Society of Toxicology 50th Anniversary
Walter E. Washington Convention Center in Washington, D.C.
March 6-10, 2011

Schedule days:
Featured highlights, events and activities:
- Live Updates from the Society of Toxicology 50th Anniversary
- "Benchmarks in Toxicology" — A joint project between NIEHS and SOT
NIEHS, NTP, and EHP Exhibit
Booth 1414/1323/1416
Monday, March 7
8:00 AM-9:00 AM, Grand Ballroom (Convention Center), Plenary Opening Lecture
Lawrence A. Tabak, Principal Deputy Director, National Institutes of Health
NIH Vision
Wednesday, March 9
9:30 AM-10:30 AM, Room 201 (Convention Center)
Meet the Directors Series: NIEHS and NTP Director, Linda Birnbaum
The National Institute of Environmental Health Sciences (NIEHS) seeks to understand how the environment influences the development and progression of human disease. This session will be a particularly valuable opportunity to update SOT members on the future directions of the NIEHS and the National Toxicology Program (NTP). Dr. Birnbaum will talk about her plans for leading NIEHS and NTP in promoting the environmental public health of the United States and the world through research directed at preventing and treating disease.
Tuesday-Wednesday, March 8-9
9:30 AM-4:30 AM, Room 203 (Convention Center)
NIH Research Funding Resource Room
Saturday, March 5
10:00 AM-5:00 PM, Koshland Science Museum (National Academy of Sciences)
K-12 Outreach: Protecting You and Your Pet through the Science of Toxicology: Paracelsus Goes to Washington; Banalata Sen, Science Education and Outreach Program Manager, EHP
Sunday, March 6
6:00 AM-8:00 AM, Buses Depart L Street (Convention Center)
Past Presidents 5K Fun Run
1:15 PM-5:00 PM, Room 202 (Convention Center), Continuing Education Session - Chair Srikanth Nadadur
Evaluating Toxicity of Engineered Nanomaterials: Issues with Conventional Toxicology Approaches
Monday, March 7
9:15 AM-12:00 PM, Room 143 (Convention Center), Symposium Session - Chair Cynthia Rider
Emerging Issues at the Intersection of Reproductive and Mixtures Toxicology
Emerging Issues at the Intersection of Reproductive and Mixtures Toxicology V. S. Wilson; C. V. Rider
9:15 AM-9:20 AM
Cynthia Rider Introduction
9:30 AM-12:30 PM, Exhibit Hall (Convention Center)
Hypersensitivity: Methods and Mechanisms
Poster Board 119. Contact Sensitizing Potential of Heptachlor in Female BALB/c Mice R. P. Frawley; W. Auttachoat; M. J. Smith; R. D. Brown; T. L. Guo; K.
L. White Jr; D. R. Germolec
9:30 AM-12:30 PM, Exhibit Hall (Convention Center)
Bioinformatic Profiling and Computational Pathway Prediction
Poster Board 240. Discovery of novel micro-RNAs from Rat lymphocytes during glucocorticoid induced apoptosis R. Shah; S. Vasa; L. Smith; J. Cidlowski
Poster Board 248. Use of C. elegans growth assay data in novel two-step hierarchical QSAR modeling workflow enhances in vivo toxicity prediction for
ToxCast Phase I chemicals A. Golbraikh; R. Shah; W. Boyd; M. Smith; A. Tropsha; J. Freedman
9:30 AM-12:30 PM, Exhibit Hall (Convention Center)
Carcinogenesis I
Poster Board 415. Tumors and Proliferative Lesions in Adult Offspring After Maternal Exposure to Methylarsonous Acid During Gestation in CD1 Mice. M.
Waalkes; B. A. Diwan; E. J. Tokar; D. J. Thomas
Poster Board 417. Toxicology study of senna in C3B6F1/N Trp53 haploinsufficient mice I. Surh; A. Brix; J. French; J. Dunnick
Poster Board 427. Pathway directed molecular analysis of large intestinal tumors induced in Fisher 344 rats exposed to aloe vera whole leaf extract in
drinking water A. R. Pandiri; R. C. Sills; M. J. Hoenerhoff; T. T. Ton; H. L. Hong; G. P. Flake; D. E. Malarkey; I. Pogribny; N. J. Walker; M. D. Boudreau
9:30 AM-12:30 PM, Exhibit Hall (Convention Center)
Metals I
Poster Board 501. Metallothionein and Acute Cadmium-Induced DNA Oxidative Damage W. Qu; L. Cheng; Y. Sun; R. P. Mason; M. Waalkes
Poster Board 502. Sexual Dimorphism of Cadmium-induced Toxicity in Rats: Involvement of Progesterone H. Shimada; T. Hashiguchi; A. Yasutake; M. P.
