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Visionary Ideas: Affected/Susceptible Populations

New Strategic Plan


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Visionary Ideas

NIEHS established a special website for visitors to submit, vote on, or comment on Visionary Ideas, as well as discuss strengths, weaknesses, opportunities, and threats for NIEHS. Visionary Ideas are as submitted, unedited for grammar or spelling.

Idea 1: Addressing the public health challenge of autism

Autism is now an urgent public health issue, affecting approximately 1% of children, and 1 in 70 boys in the US. Over the past 30 years, the prevalence of autism spectrum disorders has increased over 600%. Recent research indicates that while some of this increase can be attributed to changes in diagnostic practice and improved awareness, a substantial portion of this increase remains unexplained. Therefore, a wide scope of environmental influences that potentially increase risk of autism, including sociological, toxicological and nutritional factors, need to be further studied. This is further supported by the heterogeneity in the symptoms of autism, where many causes may lead to many different disease phenotypes.


A large effort has been dedicated to identifying and characterizing the genetic risk factors associated with autism, with relatively little attention directed at the role of environmental factors, and their interactions with genetic susceptibility. Many autism risk genes have been demonstrated to be regulated epigenetically, suggesting that environmental factors such as chemicals and diet may influence risk of the disease across generations. Identification of these and other unknown risk factors will lead to targeted prevention and intervention strategies where some exposures may be avoided so that the effects can be mitigated. Among the autism risk factors that already have some empirical support are maternal infection during pregnancy, advanced parental age, low birth weight and premature birth, and in utero exposure to certain pharmaceuticals, toxins and chemicals.


This is a crucial time in autism research. Exciting discoveries are coupled by new opportunities and important collaborations both in basic science and epidemiology. As much as autism is an urgent public health problem which needs further attention by research and science, it can also serve as a model disorder to better understand mechanisms of genetic and environmental risk factors in childhood and adult disease. Ongoing prevalence studies and longitudinal cohort projects provide the opportunity to identify exposures and change disease course and outcome. The NIEHS should embrace focused studies in autism to 1) understand how environmental exposures affect autism prevalence, onset, and progression, 2) integrate known genetic risk factors to identify gene/environment interactions that may inform autism causes as well as those of other developmental disorders and 3) help develop a new primary and secondary prevention model to improve the lives of individuals on the autism spectrum. As there is active investment in autism environmental research by private nonprofit organizations, this area of research offers an excellent opportunity for NIEHS to leverage its investments through public-private partnerships.

Idea 2: Anyone that was in the Nam should give their opinion on this

Comment 1
Anyone that was in Nam should vote and give their opinion!

Comment 2 
Support this cause.

Idea 3: Autism and Autoimmunity

Research that looks at recent independent research that Dr. Vijendra Singh has done finding that children with autism have elevated measles titer antibodies and tested positive for myelin basic protein. Research has also been done that found children with autism have colon inflammation. There needs to be more research to expand on the independent research that Dr. Vijendra Singh and others have done on autoimmunity and autism.

Idea 4: Autism and High Throughput Screening

Due to advances in technology it is now possible to use computational toxicology methodology to conduct virtual screening for gene-environment interactions as they relate to specific high profile diseases, such as autism. This is accomplished by using our current knowledge of gene pathways and protein structures and combining those with high priority chemical toxicants using ligand receptor docking technology to identify high scoring gene variant and chemical combination. Such targeted investigations will greatly reduce the cost associated with genome-wide association studies and also help to identify environmental insults, which offers the opportunity for prevention and treatment.

Comment 
Too late!! My daughter found out AFTER the MMR was administered to my grandson in 1993, he should NEVER had had this vaccine. Why? The leaflet enclosed with the vaccine stated it was contra indicated where there was a family history of certain neurological conditions. No one at the health clinic even bothered to read this leaflet. My grandson developed autism and a painful bowel condition following the MMR vaccine. PROPER screening could virtually eliminate harm due to inherited genetic risk factors. It is now possible to identify those children most at risk using genetic screening.

Idea 5: Autism: Environmental Factors and Individual Susceptibility

It is estimated by the CDC that one in every 110 children and one in every 70 boys today is diagnosed with autism, creating an urgent health crisis. Prior to the 1990's autism was a rare disorder affecting 2-4 per 10,000. Acknowledgment of this alarming increase in the number of children diagnosed with autism demands a focus away from an exclusively genetic cause to one that acknowledges the role the environment. Yet, to date, the role of environmental scientists and toxicologists in the investigation of autism has been modest. Environmental research has been identified as an area of need by the NIH-Interagency Autism Coordinating Committee (IACC). The National Institute of Environmental Health Sciences (NIEHS) has the expertise to provide critical research that can advance our understanding of the interactions between environmental factors and individual susceptibility in order to determine how these elements interrelate to cause illnesses, such as autism. The broader category of Neurodevelopmental Disorders (NDD) of which autism is the most severe, is estimated to affect one in every six children today in the US. Therefore, such critical knowledge derived from this research would also provide insights into NDDs in general and go a long way in improving the lives of our children in helping them to reach their full potential.

Comment 1 
Get rid of all vaccines too as they don't cure illnesses. Only healthy nutrition helps bodies do what they were designed to do and that is heal themselves. Get everyone on the same page about what is good nutrition -- the opposite of the Food Pyramid and go all organic without GMOs.

Comment 2 
My daughter was given the hepatitis-B vaccine at the hospital when she was a few hours old, got encephalitis at four days old with no apparent cause other than the vaccine, and was diagnosed with autism at twenty months. This same scenario has occurred thousands of times. Of course we should give priority to investigating the vaccines.

Comment 3 
The gold standard of scientific research is using the drug/vaccine vs. a placebo in a double blind study. Why has a vaccinated vs. unvaccinated study NEVER been done? Why was it necessary for the U.S. Government to indemnify all vaccine manufacturers from any liability if their products are so safe? Why did the number of vaccines administered triple after all risk of lawsuits disappeared? These are questions that need to answered NOW.

Comment 4 
This one is a no-brainer - autism is the # serious health threat to our children.

Comment 5 
My son with autism had a complete metabolic panel that showed increased oxidative markers and inflammation. These are metabolic and IMMUNE issues. Which means some foreign body is triggering this response and/or cellular processes. He is recovering much of his lost language, social skills, and bowel function using an orthomolecular approach, and intensive antioxidant administration. This alone SCREAMS environmental causation. This study should have been done 2 decades ago. The writing is on the wall.

Comment 6 
My son also reacted to his first Hep B shot shortly after birth. He had hive type skin reaction and hours of inconsolable upset. He completely regressed and lost all speech and developed seizures after his series that contained the MMR. He was then diagnosed with autism. I will never again trust a vaccine nor will I ever trust the staff in the business of medicine. I now realize that my son was nothing to them. I am the one that cares for him 24 hours a day and I have to be the one that decides any further medical care we will ever receive again. All of us families with the same story can not be imagining this. It is real.

Comment 7 
This is essential to study now!
My child was permanently neurologically disabled by SOMETHING in the environment, after having been completely healthy & normal for her first 14 months.
We don't know what caused it - it could have been vaccines, pesticides, mercury in fish, something else, some combination; nobody is properly studying this yet.
In the mean time, the lives of 100s of 1000s of children in the US alone, and their entire families, are being extremely seriously disrupted. The whole industrialized world has a similar problem - and countries like Somalia do not.
The CDC & FDA fiddle while Rome burns - and it's happening to us now.
Does anyone wonder why intelligent, well educated US parents are frustrated with the gov't health agencies and the medical profession?

Comment 8 
What will happen to the autism population when they out number the NT population? If we look at what's happening now with the Baby boomers aging out, the out look for our kids is not encouraging. Taking a broader look, what will happen to America then?

Comment 9 
I like hundreds of other parents/grandparents
am blaming this all on the series of shots given at around 18 months of age. I had a perfectly healthy grandson until then and after the shots he became sick, at which time the physician said " oh lots of kids get sick from them, just administer baby Tylenol and he will be better".
He is now 7 years of age and I have NEVER heard him talk. He is non-verbal autistic!

Comment 10 
Let it go, folks. Genes cause autism, and the best evidence tells us the incidence of autism has been stable for a very long time.
Your autistic children are beautiful people. Embrace them for who they are, and stop abusing them by constantly rejecting them and telling them how damaged they are.

Far too much research money has already been wasted chasing after Wakefield's bogeyman and bad science.

Give it a rest.

Comment 11 
Bob, you obviously don't understand how genes work. Read up on the subject before make such an ignorant statement.

Comment 12 
Oh Bob. Way to attack the heart of the people. My child is beautiful, but there is NOTHING beautiful about autism. Autism is not some mysticized ethereal phenomenon of fragile children with brilliant minds. Autism is pain, poop, meltdowns, inconsolability, unliked food on the ceiling, wandering deaths, and an inability to communicate. Autism is ugly, and through each step of recovery process our beautiful child is able to escape his neurological prison. There is nothing ever, in recorded history that would see something with a genetic etiology exponentially rise in incidence AND prevalence, whether we have reached a plateau at this time or not. If it IS genetic, it is likely an Epigenetic issue, or the way certain genes are expressed when exposed to ENVIRONMENTAL STIMULATION. We are doing the opposite of rejecting our children- we are rejecting the idea that the environment isn't to blame, and rejecting the idea that there is nothing to be done to help them. We are EMBRACING recovery, honest science, the beautiful personalities of our children SCREAMING to come out. As you obviously don't have an autistic child by the use of your pronoun "your" then you have NO. IDEA. WHAT. YOU. ARE. TALKING. ABOUT.

Comment 13 
This is so essential to put a stop to this tragic epidemic of autism
Maurine Meleck

Comment 14 
The research proposals on this website focus on possible environmental causes of autoimmune diseases, autism, chronic fatigue, chemical sensitivity/intolerance, military veterans' illnesses, as well as individuals who report symptoms associated with oil spills, fracking, hazardous waste sites, various community exposures, dioxin, home remodeling, poor indoor air quality, mold, pesticide use, and myriad other environmental exposures. But, in fact, individuals with these seemingly unrelated exposures and multi-system health problems share a great deal in common: their multi-system symptoms are often triggered by every day, low-level chemical exposures. Many also report adverse reactions to foods, medications, alcoholic beverages and/or caffeine. Dr. Nicholas Ashford of MIT and I first described this phenomenon 15 years ago. Toxicant-Induced Loss of Tolerance (TILT) is the name we gave to the underlying dynamic. It involves a two-step process whereby an initial acute or chronic toxic exposure causes loss of tolerance for everyday exposures. These new-onset intolerances perpetuate the disease process. We described how low-level exposures to common chemicals, foods, and medications may be the driving force behind the increased incidence of many hitherto unexplained medical symptoms and how masking—resulting from overlapping responses to multiple incidents—obscures the fact that everyday exposures can perpetuate illness. These concepts arose from reports by physicians, researchers and patients from more than a dozen industrialized nations. Collectively, their observations provide evidence that toxicant-induced loss of tolerance may be a new theory of disease. Currently, we are at the germ theory stage in terms of our understanding of this phenomenon. Well-founded theories—those based on careful observation, as in the case of the germ theory—are vital for developing shared scientific understanding and igniting future research.

