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Society of Toxicology 50th Anniversary

Walter E. Washington Convention Center in Washington, D.C.
March 6-10, 2011

Society of Toxicology - 50th Anniversary, 1961-2011.  Celebrating 50 Years of Service in Science.

 

Schedule days:


Featured highlights, events and activities:

 

NIEHS, NTP, and EHP Exhibit

Booth 1414/1323/1416

 

Monday, March 7 

8:00 AM-9:00 AM, Grand Ballroom (Convention Center), Plenary Opening Lecture 

Lawrence A. Tabak, Principal Deputy Director, National Institutes of Health 

NIH Vision

Wednesday, March 9 

9:30 AM-10:30 AM, Room 201 (Convention Center) 

Meet the Directors Series: NIEHS and NTP Director, Linda Birnbaum 

The National Institute of Environmental Health Sciences (NIEHS) seeks to understand how the environment influences the development and progression of human disease. This session will be a particularly valuable opportunity to update SOT members on the future directions of the NIEHS and the National Toxicology Program (NTP). Dr. Birnbaum will talk about her plans for leading NIEHS and NTP in promoting the environmental public health of the United States and the world through research directed at preventing and treating disease. 

Tuesday-Wednesday, March 8-9 

9:30 AM-4:30 AM, Room 203 (Convention Center) 

NIH Research Funding Resource Room

Saturday, March 5

10:00 AM-5:00 PM, Koshland Science Museum (National Academy of Sciences)

K-12 Outreach: Protecting You and Your Pet through the Science of Toxicology: Paracelsus Goes to Washington; Banalata Sen, Science Education and Outreach Program Manager, EHP

 


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Sunday, March 6

6:00 AM-8:00 AM, Buses Depart L Street (Convention Center)

Past Presidents 5K Fun Run

1:15 PM-5:00 PM, Room 202 (Convention Center), Continuing Education Session - Chair Srikanth Nadadur

Evaluating Toxicity of Engineered Nanomaterials: Issues with Conventional Toxicology Approaches


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Monday, March 7

9:15 AM-12:00 PM, Room 143 (Convention Center), Symposium Session - Chair Cynthia Rider

Emerging Issues at the Intersection of Reproductive and Mixtures Toxicology

Emerging Issues at the Intersection of Reproductive and Mixtures Toxicology V. S. Wilson; C. V. Rider

 

9:15 AM-9:20 AM

Cynthia Rider Introduction

9:30 AM-12:30 PM, Exhibit Hall (Convention Center)

Hypersensitivity: Methods and Mechanisms

Poster Board 119. Contact Sensitizing Potential of Heptachlor in Female BALB/c Mice R. P. Frawley; W. Auttachoat; M. J. Smith; R. D. Brown; T. L. Guo; K. 

L. White Jr; D. R. Germolec

9:30 AM-12:30 PM, Exhibit Hall (Convention Center)

Bioinformatic Profiling and Computational Pathway Prediction

Poster Board 240. Discovery of novel micro-RNAs from Rat lymphocytes during glucocorticoid induced apoptosis R. Shah; S. Vasa; L. Smith; J. Cidlowski

 

Poster Board 248. Use of C. elegans growth assay data in novel two-step hierarchical QSAR modeling workflow enhances in vivo toxicity prediction for 

ToxCast Phase I chemicals A. Golbraikh; R. Shah; W. Boyd; M. Smith; A. Tropsha; J. Freedman

9:30 AM-12:30 PM, Exhibit Hall (Convention Center)

Carcinogenesis I

Poster Board 415. Tumors and Proliferative Lesions in Adult Offspring After Maternal Exposure to Methylarsonous Acid During Gestation in CD1 Mice. M. 

Waalkes; B. A. Diwan; E. J. Tokar; D. J. Thomas

 

Poster Board 417. Toxicology study of senna in C3B6F1/N Trp53 haploinsufficient mice I. Surh; A. Brix; J. French; J. Dunnick

 

Poster Board 427. Pathway directed molecular analysis of large intestinal tumors induced in Fisher 344 rats exposed to aloe vera whole leaf extract in 

drinking water A. R. Pandiri; R. C. Sills; M. J. Hoenerhoff; T. T. Ton; H. L. Hong; G. P. Flake; D. E. Malarkey; I. Pogribny; N. J. Walker; M. D. Boudreau

9:30 AM-12:30 PM, Exhibit Hall (Convention Center)

Metals I

Poster Board 501. Metallothionein and Acute Cadmium-Induced DNA Oxidative Damage W. Qu; L. Cheng; Y. Sun; R. P. Mason; M. Waalkes

 

Poster Board 502. Sexual Dimorphism of Cadmium-induced Toxicity in Rats: Involvement of Progesterone H. Shimada; T. Hashiguchi; A. Yasutake; M. P. 

