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Superfund Research Program Sediment Bioavailability Assays - Kick-off Webinar Featuring New Research Projects

Superfund Research Program

May 7, 2012; 3 to 5pm EDT


The NIEHS Superfund Research Program (SRP) presents a web seminar featuring new grantees from a recent solicitation "Innovative Bioavailability Assays to Assess the Effectiveness of Contaminated Sediment Remediation (R01)" RFA-ES-11-005.  The presentations will include innovative assays of bioavailability that may be used to determine the effectiveness of sediment remediation in reducing risks to humans.  The purpose of the “kick-off webinar” is to stimulate discussion between grantees and stakeholders at the initiation of a project with the long-term goal of establishing linkages that last throughout the duration of the grant.  Each grantee will provide a 10 minute overview of their project providing information about the aims of the research, the bioavailability tools they are developing, and the test site or study organisms involved.  There will be time for questions.


A brief summary of each R01 project is included below along with links to the SRP grantee web pages containing more information about the projects.


To register for this webinar, please use the U.S. Environmental Protection Agency’s Clu-in Training & Events webpage .

  • Moderator: Heather Henry , Ph.D., Health Science Administrator; Program Administrator, Superfund Research Program

  • Presenter: Rolf Ulrich Halden , Ph.D., Arizona State University and Nancy Denslow, Ph.D., University of Florida
    • Presentation title: In Situ Sampling Tool for Assessing Bioavailability
    • (IS2B)
    • Abstract: The in situ sampling/bioavailability determination (IS2B) tool simultaneously determines levels of contaminants in bulk water and pore water at low method detection limits. The team will correlate DNA microarray data and biological responses in fish to chemical measurements obtained with the IS2B in Lake Apopka. Work will concentrate on emerging contaminants (triclosan, triclocarban, fipronil) as well as on historical contaminants (pp-DDE, dieldrin). This is a Multi-PI grant including both Rolf Halden and Nancy Denslow, Ph.D., (University of Florida).
    • Project: In Situ Sampling Tool for Assessing Bioavailability and Toxicity of Sediments

  • Presenter: James Ranville , Ph.D., Colorado School of Mines and Jim Shine, Ph.D., Harvard School of Public Health
    • Presentation title: Remediation Effectiveness for Mining Sites: Hysteresis and Metal Mixture Effects
    • Abstract: Ranville and his co-investigators propose to further develop a "gellyfish" assay technology that targets metal ion speciation, is capable of examining metal mixtures (Cd, Pb, Cu, and Zn), and integrates into fate and transport models. Investigations will lead to further development of a mixed metal, multi-site biotic ligand model [MMMS BLM] for aquatic toxicity, and will provide an estimate of metals bioavailability that links to human exposure risks. Laboratory, mesocosm, and field (Clear Creek, Colo., Superfund Site) studies will indicate if metal remediation effectively removes the toxic metals without affecting essential metals that mitigate toxicity.
    • Project: Remediation Effectiveness for Mining Sites: Hysteresis and Metal Mixtures Effect

  • Presenter: Jay Gan , Ph.D., University of California, Riverside
    • Presentation title: Use of Stable Isotopes in Bioavailability Assessment
    • Abstract: Gan uses stable isotope labeled hydrophobic organic contaminants (HOCs) to advance capabilities to measure (ex situ or in situ) bioavailability of HOCs in sediments. This project potentially expands the applicability of a promising passive sampling bioavailability tool (solid-phase microextraction [SPME] samplers) to use in non-equilibrium conditions. The project will assess PAHs, PCBs, DDT, and DDE and involves work at the Palos Verdes Shelf Superfund Site undergoing capping.
    • Project: Development of Stable Isotope Based Methods to Predict Bioavailability of Hydrophobic Organic Contaminants in Sediments

  • Presenter: Upal Ghosh , Ph.D., University of Maryland, Baltimore County
    • Presentation title: Combining Bioavailability Assays with Modeling to Predict PCBs in Fish After Remediation
    • Abstract: This research will advance the assessment of remediation effectiveness at Superfund sediment sites through a combination of improving the science of passive sampling, experimentally establishing the link between passive sampling measurement and human health risk drivers such as contaminants in fish, and developing and testing contaminant fate and bioaccumulation models that can use passive sampling measurements for decision making. The approach will be validated through controlled laboratory exposure studies and measurements in the field.
    • Project: Combining Bioavailability Assays with Modeling to Predict PCBs in Fish After Remediation

  • Presenter: Michael Unger , Ph.D., Stephen Kaattari, Ph.D.; and Wolfgang Vogelbein, Ph.D., Virginia Institute of Marine Science (VIMS)
    • Presentation title: A Real-time Antibody-based Field Assay to Predict Contaminant Bioavailability in Sediments
    • Abstract: Unger will calibrate and apply an automated monoclonal antibody-based sensor to quantify and characterize compositional characteristics of polycyclic aromatic hydrocarbons (PAHs) in aqueous and sediment pore water as a surrogate measure of chemical bioavailability in oysters. This sensor, which permits simultaneous monitoring of different PAH classes within a single site, will be deployed at the Elizabeth River, Va., Superfund Site undergoing dredging and capping remediation. This is a Multi-PI grant including Michael Unger; Stephen Kaattari, Ph.D.; and Wolfgang Vogelbein, Ph.D.; all from VIMS.
    • Project: A Real-time Antibody-based Field Assay to Predict Containment Bioavailability in Sediments


For more information, contact:

Heather Henry, Ph.D.
Health Scientist Administrator
Superfund Research Program
Tel (919) 541-5330


Justin Crane
Tel (919) 794-4702
Fax (919) 287-2901


Individuals with disabilities who need accommodation to participate in this event should contact Justin Crane at 919-794-4702 or TTY users should contact the Federal TTY Relay Service at 800-877-8339. Requests should be made at least 5 business days in advance of the event.

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