contains R scripts for analyzing case-sibling data using missing-parents approach as described in the manuscript Shi M, Umbach DM, Weinberg CR 2012 "Case-sibling studies that acknowledge unstudied parents and enroll unmatched individuals".
  • R-SCRIPTS
    ("/Rhythmyx/assembler/render?sys_contentid=56430&sys_revision=1&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="56430" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="56430" sys_siteid="" sys_folderid="")This package contains two R scripts for generating scenarios 1-4 described in the manuscript Shi M, Weinberg CR 2011 "How much are we missing in SNP-by-SNP analyses of GWAS?"
  • SAS Code to Fit Genetic Models
    ("/Rhythmyx/assembler/render?sys_contentid=56439&sys_revision=1&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="56439" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="56439" sys_siteid="" sys_folderid="")Various SAS code for identifying genes related to a quantitative trait, incorporating multiple siblings and missing parents.
  • TRIad Multi-Marker
    ("/Rhythmyx/assembler/render?sys_contentid=35906&sys_revision=3&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="35906" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="35906" sys_siteid="" sys_folderid="")Performs association tests for a child's or mother's genetic effects using multiple markers from triad families.
  • TRIMMEST
    ("/Rhythmyx/assembler/render?sys_contentid=56435&sys_revision=1&sys_variantid=639&sys_context=0&sys_authtype=0&sys_siteid=&sys_folderid=" sys_dependentvariantid="639" sys_dependentid="56435" inlinetype="rxhyperlink" rxinlineslot="103" sys_dependentid="56435" sys_siteid="" sys_folderid="")This package contains programs that fit log-linear models to estimate the relative risk associated with a candidate risk haplotype in a triad-based association study.

Selected Publications

  1. Umbach DM, Weinberg CR. Designing and analyzing case-control studies to exploit independence of genotype and exposure. Statistics in Medicine 1997; 16:1731-1743.[Abstract ]  
  2. Rockhill, B., Newman, B., and Weinberg, C.R.  Use and misuse of population attributable fractions.  American Journal of Public Health, 88(1): 15-19, 1998.[Abstract ]  
  3. Weinberg, C.R., Wilcox, A.J. and Lie, R.T.  A log-linear approach to case-parent triad data:  Assessing effects of disease genes that act directly or through maternal effects, and may be subject to parental imprinting.  American Journal of Human Genetics, 62(4): 969-978, 1998.[Abstract ]  
  4. Wilcox, A.J., Weinberg, C.R. and Lie, R.T. Distinguishing the effects of maternal and offspring genes through studies of 'case-parent triads.'  American Journal of Epidemiology, 148(9): 893-901, 1998.[Abstract ]  
  5. Weinberg, C.R. and Umbach, D.M. Using pooled exposure assessment to improve efficiency in case-control studies. Biometrics, 55(3): 718-726, 1999.[Abstract ]  
  6. Wilcox, A.J., Baird, D.D. and Weinberg, C.R. Time of implantation of the conceptus and loss of pregnancy. New England Journal of Medicine, 340(23): 1796-9, 1999.[Abstract ]  
  7. Weinberg, C.R. Allowing for missing parents in genetic studies of case-parent triads. American Journal of Human Genetics 64(4): 1186-1193, 1999.[Abstract ]  
  8. Janowsky, E.C., Lester, G.E., Weinberg, C.R., Millikan, R.C., Schildkraut, J. M., Garrett, P.A., Hulka, B.S. The association between low levels of 1,25-dihydroxy vitamin D and breast cancer risk. Public Health Nutrition, 2(3): 283-91, 1999.[Abstract ]  
  9. Weinberg, C.R. Methods for detecting parent-of-origin effects in genetic studies of case-parents triads. American Journal of Human Genetics, 65: 229-235, 1999.[Abstract ]  
  10. Umbach DM, Weinberg CR . The use of case-parent triads to study joint effects of genotype and exposure. American Journal of Human Genetics 2000; 66:251-261, 2000.[Abstract ]  
  11. Weinberg, C.R. and Dunson, D.B. Some issues in assessing human fertility. Invited Millennial vignette, Journal of the American Statistical Association, 95(449): 300-303, 2000.  
