Environmental Factor, May 2007, National Institute of Environmental Health Sciences
Upcoming: Zeldin to Give Talk at UNC-CH Medical School
By Eddy Ball
NIEHS Senior Scientist Darryl Zeldin, M.D., will lecture on "Cytochrome P450 Metabolites and Cardiovascular Disease" on May 14 in Chapel Hill. Zeldin is a principal investigator in the Laboratory of Respiratory Biology. He will speak at 12:00 p.m. in G202 in the Medical Biomolecular Research Building at the University of North Carolina, 103 Mason Farm Road.
According to Zeldin, cytochrome P450 epoxygenases such as CYP2J2 metabolize arachidonic acid to epoxyeicosatrienoic acids (EETs) which are converted to dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide hydrolase (EPHX2). Previous work has shown that EETs possess a myriad of potent biological effects within the cardiovascular system.
Studies with CYP2J2 transgenic and Ephx2 null mice confirm that this eicosanoid pathway is involved in maintenance of cardiovascular homeostasis. Recent studies have documented that genetic variation in both the CYP2J2 and EPHX2 genes influences cardiovascular disease risk in humans.
Genetic variation in the EPHX2 gene is associated with increased risk of incident coronary heart disease in a large prospective cohort from the United States. The development of pharmaceuticals which enhance circulating EET levels, either by activating P450 epoxygenases or inhibiting EPHX2, may represent a novel approach to cardiovascular disease prevention and/or treatment.
Zeldin's lecture is sponsored by the UNC School of Medicine. No registration is required for this lecture, and the series is open to the public.