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Your Environment. Your Health.

Society of Toxicology - 2012 Annual Meeting

San Francisco, CA
March 11-15, 2012

Daylight Savings Time

Daylight Savings Time: Begins on Sunday, March 11, 2012 at 2:00AM. Please remember to turn your clock/watch forward one hour before going to bed to ensure you arrive on time for Sunday events!

 

Society of Toxicology - 2012 Annual Meeting Agenda(378KB)

 

 

NIEHS, NTP, and EHP Exhibit

Booth 2037/2039/2137

Monday, March 12, 9:00 AM - 4:30 PM

  • NTP CEBS Demonstration: 9:30 AM - 12:30 PM

Tuesday, March 13, 8:30 AM - 4:30 PM

  • NTP DrugMatrix and ToxFX Demonstration: 11:00 AM - 12:30 PM
  • NTP CEBS Demonstration: 1:30 PM - 3:00 PM

Wednesday, March 14, 8:30 AM - 4:30 PM

  • NTP CEBS Demonstration: 9:30 AM - 11:00 AM
  • NTP DrugMatrix and ToxFX Demonstration: 11:00 AM - 12:30 PM

 

Exhibitor Hosted Session: National Toxicology Program
Introduction to the NTP DrugMatrix and ToxFX Toxicogenomic Database and Analysis Tools
Scott Auerbach
Monday, March 12, 3:30 PM - 4:30 PM; Room 105 (Convention Center)

 

ToxExpo 2013 Exhibit Space Selection Meeting
Tuesday, March 13, 4:45 PM - 6:00 PM; Room 101 (Convention Center)

 

Special Symposium: Meet the Directors
NIEHS and NTP Director, Linda Birnbaum
Wednesday, March 14, 9:00 AM - 11:45 AM; Room 302 (Convention Center)

Sunday, March 11

Overview and Application of the WHO-IPCS Harmonized Guidance for Immunotoxicity Risk Assessment for Chemicals

8:15 AM - 12:00 PM CE Room (Moscone Convention Center)

8:15 AM - 12:00 PM

6. Overview and Application of the WHO/IPCS Harmonized Guidance for Immunotoxicity Risk Assessment for Chemicals
Andrew A. Rooney; Henk Van Loveren

 

9:30 AM - 10:00 AM

Andrew A. Rooney

 

11:30 AM - 12:00 PM

Andrew A. Rooney

Stem Cells in Toxicology

8:15 AM - 12:00 PM; CE Room (Moscone Convention Center)

8:15 AM - 12:00 PM

7. Stem Cells in Toxicology
Erik J. Tokar; Michael P. Waalkes

 

8:15 AM - 8:30 AM

Erik J. Tokar

 

9:15 AM - 10:00 AM

Michael P. Waalkes

Specialized Techniques for Dose-Response Assessment and Risk Assessment of Chemical Mixtures

1:15 PM - 5:00 PM; CE Room (Moscone Convention Center)

1:15 PM - 5:00 PM

12. Specialized Techniques for Dose-Response Assessment and Risk Assessment of Chemical Mixtures
Jane Ellen Simmons; Michael J. DeVito

 

2:00 PM - 2:50 PM

Michael J. DeVito

 

9:15 AM - 10:00 AM

Michael P. Waalkes

Monday, March 12

DNA Damage Responses and Repair

9:15 AM - 12:00 PM; Room 307 (Convention Center)

9:15 AM - 12:00 PM

19. DNA Damage Responses and Repair
Richard S. Paules; Leona D. Samson

 

9:15 AM - 9:20 AM

Richard Paules

 

9:50 AM - 10:20 AM

21. Cell Signaling in Response To PARP Inhibition and Alkylating Agent Exposure
Samuel Wilson; Julie Horton; Donna Stefanick; Michelle Heacock; Padmini Kedar; Michael Carrozza

 

11:20 AM - 11:50 AM

24. Redundancy and Cross-talk in Pathways and Functions in DNA Damage Responses to the Highly Toxic DNA Double-Strand Break
Richard S. Paules; Stela S. Palii; Yuxia Cui; Jill E. Hesse; Cynthia L. Innes; Barry P. Sleckman

The Epididymis—The Forgotten Target of Toxicants

9:15 AM - 12:00 PM; Room 308 (Convention Center)

9:52 AM - 10:24 AM

51. The Effects of Antiandrogens on Epididymal Development in the Rat
Paul M. Foster

Risk Assessment: Case-Specific Characterizations

9:30 AM - 12:30 PM; Exhibit Hall

103 Poster Board -112. A Quantitative Risk Assessment of 2,3-Pentanedione, Based on Preliminary Data
David A. Dankovic; Daniel L. Morgan