In summary, it appears we are dealing with a two-stage disease process: (1) loss of tolerance resulting from an acute or chronic exposure event, followed by (2) repeated triggering of symptoms by everyday exposures, such as gasoline vapors, engine exhaust, fragrances or cleaning agents—exposures which had not been a problem for the person previously. This phenomenon became increasingly common with the widespread introduction of synthetic organic chemicals following WW II. This, coupled with the fact that 90% of Americans spend 90% of their day inside poorly ventilated structures where unprecedented types and levels of synthetic volatile organic chemicals (VOCs) are present, has led to the epidemic of chronic illnesses we are witnessing today. If we are to understand the extent to which these exposures contribute to the host of chronic illnesses mentioned on this website, doctors and researchers must have access to environmental medical research units— hospital-like research facilities in which people with major illnesses such as autism or autoimmune disorders, can be placed on an elimination diet in a chemically clean environment to see if their symptoms improve. If their symptoms resolve, then everyday exposures and foods can be reintroduced, one at a time. We are all so different and we respond differently to different exposures. NIEHS has an unprecedented opportunity: new approaches for assessing gene and protein expression and new brain imaging techniques can be used both before and after challenges in an EMU. We need to move forward, but not without this essential research tool—the Environmental Medical Unit (EMU). The EMU has been a priority recommendation of several professional and governmental conferences, yet still no research EMU exists in the U.S. It is time for NIEHS/NIH to add the EMU to its portfolio, so that we can all begin to understand the common dynamic shared by so many chronic, costly, and disabling medical conditions. The many excellent comments shared on this website testify to this need.

1. Chemical Exposures: Low Levels and High Stakes by Nicholas A. Ashford and Claudia S. Miller (Wiley). May be downloaded at no charge from www.chemicalexposures.org, along with a published and validated screening questionnaire for chemical intolerance, the Quick Environmental Exposure and Sensitivity Inventory (QEESI).
2. Toxicant-induced loss of tolerance—an emerging theory of disease? Miller CS. Environmental Health Perspectives: vol 105 Supp 2:445-453 (1997).
3. Empirical approaches for the investigation of toxicant-induced loss of tolerance. Miller C, Ashford A, Doty R, Lamielle M, Otto D, Rahill A, Wallace L. Environmental Health Perspectives: vol 105 Supp 2:515-519 (1997).
4. Toxicant-induced loss of tolerance. Miller CS. Addiction 96(1):115-139 (2000).

Idea 6: Autism spectrum diagnoses and immunization schedules

Compare the occurrence of the various autism conditions in two or more populations - none of them notably inbred - and matched for gender, educational attainment and degree of affluence of the parents, rural or urban location, etc., It would be necessary to forego matching on religious beliefs, for obvious reasons. For simplicity's sake, the study could be limited to two populations {the full recommended CDC schedule versus none) or enlarged to include alternatives (some but not all, later rather than sooner). The latter would require more sophisticated significance testing.

Idea 7: Autism: Subgroups susceptible to toxins & antigens in vaccines

There is a growing public crisis of confidence in the U.S. vaccine program. According to a recent a study of the American Academy of Pediatrics more than half of parents responding to a national survey expressed concern over serious adverse effects of vaccines, and one in four believe some vaccines cause autism. Since vaccines are studied individually for safety when approved, there has been no research that addresses cumulative and concurrent exposure to multiple vaccines the first 18 months of life. The current early infant immunization schedule recommends 28 vaccines for 14 diseases during the first 18 months of life. Immunizations are known to contain metals and chemicals that have been recognized an having toxic properties such as aluminum, ethyl mercury, formaldehyde, phenol and glutamate which are co-administered with live virus vaccines such as measles, mumps, rubella, varicella and rotavirus. The NIEHS could provide valuable scientific information in this arena through the utilization of animal models, preferably infant primate, to investigate toxicological and neurodevelopmental impacts of the combined early childhood immunization schedule. Such research is supported by scientific reports of children developing adverse events such as seizures, mitochondrial dysfunction, acute disseminated encephalomyelitis and developmental regression after multiple vaccine exposure. Environment is typically defined as any factor non-genetic in nature and includes pharmaceuticals.

Comment 1 
Vaccination should not be a scary thing for parents. This study will help us understand the impact of various substances in our vaccines, requiring manufacturers to make them as healthy as possible. If scientists are knowledgeable about the side effects, preservatives in vaccinations, and effect they have overall, they will be begin to make them safer. And if parents are confident that there is more detailed knowledge and are aware of changes that are taking place to ensure their safety, patents will begin to vaccinate more. We want detailed information and knowledge about vaccines and their impact on our children.

Comment 2 
Parents want to protect their children from disease. Yet now days, almost everyone knows a child that was developing normal but then became autistic. Thousands upon thousands parents say they saw their child change after vaccines. Parents are told to watch what their kids eat, use less toxic cleaning products, paints, and carpets but then are told to inject vaccines with ammonium sulfate, GMO yeast, bacteria and viral DNA, MSG, aluminum, formaldehyde, polysorbate 80, mercury and more. No wonder they are confused and scared. We know some cleaning products are safe when used alone but deadly when mixed but we do not have studies on the toxicity of vaccine ingredients when mixed or vaccines when combined or given close together. Considering that congress now says that 80% of the million and a half Americans with autism are under the age of 20, we need to focus our research on what has changed in the last 20 years. The laws of genetic probability has not changed in the past 20 years, the number of vaccines given to children has increased dramatically in this time frame. With autism being the fastest growing epidemic in America, we need to fast track research in this area.

Comment 3 
I have a son who had a complete encephalitic reaction to his 15 mo. dtap vaccine. not only did his doctor refuse to acknowledge what had happened, but she also said I would have to leave her practice if I did not want to keep vaccinating this same child. it took us a year to recover him. 2 months to regain eye contact, 4 mos to regain name recognition, 6 mos to regain affection, and a year to stabilize his immune system and regain sleep. it was within minutes of the shot. literally. NO way was this not 100 % related to the vaccine. IT DOES HAPPEN. as a previously FULLY vaccinating mother of 2, I will never ever let anyone in my family get another vaccine again. this MUST get studied. one of the things that angered e the most was the complete refusal of my doc or even the hospital to acknowledge the correlation even the it was the most scientifically plausible reason for all his immediate symptoms which included what is known medically as the encephalitic cry (which started half an hour after the shot, and continued for an hour and an half,) and the 103.5 fever that lasted 9 days and the loss of all appetite and the paleness and the photophobia and the lack of affect etc. all clinical signs of encephalitis, which is even a PROVEN possible side effect of the vax!!!! they would not even consider this at the time. where is the science, folks???? if you want to be doctors and scientists then be willing to look at the facts.

Comment 4 
A large study comparing completely non-vaccinated children to fully vaccinated children is imperative.

Comment 5 
At 6 months in 1991 my son had his first DPT (they used live virus back then) and within two hours he starting a high pitched screaming which I had never heard the likes of before or since. At the same time he developed a very high fever. No matter what I gave him I could not get the fever down. After 48 hours it went down but it took six weeks for him to look us in the eye again and look less agitated. I vowed to never give him the pertussis component of that vaccine again as I had heard of similar reactions. I believe if he had been younger when he got his first vaccine he may have ended up with SIDS as a paper on pub med reported. At 17 months he got the MMR and had a mild attack of measles and mild fever. Within 10 das he developed head aches and banged his head against the wall, he stopped playing appropriately and bashed his head with all his toys. He started running around in circles and looked very agitated. Within two months he had lost all the language he had developed. He was always a high functioning baby before that. He walked independently at 8 months one week. By the age of two he was well and truly lost in the world of severe autism. I did research on pub med when the internet became available and found the live pertussis vaccine was also used as an adjunct for the anthrax vaccine on soldiers who were in the Gulf war. Some of them developed signs of encephalitis and similar symptoms to my son in relation to headaches etc. Apparently the live pertussis vaccine has the ability to damage the blood brain barrier so that when the MMR came along it could have slipped through the blood brain barrier and cause a chronic encephalitis or I believe a possible chronic variant form of SSPE. My son is 19 now and is still very autistic and did not develop abstract thought. I think it is ridiculous to give children vaccines for usually mild diseases that help up to build up our immune system. I breast fed my son until he became autistic and pushed me away. He didn't really need these vaccines because my immunity to these diseases would have been passed on to him. I had measles, mumps, rubella and chicken pox as a child, (one at a time) and the body dealt with it in the form of rash and mild fever. It did not smolder away in the liver where it does not belong. These diseases are not caught be being injected naturally, they are caught by air born means or contact with saliva where the body deals with them appropriately. How can the body rid itself of diseases that are injected into you blood stream and can lay dormant or mutate in another form in the liver because the were not eradicated by fever or rash as they would normally do. They could develop treatment for people who suffered bad cases of these common childhood diseases but there is far more money to be made in vaccinating everybody than developing treatment for the very rare cases of bad reactions to these diseases. As for the effectiveness of the pertussis vaccine, all I can say is there must be a lot of different strains of it because my son caught it recently and gave it to me. We coughed a lot for 3 months but we recovered completely as our body dealt with it naturally. I didn't end up with a screaming headache or fever and subsequent autism unlike my son and only child. My husband and I come from a huge gene pool and no one except my son has developed autism, and autistic kids don't marry so I can't put his development of autism down to genes but environmental toxins in the form for antibiotics, and vaccines all help to weaken our child's immune system so it is worth examining. I don't trust the drug companies and doctors on the panels passing the safety of these vaccines because many hold shares in the drug companies or have a vested interest in some way. The MMR was only tested for three weeks as to it's safety and it was passed three votes to two as safe. The third vote in favor was from a person who had shares in the drug company. The drug companies and major share holders who own publishing companies made sure that any doctor wishing to question vaccine safety will be professionally and financially destroyed as happened to Dr, Wakefield. His name constantly comes up in main stream media to remind doctors of their possible fate should they attempt to threaten big pharma's profits by questioning vaccine safety. His name is also used in a fraudulent way to discourage parents from finding out the truth of his research for themselves. Hiring journalists like Brian Deer to do their dirty work then give him a journalist award is a perfect example of how low they can stoop to hide the truth about vaccine dangers and protect their profits. Stacking the GMC panel that deregistered Doctor Wakefield with doctors who owned shares in the vaccine company is another example. I hope future research that attempts to examine the possible links to vaccines and the onset of regressive autism is allowed to get off the ground. It is often suggested that a cheap way to examine the effects of vaccines and some environmental toxins is to examine the Amish community who I believe do not have any children who suffer from autism except two reported cased of children that were adopted into their after being vaccinated.


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Idea 8: Biomonitoring among children and adolescents

Biomonitoring is not available outside of the research arena. We should be able to implement biomonitoring as part of health care service to children, adolescents and prenatal populations, particularly in high risk groups as a method of risk reduction. With the increasing use of electronic records, data can be vital in identifying population trends, raising awareness to emerging disease incidence and epidemiological trends. Biomonitoring results could be logged into a central databank (without individual identifier) for further public health attention and action at the local level.

Comment 
Biomonitoring among children and adolescents.

Idea 9: Biospheres to Eliminate 90% of he Toxins

I would like to see the Concept of Biospheres used in Environmental Health. How do we set up the Home, Cars, Workplace, & Schools as a Biosphere to Eliminate 90% of Radon, Mold, Asbestos, Pesticides, & Chemical Exposures? How do we Eliminate 90% of the Toxic Foods from the Diet?

Comment 
If we can Eliminate or Inhibit 90% of the Stressors or Toxins causing the Illnesses-----That would be a Wonderful Visionary Goal for Environmental Medicine. Besides Antibiotics, Stem Cell, Microbiomes, Surgeries, Drug Treatments, Radiation Treatments, or Anti Virals---How about the theory of Inhibiting or Eliminating of 90% of all the Toxic Stressors that cause the Illness. This idea doesn't Deal with Abstract Futuristic Ideas of the New Medicines and the Treatments. This idea deals with common sense—The Hear and Now. It deals with the Concepts of Proven Biospheres and the Filtration of the Air and Water that we Breath. It deals with Eliminating or Inhibiting 90% of the Toxins that enter your Body. The Cancer Studies are very obvious from the People that come from a Cleaner Air like the Alaskan Indians as opposed to the people living in our Bigger Cities. If we could Cut our Cancer rate by 50% that would save in the Hundreds of Thousands of Lives Yearly in the US and save us Billions for the US in Lost Productivity and Illnesses.