Waalkes; Y. Imamura
Poster Board 508. Toxic Effects of Cadmium on Human Peripheral Lung Cells R. Person; E. Tokar; M. Waalkes
Poster Board 510. Identification of cadmium-responsive transcriptional regulators of the C. Elegans gene, cdr-1 L. E. Fuhrman; J. H. Freedman
9:30 AM-12:30 PM, Exhibit Hall (Convention Center)
Genotoxicity
Poster Board 621. Genotoxicity of Styrene-Acrylonitrile Trimer in Weanling F344 Rats R. S. Chhabra; C. A. Hobbs; L. Recio; J. Winters; K. Shepard; P.
Allen; M. Prajapati; M. Streicker; K. L. Witt
Poster Board 635. Comparison of aneuploidies of chromosomes X, Y, and 21 in the peripheral blood lymphocytes and sperm cells of workers exposed
to benzene Z. Ji; R. H. Weldon; F. Marchetti; H. Chen; G. Li; C. Xing; E. Kurtovich; S. Young; T. E. Schmid; S. Waidyanatha; S. Rappaport; A. J. Wyrobek; L.
Zhang; B. Eskenazi
9:30 AM-12:30 PM, Exhibit Hall (Convention Center)
Receptor and Receptor-Mediated Toxicity
Poster Board 707. Activating PKCβ1 at the Blood-Brain Barrier (BBB) Reverses Induction of P-glycoprotein (Pgp) Activity by Dioxin and Restores Drug
Delivery to the CNS X. Wang; B. Hawkins; D. Miller
9:30 AM-12:30 PM, Exhibit Hall (Convention Center)
Cell Signaling and Gene Regulation
Poster Board 810. Identification of transcriptional regulators of C. elegans metallothionein gene expression J. Hall; J. H. Freedman
Poster Board 835. Attenuation of the Nrf2 Signaling Pathway in Hepatocytes Lacking Sirtuin 1 (Sirt1) W. Wei; J. Xu; S. Kulkarni; X. Li; A. Slitt
12:10 PM-1:30 PM, Room 143 (Convention Center), Informational Session - Chair William Stokes
The International Cooperation on Alternative Test Methods (ICATM): Translating Science to Provide Improved Public Health Safety Assessment Tools
The International Cooperation on Alternative Test Methods (ICATM): Translating Science to Provide Improved Public Health Safety Assessment Tools W.
Stokes; M. Wind
12:10 PM-12:20 PM
William S. Stokes The International Cooperation on Alternative Test Methods (ICATM):
Translating Science into Public Health Safety Assessment Tools
1:00 PM-4:30 PM, Exhibit Hall (Convention Center)
Risk Assessment: Computational Approaches, Analyses, and Applications
Poster Board 225. Using a Multiple Stage Decision Tree to Make Activity Calls in Quantitative High-Throughput Screening (qHTS) Data K. R. Shockley; G.
E. Kissling; R. Huang; M. Xia; C. P. Austin; R. R. Tice
Poster Board 236. Assessment of Mitochondrial Toxicity of Environmental Chemicals Using a Quantitative High-Throughput Screening Approach M. S.
Attene-Ramos; R. Huang; S. Sakamuru; S. Shahane; L. Shou; K. L. Witt; R. R. Tice; C. P. Austin; M. Xia
1:00 PM-4:30 PM, Exhibit Hall (Convention Center)
Inhalation and Cardiopulmonary Toxicology
Poster Board 416. In vitro macrophage cytotoxicity of indium-phosphide and indium-tin oxide particles is dependent upon phagosome acidification after
particle uptake W. M. Gwinn; C. J. Shines; R. W. Bousquet; D. L. Morgan
1:00 PM-4:30 PM, Exhibit Hall (Convention Center)
Mechanisms of Immunotoxicity
Poster Board 635. Synergism of leptin signaling and post translational protein oxidation in bromodichloromethane exposure is key to the development of
steatohepatitis of obesity S. Chatterjee; J. Clark; M. Kadiiska; R. P. Mason
1:00 PM-4:30 PM, Exhibit Hall (Convention Center)
Biological Modeling: Computational Approaches, Mixtures, Multiroute and Lifestage Applications
Poster Board 711. Physiologically Based Pharmacokinetic Modeling (PBPK) as a Tool To Predict 2,3,7,8-Tetrachlorodibenzo-P-Dioxin (TCDD)
Pharmacokinetics (PK) During Gestation and Lactation C. Emond; M. J. Devito; M. Warner; B. Eskenazi; P. Mocarelli; L. S. Birnbaum
Poster Board 721. A PBPK Model of Micro and Nano Sized Fluorescent Polystyrene Spheres in Rats X. Chang; K. Sarlo; N. Walker; K. Blackburn; E. Clark;
J. Grothaus; C. Portier
Poster Board 734. Characterization Of Strain & Dose-Dependent Routes Of Elimination for Benzene & Its Metabolites in 4 Mouse Strains. G. A. Knudsen;