Waalkes; Y. Imamura

 

Poster Board 508. Toxic Effects of Cadmium on Human Peripheral Lung Cells R. Person; E. Tokar; M. Waalkes

 

Poster Board 510. Identification of cadmium-responsive transcriptional regulators of the C. Elegans gene, cdr-1 L. E. Fuhrman; J. H. Freedman

9:30 AM-12:30 PM, Exhibit Hall (Convention Center)

Genotoxicity

Poster Board 621. Genotoxicity of Styrene-Acrylonitrile Trimer in Weanling F344 Rats R. S. Chhabra; C. A. Hobbs; L. Recio; J. Winters; K. Shepard; P.

 Allen; M. Prajapati; M. Streicker; K. L. Witt

 

Poster Board 635. Comparison of aneuploidies of chromosomes X, Y, and 21 in the peripheral blood lymphocytes and sperm cells of workers exposed 

to benzene Z. Ji; R. H. Weldon; F. Marchetti; H. Chen; G. Li; C. Xing; E. Kurtovich; S. Young; T. E. Schmid; S. Waidyanatha; S. Rappaport; A. J. Wyrobek; L. 

Zhang; B. Eskenazi

9:30 AM-12:30 PM, Exhibit Hall (Convention Center)

Receptor and Receptor-Mediated Toxicity

Poster Board 707. Activating PKCβ1 at the Blood-Brain Barrier (BBB) Reverses Induction of P-glycoprotein (Pgp) Activity by Dioxin and Restores Drug 

Delivery to the CNS X. Wang; B. Hawkins; D. Miller

9:30 AM-12:30 PM, Exhibit Hall (Convention Center)

Cell Signaling and Gene Regulation

Poster Board 810. Identification of transcriptional regulators of C. elegans metallothionein gene expression J. Hall; J. H. Freedman

 

Poster Board 835. Attenuation of the Nrf2 Signaling Pathway in Hepatocytes Lacking Sirtuin 1 (Sirt1) W. Wei; J. Xu; S. Kulkarni; X. Li; A. Slitt

12:10 PM-1:30 PM, Room 143 (Convention Center), Informational Session - Chair William Stokes

The International Cooperation on Alternative Test Methods (ICATM): Translating Science to Provide Improved Public Health Safety Assessment Tools

The International Cooperation on Alternative Test Methods (ICATM): Translating Science to Provide Improved Public Health Safety Assessment Tools W. 

Stokes; M. Wind

 

12:10 PM-12:20 PM

William S. Stokes The International Cooperation on Alternative Test Methods (ICATM):

Translating Science into Public Health Safety Assessment Tools

1:00 PM-4:30 PM, Exhibit Hall (Convention Center)

Risk Assessment: Computational Approaches, Analyses, and Applications

Poster Board 225. Using a Multiple Stage Decision Tree to Make Activity Calls in Quantitative High-Throughput Screening (qHTS) Data K. R. Shockley; G. 

E. Kissling; R. Huang; M. Xia; C. P. Austin; R. R. Tice

 

Poster Board 236. Assessment of Mitochondrial Toxicity of Environmental Chemicals Using a Quantitative High-Throughput Screening Approach M. S. 

Attene-Ramos; R. Huang; S. Sakamuru; S. Shahane; L. Shou; K. L. Witt; R. R. Tice; C. P. Austin; M. Xia

1:00 PM-4:30 PM, Exhibit Hall (Convention Center)

Inhalation and Cardiopulmonary Toxicology

Poster Board 416. In vitro macrophage cytotoxicity of indium-phosphide and indium-tin oxide particles is dependent upon phagosome acidification after 

particle uptake W. M. Gwinn; C. J. Shines; R. W. Bousquet; D. L. Morgan

1:00 PM-4:30 PM, Exhibit Hall (Convention Center)

Mechanisms of Immunotoxicity

Poster Board 635. Synergism of leptin signaling and post translational protein oxidation in bromodichloromethane exposure is key to the development of 

steatohepatitis of obesity S. Chatterjee; J. Clark; M. Kadiiska; R. P. Mason

1:00 PM-4:30 PM, Exhibit Hall (Convention Center)

Biological Modeling: Computational Approaches, Mixtures, Multiroute and Lifestage Applications

Poster Board 711. Physiologically Based Pharmacokinetic Modeling (PBPK) as a Tool To Predict 2,3,7,8-Tetrachlorodibenzo-P-Dioxin (TCDD) 

Pharmacokinetics (PK) During Gestation and Lactation C. Emond; M. J. Devito; M. Warner; B. Eskenazi; P. Mocarelli; L. S. Birnbaum

 

Poster Board 721. A PBPK Model of Micro and Nano Sized Fluorescent Polystyrene Spheres in Rats X. Chang; K. Sarlo; N. Walker; K. Blackburn; E. Clark; 

J. Grothaus; C. Portier

 

Poster Board 734. Characterization Of Strain & Dose-Dependent Routes Of Elimination for Benzene & Its Metabolites in 4 Mouse Strains. G. A. Knudsen

R. K. Kuester; M. L. Cunningham; J. E. French; I. G. Sipes

2:00 PM-4:45 PM, Room 145 (Convention Center), Workshop Session

Technical Characterization and Dosimetry Challenges Associated with Conducting or Interpreting Nanotoxicity

