Biostatistics & Computational Biology Branch
Liang Niu, Ph.D.
Fellow – Research
Liang Niu, Ph.D., joined NIEHS in August 2012, and is currently a research fellow under the supervision of Leping Li, Ph.D. His primary research interest is in statistical genomics. Niu obtained a Ph.D. in biostatistics in 2012 and a Ph.D. in mathematics in 2008 from The Ohio State University. His primary research interest is in statistical genomics, and his most recent research focuses on statistical modeling of long-range chromatin interactions using data from Chromatin Interaction Analysis by Paired-End Tag Sequencing (ChIA-PET) or modified Hi-C assay.
Chromosome conformation capture (3C) and its derivatives (4C, 5C, ChIA-PET and Hi-C) can be used to study long-range chromatin interactions. Niu and his colleagues proposed a Bayesian framework to model the counts data from ChIA-PET or modified Hi-C data to study the chromatin interactions mediated by a protein of interest.
- Li Y, Huang W, Niu L, Umbach DM, Covo S, Li L. Characterization of constitutive CTCF/cohesin loci: a possible role in establishing topological domains in mammalian genomes, BMC Genomics. 2013; 14:553.[Abstract]