R. K. Kuester; M. L. Cunningham; J. E. French; I. G. Sipes
2:00 PM-4:45 PM, Room 145 (Convention Center), Workshop Session
Technical Characterization and Dosimetry Challenges Associated with Conducting or Interpreting Nanotoxicity
2:36 PM-3:02 PM
Minimum Material Characterizations for Nanotoxicology Studies: A Necessity or a Nuisance? N. J. Walker
2:00 PM-4:45 PM, Room 202A (Convention Center), Platform Session
Biomarkers of Carcinogenesis
2:48 PM-3:12 PM
Development and Evaluation of a Genomic Signature for the Prediction of Non-genotoxic Hepatocarcinogens in the Rat R. T. Dunn; A. Adai; A. Olaharski;
G. H. Searfoss; J. Sina; J. Aubrecht; E. Boitier; P. Nioi; D. Jacobson Kram; N. Raghavan; B. Car; S. Chen; Y. Yang; A. Kinkaid; J. Sherlock; S. Auerbach; M. Fielden
Tuesday, March 8
6:30 AM-7:50 AM, Room 147 (Convention Center), Informational Session
Emerging Science for Environmental Health Decisions: Tools, Strategies, and Evidence
Emerging Science For Environmental Health Decisions: Tools, Strategies, and Evidence W. H. Farland
7:35 AM-7:50 AM
The Path To Incorporating Emerging Science in Environmental Health Decisions Linda Birnbaum
9:00 AM-12:30 PM, Exhibit Hall (Convention Center)
Alternative Approaches to Animal Testing for Toxicological Research
Poster Board 140. Population-based quantitative high-throughput screening (qHTS) for chemical toxicity S. O'Shea; O. Kosyk; N. Abdo; E. Lock; F. Wright;
R. Huang; M. Xia; C. Austin; R. Tice; I. Rusyn
Poster Board 145. Molecular Effects of Inorganic and Organic Mercury in Caenorhabditis elegans and Human Cells M. K. McElwee; J. H. Freedman
9:00 AM-12:30 PM, Exhibit Hall (Convention Center)
Alternatives to Mammalian Models for Testing
Poster Board 243. International Validation Study of an In Vitro Cell Proliferation Test Method for Screening Potential Estrogenic Agonists and Antagonists
in MCF-7 cells F. Deal; W. Casey; P. Ceger; D. Allen; C. Yang; M. Nakamura; H. Kojima; A. Ono; H. Yoon; S. Han; W. Stokes
Poster Board 244. Final Results of an International Validation Study of an In Vitro ER TA Test Method in BG-1 cells W. Casey; P. Ceger; D. Allen; G. Clark;
P. Pazos; E. Grignard; J. de Lange; S. Bremer; M. Nakamura; H. Kojima; W. Stokes
9:00 AM-12:30 PM, Exhibit Hall (Convention Center)
Nanotoxicology: Carbon Nanotubes, Carbon Nanoparticulates, and Quantum Dots
Poster Board 646. Airway Inflammation in Mice Exposed to Ovalbumin Allergen and Multi-walled Carbon Nanotubes (MWCNT) is Regulated by
Cyclooxygenase-2 (COX-2) B. C. Sayers; E. E. Glista; A. J. Taylor; R. Langenbach; J. C. Bonner
Poster Board 417. Toxicology study of senna in C3B6F1/N Trp53 haploinsufficient mice I. Surh; A. Brix; J. French; J. Dunnick
9:00 AM-12:30 PM, Exhibit Hall (Convention Center), Poster Session - Chair Kembra Howdeshell
Reproductive Toxicology I
Poster Board 301. Fetal Phthalate Screen: Assessment of Several Phthalate Esters (PE) on Fetal Rodent Testosterone (T) Production and Gene
Expression following In Utero Exposure C. Lambright; J. Furr; M. Cardon; B. Hannas; D. Bermudez; N. Wrench; V. Wilson; P. Foster; E. Gray, Jr
9:30 AM-12:30 PM, Exhibit Hall (Convention Center)
Reproductive Toxicology II
Poster Board 354. FoxO1 associated p27kip1 decrease is essential for Fenvalerateinduced cell growth in human uterine leiomyoma (UtLM) and smooth
muscle cells (UtSMCs) X. Gao; L. Yu; L. Castro; A. B. Moore; M. I. Sifre; C. D. Bortner; D. Dixon
9:30 AM-12:30 PM, Exhibit Hall (Convention Center)
Receptor and Receptor-Mediated Toxicity
Poster Board 707. Activating PKCβ1 at the Blood-Brain Barrier (BBB) Reverses Induction of P-glycoprotein (Pgp) Activity by Dioxin and Restores Drug
Delivery to the CNS X. Wang; B. Hawkins; D. Miller
9:30 AM-12:30 PM, Exhibit Hall (Convention Center)
Hepatotoxicity
Poster Board 413. PFOA-induced liver effects in CD-1 and PPAR-alpha knock-out C57BL/6 mice A. J. Filgo; M. J. Hoenerhoff; G. E. Kissling; S. S. White; E.