 

106 Poster Board -115. Risk-Benefit Assessment of Flame-Retardant Chemicals
Arlene Blum; Vyto Babrauskas; Rebecca Fuoco; Linda Birnbaum

Safety Evaluation: Nonpharmaceuticals

9:30 AM - 12:30 PM; Exhibit Hall

265 Poster Board -352. Toxicology assessment of ortho-phthalaldehyde (OPA) following 90 days of inhalation exposure in mice and rats.
Sheetal A. Thakur; Gregory L. Baker; Joseph H. Roycroft; Lauren M. Staska; Jeffery A. Dill; Deepa B. Rao; Greg S. Travlos; Dori R. Germolec; Michael E. Wyde

Data Integration and Decision Support Systems

9:30 AM - 12:30 PM; Exhibit Hall

283 Poster Board -402. Chemical Effects in Biological Systems: A Toxicological Database
Laura A. Hall; Hui Gong; Anand Paleja; Asif Rashid; Jennifer M. Fostel

Liver

9:30 AM - 12:30 PM; Exhibit Hall

354 Poster Board -515. Peroxynitrite is central to increased hepatic leptin resistance in xenobiotic metabolism of CYP2E1- induced NASH
Saurabh Chatterjee; Erik J. Tokar; Maria Kadiiska; Michael Waalkes; Ronald P. Mason

Epidemiology: Assessments and Approaches

9:30 AM - 12:30 PM; Exhibit Hall

396 Poster Board -559. Negative Association of Environmental Exposure of Blood Lead and Blood Cadmium with Diabetes in the NHANES 1999–2006
Franco Scinicariello; Kristina A. Thayer

NIEHS Centers for Nanotechnology Health Implications Research: Building the Scientific Foundation for Evaluating Public Health Impacts of Engineered Nanomaterials

12:10 PM - 1:30 PM; Room 305 (Convention Center)

12:10 PM - 1:30 PM

432. NIEHS Centers for Nanotechnology Health Implications Research: Building the Scientific foundation for Evaluating Public Health Impacts of Engineered Nanomaterials
Justin G. Teeguarden; Martin Philbert; Srikanth S. Nadadur; Gwen Collman; Andre Nel; Terrance J. Kavanagh; Timothy R. Fennell

 

12:10 PM - 12:13 PM

Richard Woychik

 

12:13 PM - 12:25 PM

Srikanth Nadadur

Biological Modeling: Predictive PBPK Dosimetry Structures and Pharmacokinetic Data

1:00 PM - 4:30 PM; Exhibit Hall

440 Poster Board -108. An Assessment of Dioxin Exposure Across Multiple Gestational and Lactational Stages Using a PBPK Model and New Data Points from Seveso
Claude Emond; Michael DeVito; Marcy Warner; Brenda Eskenazi; Paolo Mocarelli; Linda S. Birnbaum

 

450 Poster Board -118. Use of PBPK models to evaluate associations in epidemiologic studies of reproductive outcomes with PFOA and PFOS concentrations
Anne E. Loccisano; Matthew P. Longnecker; Jerry L. Campbell; John L. Butenhoff; Melvin E. Andersen; Harvey J. Clewell

Developmental Basis of Adult Disease

1:00 PM - 4:30 PM; Exhibit Hall

478 Poster Board -150. Alterations In Neurobehavior and Hippocampal Morphology following Developmental Exposure to 3, 3', 4, 4'-Tetrachloroazobenzene In Sprague Dawley Rats
Mamta Behl; Gaylia J. Harry; Molly Vallant; Gregory S. Travlos; James L. Howard; Peter R. Mouton; Catherine J. Price; Michelle J. Hooth

 

479 Poster Board -151. A Transcriptomics Approach using HBCD to Prioritize Chemicals and Mixtures for Developmental Neurotoxicity Risk Assessment
David T. Szabo; Ruchir R. Shah; Linda S. Birnbaum

Skin Toxicology

1:00 PM - 4:30 PM; Exhibit Hall

559 Poster Board -301. Dermal carcinogenesis study of the α,β-unsaturated ketone methyl trans-styryl ketone in male and female F344/N rats and B6C3F1 mice
Michael L. Cunningham; Charles D. Hébert; Mark F. Cesta

 

