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Your Environment. Your Health.

Andrew A. Rooney

Health Assessment and Translation

Andy Rooney, Ph.D.
Andrew A. Rooney, Ph.D.
Deputy Director, Office of Health Assessment and Translation
Tel (919) 541-2999
Fax (301) 480-3299


Andrew Rooney, Ph.D., is deputy director of the Office of Health Assessment and Translation in the National Toxicology Program at NIEHS. He provides NTP with expertise in risk assessment and weight of evidence considerations for the protection of public health.


Rooney has been actively involved in the development of immunotoxicity risk assessment guidance throughout his government career.  He is a workgroup member and author of the World Health Organization (WHO)/International Programme on Chemical Safety (IPCS) draft Guidance for Immunotoxicity Risk Assessment for Chemicals that is scheduled to be finalized in 2012.  Rooney is lead author of the Immunotoxicity Risk Assessment Chapter of the IPCS guidance and co-author of three of the case studies (halogenated platinum-salts, mercury, and trichloroethylene) used to illustrate application of the guidance and present immunotoxicity risk assessments.


Rooney received his Sc.B (Honors) in Biology from Brown University, and completed his graduate training at the University of Florida, earning a M.S. and Ph.D. in Zoology.  He was awarded a National Research Grant of Canada and served as a postdoctoral research fellow in immunotoxicology at the University of Quebec, INRS-SANTÉ from 1999-2000.  Rooney began working at the US EPA as a postdoctoral fellow jointly with EPA and North Carolina State University performing his research in the Immunotoxicology Branch of the National Health and Environmental Effects Laboratory (NHEERL) from 2000-2003.  He later joined the US EPA’s Integrated Risk Information System Staff, and served as an immunotoxicology expert for the National Center for Environmental Assessment and the IRIS Program.


Rooney has contributed to numerous human health risk assessments and his work has resulted in authorship on more than 10 published final US EPA Integrated Risk Information System (IRIS) Toxicological Reviews.  He is an author on more than 20 articles in peer-reviewed scientific journals and 10 book chapters in the fields of risk assessment, immunotoxicology, reproductive, and developmental toxicology.


Selected Publications

  • Boyles AL, Harris SF, Rooney AA, and Thayer KA. 2011. Forest Plot Viewer: a fast, flexible graphing tool. Epidemiology 22(5): 746-747.[Abstract ]
  • Rooney AA, Yang Y, and Makris SL. 2008. Recent progress and diverse effects in developmental immunotoxicology:  overview of a symposium at the 46th Annual SOT Meeting, Charlotte, NC.  J Immunotoxicology 5(4):395-400.[Abstract ]
  • Rooney AA, Mattie DR, and Dodd DE. 2006.  Introduction - Toxicology and Risk Assessment Conference 2005. J Toxicol Environ Health A 69: 771-775.
  • Rooney1 AA, Pillet1 S, Bouquegneau J-M, Cyr DG, and Fournier M. (2005) Sex-specific effects of neonatal exposures to low levels of cadmium through maternal milk on development and immune functions of juvenile and adult rats. Toxicology 209(3): 289-301. note: 1both authors contributed equally.[Abstract ]
  • Rooney AA, Crain DA, Woodward A, and Guillette LJ, Jr. 2004. Seasonal variation in plasma sex steroid concentrations in juvenile American alligators. Gen Comp Endo 135(1): 25-34.[Abstract ]
  • Rooney AA, Matulka RA, and Luebke RW. 2003. Developmental atrazine exposure suppresses immune function in male, but not female Sprague-Dawley rats. Tox Sci 76(2): 366-375.[Abstract ]
  • Rooney AA, Fournier M, Bernier J and Cyr DG. 2003. Neonatal exposure to propylthiouracil (PTU) induces a shift in lymphoid cell sub-populations in the developing postnatal male rat spleen and thymus. Cell Immunol 223(2): 91-102.[Abstract ]
  • Rooney AA, Bermudez DS, and Guillette LJ, Jr. 2003. Altered histology of the thymus and spleen in contaminant-exposed juvenile American alligators. J Morph 256(3): 349-359.[Abstract ]
  • St-Pierre N, Dufresne J, Rooney AA and Cyr DG. 2003. Neonatal hypothyroidism alters the localization of gap junctional protein connexin 43 in the testis and messenger RNA levels in the epididymis of the rat. Biol Reprod 68(4): 1232-1240.[Abstract ]
  • Milnes MR, Woodward AR, Rooney AA and Guillette LJ, Jr. 2002. Plasma steroid concentrations in relation to size and age in juvenile alligators from two Florida lakes. Comp Biochem Physiol A Mol Integr Physiol 131(4): 923-930.[Abstract ]
  • Guillette LJ, Jr., Crain DA, Gunderson M, Kools S, Milnes MR, Orlando EF, Rooney AA and Woodward AR. 2000.  Alligators and endocrine disrupting contaminants: A current perspective. Am Zool 40:438-452.
  • Pickford DB, Guillette LJ, Jr., Crain DA, Rooney AA, and Woodward AR, 2000. Plasma dihydrotestosterone concentration and phallus size in juvenile American Alligators (A. mississippiensis) from contaminated and reference populations. J Herpetol 34: 233-239.
  • Burger J, Gochfeld M, Rooney AA, Orlando EF, Woodward AR, and Guillette LJ, Jr. 2000. Metals and metalloids in tissues of American alligators in three Florida lakes. Arch Environ Contam Toxicol 38(4):501-508.[Abstract ]
  • Guillette, LJ, Jr., Woodward AR, Crain DA, Pickford DB, Rooney AA and Percival HF. 1999. Plasma steroid concentrations and male phallus size in juvenile alligators from seven Florida lakes. Gen Comp Endocrinol 116(3): 356-372.[Abstract ]
  • Guillette LJ, Jr., Brock JW, Rooney AA, and Woodward AR. 1999. Serum concentrations of various environmental contaminants and their relationship to sex steroid concentrations and phallus size in juvenile American alligators. Archives of Environmental Contamination and Toxicology 36(4): 447-455.[Abstract ]
  • Crain DA, Guillette LJ, Jr., Rooney AA, and Pickford DB. 1997. Alterations in steroidogenesis in alligators (Alligator mississippiensis) exposed naturally and experimentally to environmental contaminants. Environ Health Perspect 105(5):528-533.[Abstract ]
  • Guillette LJ, Jr., Crain DA, Rooney AA, and Woodward AR. 1997. Effect of Acute Stress on Plasma Concentrations of Sex and Stress Hormones in Juvenile Alligators Living in Control and Contaminated Lakes. J Herpetol 31: 347-353.
  • Guillette LJ, Jr., Pickford DB, Crain DA, Rooney AA, and Percival HF. 1996. Reduction in penis size and plasma testosterone concentrations in juvenile alligators living in a contaminated environment. Gen Comp Endocrinol 101(1): 32-42.[Abstract ]
  • Guillette LJ, Jr., Crain DA, Rooney AA, and Pickford DB. 1995. Organization versus activation: the role of endocrine-disrupting contaminants (EDCs) during embryonic development in wildlife. Environ Health Perspect 103 (Suppl 7): 157-164.[Abstract ]

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