P. Hines; J. P. Stanko; S. E. Fenton
Poster Board 420. Quantitative (q)PCR Analysis of RNA Extracted from Formalin-Fixed Paraffin Embedded (FFPE) LIVER from Aflatoxin B1 (AFB1) Treated
Rats: Correlation with Microarray Data B. A. Merrick; S. S. Auerbach; P. S. Stockton; J. F. Foley; D. E. Malarkey; R. C. Sills; R. D. Irwin; R. R. Tice
9:00 AM-12:30 PM, Exhibit Hall (Convention Center)
Stem Cell Toxicology
Poster Board 603. Cadmium-induced transformation of human stem cells E. Tokar; M. Waalkes
9:00 AM-12:30 PM, Exhibit Hall (Convention Center)
Exposure Assessments and Biomonitoring Applications
Poster Board 823. Bisphenol A (BPA) and Hexabromocyclododecane (HBCD) Stereoisomers in U.S. Food A. Schecter; N. Malik; O. Paepke; L. Birnbaum
9:00 AM-11:45 AM, Room 143 (Convention Center), Workshop Session
Using Mode of Action Data to Guide Quantitative Cancer Risk Assessment: A Case Study of Hexavalent Chromium in Drinking Water
9:05 AM-9:20 AM
NTP Toxicology and Carcinogenesis Studies of Chromium M. D. Stout; M. J. Hooth
9:00 AM-11:45 AM, Room 202B (Convention Center), Platform Session
Gene Regulatory Mechanisms of Carcinogenesis
10:03 AM-10:24 AM
Reduction of PTEN dose impairs DNA repair and predisposes to UVB-induced skin tumorigenesis Y. He; M. Ming; L. Feng; C. Shea; K. Soltani; B. Zhao;
W. Han; R. Smart; C. Trempus; J. Pritchard
10:30 AM-11:30 AM, Room 140-A (Convention Center), Presenter Jennifer Fostel
Exhibitor Hosted Session: National Toxicology Program Chemical Effects in Biological Systems
12:00 PM-1:15 PM, Salon G (Convention Center), Host NIEHS DERT
NIH New Investigator Luncheon
1:00 PM-4:30 PM, Exhibit Hall (Convention Center)
Genetic Polymorphisms
Poster Board 209. Association of genetic variations in antioxidant enzyme genes with diisocyanate-induced asthma in exposed workers B. Yucesoy; V. J.
Johnson; K. Fluharty; J. Slaven; Z. L. Lummus; G. E. Kissling; D. R. Germolec; M. I. Luster; D. I. Bernstein
1:00 PM-4:30 PM, Exhibit Hall (Convention Center)
Late-Breaking Abstracts - Session VIII
Poster Board 109. Reproductive and Developmental Toxicity of Formaldehyde: A systematic review and supporting evidence A. Duong; C. Steinmaus; C.
M. McHale; C. P. Vaughan; J. Bishop; L. Zhang
1:00 PM-4:30 PM, Exhibit Hall (Convention Center)
Metal Neurotoxicity: Methylmercury and General
Poster Board 224. Persisting Neurochemical Effects Of Developmental Copper Exposure In Wildtype And Metallothionein 1 And 2 Knockout Mice A. Petro;
H. Sexton; C. Miranda; A. Rastogi; J. H. Freedman; E. D. Levin
1:00 PM-4:30 PM, Exhibit Hall (Convention Center)
Methods in Biomarker Discovery and Validation
Poster Board 343. Validation of Best Detection Methods for Measuring Oxidative Stress M. B. Kadiiska
1:00 PM-4:30 PM, Exhibit Hall (Convention Center)
Drug Allergy, Pseudoallergy, IDRH, and Autoimmunity
Poster Board 516. ESR Spin-Trapping Investigation of Lung Free Radicals in an Animal Model of Interstitial Pneumonia Associated With Autoimmune
Disease M. B. Kadiiska; H. Miyakawa; J. Jiang; R. Mason
1:00 PM-4:30 PM, Exhibit Hall (Convention Center)
Risk Assessment and Regulatory Policy Applications
Poster Board 526. ICCVAM Evaluation and Recommendations on the Non-radioactive LLNA: BrdU-ELISA for Evaluating Allergic Contact Dermatitis
Hazards A. Jacobs; J. Matheson; M. Wind; V. Malshet; J. Toy; W. Stokes
Poster Board 527. ICCVAM Evaluation of the Local Lymph Node Assay (LLNA) for Potency Categorization of Chemicals Causing Allergic Contact
Dermatitis in Humans P. Brown; J. Matheson; A. Jacobs; T. McMahon; D. Germolec; M. Wind; W. Stokes
Poster Board 528. ICCVAM Evaluation and Recommendations on the Nonradioactive LLNA: DA for Evaluating Allergic Contact Dermatitis Hazards J.
