Environmental Factor, October 2009, National Institute of Environmental Health Sciences
Upcoming Distinguished Lecturer Teresa Wang
By Eddy Ball
Teresa Wang, Ph.D., will present the next talk in the 2009-2010 NIEHS Distinguished Lecture Series October 26 at 11:00 a.m. in Rodbell Auditorium. Hosted by NIEHS Principal Investigator Bill Copeland, Ph.D.(http://www.niehs.nih.gov/research/atniehs/labs/lmg/mdnar/index.cfm), head of the Mitchondrial DNA Replication Group, Wang's lecture will explore "The Perils of Bad DNA Polymerases: Chromosome Chaos."
Wang (http://med.stanford.edu/profiles/frdActionServlet?choiceId=printerprofile&fid=4110) holds the Klaus Bensch Endowed Professorship in Experimental Pathology in the Department of Pathology at the Stanford University School of Medicine. She describes the long-term goal of her lab research as understanding the molecular mechanisms involved in maintaining genome stability - what trans-acting factors are involved and how they function in the process. According to Wang, the major focuses of her group are to investigate mutator phenotypes induced by aberrant chromosome replication and identify the genetic and biochemical elements that maintain the DNA replication checkpoint.
The group is ultimately striving to characterize the replication mechanisms involved in chromosome instability and the development of cancer - specifically, the replication mutants that have an elevated mutation frequency in deletion or duplication of genomic sequences and the carcinogenic effects of mutations of the S-phase checkpoint gene products in mammalian homolog genes.