Most of our Problems today are Caused by Ourselves and the Decisions that we make. If you live by a Toxic Waste Dump you could of Scrubbed the Air that you Breathed. If you live off a Freeway you could used a Hepa filter to clean the Air. If you Live by an Asbestos Mine you could stop 90% of the Asbestos by closing all your Windows and Doors and by installing Air Filters that filter 99.9% of all the Air that you Breath. If you live by a Toxic Stream---You don't have Eat the Fish and Drink the Water. If you live by a Coal/Electric Utility you could remind them that last year the US produced over 44,000,000 ton of Sulfur and that there are uses for Sulfur like---Fertilizers, Matches, Sulfa Drugs, Batteries, and Vulcanization of Rubber. You could also install a Scrubber to take the Sulfur out of your Air.


We have the Technology to Eliminate or Inhibit 90% of the Environmental Stressors that cause the Diseases. Where are these Proven Technologies in people's homes today? If you have a Mold Problem you can inhibit the Mold by installing a $200 Dehumidifier to bring the Humidity Levels Down to (20) Humidity. Most Molds goes into Hibernation below (45) Humidity. Charles Darwin did not invent the Theory of Evolution. His Grandpa Erasmus Darwin invented the theory 72 years earlier. Charles Integrated the Major (17) Theories of the Day. Prevention is just as important as the Operation or the Medicine.

Idea 10: Build specialized health facility for chemical/ toxin exposures

Less than 5% of the more than 80,000 chemicals introduced in the United States since World War II have been tested for their effects on human health and development. Our non-profit organization wants to build a specialized health facility, offering traditional & complementary treatments for those affected by chemical or toxin exposures.


By being more proactive & preventive, we hope to save millions of dollars in health care costs. Some of the toxins or events to be addressed include:


  • Agent Orange from Viet Nam
  • Gulf War illnesses
  • 9-11
  • Katrina
  • Libby, MT (asbestos)
  • Burn pits in Iraq & Afghanistan
  • Chernobyl
  • Depleted uranium
  • Bhopal, India
  • Household toxins
  • Phthalates
  • Pesticides
  • Workplace contaminants and more...

A methodical approach of diagnosing, treating, and monitoring patients will offer an improved quality of life. By offering a large array of modalities in a more all-inclusive setting, a facility will provide the physical, emotional and spiritual healing needed. Education for patients, employers, agencies, and families will be an integral part of such a project. The facility could serve as a teaching clinic and satellite clinics could become available around the country and around the world.


A power point presentation and brochure are available at www.rememberrally.com 

Comment 
I completely agree but would suggest that this conversation continue in Mary LaMielle's discussion about the need for similarly described Environmental Medical Units.

Title: Research on Chemical Sensitivities/Intolerances

Link: http://strategicplan.niehs.nih.gov/a/dtd/Research-on-Chemical-Sensitivities-Intolerances/129239-12617

Idea 11: Chemically Injured

Dear NIEHS:
I write to the NIEHS because I have been chemically sensitive for 15 years.

I believe that the primary chemical exposure(s) that brought on my condition were pesticides and petrochemicals. I believe that other chemical exposures that contributed to my condition were doctor prescribed medications. Chemicals that prevent me from having a normal life include known and unknown chemicals (trade secrets) in scented products, solvents in cleaning products, pesticides/herbicides, fire retardants and petrochemicals.

My condition has caused me to lose productive potential in my life for 15 years. I had to leave my job and have not been able to return to work. I was forced to go on SSD to survive.

I have difficulty buying food because I am exposed to exhaust fumes. I am able to eat only organically grown food because pesticide-treated food makes me sick. I am unable to eat processed foods, so I am unable to eat in a restaurant. I cannot afford to buy the food I need.
I have difficulty in obtaining medical care because the mainstream medical profession and our hospital system do not recognize this condition and therefore make little or no effort to accommodate my special needs. Specifically, in my experience, there is no effort made on the part of physicians' offices or hospitals in this country to minimize or exclude the use of perfumed or petrochemical products for personal or environmental use.

I believe that doctors who support the diagnosis of MCS are attacked by the AMA. I believe that researchers who seek to prove injury due to pesticides and other toxic chemicals are attacked and often lose their status.

I have difficulty engaging in social interaction because of our culture's widespread acceptance of the use of synthetic chemical products in gathering places such as offices, restaurants, theaters, places of worship and schools.

I know of people with MCS who live in public housing who are exposed to toxic chemicals. I believe MCS should be recognized in the Americans with Disabilities Act.

I have bought or used an airstream trailer or other type of motor home that has been retrofitted/abated for MCS as a residence because I could not tolerate a home.

I have been confined to a single room in my own home, using an air filter, organic bed, bedding, clothing, etc. following use of a chemical either "on my person" or near me.

I have been forced to eat only a single food per day, two foods per day, or three foods per day in order to stop the onslaught of reactions to various foods I was able to eat prior to the onset of my illness.

I have become aware that many chemicals that mimic estrogen are a cause of menstrual problems that occurred in association with chemical exposures.

I believe that lawn chemicals contain toxic chemicals that should be disposed of in Superfund Sites. I am aware that four state attorney generals have posted the "inert ingredients" in pesticides on the internet. I know that lawn chemicals used by TruGreen ChemLawn and others contain benzene, xylene, toluene and other carcinogens and sensitizing agents.
I know that Gulf War Illness was caused by a combination of a drug PB, that disabled the metabolic pathway so that soldier's whose uniforms were impregnated with Dursban (Chlorpyrifos) an organophosphate pesticide were rendered seriously ill. I believe that individuals within the population are genetically predisposed to be incapable of metabolizing Dursban and other commonly used pesticides.

I believe that the "Chemical Industry" has employed judges of law to stop the forward momentum of lawsuits due to personal injury caused by nearly all industrial chemicals. I am aware that so-called "class action lawsuits" against chemical producers are no longer allowed in courts of law. I know that if I am exposed to a toxic chemical and wish to sue the company, I would go up against legions of lawyers, and lose due to the miniscule chance of winning such a suit.
I believe that the federal government is largely controlled by the same Chemical Industry entities that promote the concept that unsafe chemicals are "safe."

I understand that the chemical industry uses the words "inert ingredients" in such a way as to mislead consumers to believe that "inert" means harmless. I know that "inerts" can contain either other toxic pesticides used as main ingredients or such carcinogens as should be disposed of in Superfund sites. I am aware that the lawns in America are being used as "dumps" for toxic chemicals. For this reason I can find nearly no place to live.

Due to improper building practices I believe that some individuals with MCS were exposed to toxic forms of mold either at home or workplace.

I have told neighbors that their use of lawn chemicals made me sick and were continuously exposed to those products at the hands of my neighbors. I understand that it is legal to cause an adjoining neighbor to become ill due to intolerance to pesticides.

I have felt that lawn chemical companies directed an attack on me once they learned that I cannot tolerate lawn sprays by either spraying my lawn against my wishes or failing to pre-notify me of potential drift issues.

I believe that individuals vary in their tolerance of various toxic chemicals.

I would answer the question, "Why did this happen to me?" with the following 1) Industry controls the EPA 2) Individuals have no way of genetically proving that they are sensitive to certain chemicals and prescription/over-the-counter drugs 3) I was unaware that exposure to certain chemicals can "sensitize" me to a vast array of similar chemicals 4) A "chemical-culture" in medicine exists largely due to the chemical industry funding medical schools, research on chemicals, etc. 5) My condition is not recognized by the proper subsets in medicine 6) At the time of my exposure/onset of illness there were no treatment centers and my health insurance would not pay for the few centers that exist. (7) Doctors who do treat this condition are under attack and subsequently charge a lot of money for treatment so that they can treat patients and pay their concurrent legal bills

I become ill when I find it necessary to travel by plane due to the use of pesticides, perfumes and other chemicals on airplanes.

I have been unable to rent or lease a car due to the use of solvent-based products in them such as "Febreze" and other air fresheners.

I have been unable to use public restrooms due to the use of scented air fresheners that are delivered automatically at intervals during which toxins are sprayed into the bathroom.

I have difficulty going anywhere due to outdoor smoking of cigarettes and cigars.
I do/do not take antidepressants.

I am not depressed. I have never been diagnosed with a major depressive disorder. I believe that research on MCS tends to try to promote the concept that MCS is based in psychological disorders. I believe that such research is a waste of money.

There is an increased incidence of breast cancer among women who use dry-cleaned clothing and concurrently spray their lawns with pesticides.

I believe that chemical sensitivity and chemical injury are one of the most important medical issues of the decade and need immediate research, fully funded by our country.

Many people believe that CFS/ME are highly associated with chemical exposures. Many individuals believe that prenatal exposures to various toxic chemicals may be contributing to Autism Spectrum Disorder.

Comment 1 
As the Director of an organization called the Toxics Information Project (TIP), the story above is all too familiar to me. I have heard of many similar, heartrending situations, from people for whom life in our country and culture are almost impossible.

Moreover, with the tens of thousands of chemicals to which we are continually exposed, most without testing or regulation, MCS is sure to be more and more prevalent - as some have said, the "twenty-first century disease". Right now the victims are invisible because they can't survive out in society. But, sweeping them under the rug can't work forever. And all are at risk of being the next to suffer.

Comment 2 
Please move the comments on the Visionary Idea "Chemical Injury" so that they are included in the number one issue on this site to "Research on Chemical Sensitivities/Intolerances." Chemical Sensitivities/Intolerances is the equivalent to "Chemical Injury."

MODERATORS OF THIS SITE: Egroup members who subscribe to Chemical Sensitivity/CFS-ME egroups received form letters so that very sick people could adapt those letters to place on the NIEHS website. I wrote the letter myself. I recognize the letters as having been used properly.

However, because there has been sporadic access to individuals who would have wished to post their comments and votes to "Research on Chemical Sensitivities/Intolerances" the Visionary Idea, "Chemically Injured" was set up.

These two ideas are identical and absolutely overlap.
Please move these comments and votes to the proper idea: "Research on Chemical Sensitivities/Intolerance" because individuals who are chemically injured are absolutely included in this same group. Thanks, Susan Jannarone jannarone@aol.com

Comment 3 
I agree that votes for "Chemical Injury" should be added to "Research on Chemical Sensitivities/Intolerances," to make clear the connection. Thank you, villim, for the carefully detailed story of your experiences and for the analysis, which I agree with. I have been chemically injured for over thirty years, have friends who are chemically injured, and I recognize everything you describe. This poisoning of people's lives is devastating, is affecting more and more people, and it is preventable. It is preventable.