Mathesono; A. Jacobs; M. Wind; P. Brown; R. Ward; E. Margosches; W. Stokes
Poster Board 529. Using Fewer Animals to Identify Chemical Eye Hazards: Revised Classification Criteria Necessary to Maintain Equivalent Hazard
Labeling W. Stokes; J. Haseman; E. Lipscomb; J. Truax; N. Johnson; B. Jones; D. Allen
1:00 PM-4:30 PM, Exhibit Hall (Convention Center)
Safety and Risk Assessment: Critical Characterizations for Chemicals and New Concerns
Poster Board 613. ICCVAM Recommendations on the Usefulness and Limitations of the Cytosensor Microphysiometer® (CM) Test Method For Ocular
Safety Testing J. Merrill; D. Lowther; A. Layton; J. Redden; M. Wind; W. Stokes
Poster Board 627. Environmental Predictors of US County Mortality Patterns on a National Basis. M. P. Chan; R. S. Weinhold; R. Thomas; J. M. Gohlke; C.
J. Portier
Poster Board 638. Characterization of Ionic Liquid Compounds for Toxicological Evaluation J. W. Algaier; C. C. Pearson; A. D. Ammenhauser; Q.
Lawrence; J. L. Cookinham; L. G. Siemann; R. K. Harris; B. Jayaram; C. S. Smith
1:00 PM-4:30 PM, Exhibit Hall (Convention Center), Poster Session - Chair Scott Auerbach
Omics in Toxicology Research
Poster Board 711. Characterization of the Hepatic Transcriptome Response to a Mixture of Low Molecular Weight Polybrominated Diphenyl Ethers:
Disease, Signature, Network, and Pathway Analysis S. S. Auerbach; K. R. Shockley; R. Thomas; N. J. Machesky; M. K. Vallant; C. D. Hebert; H. C. Cunny;
J. K. Dunnick
1:00 PM-4:30 PM, Exhibit Hall (Convention Center)
Developmental Toxicology
Poster Board 816. Effects of low-dose prenatal PFOA exposure on the mammary gland of CD-1 mice M. B. Macon; L. R. Villanueva; R. D. Zehr; K. Tatum
-Gibbs; M. J. Strynar; J. P. Stanko; S. S. White; L. Helfant; S. E. Fenton
1:00 PM-4:30 PM, Exhibit Hall (Convention Center)
Apoptosis/Cell Death
Poster Board 913. Neurotoxic signaling pathway of Bisphenol AF in hippocampal neuronal cells: role of calcium-induced ROS, MAPKs, and NF-κB S.
Kim; S. Lee
1:30 PM-4:15 PM, Room 144 (Convention Center), Symposium Session - Chair Andrew Rooney
Developmental Origins of Adult Disease: The Effects of Low-Dose Lead
Developmental Origins of Adult Disease: The Effect of Low Dose Lead (Pb) E. P. Hines; A. Rooney
1:30 PM-4:15 PM, Room 202B (Convention Center)
Application of Zebrafish Models in Toxicology
2:54 PM-3:15 PM
The effects of chemicals in the U.S. EPA's ToxCast Library on Caenorhabditis elegans and zebrafish development W. A. Boyd; M. V. Smith; J. H.
Freedman
1:30 PM-4:15 PM, Room 144 (Convention Center), Symposium Session - Chair Andrew Rooney
Developmental Origins of Adult Disease: The Effects of Low-Dose Lead
3:35 PM-4:15 PM
Contrasting the Developmental and Adult Origins of Adverse Effects from Lead in the draft NTP Monograph on Low-Level Lead A. A. Rooney
4:30 PM-6:00 PM, Room 207 (Convention Center)
50th Anniversary Member Celebration Meeting (SOT Members Only; Full, Associates, Postdoctoral, and Student Members Invited)
4:45 PM-6:00 PM, Room 156 (Convention Center)
ToxExpo 2012 Exhibit Space Selection Meeting
6:30 PM-9:30 PM, Grand Ballroom (Convention Center)
50th Anniversary Celebration Event
Wednesday, March 9
6:30 AM-7:50 AM, Room 144 (Convention Center), Education Career Development Session
From Pilot Grants to High-End Journals: The Science of Writing
6:53 AM-7:12 AM
Jerrold J. Heindel Grantsmanship at NIH: How to Swim with the Sharks
9:00 AM-11:45 AM, Room 204 (Convention Center), Workshop Session - Chair Cynthia Rider
Approaches for Incorporating Non-Chemical Stressors Into Cumulative Risk Assessments
Approaches for Incorporating Non-chemical Stressors into Cumulative Risk Assessments C. V. Rider; J. Simmons
9:00 AM-9:05 AM
Cynthia Rider Introduction
9:00 AM-12:30 PM, Exhibit Hall (Convention Center)
Xenobiotic Biotransformation
Poster Board 106. Metabolism of 2-Hydroxy-4-Methoxybenzophenone Depends on Species and Sex C. Wegerski; S. S. Auerbach; J. M. Sanders; M. Doyle-Eisele; J. D. McDonald
9:00 AM-12:30 PM, Exhibit Hall (Convention Center)
Arsenic
Poster Board 520. The effect of prenatal folate supplementation on DNA methylation and gene expression in male CD1 mouse fetuses exposed in utero
to arsenic V. Tsang; R. Fry; M. Niculescu; J. Saunders; M. Waalkes; M. Styblo; Z. Drobna
Poster Board 525. Epithelia Malignantly Transformed by Arsenic or Cadmium Drives Nearby Normal Stem Cells Towards a Malignant Phenotype Y. Xu; E.