2:36 PM-3:02 PM

Minimum Material Characterizations for Nanotoxicology Studies: A Necessity or a Nuisance? N. J. Walker

2:00 PM-4:45 PM, Room 202A (Convention Center), Platform Session

Biomarkers of Carcinogenesis

2:48 PM-3:12 PM

Development and Evaluation of a Genomic Signature for the Prediction of Non-genotoxic Hepatocarcinogens in the Rat R. T. Dunn; A. Adai; A. Olaharski; 

G. H. Searfoss; J. Sina; J. Aubrecht; E. Boitier; P. Nioi; D. Jacobson Kram; N. Raghavan; B. Car; S. Chen; Y. Yang; A. Kinkaid; J. Sherlock; S. Auerbach; M. Fielden


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Tuesday, March 8

6:30 AM-7:50 AM, Room 147 (Convention Center), Informational Session

Emerging Science for Environmental Health Decisions: Tools, Strategies, and Evidence

Emerging Science For Environmental Health Decisions: Tools, Strategies, and Evidence W. H. Farland 

 

7:35 AM-7:50 AM

The Path To Incorporating Emerging Science in Environmental Health Decisions Linda Birnbaum 

9:00 AM-12:30 PM, Exhibit Hall (Convention Center)

Alternative Approaches to Animal Testing for Toxicological Research 

Poster Board 140. Population-based quantitative high-throughput screening (qHTS) for chemical toxicity S. O'Shea; O. Kosyk; N. Abdo; E. Lock; F. Wright; 

R. Huang; M. Xia; C. Austin; R. Tice; I. Rusyn 

 

Poster Board 145. Molecular Effects of Inorganic and Organic Mercury in Caenorhabditis elegans and Human Cells M. K. McElwee; J. H. Freedman

9:00 AM-12:30 PM, Exhibit Hall (Convention Center)

Alternatives to Mammalian Models for Testing 

Poster Board 243. International Validation Study of an In Vitro Cell Proliferation Test Method for Screening Potential Estrogenic Agonists and Antagonists 

in MCF-7 cells F. Deal; W. Casey; P. Ceger; D. Allen; C. Yang; M. Nakamura; H. Kojima; A. Ono; H. Yoon; S. Han; W. Stokes 

 

Poster Board 244. Final Results of an International Validation Study of an In Vitro ER TA Test Method in BG-1 cells W. Casey; P. Ceger; D. Allen; G. Clark;

 P. Pazos; E. Grignard; J. de Lange; S. Bremer; M. Nakamura; H. Kojima; W. Stokes 

9:00 AM-12:30 PM, Exhibit Hall (Convention Center)

Nanotoxicology: Carbon Nanotubes, Carbon Nanoparticulates, and Quantum Dots 

Poster Board 646. Airway Inflammation in Mice Exposed to Ovalbumin Allergen and Multi-walled Carbon Nanotubes (MWCNT) is Regulated by 

Cyclooxygenase-2 (COX-2) B. C. Sayers; E. E. Glista; A. J. Taylor; R. Langenbach; J. C. Bonner 

 

Poster Board 417. Toxicology study of senna in C3B6F1/N Trp53 haploinsufficient mice I. Surh; A. Brix; J. French; J. Dunnick

9:00 AM-12:30 PM, Exhibit Hall (Convention Center), Poster Session - Chair Kembra Howdeshell

Reproductive Toxicology I 

Poster Board 301. Fetal Phthalate Screen: Assessment of Several Phthalate Esters (PE) on Fetal Rodent Testosterone (T) Production and Gene 

Expression following In Utero Exposure C. Lambright; J. Furr; M. Cardon; B. Hannas; D. Bermudez; N. Wrench; V. Wilson; P. Foster; E. Gray, Jr 

9:30 AM-12:30 PM, Exhibit Hall (Convention Center)

Reproductive Toxicology II 

Poster Board 354. FoxO1 associated p27kip1 decrease is essential for Fenvalerateinduced cell growth in human uterine leiomyoma (UtLM) and smooth 

muscle cells (UtSMCs) X. Gao; L. Yu; L. Castro; A. B. Moore; M. I. Sifre; C. D. Bortner; D. Dixon 

9:30 AM-12:30 PM, Exhibit Hall (Convention Center)

Receptor and Receptor-Mediated Toxicity

Poster Board 707. Activating PKCβ1 at the Blood-Brain Barrier (BBB) Reverses Induction of P-glycoprotein (Pgp) Activity by Dioxin and Restores Drug 

Delivery to the CNS X. Wang; B. Hawkins; D. Miller

9:30 AM-12:30 PM, Exhibit Hall (Convention Center)

Hepatotoxicity

Poster Board 413. PFOA-induced liver effects in CD-1 and PPAR-alpha knock-out C57BL/6 mice A. J. Filgo; M. J. Hoenerhoff; G. E. Kissling; S. S. White; E. 