570 Poster Board -312. Dermal Vehicle Evaluation of 2-Ethylhexyl p-methoxycinnamate
Kristin L. Aillon; Season P. Kerns; Candice C. Dillon; Bryan D. Sitzmann; Anthony J. Gutierrez; Roger K. Harris; Joseph Algaier; Bradley J. Collins; Barry S. McIntyre; Cynthia S. Smith

Alternatives to Mammalian Models II

1:00 PM - 4:30 PM; Exhibit Hall

588 Poster Board -333. Activity of US EPA's ToxCast compounds using a C. elegans growth screen
Windy A. Boyd; Marjolein V. Smith; Julie R. Rice;Jonathan H. Freedman

 

605 Poster Board -350. Selecting genes for use in a high-throughput mechanism-based toxicity screen using C. elegans
Rachel B. Goldsmith; Jason R. Pirone; Windy A. Boyd; Marjolein V. Smith; Jonathan H. Freedman

 

612 Poster Board -357. A systematic approach for studying the mitochondrial toxicity of environmental chemicals
Matias S. Attene-Ramos; Ruili Huang; Srilatha Sakamuru; Kristine Witt; Gyda Beeson; Loui Shou; Craig Beeson; Raymond Tice; Christopher Austin; Menghang Xia

 

613 Poster Board -358. The Tox21 Novel Robotic Platform for Quantitative High-Throughput Toxicological Screening
Nicole R. Miller; Matias S. Attene-Ramos; Sam Michael; Ruili Huang; Anton Simeonov; Raymond R. Tice; Christopher P. Austin; Menghang Xia

 

614 Poster Board -359. Characterizing changes in polyunsaturated fatty acid profiles in C. elegans in response to developmental stage, food, and cadmium exposure
Kathryn L. Haas; Brooke E. Tvermoes; Jonathan H. Freedman

DNA Damage and Repair

1:00 PM - 4:30 PM; Exhibit Hall

626 Poster Board -408. Caenorhabditis elegans POLQ plays a role in meiotic cell repair
Ailin Liu; Elena K. Braithwaite; Julie Hall; Windy A. Boyd; Senyene E. Hunter; Joel N. Meyer; Jonathan H. Freedman

 

632 Poster Board -414. ATR Depletion in ATM-Deficient Human Mammary Epithelial Cells Causes Significantly Attenuated G2 Checkpoint and Synergistic Lethality to Double-Strand Breaks and DNA-Damaging Agents
Yuxia Cui; Cynthia L. Innes; Richard S. Paules

Computational Toxicology: Sequences, Systems, and Strategies

1:00 PM - 4:30 PM; Exhibit Hall

765 Poster Board -626. The 1000 genomes toxicity screening project: Utilizing the power of human genome variation for population-scale in vitro testing
Nour Abdo; Menghang Xia; Oksana Kosyk; Ruili Huang; Srilatha Sakamuru; Christopher P. Austin; Raymond R. Tice; Fred A. Wright; Ivan Rusyn

 

767 Poster Board -628. Prediction of Cytochrome P450 Profiles of Environmental Chemicals with QSAR Models Built from Drug-like Molecules
Menghang Xia; Hongmao Sun; Henrike Veith; Christopher P. Austin; Raymond R. Tice; Robert J. Kavlock; Ruili Huang

 

780 Poster Board -641. Predictive in silico models of toxicity using C. elegans growth assay along with ToxCast Phase I short-term assay Data
Alexander Golbraikh; Ruchir Shah; Alexander Sedykh; Windy Boyd; Marjo Smith; Hao Zhu; Alexander Tropsha; Jonathan Freedman

Breast Cancer As a Multifactorial Disease: Interaction of Genetics, Life Stage, and the Environment

2:00 PM - 4:45 PM; Room 103 (Convention Center)

2:55 PM - 3:20 PM

802. Early-Life Exposures to Endocrine-Active Chemicals Promotes Breast Cancer Risk Later in Life
Linda S. Birnbaum

Inhalants and Cardiopulmonary—Pollutants and Irritants

2:00 PM - 4:45 PM; Room 310 (Convention Center)

3:51 PM - 4:09 PM

866. Bronchial Fibrosis in Rats Exposed to 2,3-Butanedione and 2,3-Pentanedione Vapors
D. L. Morgan; Michael P. Jokinen; Crystal L. Johnson; William M. Gwinn; Herman C. Price; Gordon P. Flake

Tuesday, March 13

State of the Science and the Future for the Predictive Power of In Vitro and In Vivo Models for Nanomaterials Toxicity Testing

9:00 AM - 11:45 AM; Room 307 (Convention Center)