Tokar; M. Waalkes
Poster Board 526. Overabundance of Putative Cancer Stem Cells in Human Skin Keratinocyte Cells Malignantly Transformed by Arsenic Y. Sun; E. Tokar;
M. Waalkes
9:00 AM-12:30 PM, Exhibit Hall (Convention Center)
Nanotoxicology: Metal Oxides, Silver, Gold, and Silica Nanoparticle Toxicity
Poster Board 717. Bioavailability and Tissue Distribution of Silver Nanoparticles in Sprague-Dawley Rats M. D. Boudreau; C. R. Cozart; P. H. Siitonen; M. V. Pogribna; N. J. Walker
Poster Board 728. A comparison of the phototoxic potency of six types of TiO2 nanoparticles W. K. Boyes; K. M. Sanders; L. L. Degn; R. M. Zucker; W. R. Mundy; B. Zhao; J. E. Roberts
9:30 AM-10:30 AM, Room 201 (Convention Center)
Meet the Directors Series: NIEHS Director, Lecturer: Linda Birnbaum
9:00 AM-11:45 AM, Room 202A (Convention Center), Symposium Session - Chair Cindy Lawler
Autism: Genetic, Epigenetic, and Environmental Factors Influencing Neural Networks
11:15 AM-11:30 AM
Autism and the Environment: Challenges and Opportunities for Advancing the Science C. Lawler
1:00 PM-4:30 PM, Exhibit Hall (Convention Center)
Developmental Basis of Adult Disease
Poster Board 242. Neonatal Genistein Exposure Causes Implantation Failure because of Permanent Alterations in Uterine Morphology and Steroid Hormone Responses W. Jefferson; S. M. Wagner; E. Padilla-Banks; C. J. Williams
Poster Board 243. Neonatal Genistein Exposure Permanently Disrupts Oviduct Gene Expression and Tissue Architecture During Pregnancy E. Padilla-Banks; W. Jefferson; S. M. Wagner; C. J. Williams
1:00 PM-4:30 PM, Exhibit Hall (Convention Center), Poster Session - Chair Minerva Mercado-Feliciano
Cellular Effects of Natural Product Extracts
Poster Board 324. Analysis of Resveratrol and its Metabolites in Pregnant Rats, Fetuses, and Pups B. L. Fletcher; M. A. Silinski; T. R. Fennell; F. K. Thomas; J. C. Blake; S. D. Cooper; R. A. Fernando; B. J. Collins
Poster Board 331. 13-Week Gavage Exposure to Gum Guggul Extract (GGE) Modulates Activity of Hepatic CYP2B and CYP3A in Harlan Sprague-Dawley Rats and B6C3F1 Mice C. A. Granville; M. K. Vallant; M. Hejtmancik; D. K. Gerken; M. E. Wyde
1:00 PM-4:30 PM, Exhibit Hall (Convention Center)
Persistent Organic Compounds (POPs)
Poster Board 352. Metabolomic analysis of serum after treatment with the emerging POP flame retardant Hexabromocyclododecane (HBCD): commercial mixture, alpha and gamma stereoisomers elicit differential effects in infantile mice. D. T. Szabo; W. Pathmasiri; J. J. Diliberto; S. Sumner; L. S. Birnbaum
1:00 PM-4:30 PM, Exhibit Hall (Convention Center)
Pharmacokinetics and Disposition
Poster Board 406. Pharmacokinetics of a pyrethroid insecticide mixture in the rat D. G. Ross; J. M. Starr; E. J. Scollon; K. M. Crofton; M. J. Wolansky; M. F. Hughes; M. J. DeVito
Poster Board 415. Toxicokinetics of Perfluorooctanoic Acid (PFOA) and Perfluorooctane Sulfonate (PFOS) after a Single Intravenous or Gavage Administration to Harlan Sprague Dawley Rats S. Hong; V. Robinson; S. Gibbs; S. W. Graves; B. Burback; M. Eifrid; C. Smith
Poster Board 416. Toxicokinetics of Perfluorohexanoic Acid (PFHXA) and Perfluorohexane-1-Sulphonic Acid Potassium Salt (PFHSKSLT) after a Single Intravenous or Gavage Administration to Harlan Sprague Dawley Rats S. Gibbs; V. Robinson; S. Hong; S. W. Graves; B. Burback; C. Granville; M. Eifrid; C. Smith
Poster Board 419. Metabolism and Disposition of 2-Methoxy-4-Nitroaniline in Male and Female Sprague Dawley Rats and B6C3F1 Mice S. Waidyanatha; Q. Zhan; I. Surh; S. Warren; P. Patel; S. Black; J. Burgess; J. Mathews
Poster Board 420. Metabolism and Disposition of n-butylparaben following oral and dermal administration J. Mathews; S. Black; C. Blystone; S. Brown; P. Patel; A. Etheridge; S. Waidyanatha