Comment 4 
The research proposals on this website focus on possible environmental causes of autoimmune diseases, autism, chronic fatigue, chemical sensitivity/intolerance, military veterans' illnesses, as well as individuals who report symptoms associated with oil spills, fracking, hazardous waste sites, various community exposures, dioxin, home remodeling, poor indoor air quality, mold, pesticide use, and myriad other environmental exposures. But, in fact, individuals with these seemingly unrelated exposures and multi-system health problems share a great deal in common: their multi-system symptoms are often triggered by every day, low-level chemical exposures. Many also report adverse reactions to foods, medications, alcoholic beverages and/or caffeine. Dr. Nicholas Ashford of MIT and I first described this phenomenon 15 years ago. Toxicant-Induced Loss of Tolerance (TILT) is the name we gave to the underlying dynamic. It involves a two-step process whereby an initial acute or chronic toxic exposure causes loss of tolerance for everyday exposures. These new-onset intolerances perpetuate the disease process. We described how low-level exposures to common chemicals, foods, and medications may be the driving force behind the increased incidence of many hitherto unexplained medical symptoms and how masking—resulting from overlapping responses to multiple incidents—obscures the fact that everyday exposures can perpetuate illness. These concepts arose from reports by physicians, researchers and patients from more than a dozen industrialized nations. Collectively, their observations provide evidence that toxicant-induced loss of tolerance may be a new theory of disease. Currently, we are at the germ theory stage in terms of our understanding of this phenomenon. Well-founded theories—those based on careful observation, as in the case of the germ theory—are vital for developing shared scientific understanding and igniting future research.

In summary, it appears we are dealing with a two-stage disease process: (1) loss of tolerance resulting from an acute or chronic exposure event, followed by (2) repeated triggering of symptoms by everyday exposures, such as gasoline vapors, engine exhaust, fragrances or cleaning agents—exposures which had not been a problem for the person previously. This phenomenon became increasingly common with the widespread introduction of synthetic organic chemicals following WW II. This, coupled with the fact that 90% of Americans spend 90% of their day inside poorly ventilated structures where unprecedented types and levels of synthetic volatile organic chemicals (VOCs) are present, has led to the epidemic of chronic illnesses we are witnessing today. If we are to understand the extent to which these exposures contribute to the host of chronic illnesses mentioned on this website, doctors and researchers must have access to environmental medical research units— hospital-like research facilities in which people with major illnesses such as autism or autoimmune disorders, can be placed on an elimination diet in a chemically clean environment to see if their symptoms improve. If their symptoms resolve, then everyday exposures and foods can be reintroduced, one at a time. We are all so different and we respond differently to different exposures. NIEHS has an unprecedented opportunity: new approaches for assessing gene and protein expression and new brain imaging techniques can be used both before and after challenges in an EMU. We need to move forward, but not without this essential research tool—the Environmental Medical Unit (EMU). The EMU has been a priority recommendation of several professional and governmental conferences, yet still no research EMU exists in the U.S. It is time for NIEHS/NIH to add the EMU to its portfolio, so that we can all begin to understand the common dynamic shared by so many chronic, costly, and disabling medical conditions. The many excellent comments shared on this website testify to this need.

1. Chemical Exposures: Low Levels and High Stakes by Nicholas A. Ashford and Claudia S. Miller (Wiley). May be downloaded at no charge from www.chemicalexposures.org, along with a published and validated screening questionnaire for chemical intolerance, the Quick Environmental Exposure and Sensitivity Inventory (QEESI).
2. Toxicant-induced loss of tolerance—an emerging theory of disease? Miller CS. Environmental Health Perspectives: vol 105 Supp 2:445-453 (1997).
3. Empirical approaches for the investigation of toxicant-induced loss of tolerance. Miller C, Ashford A, Doty R, Lamielle M, Otto D, Rahill A, Wallace L. Environmental Health Perspectives: vol 105 Supp 2:515-519 (1997).
4. Toxicant-induced loss of tolerance. Miller CS. Addiction 96(1):115-139 (2000).

Idea 12: Chemoprevention and Environmental Health

New strategies for interventions using chemoprevention in populations exposed to specific environmental agents can lower disease risk in these affected communities.

Idea 13: Children's Centers To Study Prenatal Effects of Dioxins

The children of Vietnam veterans are the largest living laboratory for studying the possible adverse reproductive outcomes of their parent(s)' exposures to dioxins. Data collection on

thousands of cases of children reported by their parents to the National Birth Defect Registry suggests a pattern of adverse outcomes that includes increases in learning, attention, immune and endocrine disorders. Creating a NIEHS center(s) to study these reproductive outcomes could contribute to a valuable database of knowledge on the reproductive effects of dioxins that would be applicable to exposures in the civilian environment.

Comment 1 
This idea of Centers to Study Prenatal Effects of Dioxins is long overdue. Vietnam Veterans for decades felt that our exposure to the Dioxin in Agent Orange resulted in Birth Defects, Learning Disabilities and miscarriages within our families. To go forward with this concept is a must and we need to support it with all of our resources.

Comment 2 
Strongly support this. A study shows that an endocrine disruptor (dioxin is one)resulted in epigenetic impacts into future generation. (Carlos Guerrero-Bosagna Sep 2010) "confirms that an environmental agent has the ability to induce epigenetic transgenerational changes in the sperm epigenome."

The study investigates "genome-wide promoter DNA methylation alterations in the sperm of F3 generation rats whose F0 generation mother was exposed to vinclozolin."

Comment 3 
As a Vietnam Veteran Parkinson's, I am 100% in favor of this study since I have 2 male offspring that struggle with depression _ one is bi-polar and one also had open heart surgery at the age of 30 for a micro heart valve issue.

Comment 4 
Vietnam Veterans have been suffering from exposure to dioxins in Agent Orange for years without our governments support. They and their families have witnessed the effects of these poisons... birth defects, ADHD, miscarriages, etc. which all can be traced back to the poisons they were submersed in, in service to our country. We should be doing everything we can to help our Vietnam Veterans and their immediate families.

Comment 5 
Absolutely, this research needs to be done. At the same time, let's move forward with more meaningful assistance for families burdened by disabilities and other health problems that "may or may not be" associated with Agent Orange (not proven 100%, but the presumptive evidence is pretty strong). Let's not wait until all the study results are completed and peer reviewed before we respond, both in the U.S. and in Vietnam.

Comment 6 
Absolutely, this research needs to be done. It is time that vets and their families have answers. Let's make this number one.

Comment 7 
I support Betty Mekdeci and her organizations work 100% and especially her idea, as stated above; for NIEHS to create a center to study the children of Vietnam veterans. We desperately need a center in order to conduct studies that will help us to understand what has happened to, not only, our children but what is happening to our grandchildren. Since 2007, my daughter and I, have been working to find as many of the children/grandchildren as we can to provide support. We have found that 85% of the children/grandchildren that have joined our support community report they have (and/or are suffering from) birth defects, mental or/and physical illnesses, and/or learning problems/disabilities. We also have learned there are many adult children approaching their 40s and/or are now in their early 40s. Therefore, time is of the essence. Thank You Betty for not only your work, on behalf of our children/grandchildren, but also your continued dedication to the families of Vietnam veterans; Sharon Perry

Comment 8 
tkerker6897_1@ Said: Strongly support this work.

Comment 9 
I am a Vietnam War veteran who handled and hand sprayed Agent Orange herbicide, Agent White and Agent Blue on Andersen AFB Guam and off base Guam from Sept 1968 to Jun 1978 for the U.S. Air Force. I was initially and immediately affected by direct exposure with severe chloracne and sterility. I have many severe disease now including ischemic heart disease (emergency open heart surgery) and auto inflammatory disease/autoimmune diseases like anklylosing spondylitis, spinal stenosis, osteoporosis and rheumatoid arthritis and peripheral neuropathy as well as MS AND PARKINSONS. my daughter was born with reactive asthma and obesity and hip dysplasia as well as joint disease. Her daughter was recently born with multiple birth defects like twelve toes and twelve fingers and heart problems. she just has surgery at the Erie Shriners children's hospital in Erie Pa.

Comment 10 
I am a child of a Vietnam Vet who has Agent Orange exposure. I'm so glad to here this is being done.

Comment 11 
I am a child of a Vietnam Vet and Korean Conflict Vet. I could not reproduce due to severe ovarian cysts, endometriosis and adhesions. My body develops malignant and benign cysts EVERYWHERE at will. I always suspected this as well as the lead-based paint they used in base housing: I was always exposed. This is my email - I want to be part of this study: carolherrington1959@gmail.com

Comment 12 
Yes....count me in as well. It would seem I have peculiarities with respect to skin and rheumatology type things/immune response unique to most in my family. My son has severe allergies & ADHD. michellegarrisonwilliams@gmail.com

Comment 13 
I wholeheartedly support this effort. I am the proud son of a Vietnam Veteran, and I have several disorders, from moderate to severe allergies to Asperger's Syndrome. I also lost

my left eye to a retinoblastoma at the age of 14 years. Please count me in: jjbusto83@yahoo.com

Comment 14 
Long overdue this study needed to be done years ago! Me and so many others suffer from our parents AO exposure years ago.

Comment 15 
God bless you Betty for doing this and persevering!!
I am the proud daughter of a Vietnam Veteran who served 3 tours including two as a forward observer and he remembers being doused with Agent Orange and drinking water from contaminated areas (he didn't have much choice since they were in the jungle). I was born without my right outer ear, have uterine fibroids all over, Polycystic Ovarian Syndrome, Interstitial Cystitis, horrendous migraines, and other health issues. Please include me in this study as well: lilcarlton@aol.com

Also, my husband was born on Guam (his dad was stationed on Guam during Vietnam and decided to stay there to raise his family) and I did research awhile back and found that Agent Orange was stored and used on Guam (Just like MSgt Foster mentioned above in his post) and always wondered if that is why he has such random severe skin issues that nothing seems to work on. God bless everyone who served and those dealing with the issues now. Please approve this study and help those who have helped their country by serving and sacrificing their health and those of their children. Please don't listen to the ignorance from those who haven't done their research like the ignorant Genetics Counselor I went to who claims everything is a fluke and Agent Orange doesn't stay in the body that long (he served from 1969-1971 and I was born in 1978). Really, then how come my dad was fine for years and now has health problems along with tons of other veterans??? I did the research myself when I was in high school to see for myself if Agent Orange really did cause my birth defect and, after doing the research I am convinced more than ever. Once you're exposed to Agent Orange, it's there.

Comment 16 
Long overdue study. Why is it that the military has to give all.

Comment 17 
Please support this work for the future generations in hopes that other children and grandchildren of those exposed to not only Agent orange, but other toxic chemicals can be assisted as well. Wife of US Vietnam Veteran

Comment 18 
I was a Viet Nam Veteran whose daughter has early onset diabetes. Finally we may get a study of birth defects!

Comment 19 
Bless Birth Defect Research for Children and Betty Mekdeci for proposing this project. Its benefits will come too late for my Prostate Cancer, Skin Cancer and Chronic Lymphocytic Leukemia, but they could make a difference for my Grandkids.

Comment 20 
It has taken too long for such a study. So many Vietnam and Korean veterans and families, with veterans exposed to dioxin have suffered so much for so long without help or support. Please do this for the sake of the honor of our country. Ltc Eugene Richardson, USA Retired, Disabled American Veteran due to Agent Orange exposure, Vietnam 67-68

Comment 21 
This study is long overdue and the outcomes should go a long way in regulation and enforcement for the safety of this entire nation for future generations; as well as other industrialized nations where dioxins and like chemicals have become an issue.
Charles Kelley Vietnam 67-68

Comment 22 
I have spinal birth defects and 11 of my family members have been effected only one qualifies for aid from the VA myself, my father was 22 years army and not in Vietnam he fought in Korea if I am here and my family was infected then you need to look at Korea and stated side contamination's listed on VA.gov my sisters child not pelvic region died six months myself deformed in the pelvic region, GYN organs to, my daughter thyroid skipped my other daughter hit my grand daughter 32 lbs and 5 yrs old vomits all the time sugar all over the place. skipped my brothers kids from Guam dioxin and effected there children Cameron is on disability rashes failure to thrive like my granddaughter. allergic to everything and I do mean everything. poor guy. help me find out what's wrong with us, my father died 64 emphysema heart pulmonary issues I am 42 years old and the oldest family member imagine that!! all the military men died already all brothers fought Korea, and were trained in fields sprayed in FT KNOX TN

Comment 23 
I wish to be part of this study contact me at mmarino0@yahoo.com that is a zero at the end of mmarino we will be happy to provide genetic samples from all living members of our family. I hear so many accusations about victims wanting money fighting for years with no help put your DNA were your mouth is her is ours. We are real we are here. contamination sights USA 42 fifteen were training sighs for wars, Korea, and Vietnam others included GUAM Puerto Rico, Germany oh almost forgot Cambodia Hawaii, FL NC KY TN NC again 11 members effected

Comment 24 
I totally support this study! I am a daughter of a Vietnam Veteran who was exposed to Agent Orange. I have mild Spina Bifida, Scoliosis, underactive thyroid, heart issues, etc. Funny, no one else in my family have some of these issues. I am certain they are from my dad being exposed to Agent Orange.