  12. Dunson, D. and Weinberg, C.R. Modeling human fertility in the presence of measurement error. Biometrics, 56:288-92, 2000.[Abstract ]  
  13. Dunson, D.B. and Weinberg, C.R. Accounting for unreported and missing intercourse in human fertility studies. Statistics in Medicine, 19: 665-79, 2000.[Abstract ]  
  14. Weinberg, C.R. and Umbach, D.M. Choosing a retrospective design to assess joint genetic and environmental contributions to risk. American Journal of Epidemiology, 152(3): 197-203, 2000[Abstract ]  
  15. Dunson, D.B., Weinberg, C.R., Baird, D.D., Kesner, J., and Wilcox, A.J. Assessing human fertility using several markers of ovulation.  Statistics in Medicine20(6): 965-78, 2001.[Abstract ]  
  16. Dunson, D.B. Weinberg, C.R. and Wilcox, A.J. Modelling multiple ovulation, fertilization, and embryo loss in human fertility studies. Biostatistics, 2(2): 131-145, 2001.[Abstract ]  
  17. Rieger, R., Kaplan, N. and Weinberg, C.R. Efficient use of sibling data for testing for linkage and association.  Genetic Epidemiology, 20(2): 175-91, 2001.[Abstract ]  
  18. Li, L., Darden, T.A., Weinberg, C.R., Levine, A.J. and Pedersen, L.G.  Gene assessment and sample classification for gene expression data using a genetic algorithm/k-nearest neighbor method. Combinatorial Chemistry and High Throughput Screening, 4(8): 727-39, 2001.[Abstract ]  
  19. Weinberg, C.R.  It's time to rehabilitate the P-value.  Invited editorial, Epidemiology, 12(3): 288-290,  2001.[Abstract ]  
  20. Hoffman, Elaine Borland, Sen, P.K., and Weinberg, C.R.  Within-cluster resampling. Biometrika, 88(4):1121-34, 2001.  
  21. Schroeder, J. and Weinberg, C.R.  Use of missing-data methods to correct bias and improve precision in case-control studies where cases are subtyped but subtype information is incomplete. American Journal of Epidemiology, 154(10): 954-62, 2001.[Abstract ]  
  22. Li, L., Weinberg, C.R., Darden, T.A. and Pedersen, L.G.  Gene selection for sample classification based on gene expression data:  study of sensitivity  to choice of parameters of the GA/KNN method. Bioinformatics, 17(12): 1131-42, 2001.[Abstract ]  
  23. Rieger, R. and Weinberg, C.R. Analysis of clustered binary outcomes using within-cluster paired resampling. Biometrics, 58:332-341, 2002.[Abstract ]  
  24. Infante-Rivard, C., Rivard, G-E, Yotov, W., Genin, E., Guiguet, M., Weinberg, C., Gauthier R., Feoli-Fonseca, J-C  Absence of association of thrombophilic polymorthisms with intrauterine growth restriction. New England Journal of Medicine347(1): 19-25, 2002.[Abstract ]  
  25. Basso, O., Weinberg, C.R., Wilcox, A.J., Baird D.D., Olsen J.  Subfecundity as a correlate of pre-eclampsia:  A study within the Danish National Birth Cohort.  American Journal of Epidemiology, 157(3):195-202 2003.[Abstract ]  
  26. Baird, D.D., Weinberg, C.R., McConnaughey, D.R., and Wilcox, A.J. Rescue of the corpus luteum in human pregnancy. Biology of Reproduction, Feb; 68(2):448-56, 2003.[Abstract ]  
  27. Weinberg, C.R.  Studying parents and grandparents to assess genetic contributions to early-onset disease.  American Journal of Human Genetics, 72(2):438-47, 2003.[Abstract ]  
  28. Peddada, S.D., Lobenhofer, E.K., Li, L., Afshari, C.A., Weinberg, C.R., Umbach, D.M.  Gene selection and clustering for time-course and dose-response microarray experiments using order-restricted inference. Bioinformatics, 19(7):834-41, 2003.[Abstract ]  