Poster Board 421. Dimethylethanolamine Increased Serum Choline, But Did Not Alter [14C]-Choline Tissue Distribution In Wistar Han Rats J. M. Sanders; C. J. Wegerski; M. Doyle-Eisele; J. D. McDonald
Poster Board 426. Genetic variation in isogenic strains of laboratory mice alters disposition in kidneys and livers after acute exposure to [14C] benzene R. Kuester; G. A. Knudsen; M. L. Cunningham; G. Sipes
1:00 PM-4:30 PM, Exhibit Hall (Convention Center)
Mechanisms of Aspiration Injury and Airway Disease
Poster Board 519. Systemic Uptake Of 14C 2,3-Butanedione Administered by Intratracheal Instillation in Male Sprague Dawley Rats And Oropharyngeal Aspiration in Male B6C3F1 Mice T. Fennell; D. Morgan; S. Watson; S. Waidyanatha
1:00 PM-4:30 PM, Exhibit Hall (Convention Center)
Endocrine Toxicology
Poster Board 620. PCB-153 and BDE-47 Increase Thyroxine (T4 ) Catabolism in Rat and Human Hepatocytes V. M. Richardson; M. J. DeVito
Poster Board 621. Triclosan Decreases Rat Thyroxine: Mode-of-Action, Developmental Susceptibility and Human Relevance K. B. Paul; J. M. Hedge; S. O. Simmons; M. J. DeVito; K. M. Crofton
Poster Board 631. Integrating human and toxicological evidence to understand PCB effects on the developing brain F. Parham; A. Wise; D. A. Axelrad; K. Z. Guyton; C. J. Portier; L. Zeise; R. T. Zoeller; T. J. Woodruff
Poster Board 645. Evaluation of subchronic toxicity and estrogenic activity of black cohosh in female weanling B6C3F1 mice exposed by gavage M. Mercado-Feliciano; M. D. Stout; C. A. Granville; M. Hejtmancik; R. Newbold; M. K. Vallant; P. M. Foster
1:00 PM-4:30 PM, Exhibit Hall (Convention Center)
Food Safety and Nutrition
Poster Board 833. Composition of Multiple Lots of Evening Primrose Oil Compared with Corn Oil T. Cristy; S. Graves; V. G. Robinson; C. Smith
1:00 PM-4:30 PM, Exhibit Hall (Convention Center)
Late-Breaking Abstracts - Session VIII
Poster Board 914. Lung Function and Pathogenesis of Bronchiolitis Obliterans in Rats Exposed to 2,3-Pentanedione D. L. Morgan; H. C. Price; C. L. Johnson; M. P. Jokinen; W. M. Gwinn; G. P. Flake
1:30 PM-4:15 PM, Room 202B (Convention Center), Platform Session
Nrf2 and Antioxidant Response Networks
3:15 PM-3:35 PM
Profiling Environmental Chemicals in the Antioxidant Response Element Pathway using Quantitative High-Throughput Screening (qHTS) S. J. Shukla; R. Huang; S. O. Simmons; R. R. Tice; K. L. Witt; M. Xia
3:35 PM-3:55 PM
Nuclear factor E2-related factor 1 is involved in arsenic-induced antioxidant response in human keratinocytes R. Zhao; Y. Hou; P. Xue; C. G. Woods; J. Fu; M. P. Waalkes; M. E. Andersen; J. Pi
4:30 PM-5:50 PM, Room 143 (Convention Center), Informational Session
Progress of the Tox21 Consortium in High-Throughput Bioactivity Profiling of Chemicals
Progress Of The Tox21 Consortium In High-Throughput Bioactivity Profiling Of Chemicals R. Kavlock; C. Austin
4:30 PM-4:35 PM
Chris Austin Introduction
4:35 PM-4:53 PM
Ann Richard The Strategy for Design of the 10,000 Chemical Library and Chemoinformatic Characterization
4:53 PM-5:11 PM
Kristine Witt The Strategy for Assay Selection and Assay Queue
5:11 PM-5:29 PM
Ruili Huang Informatic Approaches to Analysis of 10K Chemical Library
5:29 PM-5:47 PM
David Jacobson-Kram Using Human Data to Understand and Interpret Tox21 Screening Results
5:47 PM-5:50 PM
Robert Kavlock Closing Remarks
7:00 PM-8:30 PM, Grand Ballroom Central (Renaissance Hotel)
President's Reception (By Invitation Only)
Thursday, March 10
6:30 AM-7:50 AM, Room 145 (Convention Center), Education Career Development Session
Chair Minerva Mercado-Feliciano
Bringing Toxicology to the Decision-Makers Table: Opportunities for Science Policy Positions in Washington, D.C.