P. Hines; J. P. Stanko; S. E. Fenton 

 

Poster Board 420. Quantitative (q)PCR Analysis of RNA Extracted from Formalin-Fixed Paraffin Embedded (FFPE) LIVER from Aflatoxin B1 (AFB1) Treated 

Rats: Correlation with Microarray Data B. A. Merrick; S. S. Auerbach; P. S. Stockton; J. F. Foley; D. E. Malarkey; R. C. Sills; R. D. Irwin; R. R. Tice

9:00 AM-12:30 PM, Exhibit Hall (Convention Center)

Stem Cell Toxicology 

Poster Board 603. Cadmium-induced transformation of human stem cells E. Tokar; M. Waalkes 

9:00 AM-12:30 PM, Exhibit Hall (Convention Center)

Exposure Assessments and Biomonitoring Applications 

Poster Board 823. Bisphenol A (BPA) and Hexabromocyclododecane (HBCD) Stereoisomers in U.S. Food A. Schecter; N. Malik; O. Paepke; L. Birnbaum 

9:00 AM-11:45 AM, Room 143 (Convention Center), Workshop Session

Using Mode of Action Data to Guide Quantitative Cancer Risk Assessment: A Case Study of Hexavalent Chromium in Drinking Water 

9:05 AM-9:20 AM

NTP Toxicology and Carcinogenesis Studies of Chromium M. D. Stout; M. J. Hooth

9:00 AM-11:45 AM, Room 202B (Convention Center), Platform Session

Gene Regulatory Mechanisms of Carcinogenesis 

10:03 AM-10:24 AM

Reduction of PTEN dose impairs DNA repair and predisposes to UVB-induced skin tumorigenesis Y. He; M. Ming; L. Feng; C. Shea; K. Soltani; B. Zhao;

 W. Han; R. Smart; C. Trempus; J. Pritchard

10:30 AM-11:30 AM, Room 140-A (Convention Center), Presenter Jennifer Fostel

Exhibitor Hosted Session: National Toxicology Program Chemical Effects in Biological Systems 

12:00 PM-1:15 PM, Salon G (Convention Center), Host NIEHS DERT

NIH New Investigator Luncheon 

1:00 PM-4:30 PM, Exhibit Hall (Convention Center)

Genetic Polymorphisms 

Poster Board 209. Association of genetic variations in antioxidant enzyme genes with diisocyanate-induced asthma in exposed workers B. Yucesoy; V. J.

 Johnson; K. Fluharty; J. Slaven; Z. L. Lummus; G. E. Kissling; D. R. Germolec; M. I. Luster; D. I. Bernstein

1:00 PM-4:30 PM, Exhibit Hall (Convention Center)

Late-Breaking Abstracts - Session VIII 

Poster Board 109. Reproductive and Developmental Toxicity of Formaldehyde: A systematic review and supporting evidence A. Duong; C. Steinmaus; C.

 M. McHale; C. P. Vaughan; J. Bishop; L. Zhang 

1:00 PM-4:30 PM, Exhibit Hall (Convention Center)

Metal Neurotoxicity: Methylmercury and General

Poster Board 224. Persisting Neurochemical Effects Of Developmental Copper Exposure In Wildtype And Metallothionein 1 And 2 Knockout Mice A. Petro;

 H. Sexton; C. Miranda; A. Rastogi; J. H. Freedman; E. D. Levin

1:00 PM-4:30 PM, Exhibit Hall (Convention Center)

Methods in Biomarker Discovery and Validation

Poster Board 343. Validation of Best Detection Methods for Measuring Oxidative Stress M. B. Kadiiska

1:00 PM-4:30 PM, Exhibit Hall (Convention Center)

Drug Allergy, Pseudoallergy, IDRH, and Autoimmunity

Poster Board 516. ESR Spin-Trapping Investigation of Lung Free Radicals in an Animal Model of Interstitial Pneumonia Associated With Autoimmune 

Disease M. B. Kadiiska; H. Miyakawa; J. Jiang; R. Mason

1:00 PM-4:30 PM, Exhibit Hall (Convention Center)

Risk Assessment and Regulatory Policy Applications

Poster Board 526. ICCVAM Evaluation and Recommendations on the Non-radioactive LLNA: BrdU-ELISA for Evaluating Allergic Contact Dermatitis 

Hazards A. Jacobs; J. Matheson; M. Wind; V. Malshet; J. Toy; W. Stokes

 

Poster Board 527. ICCVAM Evaluation of the Local Lymph Node Assay (LLNA) for Potency Categorization of Chemicals Causing Allergic Contact 

Dermatitis in Humans P. Brown; J. Matheson; A. Jacobs; T. McMahon; D. Germolec; M. Wind; W. Stokes

 

Poster Board 528. ICCVAM Evaluation and Recommendations on the Nonradioactive LLNA: DA for Evaluating Allergic Contact Dermatitis Hazards J.