  29. Weinberg, C.R. and Morris, R.  Invited Commentary:  Testing for Hardy-Weinberg disequilibrium using a genome SNP scan based on cases only.   American Journal of Epidemiology, 158(5):401-3, 2003.[Abstract ]  
  30. Harville, E.W., Wilcox, A.J., Baird, D.D., and Weinberg, C.R. Vaginal bleeding in very early pregnancy. Human Reproduction, 18(9): 1944-7, 2003.[Abstract ]  
  31. Weinberg, C.R. Invited Commentary:  Making the most of genotype asymmetries. American Journal of Epidemiology, 158(11): 1033-5, 2003.[Abstract ]  
  32. Basso, O., Wilcox, A.J., Baird, D.D., Weinberg, C.R., and Olsen, J.  Height and risk of severe pre-eclampsia: A study within the Danish National Birth Registry. International Journal of Epidemiology, 33(4): 858-63, 2004.[Abstract ]  
  33. Kistner, E.O. and Weinberg, C.R. A method for using complete and incomplete trios to identify genes related to a quantitative trait. Genetic Epidemiology, 27(1): 33-42, 2004.[Abstract ]  
  34. Liu, D., Umbach, D., Peddada, S., Li, L., Crockett, P., Weinberg, C.R. A random-periods model for expression of cell-cycle genes.  Proceedings of the National Academies of Science, 101(19): 7240-45, 2004.[Abstract ]  
  35. Wilcox, A.J., Baird DD, Weinberg, CR, Dunson, D, McConnaughey, DR., Kesner, J.S. On the frequency of intercourse around ovulation: Evidence for biologic influences.  Human Reproduction, 19(7):1539-43, 2004.[Abstract ]  
  36. Liu, D., Weinberg, C.R. and Peddada, S.D.  A geometric approach to determine association and coherence of the activation times of cell-cycling genes under differing experimental conditions. Bioinformatics, 20(16): 2521-8, 2004.[Abstract ]  
  37. Weinberg, C.R.  Barker meets Simpson.  Invited Commentary, American Journal of Epidemiology161(1): 33-35, 2005.[Abstract ]  
  38. Sallmén, M, Weinberg, CR, Baird, DD, Lindbohm, M-L, Wilcox, AJ.  Has human fertility declined over time?  Why we may never know.  Epidemiology, 16(4): 494-9, 2005.[Abstract ]  
  39. McChesney, R., Wilcox, A.J., O’Connor J.F., Weinberg, C.R., Baird, D.D., Schlatterer, J.P., McConnaughey, D.R., Birken, S., and Canfield R.E.  Urinary analytes of beta-hCG:  Longitudinal patterns during early pregnancy.  Human Reproduction, 20(4): 928-35, 2005.[Abstract ]  
  40. Mitchell, L.E., Weinberg, C.R..  Evaluation of maternal and offspring genetic effects on disease risk using a family-based approach:  The “pent” design. American Journal of Epidemiology, 162(7): 676-85, 2005.[Abstract ]  
  41. Sarkar, K., Weinberg, C.R., Oddis, C.V., Medsger, T.A., Plotz, P.H., Reveille, J.D., Arnett, F.C., Targoff, I.N., Genth, E., Love, L.A., Miller, F.W.  Seasonal influence in the onset of serologic groups of idiopathic inflammatory myopathies. Arthritis and Rheumatism, 52(8): 2433-8, 2005.[Abstract ]  
  42. Kistner, E. and Weinberg, C.R.  A method for identifying genes related to a quantitative trait, incorporating multiple siblings and missing parents.  Genetic Epidemiology, 29(2): 155-65, 2005.[Abstract ]  
  43. Infante-Rivard, C., Weinberg, C.R.  Parent-of-origin transmission of thrombophillic alleles to intrauterine-growth-restricted newborns and transmission-ratio distortion in unaffected newborns.  American Journal of Epidemiology, 162(9): 891-7. 2005.[Abstract ]  