9:00 AM - 11:45 AM

898. State of the Science and the Future for the Predictive Power of In Vitro and In Vivo Models for Nanomaterials Toxicity Testing
Alison Elder; Srikanth Nadadur

 

9:05 AM - 9:35 AM

899. Overview of the NIEHS-sponsored NanoGO Program
Srikanth Nadadur

Sufficient Similarity of Whole Representative Mixtures or a Relative Potency Factor Approach: Polycyclic Aromatic Hydrocarbons as a Case Study

9:00 AM - 11:45 AM; Room 304 (Convention Center)

9:00 AM - 11:45 AM

903. Sufficient Similarity of Whole Representative Mixtures or a Relative Potency Factor Approach: Polycyclic Aromatic Hydrocarbons as a Case Study
Cynthia V. Rider

 

9:00 AM - 9:05 AM

Cynthia Rider

Disease Prevention and Clinical and Translational Toxicology

9:00 AM - 12:30 PM; Exhibit Hall

948 Poster Board -110. Identification of Candidate Genes Involved in Differential Susceptibility and Response to Respiratory Syncytial Virus Infection
Jonathan Ciencewicki; Xuting Wang; Jacqui Marzec; Fernando Polack; Douglas Bell; Steven Kleeberger

Neurotoxicity: General

9:00 AM - 12:30 PM; Exhibit Hall

1026 Poster Board -236. Effects Of Mobile Phone Radiation on Hsp90 in Rat Brain
Elvis Cuevas; Michel E. Wyde; Susan M. Lantz; Bonnie R. Robinson; Wesley R. Hamilton; Paul C. Howard; Nigel J. Walker; Merle G. Paule; Syed F. Ali

Inhalants and Cardiopulmonary: Chemical Agents

9:00 AM - 12:30 PM; Exhibit Hall

1053 Poster Board -270. Acute Toxicological Responses of Fischer Rats to Naturally Occurring Asbestos from the United States and Canada
Jaime M. Cyphert; Danielle J. Padilla-Carlin; Abraham Nyska; Jonathan H. Shannahan; Mette C. Schladweiler; Urmila P. Kodavanti; Stephen H. Gavett

Food Safety and Nutrition II

9:00 AM - 12:30 PM; Exhibit Hall

1102 Poster Board -335. Hexabromocyclododecane (HBCD) Stereoisomers in US Food and Adult Daily Dietary Intake
Linda S. Birnbaum; A. Schecter; D. T. Szabo; J. A. Colacino ; T. Gent; N. Bass; O. Paepke; L. S. Hynan; T. R. Harris; S. Malla

"Omics in Toxicology"

9:00 AM - 12:30 PM; Exhibit Hall

1225 Poster Board -527. RNA-SEQ Profiling Reveals Novel Gene Expression Pattern after Subchronic Aflatoxin B1 (AFB1) in Rats.
Bruce A. Merrick; Scott S. Auerbach; Suzy M. Stiegelmeyer; Dhiral P. Phadke; Ruchir R. Shah; Raymond R. Tice

 

1234 Poster Board -536. Characterization of polybrominated diphenyl ether toxicity in Wistar Han rats and use of liver microarray data for predicting disease susceptibilities
Keith Shockley; Amy E. Brix; Molly K. Vallant; Helen C. Cunny; June K. Dunnick

Epigenetics

9:00 AM - 12:30 PM; Exhibit Hall

1254 Poster Board -560. Arsenic-Induced Malignant Transformation Contributes to Long-Range Epigenetic Silencing through DNA Methylation
Paul Severson; Erik J. Tokar; Michael P. Waalkes; Bernard W. Futscher

Arsenic Toxicology

1:00 PM - 4:30 PM; Exhibit Hall

1446 Poster Board -315. Oncogenic Transformation of Normal Prostate Stem Cells by Nearby, Noncontiguous Malignant Prostate Epithelia Potentially Involves Interleukin-6
Yuanyuan Xu; Erik J. Tokar; Yang Sun; Michael P. Waalkes

 

1454 Poster Board -323. Methylarsonous acid (MMAIII) causes oxidative DNA damage independent of the ability of a cell to biomethylate inorganic arsenic
Erik J. Tokar; Chikara Kojima; Ronald P. Mason; Michael P. Waalkes

Exposure Characterization: New Analytical Sampling Methods, Biomonitoring, and Assessment Applications