 Mathesono; A. Jacobs; M. Wind; P. Brown; R. Ward; E. Margosches; W. Stokes

 

Poster Board 529. Using Fewer Animals to Identify Chemical Eye Hazards: Revised Classification Criteria Necessary to Maintain Equivalent Hazard 

Labeling W. Stokes; J. Haseman; E. Lipscomb; J. Truax; N. Johnson; B. Jones; D. Allen

1:00 PM-4:30 PM, Exhibit Hall (Convention Center)

Safety and Risk Assessment: Critical Characterizations for Chemicals and New Concerns

Poster Board 613. ICCVAM Recommendations on the Usefulness and Limitations of the Cytosensor Microphysiometer® (CM) Test Method For Ocular 

Safety Testing J. Merrill; D. Lowther; A. Layton; J. Redden; M. Wind; W. Stokes

 

Poster Board 627. Environmental Predictors of US County Mortality Patterns on a National Basis. M. P. Chan; R. S. Weinhold; R. Thomas; J. M. Gohlke; C.

 J. Portier

 

Poster Board 638. Characterization of Ionic Liquid Compounds for Toxicological Evaluation J. W. Algaier; C. C. Pearson; A. D. Ammenhauser; Q. 

Lawrence; J. L. Cookinham; L. G. Siemann; R. K. Harris; B. Jayaram; C. S. Smith 

1:00 PM-4:30 PM, Exhibit Hall (Convention Center), Poster Session - Chair Scott Auerbach

Omics in Toxicology Research

Poster Board 711. Characterization of the Hepatic Transcriptome Response to a Mixture of Low Molecular Weight Polybrominated Diphenyl Ethers:

 Disease, Signature, Network, and Pathway Analysis S. S. Auerbach; K. R. Shockley; R. Thomas; N. J. Machesky; M. K. Vallant; C. D. Hebert; H. C. Cunny;

 J. K. Dunnick

1:00 PM-4:30 PM, Exhibit Hall (Convention Center)

Developmental Toxicology

Poster Board 816. Effects of low-dose prenatal PFOA exposure on the mammary gland of CD-1 mice M. B. Macon; L. R. Villanueva; R. D. Zehr; K. Tatum

-Gibbs; M. J. Strynar; J. P. Stanko; S. S. White; L. Helfant; S. E. Fenton

1:00 PM-4:30 PM, Exhibit Hall (Convention Center)

Apoptosis/Cell Death

Poster Board 913. Neurotoxic signaling pathway of Bisphenol AF in hippocampal neuronal cells: role of calcium-induced ROS, MAPKs, and NF-κB S.

 Kim; S. Lee

1:30 PM-4:15 PM, Room 144 (Convention Center), Symposium Session - Chair Andrew Rooney

Developmental Origins of Adult Disease: The Effects of Low-Dose Lead

Developmental Origins of Adult Disease: The Effect of Low Dose Lead (Pb) E. P. Hines; A. Rooney

1:30 PM-4:15 PM, Room 202B (Convention Center)

Application of Zebrafish Models in Toxicology

2:54 PM-3:15 PM

The effects of chemicals in the U.S. EPA's ToxCast Library on Caenorhabditis elegans and zebrafish development W. A. Boyd; M. V. Smith; J. H.

 Freedman

1:30 PM-4:15 PM, Room 144 (Convention Center), Symposium Session - Chair Andrew Rooney

Developmental Origins of Adult Disease: The Effects of Low-Dose Lead

3:35 PM-4:15 PM

Contrasting the Developmental and Adult Origins of Adverse Effects from Lead in the draft NTP Monograph on Low-Level Lead A. A. Rooney

4:30 PM-6:00 PM, Room 207 (Convention Center)

50th Anniversary Member Celebration Meeting (SOT Members Only; Full, Associates, Postdoctoral, and Student Members Invited)

4:45 PM-6:00 PM, Room 156 (Convention Center)

ToxExpo 2012 Exhibit Space Selection Meeting

6:30 PM-9:30 PM, Grand Ballroom (Convention Center)

50th Anniversary Celebration Event


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Wednesday, March 9

6:30 AM-7:50 AM, Room 144 (Convention Center), Education Career Development Session

From Pilot Grants to High-End Journals: The Science of Writing

6:53 AM-7:12 AM

Jerrold J. Heindel Grantsmanship at NIH: How to Swim with the Sharks

9:00 AM-11:45 AM, Room 204 (Convention Center), Workshop Session - Chair Cynthia Rider

Approaches for Incorporating Non-Chemical Stressors Into Cumulative Risk Assessments

Approaches for Incorporating Non-chemical Stressors into Cumulative Risk Assessments C. V. Rider; J. Simmons

 

9:00 AM-9:05 AM

Cynthia Rider Introduction

9:00 AM-12:30 PM, Exhibit Hall (Convention Center)

Xenobiotic Biotransformation

Poster Board 106. Metabolism of 2-Hydroxy-4-Methoxybenzophenone Depends on Species and Sex C. Wegerski; S. S. Auerbach; J. M. Sanders; M. Doyle-Eisele; J. D. McDonald

9:00 AM-12:30 PM, Exhibit Hall (Convention Center)

Arsenic

Poster Board 520. The effect of prenatal folate supplementation on DNA methylation and gene expression in male CD1 mouse fetuses exposed in utero

 to arsenic V. Tsang; R. Fry; M. Niculescu; J. Saunders; M. Waalkes; M. Styblo; Z. Drobna

 

Poster Board 525. Epithelia Malignantly Transformed by Arsenic or Cadmium Drives Nearby Normal Stem Cells Towards a Malignant Phenotype Y. Xu; E.