  44. Weinberg, C.R. and Umbach, D.M.  A hybrid design for studying genetic influences on risk of diseases with onset in early life.  American Journal of Human Genetics, 77(4): 627-36, 2005.[Abstract ]  
  45. Infante-Rivard, C., Weinberg, C.R. Guiguet, M.  Xenobiotic-metabolizing genes and small-for-gestational-age births: interaction with maternal smoking.  Epidemiology, 17(1): 38-46, 2006.[Abstract ]  
  46. Krewski D, Lubin JH, Zielinski JM, Alavanja M, Catalan V, Field W, Klotz JB, Letourneau EG, Lynch CF, Lyon JL, Sandler DP, Schoenberg JB, Steck DJ, Stolwijk JA, Weinberg CR, Wilcox HB.  A combined analysis of North American Case-control studies of residential radon and lung cancer. J Tox Env Health, 69(7): 533-97, 2006.[Abstract ]  
  47. Sandler, D.P., Weinberg, C.R., Shore, D.L., Archer, V.E., Bishop-Stone, M., Lyon, J.L., Rothney-Kozlak, L., Shepherd, M., Stolwijk, J.A.J. Indoor radon and lung cancer risk in Connecticut and Utah. J Tox Env Health, A 69(7):633-54, 2006[Abstract ]  
  48. Kistner, E.O., Infante-Rivard C., Weinberg, C.R.  A method for using incomplete triads to test maternally mediated genetic effects and parent-of-origin effects in relation to a quantitative trait. American Journal of Epidemiology, 163(3): 255-61, 2006.[Abstract ]  
  49. Liu, D., Peddada, S.D., Li, L., Weinberg, C.R. Phase analysis of circadian-related genes in two tissues. BMC Bioinformatics, 2006 Feb 23, 7: 87.[Abstract ]  
  50. Basso, O., Wilcox, A.J. and Weinberg, C.R. Birth weight and mortality:  Causality or confounding? American Journal of Epidemiology, 164(4): 303-11, 2006[Abstract ]  
  51. Howards, P., Hertz-Picciotto, I., Weinberg, C.R. and Poole, C.  Misclassification of gestational age in the study of spontaneous abortion. American Journal of Epidemiology, 164(11): 1126-36, 2006.[Abstract ]  
  52. Basso, O., Rassmussen, S., Weinberg, C.R., Wilcox, A.J., Irgens, L.M., Skjaerven, R. Trends in fetal and infant survival following preeclampsia. Journal of the American Medical Association, 296(11): 1357-62, 2006.[Abstract ]  
  53. Promislow, J.H.E., Baird, D.D., Wilcox, A.J., Weinberg, C.R. Bleeding following pregnancy loss prior to six weeks gestation. In press, Human Reproduction, 2007.[Abstract ]  
  54. Rampersaud, E., Morris, R.W., Weinberg, C.R., Speer, M.C. and Martin, E.R.  Power calculations for likelihood ratio tests for genetic risks, maternal effects and parent-of-origin (POO) effects in the presence of missing parental genotypes when unaffected siblings are available. Genetic Epidemiology, 31(1): 18-30, 2007.[Abstract ]  
  55. Shi, M., Christensen, K., Weinberg, C.R., Romitti, P., Bathum, L., Lozada, A., Murray, J.C.  Comprehensive gene environment interaction analysis of 16 genes involved in detoxification pathways in the causes of orofacial clefts. American Journal of Human Genetics 80(1): 76-90, 2007.[Abstract ]  
  56. Infante-Rivard, C., Vermunt, J.K., Weinberg, C.R. Excess transmission of the NQ01 C609T allele in families of children with acute lymphoblastic leukemia.  In press, American Journal of Epidemiology, 2007.  
  57. Weinberg, C.R., Shore, D., Umbach, D.M., and Sandler, D.P. Using risk-based sampling to enrich cohorts for endpoints, genes and exposures.  In press, American Journal of Epidemiology, 2007.  
