NIEHS - NCATS - UNC DREAM Toxicogenetics Challenge
An innovative crowdsourced computational Challenge, called the NIEHS-NCATS-UNC DREAM Toxicogenetics Challenge launched on June 11, 2013. The objective of this Challenge was to obtain a greater understanding about how a person’s individual genetics can influence cytotoxic response to exposure to widely used chemicals. It was lead and organized by scientists from Sage Bionetworks, DREAM, the University of North Carolina, the National Institute of Environmental Health Sciences (NIEHS) and the National Center for Advancing Translational Sciences (NCATS).
The Challenge closed on September 15, 2013, and the (top-scoring team(s) ) identified; representatives of these teams have been invited to present their prediction models at the November, 2013 DREAM Conference ( RECOMB/ISCB Conference on Regulatory and Systems Genomics ) taking place in Toronto, Canada.
Read more about the Challenge in the June 11, 2013 press release .
NIEHS Hosts Toxicogenetics Challenge Seminar on December 2, 2013
About 60 scientists gathered Dec. 2 at NIEHS for an informative seminar, "Crowdsourcing Tox21 Qualitative High Throughput Screening Data", focusing on the NIEHS–NCATS–UNC DREAM Toxicogenetics Challenge.
Speakers described the Tox21 project that generated the data used in the Challenge, the innovative approaches employed by the teams that won the two subchallenges, and the value of crowdsourcing to advance and accelerate scientific knowledge.
For more info about the seminar, read the Environmental Factor story
2013 DREAM Conference in November
Winning team members from each subchallenge spoke at the 2013 DREAM Conference, on November 8th in Toronto, Canada, in conjunction with the RECOMB/ISCB Conference on Regulatory and Systems Genomics , one of the premier annual meetings for computational and experimental scientists in the areas of regulatory genomics and systems biology.
NIEHS Deputy Director Richard Woychik, Ph.D. and his colleagues at NIEHS have been instrumental in working with Sage and others to develop and support the Challenges.
Teams from the Quantitative Biomedical Research Center (QBRC) at the University of Texas Southwestern Medical Center (UTSW) were named best performer in both of the subchallenges. Team Yang Lab, represented in Toronto by Ph.D. student Tao Wang, took the honors for subchallenge 1. Team QBRC, also represented in Toronto by Tao Wang, on behalf of assistant professor Hao Tang, Ph.D., came in first in subchallenge 2. Associate professor Yang Xie, Ph.D., was also there to accept the award. The second best performer for subchallenge 1 was Team Cassis from the Centre for Computational Biology in Paris, which was represented at the conference by team member Elsa Bernard, a Ph.D. student at the Institut Curie one of the Centre’s joint laboratory member institutions.
Partnership with Nature Biotechnology
Nature Biotechnology has agreed to support the submission and peer review of an overview paper describing the NIEHS/NCATS/UNC DREAM Toxicogenetics Challenge.
Learn more about the NIEHS-NCATS-UNC DREAM Toxcicogenetics Challenge.