1:00 PM - 4:30 PM; Exhibit Hall

1471 Poster Board -348. Analytical Method Validation of tris(2-Chloroisopropyl)phosphate (TCPP) in Harlan Sprague Dawley Maternal Rat Blood
Joseph Algaier; Season P. Kerns; Candice C. Dillon; Bryan D. Sitzmann; Amanda L. Hoskins; Johnathan L. Cobb; Dama M. Logan; Aura D. Ammenhauser; Peter J. Schebler; Roger K. Harris; Bradley J. Collins; Cynthia S. Smith

Pharmacogenomics/Genetic Polymorphisms

1:00 PM - 4:30 PM; Exhibit Hall

1607 Poster Board -558. Genetic variants in HLA genes are associated with diisocyanate-induced asthma in exposed workers
Berran Yucesoy; Victor J. Johnson; Kara Fluharty; Wei Wang; Bonnie Frye; Zana L. Lummus; Rao Marepalli; Hansen Bannerman-Thompson ; Denyse Gautrin; Jean-Luc Malo; André Cartier; Dori R. Germolec; Michael I. Luster; David I. Bernstein

Novel Topics in Environmental Polycyclic Aromatic Hydrocarbon Metabolism Leading to Carcinogenesis

1:30 PM - 4:15 PM; Room 305 (Convention Center)

1690. Novel Topics in Environmental Polycyclic Aromatic Hydrocarbon Metabolism Leading to Carcinogenesis
Danielle Carlin; Bhagavatula Moorthy

Risk Assessment Approaches: Data-Derived Extrapolations, QSAR, In Silico Strategies, and Surrogates

1:30 PM - 4:15 PM; Room 310 (Convention Center)

1:30 PM - 1:49 PM

1725. Application of Machine Learning in the Development of a Weighting Framework for Evaluating Estimates of Relative Potency For Dioxin-Like Compounds
D. S. Wikoff; M. J. DeVito; N. J. Walker; J. G. Hixon; M. A. Harris; J. A. Tachovsky; L. S. Birnbaum; L. C. Haws

 

3:39 PM - 3:57 PM

1732. Evaluating Tools and Models Used for Quantitative Extrapolation of In Vitro to In Vivo Data for Neurotoxicants
Melissa P. Chan; Michael J. DeVito; Timothy J. Shafer; Rogelio Tornero-Velez; Michael F. Hughes

Wednesday, March 14

Caught in the Act: Free Radical Detection and Implications in Pathways to Toxicity

9:00 AM - 11:45 AM; Room 304 (Convention Center)

10:41 AM - 11:13 AM

1768. Free Radicals and Oxidized Macromolecules: Roles in Biomarker Toxicology
Maria Kadiiska

Bioinformatics: Signature Applications and Network Analyses

9:00 AM - 11:45 AM; Room 301 (Convention Center)

10:51 AM - 11:09 AM

1794. AhR-Mediated Gene Expression Across Multiple Developing Mouse Tissues
Xiaoqing Chang; J. Foley; J. M. Gohlke; C. J. Portier; M. Devito

Alternatives to Mammalian Models I

9:00 AM - 12:30 PM; Exhibit Hall

1822 Poster Board -108. ICCVAM Recommendations and Limitations of the BG1Luc ER TA Test Method for Identifying Estrogen Receptor Agonists and Antagonists
D. Hattan; K. Carlson; A. Jacobs; J. Bray; W. Casey; W. Stokes

 

1823 Poster Board -109. ICCVAM Performance Standards for the BG1Luc ER TA Test Method
Warren Casey; David Hattan; K. Carlson; A. Jacobs; J. Bray;  J. Hamm; P. Ceger; D. Allen; W. Stokes

Regulatory Policy: Procedures and Predictions

9:00 AM - 12:30 PM; Exhibit Hall

1853 Poster Board -141. Comparison of the DPRA with a Three-Test Battery for In Vitro Evaluation of Skin Sensitization
W. Stokes; T. Burns; J. Strickland; L. Rinckel; D. Allen

 

1856 Poster Board -144. Analysis to Determine if Acute Oral Systemic Toxicity Data Can Be Used to Estimate and Avoid Acute Dermal Systemic Toxicity Testing
M. Paris; J. Strickland; F. Stack; D. Allen; W. Casey;W. Stokes

 

1857 Poster Board -145. Updated NICEATM Evaluation of the Reduced Murine Local Lymph Node Assay
T. Burns; D. Allen; J. Strickland; E. Salicru; W. Stokes

 

1858 Poster Board -146. Evaluation of Two Nonradiolabeled Murine Local Lymph Node Assays (LLNA) for Potency Categorization of Substances Causing Allergic Contact Dermatitis in Humans
J. Strickland; F. Stack; T. Burns; D. Allen; W. Casey; W. Stokes

