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Under the Microscope: Rob Wine's Research

By NIEHS
August 2005

dentate gyrus granule cell neurons
Given new information regarding the generation of new neurons as a repair mechanism of the adult brain, methods to identify and distinguish mature versus new neurons are being established. In this image of dentate gyrus granule cell neurons from normal mouse hippocampus, mature neurons appear green (NeuN), while recently generated immature neurons are labeled red (Nestin). The blue nuclear counterstain identifies all cells in the region. (Photo by Rob Wine)

Glial cells
Glial cells in the brain are capable of mounting a rapid and vigorous response to injury or inflammation. In this micrograph, reactive and phagocytic microglia, which appear green (lectin+) are removing dead neurons and mediating the inflammatory response. Astrocytes, which are labeled red (GFAP), are thought to play more of a protective, nurturing role in neuronal-glial interactions are widely distributed throughout the hippocampus, primarily around unaffected neurons. Cell nuclei are stained blue. (Photo by Rob Wine)

The following photographs were submitted by Rob Wine, a biologist in the Laboratory of Neurobiology.

neurons
Six hours after receiving a single dose of the hippocampal toxicant, trimethyltin, receptor mediated apoptotic death occurs in neurons in the hippocampus. These neurons express both active caspase 3 (green) and tumor necrosis factor receptor 1 (red). Nissl substance, enriched in neurons, is labeled blue. (Photo by Rob Wine)



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