Environmental Factor, December 2007, National Institute of Environmental Health Sciences
Upcoming Distinguished Lecture Features Errol C. Friedberg
By Eddy Ball
The 2007-2008 NIEHS Distinguished Lecture Series continues at 11:00 a.m. on December 11 with a talk by Errol C. Friedberg, M.D., titled "Specialized DNA Polymerases in Higher Organisms: Insights from the Polk Knock-Out Mouse." Friedberg's talk will take place in Rodbell Auditorium and be hosted by DNA Replication Fidelity Group Chief Thomas Kunkel, Ph.D., and IRTA Fellow Zachary Pursell, Ph.D., of the Laboratory of Molecular Genetics.
Friedberg holds the Senator Betty and Dr. Andy Andujar Distinguished Chairmanship of Pathology at the University of Texas Southwestern Medical Center at Dallas. He is widely recognized as a leader in the field of DNA damage and repair and as an investigator whose work has contributed to many seminal discoveries in this area of fundamental biomedical research.
By making targeted gene disruptions, Friedberg's lab has developed mouse models for hereditary human diseases. The lab is investigating the predisposition of these mice to various carcinogens, as well as the molecular pathogenesis of cancer in these mouse models. By manipulating expression of translesion DNA polymerases in mice, especially pol kappa (Polk), Friedberg's lab works to increase understanding of the molecular mechanisms by which cells repair and tolerate DNA damage and thereby mitigate against the phenotypic consequences of mutational alterations.