Crystal structure of UvrB
Slide 1 is the crystal structure of UvrB. The different colors show different domains. UvrB is folded like a large family of proteins called helicases which work to open up the two strands of DNA. The blue beta-hairpin suggested a site for DNA binding.
When the structure of UvrB was compared to other helicases that had been crystalized with DNA we found that the DNA tracks close to the beta-hairpin (slide 2).
The final slide shows how we believe the DNA tracks along the surface of the protein.