Disposition and Pharmacokinetics

9:00 AM - 12:30 PM; Exhibit Hall

1874 Poster Board -207. Method for the Analysis of 8-2 Fluorotelomer Alcohol in Rat Plasma, Liver, Kidney, and Brain and its Application to a Single Dose Oral Gavage Toxicokinetic Study
Liam Moran; Steve W. Graves; Brian Burback; Seth Gibbs; Beby Jayaram; Veronica Robinson; Cynthia Smith

 

1875 Poster Board -208. Toxicokinetics of Perfluorodecanoic Acid (PFDA) after a Single Intravenous or Gavage Administration to Harlan Sprague Dawley Rats
Seth Gibbs; S. Peter Hong; Steve W. Graves; Courtney Granville; Beby Jayaram; C. R. Blystone; Veronica Robinson; Cynthia Smith

 

1878 Poster Board -211. Toxicokinetics of the pyrethroid insecticide bifenthrin in blood and brain of the rat
David G. Ross; James M. Starr; Brenda C. Edwards; Jennifer Hutchison; Michael J. Devito; Michael F. Hughes

 

1887 Poster Board -220. Disposition And Metabolism of β-N-Methylamino-L-Alanine in Sprague Dawley Rats and B6C3F1 Mice
C. Wegerski; J. M. Sanders; M. Doyle-Eisele; Jake McDonald

 

1889 Poster Board -222. Investigation of the metabolism of 1,3-Dichloro-2-Propanol to Epichlorohydrin In Vivo in Male Harlan Sprague Dawley Rats
Suramya Waidyanatha; Norman Gaudette; Yan Hong;Po Chan; Timothy Fennell

 

1890 Poster Board -223. Determination of n-Butylparaben and Metabolites in Harlan Sprague Dawley Rat Plasma, Aminiotic Fluid, Fetal Tissue, and Pups
Timothy Fennell; Wojciech Krol; C. R. Blystone; Suramya Waidyanatha

 

1894 Poster Board -227. Investigating Complex Phenotypes: Haplotype Association Mapping Benzene Pharmacokinetics in Isogenic Mouse Strains
Gabriel A. Knudsen; Jon E. French; Michael C. Cunningham; I. G. Sipes

 

1895 Poster Board -228. Disposition And Metabolism of The Rubber Peptizing Agent, 2,2-Dithiobisbenzanilide, in Sprague Dawley Rats and B6C3F1 Mice
J. M. Sanders; C. Wegerski; M. Doyle-Eisele; Jake McDonald

Developmental Toxicology

9:00 AM - 12:30 PM; Exhibit Hall

1913 Poster Board -246. Low-dose prenatal perfluorooctanoic acid exposure reduces estrogen receptor-α and alters α-smooth muscle actin protein expression of mammary glands in late adolescent female offspring
Madisa B. Macon; Casey E. Reed; Deirdre K. Robinson; Adam J. Filgo; Suzanne E. Fenton

Molecular Basis of Carcinogenesis

9:00 AM - 12:30 PM; Exhibit Hall

2003 Poster Board -362. Loss of p53 accelerates tumor formation in RAP80 mice
Zhengyu Yin; Daniel Menendez; Kyathanahalli Janardhan; Jef French; Michael Resnick; Anton Jetten

Stem Cell Biology and Toxicology

9:00 AM - 12:30 PM; Exhibit Hall

2078 Poster Board -472. Arsenic-Induced Malignant Transformation of Human Skin Keratinocyte Stem Cells
Yang Sun
; Erik J. Tokar; Yuantuan Xu; Michael P. Waalkes

Genotoxicity Testing

9:00 AM - 12:30 PM; Exhibit Hall

2081 Poster Board -503. Development of a High-Content High-Throughput Screening Platform for Genotoxicity Assessment
Bonnie Goodwin; Kristine Witt; Christopher Austin; Raymond Tice; Menghang Xia

Exposure Assessment: Case-Specific Characterizations

9:00 AM - 12:30 PM; Exhibit Hall

2118 Poster Board -542. Polyfluoroalkyl Compounds (PFCs) in Texas—Children from Birth through 12 Years of Age
Arnold J. Schecter; Noor Bass; Antonia Calafat; Kayoko Kato; Justin Colacino; T Robert Harris; Linda S. Hynan; Tyra Gent; Sunitha Malla; Linda Birnbaum

