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Crystal structure of UvrB

DNA repair

The crystal structure of UvrB
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Slide 1 is the crystal structure of UvrB. The different colors show different domains. UvrB is folded like a large family of proteins called helicases which work to open up the two strands of DNA. The blue beta-hairpin suggested a site for DNA binding.


DNA tracks close to the beta-hairpin
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When the structure of UvrB was compared to other helicases that had been crystalized with DNA we found that the DNA tracks close to the beta-hairpin (slide 2).


DNA tracks along the surface of the protein
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The final slide shows how we believe the DNA tracks along the surface of the protein.
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Last Reviewed: June 21, 2007