Comment 25 
It is hard for me to believe that some one would not vote for this as it is so needed. What kind of person would not want this checked into as we are talking about Children that have been born with problems and parent need to know why??? This is the best way to get to the bottom of this. If the government was not so afraid that they will be held responsible for the problems of these children and the pain that the families have had to go through for the past 40 years and not it is showing up in another generation. This would have been done from day one when they saw babies being born on bases with so many problems that they were handed over to regular hospitals for the specialist to work with.

Comment 26 
This has needed so badly for a long time! I totally support this!

Comment 27 
As a Nam Vet I have Parkinson's, and I am Diabetic on the needle. I am rated 90% PTSD and am a Combat Disabled Veteran. I have had a claim open since Oct. 2009 for the Parkinson's and another claim for unemployability. Does anyone know how long I have to wait to be considered Totally Disabled ? I thought we were going to have priority under the Nuemyer Case ??? You can't prove it to me here today. I'm Sick of waiting and listening to everyone say your going to win your case but then it never comes. Hell, I used to get letters saying that there still working on my claim. I don't even get those anymore. My daughter was born with a Hemangeoma on Middle Ring Finger and we had to have it amputated at birth. She is 29 years old now. She has suffered with her teeth all her life because of soft gum tissue. She has also endured a lot with her fathers

abusive and explosive behavior as a child. She now has a Baby that has had Seizures since birth and today has Asthma and Attention Deficit problems.

Comment 28 
I'm also a Vietnam Veteran living with Parkinson's and even though my wife and I do not have children, I feel strongly about this issue. We need to look out for the ones that aren't able to do so for themselves. We also need to remember that it's the young that we expect to take care of us at some point or another! They are our future!

Comment 29 
My exposure to Agent Orange (Dioxin) has had profound impacts upon my 40 year old daughter's life both physically and mentally. In depth scientific study of this sort is the responsible and necessary course of action.

Comment 30 
another study...this should have been approved a long, long time ago

Comment 31 
Please support this idea.

Comment 32 
I just wonder why so long, should've been done eons ago

Comment 33 
Please support this study...it's way overdue.

Comment 34 
I have wondered how it, the exposure of the defoliants would have on my children. My daughter has had problems for years...

Comment 35 
I am a Vietnam War veteran who handled and hand sprayed Agent Orange. I am 100% service connected with many illnesses and diseases. I also have a son who has SPINA BIFIDA and other illnesses that are related to parental exposure of A.O. herbicides. It's about time!

Comment 36 
I also support this study...I have had numerous health issues over the years, many which doctors are baffled by still. Sarcoidosis, MS (possible), ADHD, Anxiety, OCD, Depression

and also my son who is only 10 yrs old is going through hell right now...diagnosed with: ADHD, Asperger's Syndrome, Generalized Anxiety Disorder, OCD and my Dad was a Vietnam Vet exposed to Agent Orange. If this is really true then it makes perfect sense why I'm going through what I'm going through trying to fight the "Laws" to get my child who should be entitled to special education services the services he needs! COUNT ME AND MY FAMILY IN!!!!

Comment 37 
I agree and its about time you start to look beyond our life's. We had to adopt due to the fact I could "not" father children. I have doctor's reports to support what I am writing.

Comment 38 
I am the wife of a Vietnam vet. He has heart problems, type II diabetes and Parkinson's. Our daughter was born in 1979 with Cornelia de Lange Syndrome. We were told by the VA that this is not on the list of known problems with children born of Viet Vets. My non-medical understanding of the cause of CdLS is that something happens to the Gene when it is splitting (or something like that). The children are mildly to severely retarded, most have some form of dwarfism and there are other various and serious medical conditions www.cdlsusa.org. I definitely support this.

Comment 39 
I strongly support this action and will do all I can to help

Comment 40 
We, in the Agent Orange working group are now closely working with the Birth Defect Registry and Autism Speaks to arrange for statistics on Agent Orange children and grandchildren. We, now have proof positive of DNA mutations being handed down from vet to child and from child to grandchild. If you wish to take part in this questionnaire and DNA testing program, please contact: For vets: rpkopy@yahoo.com,
chuck_pal@yahoo.com; For children/grandchildren and Autism: giovannislegacy@yahoo.com. If you have any questions, please email your phone number and we will call for privacy purposes.

Comment 41 
Both of my children were born with birth defects. My oldest daughter had to have a total hysterectomy at the age of 25, after several miscarriages and was never able to bear a child. She would have been the most wonderful biological mother, but her entire reproductive system was deformed and had to be removed before her cysts could become cancerous. My younger daughter was born without the left half of her brain and battles physical disabilities every day of her life. My husband has cancer and diabetes from his exposure to Agent Orange poisoning in Vietnam in 1969 & 1970. We've been trying for 30 years to get a study like this done. It's not time, it's way beyond time. God bless our Vietnam veterans and their families.

Comment 42 
Kathy says
My daughter has had numerous allergies for which she is being treated. My son has a digestive disease, and is diagnoses with ADD.

I SUPPORT THIS STUDY.

Comment 43 
This study should have been done 40 years ago. After my wife had two miscarriages and another daughter who was born 3 months premature with multiple disabilities, I suspected it may have something to do with the dioxin and malathion exposure during my

tour in Vietnam. I was stationed at Long Bien and that was one of the most contaminated places in country.

Comment 44 
We need this study!!! Our health problems are NOT arbitrary.

Comment 45 
Let's get on with the study ASAP. We are dying, our children are dying, and now our grandchildren are having major issues - all as a result of Agent Orange and the ongoing delays caused by our own government. No more waiting for further studies.

Comment 46 
My husband was in Vietnam and was sprayed with agent orange our daughter was born with cerebral palsy and has asthma an had a hysterectomy because of fibroids our son was born with hypospadias would u please put us on your register and keep us informed jackiek74@yahoo.com thank you

Comment 47 
As a Vietnam Vet, USMC 1968-69, I agree that there is a link between Vietnam veterans who were exposed to Agent Orange and birth defects in the children and grandchildren. my son was born with nerve damage to his ears. As a result he has profound hearing loss in one ear and severe hearing loss in the other. There is no link to previous generations in either family in regard to hearing problems or deafness. At many events where veterans gather I've asked for a showing of hands of Vietnam Veterans who were exposed to A/O and have children with hearing loss, the ratio is well above the norm.
We need to gather as much information as possible to help the children and future generations become represented in the law and the only way to do that is to gather statistical scientific data so please, register and give your input.
Thank you,
Ted

Comment 48 
I'm a Vietnam Veteran who has two grandchildren I was in AO and it is about time somebody did something about our kids and grandchildren!!!!!!

Comment 49 
I also am a Vietnam Veteran 1969/1970 era. I am 100 percent disabled for Coronary Heart & Artery Disease, MI @ 34 years old, multiple Stents in heart 2005, CABG 3X in 2010. Diabetes II w/peripheral neuropathy all extremities. Parkinson's Plus Disease with Seizure Disorders. Basal Ganglion Brain Disease. Microvascular Disease.

Gastrointestinal Disease. All my children 2 girls, 1 boy are experiencing various problems that are not related to any paternal or maternal ancestry medical history issues from my or my wife families. Grandchildren are all ADHD. Much more to offer but now is not the time or place to do so. I strongly believe that further in-depth research be performed with respect to affects that Agent Orange exposure can affect the offspring of the person that was exposed as I was. Please Vote positive for this research project our families deserve this. Thank you. John P McCartan Sr DAV Army Vietnam Veteran

Comment 50 
Individuals who have acquired Chemical Sensitivities/Intolerances have been exposed to Agent Orange in the form of 2,4-D, used as a lawn-care herbicide. I began to get very ill, with unexplained vomiting and 6 months of diarrhea, and finally a fruitless search in the hospital for a rare cancer. I am unable to be around almost all petrochemicals, and I represent three million people in this country who have fought the chemical industry because they were exposed to formaldehyde, glutaraldehyde, dioxin, pesticides, the so-called toxic "inert ingredients in pesticides including all other pesticides, benzene, xylene, toluene, naphthalene) OTC items such as Lysol (contaminated with Dioxin), Clorox and other bleaches, Chlordane (used in house foundations to prevent termites), photographic chemicals, printing chemicals, dry cleaning chemicals, especially perchloroethylene, sick buildings, carpeting, trailers, new cars, and many, many other forms of sensitizing agents that all chemically have at least one benzene ring or a chlorinated biphenyl which is two attached benzene rings, which has multiple chlorine atoms attached. The science on Chemical Injury and Chemical Sensitivity is fairly simple. Body fat storage of toxic chemicals and end-organ injury cause a panoply of chemical injuries and sensitivities. Birth defects may be due to "time of exposure," and epigenetics. With all the information that has been gathered to support the ways in which chemicals injure humans, the CHEMICAL INDUSTRY has only hired more lawyers, passed more bills, introduced more toxins such as the gas used on strawberries, methyl iodide (that our children eat very early in life--that we are told to eat in abundance), corrupted more government officials and generally denied ruining people's lives. I contend that the people who can no longer tolerate our world, or environment, or housing, our cars, our computers, our water, our way of living are the sentinels of more than 90% of all diseases. Yet, we have been dismissed and ALL of the studies that might support research into Chemical Sensitivities, and subsequently tell Americans that all registered pesticides are unsafe (or else the chemical industry would not have formed the EPA to cover themselves legally) and that Agent Orange is not the most dangerous of these pesticides. My brother-in-law flew a jet delivering Agent Orange and developed Hodgkin's and narrowly survived. Yet, he was able to receive compassionate care and treatment. NOT SO with those with chemical injury, chemical sensitivities and the like. We are often left to fend for ourselves. Our spouses are likely to leave us. Our friends believe that we have emotional "issues." Doctors who do try to treat us undergo multiple and continuous lawsuits by the AMA (hired by the chemical industry) so that no one upsets the proverbial applecart of sell-you-chemicals that make you sick, and then sell-you-drugs that don't work! We must all become educated on how products such as PB (Pyrostigmine Bromide) are carelessly given to our military and create individuals who are genetically identical to someone like me, who cannot metabolize Dursban because I was probably born that way, or was genetically altered by some other chemical exposure. Cast some votes and some support for people with Chemical Sensitivities. We can TELL the government what is making people sick without very much research. Our brains, hearts, digestive systems, central nervous systems are able to identify toxins! Please support us. If you have been injured by Dioxin in Agent Orange, you are Chemically Sensitive! SJ

Comment 51 
I'm a Vietnam vet, 67-68, with 5 children who all have had issues with adhd. I never

thought about the exposure we had to agent orange and it's effects on our children. I strongly agree that this study should go forward. I'm proud of my service but feel that not enough has been done to take care of the problems that have existed from that service.