NrF2

9:00 AM - 12:30 PM; Exhibit Hall

2129 Poster Board -553. Nuclear Factor E2-Related Factor-2 (Nrf2) Regulates P-glycoprotein Expression at the Blood-Brain Barrier (BBB) by Acting Through p38 MAP Kinase
Xueqian Wang; David Miller

 

2130 Poster Board -554. The Role of Sirtuin-1 on TBHQ Induction of NRF2 and Prototypical NRF2 Target Gene Expression
Wei Wei; Jialin Xu; Supriya Kulkarni; Ajay Donepudi; Vijay More; Connie Wang; Xiaoling Li; Angela Slitt

Gene Regulation and Signal Transduction

9:00 AM - 12:30 PM; Exhibit Hall

2150 Poster Board -620. Identification of a novel pathway involved in the negative regulation of metallothionein transcription
Jonathan H. Freedman; Julie Hall

Scientific, Regulatory, and Public Perspectives on the Credibility and Use of Alternative Toxicological Test Methods in a Legislative Framework

12:00 PM - 1:20 PM; Room 307 (Convention Center)

12:00 PM - 1:20 PM

2183. Scientific, Regulatory, and Public Perspectives on the Credibility and Use of Alternative Toxicological Test Methods in a Legislative Framework
Linda S. Birnbaum; Robert S. Skoglund; Daland R. Juberg; Melvin E. Andersen; Steven P. Bradbury; Martin L. Stephens; Thomas A. Hartung

 

12:00 PM - 12:12 PM

Linda S. Birnbaum

Endocrine Toxicity

1:00 PM - 4:30 PM; Exhibit Hall

2189 Poster Board -104. Thyroxine (T4) Catabolism in Human and Rat Hepatocytes Increases Following Exposure to Hepatic Enzyme Inducers
Vicki M. Richardson; Michael J. Devito

 

2209 Poster Board -124. Validated Analysis Method for 2-Ethylhexyl p-methoxycinnamate in Verified Casein 5K96 Rodent Diet
Bradley J. Collins; Kristin L. Aillon; Angela K. Sullivan; Richard L. Mathias; Kimberly D. Adams; Joseph Algaier; Roger K. Harris; Barry S. McIntyre; Cynthia S. Smith

 

2214 Poster Board -129. Formulation Development and Analysis for Various Sunscreen Agents in Corn Oil Vehicle and DMSO in Support of Toxicological Studies
James C. Blake; Gwendolyn McNeill; Donna Coleman; Chad Crafford; Shaun Norton; Melanie A. Silinski; Reshan A. Fernando; Bradley J. Collins; Veronica G. Robinson

 

2226 Poster Board -141. Personal care products have detectable estrogenic and antiestrogenic activity
Cathy Z. Yang; Gayathri J. Kollessery; George D. Bittner; Sharon Myers; Donna D. Baird; Kristine L. Witt; Raymond R. Tice

Male Reproductive Toxicology

1:00 PM - 4:30 PM; Exhibit Hall

2336 Poster Board -304. Black Cohosh (Actaea Racemosa) Affects Reproduction in the Harlan Sprague Dawley Rat
Minerva Mercado Feliciano; Jack Bishop; Katie J. Turner; Barry McIntyre; Paul M. Foster

 

2338 Poster Board -306. Evaluation of genomic biomarkers and relative potency of phthalate-induced male reproductive developmental toxicity using a targeted rtPCR array approach
Bethany Hannas; Christy Lambright; Johnathan Furr; Nicola Evans; Paul M.D. Foster; Leon Earl Gray; Vickie S. Wilson

 

2340 Poster Board -308. A fetal rat testis endocrine and genomic "Signature" accurately predicts the Phthalate Syndrome of malformations.
Leon E. Gray; Bethany Hannas; Johnathan Furr; Christy Lambright; Nicola Evans; Vickie Wilson; Paul Foster

Reproductive Toxicology II

1:00 PM - 4:30 PM; Exhibit Hall

2369 Poster Board -342. Decreased reproductive indices in h-NAG-1 (GDF-15) mice correlated to potential alterations in mammary gland function
Glenda J. Moser; M. Streicker; M. Ehinger; M. Brown; C. Favaro; J. Kosak; T. Eling; A. Binder; K. Korach

 

2380 Poster Board -353. Reproductive Assessment by Continuous Breeding of Hexachlorobenzene in Sprague Dawley Rats
Chad R. Blystone; Jack B. Bishop; Gary W. Wolfe; Michelle J. Hooth

 

2381 Poster Board -354. Normal and Chemically-Altered Mammary Gland Development in the Male and Female Harlan Sprague Dawley Rat
Adam J. Filgo; A. R. Borde; P. Borde; L. M. Beck; C. E. Reed

