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Crystal structure of UvrB

DNA repair

 

Slide 1 is the crystal structure of UvrB. The different colors show different domains. UvrB is folded like a large family of proteins called helicases which work to open up the two strands of DNA. The blue beta-hairpin suggested a site for DNA binding. 

 

 When the structure of UvrB was compared to other helicases that had been crystalized with DNA we found that the DNA tracks close to the beta-hairpin (slide 2).

 

The final slide shows how we believe the DNA tracks along the surface of the protein.

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