Bringing Toxicology to the Decision-Makers Table: Opportunities for Science Policy and Regulatory Science Positions in Washington DC. N. Beck; M.
Mercado-Feliciano
6:30 AM-6:36 AM
Nancy Beck and Minerva Mercado-Feliciano Introduction
8:30 AM-12:00 PM, East Salon Area (Convention Center)
Alternatives to Mammalian Models
Poster Board 109. Development of a Caenorhabditis elegans movement assay for assessing neurotoxicity J. H. Freedman; D. W. Snyder; W. A. Boyd; G. E. Kissling
8:30 AM-12:00 PM, East Salon Area (Convention Center)
Disease Prevention
Poster Board 182. International Workshop on Alternative Methods to Reduce, Refine, and Replace the Use of Animals in Vaccine Potency and Safety Testing J. Kulpa-Eddy; R. McFarland; R. Isbrucker; M. Halder; H. Kojima; B. Jones; N. Johnson; D. Allen; E. Lipscomb; S. Morefield; W. Casey; W. Stokes
Poster Board 190. Estimating the global public health implications of electricity and coal consumption J. M. Gohlke; R. Thomas; A. Woodward; D. Campbell-Lendrum; A. Pruss- Ustun; S. Hales; C. J. Portier
8:30 AM-12:00 PM, East Salon Area (Convention Center)
Developmental Neurotoxicity: General
Poster Board 234. Effects of radio frequency radiation exposure from mobile phones on brain microvessel endothelial cells, a model of blood brain barrier: An in vitro study E. Cuevas; S. M. Lantz; W. J. Trickler; B. R. Robinson; G. D. Newport; P. C. Howard; N. J. Walker; M. Wyde; A. Desta; M. G. Paule; S. F. Ali
8:30 AM-12:00 PM, East Salon Area (Convention Center)
Carcinogenesis II
Poster Board 242. Liver toxicity following Kava Kava administration in F344 Rats and B6C3F1 Mice M. Behl; R. S. Chhabra; A. Nyska; L. Fomby; B. R. Sparrow; M. R. Hejmancik; P. C. Chan
Poster Board 247. RAP80 Plays a Critical Role in Maintaining Genomic Stability Z. Yin; A. M. Jetten
Poster Board 255. Covalent Binding of 14C 2-Methoxy-4-Nitroaniline in Male Sprague Dawley Rats R. Snyder; S. Waidyanatha; I. Surh; T. Banks; P. Patel; S. Black; T. Fennell
8:30 AM-12:00 PM, Room 202
Grace Period Abstracts
Poster Board 130. Optimization of the Local Lymph Node Assay: Bromodeoxyuridine Detected by Flow Cytometry (LLNA:BrdU-FC) in BALB/c Mice for Hypersensitivity Evaluation T. L. Guo; D. R. Germolec; C. E. McLoughlin; M. J. Smith; K. L. White, Jr.; W. Auttachoat
Poster Board 106. Immunoexpression of Estrogen Receptors Alpha and Beta α and β Progesterone Receptor [PR] and Proliferating Cell Nuclear Antigen [PCNA] in Leiomyoma and Normal Myometrial Tissues from the Miniature Pig, Sus scrofa: A New Fibroid Model K. Mozzachio; A. B. Moore; N. D. Flagler; C. Swanson; D. Dixon
Poster Board 144. A model to explore the spectrum of diverse microglial functions with injury G. J. Harry; A. D. Kraft; C. A. McPherson\
Poster Board 149. Investigating the mechanisms of aromatic amine-induced protein free radical formation by QSARs: implications for drug-induced agranulocytosis A. G. Siraki; J. Jiang; R. P. Mason
Poster Board 209. Chemical injury-induced neurogenesis: Potential contribution of resident microglia C. McPherson; G. J. Harry
9:00 AM-11:45 AM, Room 143 (Convention Center), Symposium Session
Developmental Exposure to Environmental Toxicants: From Persistent Toxicities to Diseases
Developmental Exposure to Environmental Toxicants: From Persistent Toxicities to Diseases M. La Merrill; T. Simones; B. Hannas; J. Larocca; S. Li; B. Winans; K. M. Streifel; E. Tokar; E. Kendig
9:00 AM-11:45 AM, Room 201 (Convention Center), Workshop Session - Chair Dori Germolec
Autoimmunity Versus Systemic Hypersensitivity: Commonalities Useful for Immunotoxicity Testing
Autoimmunity Versus Systemic Hypersensitivity: Commonalities Useful For Immunotoxicity Testing R. Pieters; D. Germolec
9:00 AM-11:45 AM, Room 143 (Convention Center), Symposium Session
Developmental Exposure to Environmental Toxicants: From Persistent Toxicities to Diseases
9:58 AM-10:23 AM
The Role of Stem Cells in Arsenic-induced Transplacental Carcinogenesis E. J. Tokar; M. P. Waalkes