 Tokar; M. Waalkes

 

Poster Board 526. Overabundance of Putative Cancer Stem Cells in Human Skin Keratinocyte Cells Malignantly Transformed by Arsenic Y. Sun; E. Tokar;

 M. Waalkes

9:00 AM-12:30 PM, Exhibit Hall (Convention Center)

Nanotoxicology: Metal Oxides, Silver, Gold, and Silica Nanoparticle Toxicity

Poster Board 717. Bioavailability and Tissue Distribution of Silver Nanoparticles in Sprague-Dawley Rats M. D. Boudreau; C. R. Cozart; P. H. Siitonen; M. V. Pogribna; N. J. Walker

 

Poster Board 728. A comparison of the phototoxic potency of six types of TiO2 nanoparticles W. K. Boyes; K. M. Sanders; L. L. Degn; R. M. Zucker; W. R. Mundy; B. Zhao; J. E. Roberts

9:30 AM-10:30 AM, Room 201 (Convention Center)

Meet the Directors Series: NIEHS Director, Lecturer: Linda Birnbaum

9:00 AM-11:45 AM, Room 202A (Convention Center), Symposium Session - Chair Cindy Lawler

Autism: Genetic, Epigenetic, and Environmental Factors Influencing Neural Networks

11:15 AM-11:30 AM

Autism and the Environment: Challenges and Opportunities for Advancing the Science C. Lawler

1:00 PM-4:30 PM, Exhibit Hall (Convention Center)

Developmental Basis of Adult Disease

Poster Board 242. Neonatal Genistein Exposure Causes Implantation Failure because of Permanent Alterations in Uterine Morphology and Steroid Hormone Responses W. Jefferson; S. M. Wagner; E. Padilla-Banks; C. J. Williams

 

Poster Board 243. Neonatal Genistein Exposure Permanently Disrupts Oviduct Gene Expression and Tissue Architecture During Pregnancy E. Padilla-Banks; W. Jefferson; S. M. Wagner; C. J. Williams

1:00 PM-4:30 PM, Exhibit Hall (Convention Center), Poster Session - Chair Minerva Mercado-Feliciano

Cellular Effects of Natural Product Extracts

Poster Board 324. Analysis of Resveratrol and its Metabolites in Pregnant Rats, Fetuses, and Pups B. L. Fletcher; M. A. Silinski; T. R. Fennell; F. K. Thomas; J. C. Blake; S. D. Cooper; R. A. Fernando; B. J. Collins

 

Poster Board 331. 13-Week Gavage Exposure to Gum Guggul Extract (GGE) Modulates Activity of Hepatic CYP2B and CYP3A in Harlan Sprague-Dawley Rats and B6C3F1 Mice C. A. Granville; M. K. Vallant; M. Hejtmancik; D. K. Gerken; M. E. Wyde

1:00 PM-4:30 PM, Exhibit Hall (Convention Center)

Persistent Organic Compounds (POPs)

Poster Board 352. Metabolomic analysis of serum after treatment with the emerging POP flame retardant Hexabromocyclododecane (HBCD): commercial mixture, alpha and gamma stereoisomers elicit differential effects in infantile mice. D. T. Szabo; W. Pathmasiri; J. J. Diliberto; S. Sumner; L. S. Birnbaum

1:00 PM-4:30 PM, Exhibit Hall (Convention Center)

Pharmacokinetics and Disposition

Poster Board 406. Pharmacokinetics of a pyrethroid insecticide mixture in the rat D. G. Ross; J. M. Starr; E. J. Scollon; K. M. Crofton; M. J. Wolansky; M. F. Hughes; M. J. DeVito

 

Poster Board 415. Toxicokinetics of Perfluorooctanoic Acid (PFOA) and Perfluorooctane Sulfonate (PFOS) after a Single Intravenous or Gavage Administration to Harlan Sprague Dawley Rats S. Hong; V. Robinson; S. Gibbs; S. W. Graves; B. Burback; M. Eifrid; C. Smith

 

Poster Board 416. Toxicokinetics of Perfluorohexanoic Acid (PFHXA) and Perfluorohexane-1-Sulphonic Acid Potassium Salt (PFHSKSLT) after a Single Intravenous or Gavage Administration to Harlan Sprague Dawley Rats S. Gibbs; V. Robinson; S. Hong; S. W. Graves; B. Burback; C. Granville; M. Eifrid; C. Smith

 

Poster Board 419. Metabolism and Disposition of 2-Methoxy-4-Nitroaniline in Male and Female Sprague Dawley Rats and B6C3F1 Mice S. Waidyanatha; Q. Zhan; I. Surh; S. Warren; P. Patel; S. Black; J. Burgess; J. Mathews

