Environmental Factor, May 2007, National Institute of Environmental Health Sciences
Upcoming: Distinguished Lecturer to Discuss Gene Transcription
By Eddy Ball
Bert. W. O'Malley, M.D. will deliver the final talk in the 2006-2007 NIEHS Distinguished Lecture Series on May 22 at 11:00 in Rodbell Auditorium. O'Malley is a professor and the chair of the Department of Molecular/Cell Biology at Baylor College of Medicine. He will address "The Expanding Roles of Nuclear Receptor Coactivators."
O'Malley's lab has cloned and studied a number of different subfamilies of nuclear receptor family coactivators and examined their role in enhancing gene transcription. He describes coactivators as the "boosters" or "amplifiers" of the transcriptional regulation exerted by nuclear receptors and has looked into their role in the epigenetic changes that are involved in tumor development. According to current thinking, steroid receptors/coactivators affect steps in gene expression that include initiation, re-initiation, mRNA processing and termination.
He and his associates recently described for the first time the pathway of a powerful promoter of tumor growth, steroid receptor coactivator 3, and the action of a tumor suppressor molecule REG-gamma - a development that may prove to have important clinical applications in the treatment of breast, prostate and similar cancers.
John Cidlowski, Ph.D., is the lecture host.