Comment 52 
I am the wife of an agent orange victim and so far my children are ok, but I'm concerned for their welfare as well as my grandchildren and all those affected by agent orange Becky Gibbs Rolla mo.

Comment 53 
I am a daughter of a Vietnam Vet who already partially disabled from A.O. exposure & our family is Medical Anomalies 101 with have rare diseases doctors usually only hear about in medical books! In our family we are now into great-grandchildren being decimated by birth defects & possibly 1 life lost to it (R.I.P. baby Jayden!)

Please do everything you can to push this project through!

Comment 54 
So many, many of our Vietnam veterans are reporting health problems in their children and grandchildren, which they believe to be associated to their to Agent Orange. Daily at VVA, we receive calls from veterans and their families, with tragic stories of unexplained birth defects, cancers, immune system problems, learning disabilities, mood disorders, and on, all with no family history. We have already lost so many children and grandchildren. This proposed study would go a long way to getting answers, treatment, and attention so desperately needed. Of grave concern are the future generations--just how long will this unfortunate legacy continue? Our veterans are stepping forward to share their stories in the hopes of getting care and answers before they are gone. To read some of their stories and learn about what they are facing, go to http://www.vva.org/Committees/AgentOrange/index.html#FAO
This proposed study is long-overdue and much needed.
The generational issue of Agent Orange is a top legislative priority for Vietnam Veterans of America.
Kudos to those at NIEHS responsible for proposing this project.

Comment 55 
This is an important project to keep a data base and develop statistics, to address the number of birth defects and to analyze data and project the future effects into future generations. I am a Vietnam Veteran and my first born Casey was born with a congenital heart defect, cleft palate, prune belly, and other abnormalities, plus had a seizure at birth. I lost my son shortly after his 3rd birthday after a heart surgery went bad and he went into a comma for 7 weeks before dying in my arms. What angers me is that the VA did not and will not recognize my Agent Orange connection as they only recognize a few specific birth defects of Agent Orange male veteran victims. If we can document the number of male veterans whose wives never served or were in country that like me have or had children with any kind of defects we will have a case and the recognition that we need. This denial by our government is a major betrayal and a trigger for my PTSD

Comment 56 
way overdue (as many have noted!). Probably should be in tandem with a study paid for by us in Vietnam - as opposed to selling cluster bombs, land mines, and etc. and supporting, at billions/month expeditionary forces in the Middle East who are being exposed to a whole other set of toxins.

Comment 57 
Agent Orange is a important issue that needs to be recognized and supported!

Comment 58 
I would love to be a lab rat!

Comment 59 
I'm a Vietnam Vet and my only son has had problems since he was born. I believe this study should have been done long ago. He also has 2 children, my only grandchildren.

Comment 60 
My husband has PD & our son Mark was born with Osteo Genies Imperfecta, thinning of the bones, he was dwarf ,heart on the wrong side, he was to young to tell if he would be blind, have sight, hearing, speech, mentally handicap. His skull was so thin his brain was growing out of it. He had a broken arm when born. He lived for only a month & if he lived to adulthood, he would always have broken bones even a sneeze would cause them to break. No history of the disease on either side of family. Karen & James Wallo

Comment 61 
My Dad has type 2 diabetes due to Agent Orange from the Viet Nam War and i am lucky enough to be healthy and my children also so far. I wish more Nam Vets had gotten the proper care they needed long ago like all of us wish and I feel this study is owed to them and their children and grandchildren and great grand children and so on...I often wonder if it was possible it had anything to do with my preeclampsia during my 2nd child's birth which led to premature delivery and also hypertension during my first child's birth. A lot of work would have to be done to figure that out I'm sure. Id like to see those who need help get it for once. Tired of all the hand outs in this country to those who don't do a thing instead of those who have sacrificed their lives. Sorry to rag. Thank you Veterans <3

Comment 62 
I noticed a man made a note to his child having soft gum issues Cameron had the same thing they removed all his teeth, they came in rotting, he is four now rashes all the time and the size of a two year old he is allergic to everything they said he was a dwarf at first, genetic came back as he is not a dwarf they really don't know what's wrong with him, myself and my girls are having premature births and also I lost a son, my granddaughter is small for her age her sugar is all over the place and diagnosed failure to thrive same as Cameron its hard to hold the grand kids and not know what's wrong but watch them vomit hold them and not know how to help I feel so helpless YES THIS STUDY IS NEEDED. help us help them.

Comment 63 
My grand daughter is also really small with terrible rashes, heart murmur, twelve toes and twelve fingers, vomits all the time she is one now. I handled and hand sprayed agent orange herbicides on Guam for ten years from Sept 1968 to June 1978. She had all of her teeth at the age of four months. all of those i know that were on Guam with me have multiple late term miscarriages, still births, autoimmune diseases, etc. the military dependents on Andersen AFB Guam are all ill with all of the female children now having multiple late term miscarriages. There are many still born American children on Guam buried there from military families stationed there. All because of the herbicides I sprayed there for ten years. I asked them to find all of those kids but they refused. they ignored my pleas to help those kids.

Comment 64 
My husband was a Vietnam veteran who passed away 2 1/2 years ago from ischemic heart, diabetes, arthritis, high blood pressure, bilateral neuropathy, chloracne, and severe mental health issues. I had problems carrying both of our sons during pregnancy. My eldest son got high blood pressure at age 15, enlarged heart not to rule out aortic coarctation, hydroceles diagnosed at age 6, ADHD, opposition defiance disorder, chloracne in his groin, anemia, asthma. My youngest has high blood pressure, mild Tourette's syndrome with OCD (name calling is one of his tics), severe allergies to almost every tree in the forest (diagnosed at age 16, these allergies came on very suddenly), loose joints, ADHD, and opposition defiance syndrome. It's time this country reaches out to the children of Vietnam veterans. Some of the conditions are like the chemical itself in that they aren't all manifested at birth, but throughout a person's lifetime. VA needs to compensate these children. And, not strictly to children of female Vietnam vets. More males fought than females and their offspring have the same conditions as the female vets' children.

Comment 65 
It's the least we can do for the men and women who served in that God-forsaken war. We poisoned most of our own soldiers and poisoned a whole generation of Vietnam men, women and children -- all harmed by a chemical industry still poisoning all of us.

Comment 66 
Folks if we don't try everything that we can, no one else will. Now, That there says it all. Your kids and their children will continue to non-exist and we all know that dealing with the people that used it (AGENT ORANGE) We continue to elect the wrong people to clean our only world we have to share. These studies and the care for "our" children are first.

I TOTALLY AGREE WITH IT!!!!!

GERALD L.HOUP TET 1968-69 VIETNAM

Comment 67 
Vietnam veterans have been suffering too long. This research is long overdue and should have been done when previous birth defects were discovered. We are now dealing with a serious situation that involves multigenerational defects from dioxin and other toxic substances. How many parents, grandparents, and children have we already lost. Why is this not front page news. Look at the Vietnamese people to see what we have done on a large scale. I personally know a large number of people who already have children and grandchildren that have died or are seriously ill. Many of my Vietnam Veteran friends have already died from toxic exposures (dioxin).

Comment 68 
My aunt's brother-in-law was a Vietnam veteran and died from Agent Orange-related cancer. His children have multiple health problems resulting from his exposure. This project idea is long overdue.

Comment 69 
Please add me to your study list. plscgx2@yahoo.com. I am the oldest daughter of a Vietnam vet. I believe my father was effected by Agent Orange. Agent orange was created by Monsanto and this company has their hands in all of our food items. They need to be accountable for their doings. We need a study done and do away with Monsanto and their Round-up, Equal, GMO created seeds and foods, rbgh- tainted milk...and the list goes on and on and on.

Comment 70 
As a combat veteran exposed to Agent Orange (and a T-2 Diabetic), I am elated to see that the long term effects of the dioxins may finally be studied. If not for us, for our children and grandchildren. Those of us who fought do not have all that many years left. Our offspring, hopefully, do.

Comment 71 
thank you, I voted ,only one vote ,but many ones is huge

Comment 72 
I and my brother are both Agent Orange kids. I support any research program in regards to this topic. There are so many issues to be addressed, the studies are long overdue. I chose not to have children, but my brother has two so far. I feel that the need to gather information is important for the sake of additional generations. I would be more than happy to participate in any research studies available.

Comment 73 
I am a Vietnam vet who spent 3 years at Eglin AFB in Florida immediately before I went to Vietnam. Eglin is where Agent Orange was used in test situations (Operation Ranch hand). I don't know if we were close enough to the testing area to get any drifted contamination (it was claimed that we were not, if I remember correctly), but my son was born a year after we got there and my daughter was born just after we left. I wonder....

Comment 74 
I am a blue water sailor whose ship operated in the rivers of Vietnam. Due to the Haas decision we were NOT exposed to Agent Orange. My child and my grandchildren have medical problems that have the footprints of Agent Orange all over them. Yet there is no way to prove it. This is simply wrong!

Comment 75 
I am 64 and a Vietnam Veteran, I have two adult children and I am now dealing with my second bout with throat Cancer and I cannot imagine anyone being against this necessary study. Please commit to this quickly, we are talking about American's who are the offspring of other Americans who served their country in a combat theatre. Enough said.

Comment 76 
I am 63, my grand son has Autism. My sons wife's father, served in Vietnam with the Marines, and has died. I served with the 1st Air Cav.67/68 Bco.2/5.

Comment 77 
I am a 60 year old Vietnam Vet and my oldest child has a learning disability and two of her siblings suffered from seizures. Something is wrong!

Comment 78 
I'm a Vietnam veteran from 67- 68. I strongly support this effort. I have recently been diagnosed with mylodysplastic syndrome. Related? I don't know. Thank you for your effort in this.

Comment 79 
I am a Vietnam veteran, 1965-1968.Ispeak for the 3,000+ men I commanded during that time. I have written literally hundreds of letters in support of many of their efforts to obtain VA action based on their contraction of diseases related to Agent Orange exposure. This undertaking is over 40 years late in coming!
GOD SPEED---GOD BLESS!

Comment 80 
I am a Vietnam Veteran. I served with the First Air Cav HHC 1/5 67-68. I appreciate all of the work that your organization is doing to get the government to take action for our families who suffer from these terrible dioxin related issues. The evidence is overwhelming that agent orange exposure has affected our health and quality of life. 43 years later this Vietnam Vet is still fighting that war and it's after effects.

Comment 81 
I am a Vietnam vet, ( C - Co - 2/16 1st Inf Div ) . I served there '66 - '67. We need as much help as can be possible, I.e. Research etc. God Bless us all.
Welcome Home!

Comment 82 
I served in Viet Nam from 68 to 69 and my son was born with a disease called Spina Bifida, but they say there are different forms of this disease and my sons is not one of them. Maybe a little more research will prove differently.

Comment 83 
Vietnam combat service -66-67, we used to watch them fly over and spray Agent Orange. The planes were that low. Now, I have two kidneys completely gone, had to have a transplanted kidney. Also, my son was born with Downs Syndrome. Co-Incidence_ I think not. Cashequity

Comment 84 
It is about time after all the exposure to Agent Orange, our kids have been thru all the suffering we pass on to them

Comment 85 
I was in Nam 68-69. I had 3 children one of whom was diagnosed with ADD and hyperactivity, compulsive obsessive behavior, frontal lobe disorder and when he was 21 he was also diagnosed with possible Bipolar disorder. There is no family history of any of this in our family and for so many issues to show up in one person is unexplainable. I have all medical records, but my son has since passed. I recently had a radical prostatectomy and the cancer they found was very aggressive and is being attributed to agent orange exposure. There is no doubt in my mind that agent orange is the factor in my family medical problems.