 

Poster Board 420. Metabolism and Disposition of n-butylparaben following oral and dermal administration J. Mathews; S. Black; C. Blystone; S. Brown; P. Patel; A. Etheridge; S. Waidyanatha

 

Poster Board 421. Dimethylethanolamine Increased Serum Choline, But Did Not Alter [14C]-Choline Tissue Distribution In Wistar Han Rats J. M. Sanders; C. J. Wegerski; M. Doyle-Eisele; J. D. McDonald

 

Poster Board 426. Genetic variation in isogenic strains of laboratory mice alters disposition in kidneys and livers after acute exposure to [14C] benzene R. Kuester; G. A. Knudsen; M. L. Cunningham; G. Sipes

1:00 PM-4:30 PM, Exhibit Hall (Convention Center)

Mechanisms of Aspiration Injury and Airway Disease

Poster Board 519. Systemic Uptake Of 14C 2,3-Butanedione Administered by Intratracheal Instillation in Male Sprague Dawley Rats And Oropharyngeal Aspiration in Male B6C3F1 Mice T. Fennell; D. Morgan; S. Watson; S. Waidyanatha

1:00 PM-4:30 PM, Exhibit Hall (Convention Center)

Endocrine Toxicology

Poster Board 620. PCB-153 and BDE-47 Increase Thyroxine (T4 ) Catabolism in Rat and Human Hepatocytes V. M. Richardson; M. J. DeVito

 

Poster Board 621. Triclosan Decreases Rat Thyroxine: Mode-of-Action, Developmental Susceptibility and Human Relevance K. B. Paul; J. M. Hedge; S. O. Simmons; M. J. DeVito; K. M. Crofton

 

Poster Board 631. Integrating human and toxicological evidence to understand PCB effects on the developing brain F. Parham; A. Wise; D. A. Axelrad; K. Z. Guyton; C. J. Portier; L. Zeise; R. T. Zoeller; T. J. Woodruff

 

Poster Board 645. Evaluation of subchronic toxicity and estrogenic activity of black cohosh in female weanling B6C3F1 mice exposed by gavage M. Mercado-Feliciano; M. D. Stout; C. A. Granville; M. Hejtmancik; R. Newbold; M. K. Vallant; P. M. Foster

1:00 PM-4:30 PM, Exhibit Hall (Convention Center)

Food Safety and Nutrition

Poster Board 833. Composition of Multiple Lots of Evening Primrose Oil Compared with Corn Oil T. Cristy; S. Graves; V. G. Robinson; C. Smith

1:00 PM-4:30 PM, Exhibit Hall (Convention Center)

Late-Breaking Abstracts - Session VIII

Poster Board 914. Lung Function and Pathogenesis of Bronchiolitis Obliterans in Rats Exposed to 2,3-Pentanedione D. L. Morgan; H. C. Price; C. L. Johnson; M. P. Jokinen; W. M. Gwinn; G. P. Flake

1:30 PM-4:15 PM, Room 202B (Convention Center), Platform Session

Nrf2 and Antioxidant Response Networks

3:15 PM-3:35 PM

Profiling Environmental Chemicals in the Antioxidant Response Element Pathway using Quantitative High-Throughput Screening (qHTS) S. J. Shukla; R. Huang; S. O. Simmons; R. R. Tice; K. L. Witt; M. Xia

 

3:35 PM-3:55 PM

Nuclear factor E2-related factor 1 is involved in arsenic-induced antioxidant response in human keratinocytes R. Zhao; Y. Hou; P. Xue; C. G. Woods; J. Fu; M. P. Waalkes; M. E. Andersen; J. Pi

4:30 PM-5:50 PM, Room 143 (Convention Center), Informational Session

Progress of the Tox21 Consortium in High-Throughput Bioactivity Profiling of Chemicals

Progress Of The Tox21 Consortium In High-Throughput Bioactivity Profiling Of Chemicals R. Kavlock; C. Austin

 

4:30 PM-4:35 PM

Chris Austin Introduction

 

4:35 PM-4:53 PM

Ann Richard The Strategy for Design of the 10,000 Chemical Library and Chemoinformatic Characterization

 

4:53 PM-5:11 PM

Kristine Witt The Strategy for Assay Selection and Assay Queue

 

5:11 PM-5:29 PM

Ruili Huang Informatic Approaches to Analysis of 10K Chemical Library

 

5:29 PM-5:47 PM

David Jacobson-Kram Using Human Data to Understand and Interpret Tox21 Screening Results

 

5:47 PM-5:50 PM

Robert Kavlock Closing Remarks

7:00 PM-8:30 PM, Grand Ballroom Central (Renaissance Hotel)

President's Reception (By Invitation Only)


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Thursday, March 10

6:30 AM-7:50 AM, Room 145 (Convention Center), Education Career Development Session

Chair Minerva Mercado-Feliciano

Bringing Toxicology to the Decision-Makers Table: Opportunities for Science Policy Positions in Washington, D.C.