  58. Vegosen, L.J., Weinberg, C.R., O'Hanlon, T.P., Targoff, I.T., Miller, F.W., Rider, L.G. Seasonal birth patterns in subgroups of myositis suggest a role for early environmental exposures in etiology. Arthritis and Rheumatism, 8: 2719-2729, 2007.[Abstract ]  
  59. Jukic, A.M.Z., Weinberg, C.W., Baird, D.D., Wilcox, A.J. Life-study and reproductive factors associated with follicular phase length. Journal of women's health (2002) 16(9):1340-1347, 2007.[Abstract ]  
  60. Jukic, A.M.Z., Weinberg, C.W., Wilcox, A.J., McConnaughey, D.R., Hornsby, P.P., Baird, D.D. Accuracy of reporting of menstrual cycle length. American journal of epidemiology 167(1):25-33, 2008.[Abstract ]  
  61. Nepomnaschy, P.A., Weinberg, C.R., Wilcox, A.J., Baird, D.D. Urinary hCG patterns during the week following implantation. Human reproduction (Oxford, England) 23(2):271-277, 2008.[Abstract ]  
  62. Shi, M., Umbach, D.M., Vermeulen, S.H., Weinberg, C.R. Making the most of case-mother/control-mother studies. American journal of epidemiology 168(5):541-547, 2008.[Abstract ]
  63. Boyles, A.L., Wilcox, A.J., Taylor, J.A., Shi, M., Weinberg, C.R., Meyer, K., Fredriksen Å, Ueland, P.M., Johansen, A.M., Drevon, C.A., Jugessur, A., Trung, T.N., Gjessing, H.K., Vollset, S.E., Murray, J.C., Christensen, K., Lie, R.T. Oral facial clefts and gene polymorphisms in metabolism of folate/one-carbon and vitamin A: a pathway-wide association study. Genetic Epidemiology 33(3):247-255, 2009.[Abstract ]  
  64. Shi, M., Umbach D.M., Weinberg C.R. Using case-parent triads to estimate relative risks associated with a candidate haplotype. Annals of human genetics, 73(Pt 3):346-359, 2009.[Abstract ]  
  65. Nepomnaschy, P.A., Baird, D.D., Weinberg, C.R., Hoppin, J.A., Longnecker, M.P., Wilcox, A.J. Within-person variability in urinary bisphenol A concentrations: Measurement from specimens after long-term frozen storage. Environmental research 109(6):734-737, 2009.[Abstract ]  
  66. Baird, D.D., Saldana, T.M., Nepomnaschy, P.A., Hoppin, J.A., Longnecker, M.P., Weinberg, C.R., Wilcox, A.J. Within-person variability in urinary phthalate metabolite concentrations: Measurements from specimens after long-term frozen storage. Journal of exposure science & environmental epidemiology 20(2):169-175, 2010.[Abstract ]  
  67. Jukic, A.M.Z., Weinberg, C.R., Wilcox, A.J., Baird, D.D. Effects of early pregnancy loss on hormone levels in the subsequent menstrual cycle. Gynecological endocrinology 26(12):897-901, 2010.[Abstract ]  
  68. Wacholder, S., Han, S., Weinberg, C.R. Inference from a multiplicative model of joint genetic effects or ovarian cancer risk. Journal of the National Cancer Institute 103(2):82-83, 2011.[Abstract ]  
  69. Jukic, A.M.Z., Weinberg, C.R., Baird, D.D., Wilcox, A.J. The association of maternal factors with delayed implantation and the initial rise of urinary human chorionic gonadotropin. Human Reproduction 26(4):920-926, 2011.[Abstract ]  
  70. Shi, M., Umbach, D.M., Weinberg, C.R. Family based Gene-by-Environment Interaction Studies: Revelations and Remedies. Epidemiology (Cambridge, Mass.) 22(3):400-407, 2011.[Abstract ]  
  71. Shi, M., London, S.J., Chiu, G.Y., Hancock, D.B., Zaykin, D., Weinberg, C.R. Using imputed genotypes for relative risk estimation in case-parent studies. American journal of epidemiology 173(5):553-559, 2011.[Abstract ]
  72. Saha-Chaudhuri P, Umbach DM, Weinberg CR. Pooled Exposure Assessment for Matched Case-Control Studies. Epidemiology 22(5):704-712, 2011.[Abstract ]
  73. Xu M, Weinberg CR, Umbach DM, Li L. coMOTIF: A method for Identifying Transcription Co-regulator Binding Sites in ChIP-seq Data. Bioinformatics (Oxford, England), 2011, 27(19):2625-2632.[Abstract ]  
  74. Wilcox AJ, Weinberg CR, Basso O. On the Pitfalls of Adjusting for Gestational Age at Birth. American journal of epidemiology, 2011, 174(9):1062-1068.[Abstract ]  
  75. Weinberg, C.R., Shi, M., Umbach, D.M. A sibling-augmented case-only approach for assessing multiplicative gene-environment interactions. American journal of epidemiology  174(10):1183-1189, 2011.[Abstract ]  
  76. Shi M, Weinberg CR. How much are we missing in SNP-by-SNP analyses of genome-wide association studies?. Epidemiology (Cambridge, Mass.) 22(6):845-847, 2011.[Abstract ]
  77. Kim S, Sandler DP, Carswell G, De Roo LA, Parks CG, Cawthon R, Weinberg CR, Taylor JA. Telomere length in peripheral blood and breast cancer risk in a prospective case-cohort analysis: results from the Sister Study. Cancer causes & control 22(7):1061-6, 2011.[Abstract ]
  78. Kim S, Sandler DP, Carswell G, Weinberg CR, Taylor JA. Reliability and short-term intra-individual variabiltiy of telomere length measurement using monochrome multiplexing quantitative PCR. PloS one 6(9):e25774, 2011.[Abstract ]
  79. Weinberg CR, Shi M, Umbach DM. Re.: "Genetic association and gene-environment interaction: a new method for overcoming the lack of exposure information in controls". American journal of epidemiology  173(11):1346-7, 2011.[Abstract ]
  80. Weinberg CR. An Editor Replies: Graphical scales and public health relevance. American journal of epidemiology  174(3):377-, 2011.