Comment 86 
We owe this to our Vietnam Veterans and their families.

Comment 87 
I am a wife of a 68-69 Viet Nam vet. My husband suffered for years of a lymphatic disease that caused him to be hospital a couple of times a year--had to write to a congressman to get him to the Washington, D.C. Vets hospital and then they called in NIH and we finally got a few answers. PTSD--still occurring.
Our oldest daughter found out a few years ago (38) that she has a heart defect that will need surgery in her fifties. Our second daughter has feet swelling with no definite diagnosis or cause. Our son served in Iraq and is not in drug rehab. CAN ANY OF THESE MEDICAL ISSUES BE RELATED TO AGENT ORANGE? LET'S FIND OUT!!!!

Comment 88 
My oldest son has no problems (Before Vietnam)

My Younger son was born with eyes that jump all the time & many other physical problems. It must have something to do with the AO.....

Comment 89 
My husband is using his second pacemaker, and has AML. Our daughter had a benign astrocytoma when she was two. I am in favor of this study.

Comment 90 
The thing I noted from all my associations with Vietnam Vets is the kids teeth - too many. As well as other problems.

Comment 91 
My grandson, Jerry Lee Groft Jr. suffered acute Leukemia at age 8. The Doctors didn't give a very hopeful prognosis at all, in fact his odds were very grim. After 3 1/2 Years of constant chemotherapy and Radiation he seems to have beaten this horrible disease. Leukemia does not run in either side of both parents and grandparents. Having served 2 tours of duty in the I corps with the usmc I KNOW I was exposed to agent Orange. This is how he came down with leukemia I am convinced.

James H. Groft, Hanover, PA

Comment 92 
There have been too many (one is too many) children & grandchildren of veterans exposed to Agent Orange whose lives and whose families lives have been changed in a tragic way. The manufacturers of Agent Orange, DOD, and many others were aware of the toxic effects even before use in 'NAM'. As a tax payer, I want my taxes to be used to support these families, and not to subsidize individuals and big business interests.

Comment 93 
My husband was in Vietnam and both our children (born after he returned) have a number of issues -- too many teeth, asthma and allergies, etc. All chronic health issues that were never in our families -- until after exposure to Agent Orange. It's past time to study this toxic chemical's harmful effect and to reach out to those whose lives are impacted on a daily basis.

Comment 94 
This is decades overdue! It's as simple as that.

Comment 95 
This National Birth Defect Registry should have been started when we Vietnam veterans came back with all the illness' we complained about. No one told us that there may be a problem with our children health or that may be our grand children would be sickly

Comment 96 
We have been fighting for full disclosure for more than 20 years. As you all might already know, the govt wants 'US' to take responsibility for our actions, because 'THEY' do NOT want any responsibility except for spending our tax dollars elsewhere.

.How come our Great Naval Ship 'Comfort' can travel around the globe and provide health care to those in need, without anything other than the patient present. While here stateside, those with 'TriCare' have to constantly fill out forms, verify dependents ages and still pay a co-pay!

.www.VeteransPostNews.com

Comment 97 
It's about time this study is done. Too much time has passed and many things have been neglected when it comes to this topic. It's time to take care of those with problems related to Dioxin.

Comment 98 
This is LONG overdue.

And soon we will be fighting for a study to learn genetic effects of exposure to DUMP.

Depleted Uranium Munitions Poisoning.

Comment 99 
I am an Vietnam vet and 100% compensated for IHD. I spent the year of 1968 at Chu Lai. I have a son who was born 10 weeks before I went over and is healthy as a horse. I have a daughter born three (3) years after I returned and she has had health problems in her adult life. We have wondered if there is a connection between her health and Agent Orange. We would like to participate in any study that could help to answer this question.

Comment 100 
Get too work as fast as possible so other children are not brought into this world suffering from dioxin diseases

Comment 101 
I am a Vietnam Vet with Parkinson's and many other health issues. I agree strongly on this study. My child also has many health issues and most are chronic.

Comment 102 
I was exposed to, and drank water, contaminated with Agent Orange in November of 1964, while serving with the U.S. Coast Guard on the island of Iwo Jima. On October 12, 1970, my son was born with a major birth defect: Spastic Cerebral Palsy. The left side of his body grew at a much faster rate than the right side of his body. He has since passed this "Birth Defect" on to his son. "Birth Defects" DO NOT run in my family! In 1994, through the Maryland Veteran's Health Care Hospital, in Baltimore, Maryland, I asked for an Agent Orange Examination and was chased out of the doctor's office. In 1998, I "think" my name was added to the Agent Orange Registry, but I have not been able to confirm it as of this date. All of my U.S. Coast Guard Records (Personnel & Medical) have been destroyed prior to 1974. All I have is a worn out copy of my DD-214. I am a Life Member of the Vietnam Veterans of America, Chapter 648, Easton, Maryland. Surely there is a cover up going on within National Government concerning exposure to Agent Orange.

Comment 103 
BetsyS
My husband was in Vietnam, and both our children have infections that come up on them just like he does. They have never come up with a reason why this happens and both are grown with their own child. Both grandchildren have skin problems too. So happy for someone to finally want to test this.

Comment 104 
My father was exposed to Agent Orange before I was conceived, he has severe Parkinson's Disease now. I have been told all my life that I am too slow, like cutting hair, cleaning a house, preparing or serving a meal, it takes me longer to study, but I am determined to succeed anyway. I think this study is long overdue.

Comment 105 
My children and grand children have been adversely affected by the agent orange that my husband was exposed to, and in his senior years has been affected by this exposure in Vietnam. I would love to have more research done on Agent Orange.

Comment 106 
I am an advocate for chemically sensitive, chemically-injured, chemically intolerant, and MCS/CFS patients.

Parents who believe their children are sick DUE TO PESTICIDE EXPOSURE OF ANY KIND AT ANY TIME BEFORE BIRTH or INUTERO must learn to reduce/remove continuous exposures to any more toxic solvents found in many, many products.

Join WSMCSN@yahoogroups.com to read archives and read about toxic chemical research that appears every day, or every week. Our children are not sick because we do not expose our children to toxins any more. We fight for our children's health, just as we are doing now. We keep our children's bedding organic. We do not wash their clothing in scented, pesticide-filled detergents. We do not expose our children to fragrances at all, because many contain some form of pesticides. We feed our children only organic food and purified water. We provide our children with rotation diets, supplements and compassionate nurturing even when they try to attend college. Often, we go head to head with their colleges, who fail to provide a perfume-free environment. Our children sweat/sauna, and exercise every day. We know how to GET CHILDREN WELL and how to KEEP CHILDREN WELL.

Last evening, I proposed to publish the information that four state-attorney-generals posted online on the internet. Elliott Spitzer is one of the past SAG's who was involved in posting the information below. To summarize, Steve Tvedten has lost a child due to pesticide poisoning. He has set up a webpage that explains how INDUSTRY IS POISIONING AMERICA. If you or your child suffers from neurologic, autoimmune or cancer-related disease, using PESTICIDE IS TANTAMOUNT to throwing a match on gasoline. Your child cannot THINK due to solvents found in pesticides and all petrochemical products. Your child cannot LEARN due to solvent exposures. Your child cannot ACCOMPLISH goals in life due to the continued use of solvents/pesticides/toxic paints, furniture, perfumes, detergents, shampoos, soaps, dish washing detergent, magic markers, other petrochemically based out-gassing plastics, vinyl and other related items used near and on your child on a continuous basis. Your child cannot have a HEALTHY GRANDCHILD because of continuous exposure to these toxins in their life.

Can your child live without all those toxins? ABSOLUTELY, YES. Chemically intolerant people live without many things. The first thing is to live toxin-free. We actually MOVE, LOSE MONEY, quit jobs, and do virtually everything the illness demand that we do.

Learn from us.

Children with Chemical Sensitivities and Intolerances live without many of the things that they need, such as medical care, research or treatment. Please consider voting in favor of this research next time around, because we know what is making you and your children sick, and we can help. Let's join forces and begin by reading below, what you might be doing wrong near your loved-ones, when you buy or use any form of EPA-registered pesticide, herbicide or fungicide.

The first rule is that EPA-registered ANYTHING is toxic!SJ

The Secret Hazards of Pesticides:

Inert Ingredients

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Attorney General of New York

New York State

Office of the Attorney General

Environmental Protection Bureau

February 1996

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Contents

The Secret Hazards of Pesticides: Inert Ingredients

Table 1: Percent Inerts in Some Pesticide Products

Table 2: Some Adverse Health Effects of Certain Inert Pesticide Ingredients

Table 3: Guide to Selected Regulations Covering Chemicals Also Used As Inerts

Explanation of Regulations and Advisories for Selected Chemicals Used As Inerts

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The Secret Hazards of Pesticides: Inert Ingredients

Look at any label on a pesticide product and you will find a list of "active" ingredients, with a few long chemical names, and then typically the phrase "inert ingredients," with only a single percentage figure given and no listing of individual ingredients. The active ingredients are the chemicals used to control the target pest and must be listed on the label. The so-called "inert" ingredients are used as carriers for the active ingredients, to help dissolve them, make them easier to apply or to preserve them.

Unfortunately, many people will conclude from the term "inert" that such ingredients could not possibly have any adverse health or environmental effects. This is not the case at all. The chemicals used as inerts include some of the most dangerous substances known. Some of these chemicals are suspected carcinogens and have been linked to other long-term health problems like central nervous system disorders, liver and kidney damage and birth defects. They can also cause short-term health effects like eye and skin irritation, nausea, dizziness and respiratory difficulty. The U. S. Environmental Protection Agency (EPA), the agency responsible for regulating the use of pesticides, has categorized inert ingredients into four groups: substances known to cause long-term health damage and harm the environment, chemicals suspected of causing such health or environmental damage, chemicals of unknown toxicity, and those of minimal concern. Although EPA has published a list of chemicals used as inerts, this list does not tell consumers which products contain these inerts. Furthermore, pesticide manufacturers are not required to list all inerts on the product label. Thus, people must play blind man's bluff when it comes to which inerts might be in the pesticides they buy or are used where they live, work or play.

Inerts usually make up at least half if not most of consumer pesticide products. For instance, 99.1 percent of Raid's Ant and Roach Killer is inert ingredients and Ortho Diazinon Dust is 96 percent inerts. Of the 85 pesticide products examined by the Attorney General's office, 75 percent contained over 90 percent inert ingredients (see Table 1 on page 7 for a list of these products). Despite the health effects EPA associates with inerts, people do not know to which chemicals they may be exposed since inerts are not identified on the label. Health effects of some inert ingredients are listed in Table 2 on page 9.

Pesticides are widely used throughout the United States in non-agricultural settings--in homes, outside homes, in offices, schools, and recreational areas. Over 70 million pounds of pesticides are applied on lawns alone every year. The use of lawn care pesticides is increasing at about 5 to 8 percent annually. In fact, four times as many pesticides are used on home lawns as are used to grow food crops. Commercial lawn care is now a $1.5 billion industry. In addition, according to a 1985 study, pesticides used on golf courses accounted for nearly 12 million pounds nationwide. And all these pesticide products--whether used in lawn care, household fumigation, pet care or in personal-care products like insect repellents--contain substantial amounts of inert ingredients.

Who knows what the secret inert ingredients are? Obviously, the pesticide manufacturers and formulators know. Under the Federal Insecticide, Fungicide and Rodenticide Act (FIFRA) pesticide registrants (primarily manufacturers and formulators) must report the identity of inert ingredients to EPA. So one might assume that EPA knows the identity of the inert ingredients in every registered pesticide product. Unfortunately, that does not appear to be the case.

