Environmental Factor, January 2010, National Institute of Environmental Health Sciences
Dan Littman Will Give Next Distinguished Lecture
By Eddy Ball
The NIEHS 2009-2010 Distinguished Lecture Series will feature a talk January 19 by Dan Littman, M.D., Ph.D., on the "Role of Environmental and Intrinsic Factors in the Differentiation of Inflammatory T Cells." Hosted by NIEHS Laboratory of Respiratory Biology Principal Investigators Anton Jetten, Ph.D(http://www.niehs.nih.gov/research/atniehs/labs/lrb/cell-bio/index.cfm)., and Donald Cook, Ph.D.(http://www.niehs.nih.gov/research/atniehs/labs/lrb/immuno-gen/index.cfm), Littman's lecture begins at 11:00 a.m. in the Rodbell Auditorium at NIEHS.
Littman(http://pathology.med.nyu.edu/people/faculty/littman-dan-r) is the Helen L. and Martin S. Kimmel Professor of Molecular Immunology and professor of Pathology and Microbiology at the New York University (NYU) School of Medicine. He is also an investigator in the Howard Hughes Medical Institute Program in Molecular Pathogenesis of the Skirball Institute of Biomolecular Medicine(http://saturn.med.nyu.edu/) at the NYU Langone Medical Center.
Expert in the field of T lymphocyte development and retroviral pathogenesis
His laboratory(http://saturn.med.nyu.edu/research/mp/littmanlab/researchmain.html) investigates the molecular events underlying T lymphocyte differentiation and activation, and how the human immunodeficiency virus (HIV) causes systemic depletion of helper T cells. In both areas, he studies the functions of T cell surface molecules and their interactions with intracellular signal transducing components.
In addition, his lab has been in the forefront of studies determining the role of several transcription factors, including the retinoid-related orphan receptor ROR-gt, in T cell lineage determination and the potential of ROR-gt as a target in the treatment of autoimmune disease. Littman consistently publishes in top tier journals and is frequently invited to present his work at international meetings.