  81. Weinberg CR. Interaction and exposure modification: Are we asking the right questions? American journal of epidemiology 2012 175(7):602-5.[Abstract ]
  82. Howards PP, Schisterman EF, Poole C, Kaufman JS, Weinberg CR. "Toward a clearer definition of confounding" revisited with directed acyclic graphs. American journal of epidemiology 176(6):506-11, 2012.[Abstract ]
  83. Fei C , Deroo LA, Sandler DP, Weinberg CR. Fertility drugs and young-onset breast cancer: Results from the Two Sister Study. Journal of the National Cancer Institute 104(13):1021-7, 2012.[Abstract ]
  84. Fei C, Weinberg C, Olsen J. Commentary: perfluorinated chemicals and time to pregnancy: a link based on reverse causation? Epidemiology (Cambridge, Mass.) 23(2):264-6, 2012.[Abstract ]
  85. Weinberg CR. Commentary: thoughts on assessing evidence for gene by environment interaction. International journal of epidemiology 41(3):705-7, 2012.[Abstract ]
  86. Fei C, DeRoo LA, Sandler DP, Weinberg CR. Menopausal symptoms and the risk of young-onset breast cancer. European journal of cancer 49(4):798-804, 2012.
    [Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=23021929) ]
  87. Shi M, Umbach DM, Weinberg CR. Case-sibling studies that acknowledge unstudied parents and enroll unmatched individuals. International journal of epidemiology 42(1):298-307, 2013.[Abstract ]
  88. D'Aloisio AA, DeRoo LA., Baird DD, Weinberg CR, Sandler DP. Prenatal and infant exposures and age at menarche. Epidemiology (Cambridge, Mass.) 24(2):277-284, 2013. [Abstract ]
  89. Lin D, Weinberg CR, Feng R, Hochner H, Chen J. A multi-locus likelihood method for assessing parent-or-origin effects using case-control mother-child pairs. Genetic Epidemiology 37(2):152-162, 2013.[Abstract ]
  90. Xu Z, Bolick SCE, DeRoo LA, Weinberg CR, Sandler DP, Taylor JA. DNA methylation in blood is associated with breast cancer: A study in prospective samples from the Sister Study. Journal of the National Cancer Institute 105(10):694-700, 2013.[Abstract ]
  91. Jukic AMZ, Baird DD, Weinberg CR, McConnaughey DR, Wilcox AJ. Length of human pregnancy and contributors to its natural variation. Human reproduction (Oxford, England) 28(10):2848-2855, 2013.[Abstract ]
  92. DeRoo LA, Bolick SCE, Xu Z, Umbach DM, Shore D, Weinberg CR, Sandler DP, Taylor JA. Global DNA methylation and one-carbon metabolism gene polymorphisms and the risk of breast cancer in the Sister Study. Carcinogenesis 35(2):333-338, 2014.[Abstract ]
  93. Dinse GE, Jusko TA, Ho LA, Annam K, Graubard BI, Hertz-Picciotto I, Miller FW, Gillespie BW, Weinberg CR. Accommodating measurements below a limit of detection: a novel application of cox regression. American journal of epidemiology 2014 179(8):1018-1024.[Abstract ]
  94. Weinberg C.R., Shi M., DeRoo L., Taylor J.A., Sandler D.P., Umbach D.M. Asymmetry in family history implicates nonstandard genetic mechanisms: application to the genetics of breast cancer. PLoS genetics 10(3):e1004174, 2014.[Abstract ]


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