 

2385 Poster Board -358. A Novel Quantitative Method for the Comparison of Mammary Gland Development in Multiple Strains of Rat
Jason P. Stanko; Suzanne E. Fenton

Natural Products

1:00 PM - 4:30 PM; Exhibit Hall

2406 Poster Board -411. Composition of Multiple Lots of Valerian (Valeriana officinalis) Extracts, Root Powders, and Oils
Timothy Cristy; Steve Graves; Cynthia Smith; Beby Jayaram

Metals

1:00 PM - 4:30 PM; Exhibit Hall

2478 Poster Board -517. Potential Role of Stem Cells in Cadmium-induced Oncogenic Transformation of Human Lung Cells
Rachel J. Person; Erik J. Tokar; Michael P. Waalkes

 

2480 Poster Board -519. Cadmium Appears to Initially Kill Then Select for Stem Cells an a Human Pancreatic Epithelial Cell Line
Wei Qu; Alan K. Chin; Michael P. Waalkes

 

2485 Poster Board -524. MTF-1 and CARM1 participate in a complex to regulate metallothionein expression and metal homeostasis
Elena K. Braithwaite; Jonathan H. Freedman

 

2492 Poster Board -531. Evaluation of the subchronic toxicity of sodium tungstate dihydrate in male and female Harlan Sprague Dawley rats and B6C3F1/N mice administered dosed drinking water
Michelle Hooth; David Malarkey; Gregory Travlos; Laurene Fomby; Matthew Buccellato; Crystal Briscoe; Michael Ryan; Milton Hejtmancik; Veronica Godfrey Robinson; Cynthia Smith; Steven Graves; Lori Reed; Kristine Witt; Matthew Stout

 

2498 Poster Board -537. Development, Validation and Application of a Method for Determination of Zinc in Rat Whole Blood
Keith Levine; Amal S. Essader; Jason M. Perlmutter; Daniel J. Young; Reshan A. Fernando; Bradley J. Collins; Veronica G. Robinson

Persistent Organic Chemicals

1:00 PM - 4:30 PM; Exhibit Hall

2507 Poster Board -553. Immunological Evaluation Of The Relative Potency Of A Single Oral Administration Of Brominated And Chlorinated Dioxins And Furans In Female B6C3F1 Mice
Rachel Frawley; Kimber White Jr; Matthew Smith; Nigel Walker; Linda Birnbaum; Michael Devito; Dori Germolec

Trivalent Arsenic Metabolites and Arsenic Toxicity

1:30 PM - 4:15 PM; Room 304 (Convention Center)

1:30 PM - 4:15 PM

2583. Trivalent Arsenic Metabolites and Arsenic Toxicity
Luz M. Del Razo; Michael P. Waalkes; Miroslav Styblo; Zuzana Drobna; Dana Loomis; Elaina M. Kenyon

 

2:02 PM - 2:29 PM

2585. Mode of Action of Methylated Trivalent Arsenic with a Focus on the Potential Action as a Carcinogen.
Michael P. Waalkes; Chikara Kojima; R. Orihuela; Erik J. Tokar

Refining Your Science Communication Skills

4:30 PM - 5:50 PM; Room 307 (Convention Center)

4:30 PM - 5:50 PM

2656. Refining Your Science Communication Skills
Minerva Mercado-Feliciano; Tim Pastoor; George Gray; Nigel Walker; Nancy Beck

 

4:30 PM - 4:35 PM

Minerva Mercado-Feliciano

 

5:05 PM - 5:20 PM

Nigel J. Walker

Thursday, March 15

Carcinogenesis

8:30 AM - 12:00 PM; Gateway Ballroom (Convention Center)

2660 Poster Board -104. Carcinogenesis study of trimethylolpropane triacrylate in F344/N rats and B6C3F1 mice
In Ok Surh; Deepa B. Rao; Mark Cesta; Rajendra Chhabra

 

2662 Poster Board -106. Potential Carcinogenic Transformation of Myeloid Progenitor Cells with Formaldehyde
Laura Fuhrman; Erik J. Tokar; Michael P. Waalkes

Chemical Standardization of Botanical Medicines for Safe and Effective Use as Therapeutic Agents

9:00 AM - 11:45 AM; Room 307 (Convention Center)

9:05 AM - 9:37 AM

2733. Characterization and Use of Herbal Preparations as Test Articles in Safety Assessments—Analytical Challenges and Reasonable Solutions
Cynthia S. Smith

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