Bringing Toxicology to the Decision-Makers Table: Opportunities for Science Policy and Regulatory Science Positions in Washington DC. N. Beck; M.

Mercado-Feliciano

 

6:30 AM-6:36 AM

Nancy Beck and Minerva Mercado-Feliciano Introduction

8:30 AM-12:00 PM, East Salon Area (Convention Center)

Alternatives to Mammalian Models

Poster Board 109. Development of a Caenorhabditis elegans movement assay for assessing neurotoxicity J. H. Freedman; D. W. Snyder; W. A. Boyd; G. E. Kissling

8:30 AM-12:00 PM, East Salon Area (Convention Center)

Disease Prevention

Poster Board 182. International Workshop on Alternative Methods to Reduce, Refine, and Replace the Use of Animals in Vaccine Potency and Safety Testing J. Kulpa-Eddy; R. McFarland; R. Isbrucker; M. Halder; H. Kojima; B. Jones; N. Johnson; D. Allen; E. Lipscomb; S. Morefield; W. Casey; W. Stokes

 

Poster Board 190. Estimating the global public health implications of electricity and coal consumption J. M. Gohlke; R. Thomas; A. Woodward; D. Campbell-Lendrum; A. Pruss- Ustun; S. Hales; C. J. Portier

8:30 AM-12:00 PM, East Salon Area (Convention Center)

Developmental Neurotoxicity: General

Poster Board 234. Effects of radio frequency radiation exposure from mobile phones on brain microvessel endothelial cells, a model of blood brain barrier: An in vitro study E. Cuevas; S. M. Lantz; W. J. Trickler; B. R. Robinson; G. D. Newport; P. C. Howard; N. J. Walker; M. Wyde; A. Desta; M. G. Paule; S. F. Ali

8:30 AM-12:00 PM, East Salon Area (Convention Center)

Carcinogenesis II

Poster Board 242. Liver toxicity following Kava Kava administration in F344 Rats and B6C3F1 Mice M. Behl; R. S. Chhabra; A. Nyska; L. Fomby; B. R. Sparrow; M. R. Hejmancik; P. C. Chan

 

Poster Board 247. RAP80 Plays a Critical Role in Maintaining Genomic Stability Z. Yin; A. M. Jetten

 

Poster Board 255. Covalent Binding of 14C 2-Methoxy-4-Nitroaniline in Male Sprague Dawley Rats R. Snyder; S. Waidyanatha; I. Surh; T. Banks; P. Patel; S. Black; T. Fennell

8:30 AM-12:00 PM, Room 202

Grace Period Abstracts

Poster Board 130. Optimization of the Local Lymph Node Assay: Bromodeoxyuridine Detected by Flow Cytometry (LLNA:BrdU-FC) in BALB/c Mice for Hypersensitivity Evaluation T. L. Guo; D. R. Germolec; C. E. McLoughlin; M. J. Smith; K. L. White, Jr.; W. Auttachoat

 

Poster Board 106. Immunoexpression of Estrogen Receptors Alpha and Beta α and β Progesterone Receptor [PR] and Proliferating Cell Nuclear Antigen [PCNA] in Leiomyoma and Normal Myometrial Tissues from the Miniature Pig, Sus scrofa: A New Fibroid Model K. Mozzachio; A. B. Moore; N. D. Flagler; C. Swanson; D. Dixon

 

Poster Board 144. A model to explore the spectrum of diverse microglial functions with injury G. J. Harry; A. D. Kraft; C. A. McPherson\

 

Poster Board 149. Investigating the mechanisms of aromatic amine-induced protein free radical formation by QSARs: implications for drug-induced agranulocytosis A. G. Siraki; J. Jiang; R. P. Mason

 

Poster Board 209. Chemical injury-induced neurogenesis: Potential contribution of resident microglia C. McPherson; G. J. Harry

9:00 AM-11:45 AM, Room 143 (Convention Center), Symposium Session

Developmental Exposure to Environmental Toxicants: From Persistent Toxicities to Diseases

Developmental Exposure to Environmental Toxicants: From Persistent Toxicities to Diseases M. La Merrill; T. Simones; B. Hannas; J. Larocca; S. Li; B. Winans; K. M. Streifel; E. Tokar; E. Kendig

9:00 AM-11:45 AM, Room 201 (Convention Center), Workshop Session - Chair Dori Germolec

Autoimmunity Versus Systemic Hypersensitivity: Commonalities Useful for Immunotoxicity Testing

Autoimmunity Versus Systemic Hypersensitivity: Commonalities Useful For Immunotoxicity Testing R. Pieters; D. Germolec

9:00 AM-11:45 AM, Room 143 (Convention Center), Symposium Session

Developmental Exposure to Environmental Toxicants: From Persistent Toxicities to Diseases

9:58 AM-10:23 AM

The Role of Stem Cells in Arsenic-induced Transplacental Carcinogenesis E. J. Tokar; M. P. Waalkes


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