In 1987, EPA announced an "Inerts Strategy" designed to eliminate the most toxic inert ingredients from use, require improved label disclosure of inert ingredients, increase disclosure of inert ingredients, and increase the toxicity testing required for inerts. That strategy, if effectively implemented, could have enhanced the level of protection afforded to the public. In 1991, the EPA Inspector General reported on an investigation of EPA's implementation of its own "Inerts Strategy." The Inspector General reported that:

"EPA has not... enforced the 1987 Inert Strategy requirements for inerts with toxic effects... EPA identified 68 inerts as potentially toxic, and assigned them to a high priority for testing... EPA has no specific procedures or timetables for insuring that these inerts are reviewed."

"EPA is not sure how many chemicals registrants are using as inert ingredients because the inerts were not accurately coded into... [the EPA database]... there were about 600 registrations for which ... the chemical name was not available."(1)

How has EPA responded to this criticism of its implementation of the Inerts Strategy? Not very effectively. According to a 1993 internal memo from the EPA Inspector General's office, corrective actions originally scheduled for completion in 1992 or 1993 had been delayed until 1995 or beyond. Attempts to develop a computer database for inert ingredients had failed, and further development of the system was contingent upon further funding.(2)

Thus, the EPA does not necessarily know the identity of the inert ingredients in the pesticide products sold to the general public, and that situation may not be resolved for years to come.

Even when EPA knows the identity of the inerts, FIFRA instructs it to keep that information secret if the manufacturer requests confidentiality unless the agency decides "that disclosure is necessary to protect against an unreasonable risk of injury to health or the environment".(3) Enacted almost half a century ago, the "trade secrecy" section of FIFRA was intended to protect manufacturers from any competitors who might copy the recipe for a successful product. Today, inert pesticide ingredients are still considered confidential under this obsolete regulation even though "trade secrets" are not necessarily secrets within the industry. Companies can now use commonly available "reverse engineering" techniques to find out the inert ingredients in their competitors' products. Now, this information is secret only to the public.

The Attorney General's office went directly to pesticide manufacturers to ask them to name the inert ingredients in some of their products sold in New York State. Many of the companies contacted refused to provide such information. Others agreed to identify inert ingredients only with an expectation of confidentiality. However, a few companies did cooperate without reservation. Thus, the survey shows that inerts information is generally not available to the public; most companies continue to withhold the identity of inert ingredients under a claim of confidentiality.

Ironically, many non-pesticide products containing the same chemicals used as inert ingredients in pesticides are governed by various laws, regulations, standards or guidelines because of their potential toxicity. There are limits for many of these chemicals in air, water and the workplace. There are restrictions on disposal of these chemicals, penalties for spills and special requirements for their transportation. These laws include the Toxic Substances Control Act, the Clean Water Act, the Clean Air

Act, the Resource Conservation and Recovery Act (RCRA), and regulations issued by EPA and the Occupational Safety and Health Administration, as well as guidelines from the National Institute for Occupational Safety and Health. (See Table 3 on page 11 for a selected list of regulations, laws, and advisories concerning chemicals used as inerts.)

Even though some laws limit human exposure to these chemicals by restricting their release into air, water or the workplace, there is no way of knowing when the same chemicals are released as inert ingredients in pesticides. As long as pesticide ingredients are kept secret, people cannot even take steps to avoid exposure. And if an individual experiences a health problem in reaction to a pesticide, precious time can be lost while the doctor tries to obtain information concerning the chemicals to which the patient has been exposed.

The Federal Insecticide, Fungicide and Rodenticide Act should be amended to require pesticide manufacturers and formulators to disclose the total composition of pesticide products sold to the public. Product labels should identify each inert ingredient in the formulation. This information is simply too important to keep secret any longer because what the public does not know now about pesticides may very well hurt them some day.

Credits

This report was originally prepared in June 1991 by Michael H. Surgan, Ph.D., Chief Scientist and Assistant Attorneys General Deborah Volberg, Nancy Stearns and James A. Sevinsky, with assistance from other members of the Environmental Protection Bureau.

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Tables

Table 1: Percent Inerts in a Sampling of Pesticide Products(4)

HOUSEHOLD PESTICIDE MANUFACTURER PERCENT INERT

Ant, Roach, and Spider Killer Dexol Industries 99.5

Aphid and Mite Attack Ringer Corp. 97.96

Crawling Insect Attack Ringer Corp. 99.56

Flea Kill Fogger The d-Con Co. Inc. 98.35

Hyponex Bug Spray Hyponex Corp. 99.78

Insecticidal Soap for Indoor Plants Safer, Inc. 98.0

Mite Killer Safer, Inc. 98.0

No-Roach Gaston Johnston Corp. 82.034

Ortho Flea-B-Gon Chevron Chemical Co. 99.17

Ortho Hi-Power Ant, Roach & Spider Killer Chevron Chemical Co. 95.11

Ortho Hornet & Wasp Killer Chevron Chemical Co. 99.50

Raid Ant & Roach Killer S.C.Johnson & Sons Inc. 99.10

Raid Flying Insect Killer S.C.Johnson & Sons Inc. 99.2

Raid Fogger II S.C.Johnson & Sons Inc. 85.0

Raid Fumigator S.C.Johnson & Sons Inc. 87.4

Raid House and Garden Bug Killer S.C.Johnson & Sons Inc. 97.504

Spectracide Garden, Rose & Household Plant Spray Kenco Chem. & Mfg. Corp. 99.5

Spectracide Home Insect Control Kenco Chem. & Mfg. Corp. 99.17

Spectracide Indoor Fogger Kenco Chem. & Mfg. Corp. 99.40

Spectracide Wasp and Hornet Killer Kenco Chem. & Mfg. Corp. 99.3664

Wasp and Hornet Attack Ringer Corp. 99.56

LAWN CARE FUNGICIDE

Lawn and Turf Fungicide Faesy & Besthoff, Inc. 92.0

Lawn Disease Preventer Glorion Corp. 95.0

Lawn Fungicide Lebanon Chemical Corp. 99.945

LAWN CARE HERBICIDE

2-Way Green Power Lebanon Chemical Corp. 96.52

Balan 2, 5G Elanco Products Co. 97.5

Expel Dandelion Killer Lebanon Chemical Corp. 97.92

Longlife Weed and Feed Frank's Nursery & Crafts 99.9845

Preen'n Green Lebanon Chemical Co. 99.26

Spectracide Grass and Weed Killer Kenco Chem. & Mfg. Corp. 99.7

Step 1 Crab Grass Prevention O.M.Scott & Sons Co. 99.85

Step 2 Weed Control O.M.Scott & Sons Co. 97.205

Super Turf Builder Plus 2 O.M.Scott & Sons Co. 97.66

Super Turf Builder Plus Halts O.M.Scott & Sons Co. 98.97

Surety Weed and Feed Plus Howard Johnson Ent. Inc. 99.063

Team 2G Elanco Products Co. 98.0

XL 2G Elanco Products Co. 98.9

LAWN CARE INSECTICIDE

Bugout Lebanon Chemical Corp. 98.86

Chinch Bug & Grub Preventer Glorion Corp. 97.28

Deluxe Weed and Feed Glorion Corp. 97.28

Grub Buster Free Flow Fertilizer 98.5

Insect Control O.M.Scott & Sons Co. 96.40

Lawn Insect Control Glorion Corp. 98.86

Lawn Insect Control O.M.Scott & Sons Co. 94.16

Lawn Insecticide Free Flow Fertilizer 95

Lawn Insecticide Greensweep Household Products 58.5

LAWN CARE INSECTICIDE MANUFACTURER PERCENT INERT

Longlife Lawn & Garden Insecticide Frank's Nursery & Crafts 95.000

Oftanol Glorion Corp. 98.5

Spectracide Lawn & Garden Insect Kenco Chem. & Mfg. Corp. 95

Control (granular)

Spectracide Lawn & Garden Kenco Chem. & Mfg. Corp. 18.7

Insect Control (liquid)

Step 3 Insect Control O.M.Scott & Sons Co. 96.40

GENERAL HERBICIDES

2 in 1 Crabgrass Preventer Glorion Corp. 98.78

AAtrex 4L CIBA-GEIGY Corp. 57.0

Arsenal American Cyanamid Co. 72.4

Chopper American Cyanamid Co. 72.4

Ortho Kleenup Super Edger Chevron Chemical Co. 99.50

Prowl American Cyanamid Co. 57.7

GARDEN FUNGICIDE ...

Dexol Bordeaux Mixture Dexol Industries 87.35

Garden Fungicide Safer, Inc. 99.6

Pipron L.C. Elanco Products Co. 17.6

Rubigan E.C. Elanco Prodcuts Co. 87.5

GARDEN INSECTICIDE

Liquid Sevin Faesy & Besthoff, Inc. 77.5

Ortho 3-Way Rose & Flower Care Chevron Chemical Co. 98.85

Rose & Flower Spray or Dust Bonide Chemical Co. Inc. 84.5

Spectracide Rose & Garden Insect Killer Kenco Chem. & Mfg. Corp. 99.88

OUTDOOR INSECTICIDE

Abate 1-SG American Cyanamid Co. 99

Amdro American Cyanamid Co. 99.12

Cygon 400 American Cyanamid Co. 56.5

Gypsy Moth Biological Control Acme Burgess Inc. 99.14

Mosquito Attack Ringer Corp. 50

Ortho Diazinon Soil & Foliage Dust Chevron Chemical Co. 96

Ortho Diazinon Plus Insect Spray Chevron Chemical Co. 75

Ortho Home Orchard Spray Chevron Chemical Co. 62.5

Ortho Isotox Insect Killer Chevron Chemical Co. 90.6

Ortho Orthene Systemic Insect Control Chevron Chemical Co. 90.6

Ortho Rose & Flower Insect Killer Chevron Chemical Co. 99.70

Ortho Sevin Chevron Chemical Co. 95

Raid Yard Guard S.C.Johnson & Sons Inc. 99.125

Yard and Garden Insect Attack Ringer Corp. 99.56

PET CARE

Hartz 2 in 1 Flea and Tick The Hartz Mountain Corp. 99.332

INSECT REPELLENT

Cutter Insect Repellent Miles Laboratory 67

Off S.C.Johnson & Sons Inc. 85.00

Ortho Outdoor Insect Fogger Chevron Chemical Co. 91.385

MOLLUSCICIDE

Deadline Pace National Corp. 96

Ortho Slug-geta Chevron Chemical Co. 98

Table 2. Some Adverse Health Effects Of Certain Inert Pesticide Ingredients

Chemical Effects

Carbon tetrachloride* Irritation of skin, eyes nose, throat; dizziness, vomiting, abdominal pain; diarrhea; damage to

kidneys, liver; central nervous system depression; suspected carcinogen.

Chlorobenzene* Eye and skin irritation, burns and inflammation; chest pain, slow heart rate, ECG irregularities;lung, liver and kidney damage; central nervous system depression; coma. Chloroform* Irritation to eyes and gastrointestinal tract; damage to liver and kidneys; central nervous system depression; nausea, dizziness, fatigue, respiratory distress; gonadal atrophy; fetal resorption; mutagen; coma and

death by cardiac arrest; suspected carcinogen. Chloroethane Irritation of eyes; abdominal cramps, nausea, vomiting; liver and kidney damage; nervous system

dysfunction; blood cell disorders; suspected carcinogen. Cresols Skin irritation, burns, and inflammation; irritation of eye, permanent damage and blindness; pneumonia;

pancreatitis; central nervous system disorders; kidney failure. Dibutylphthalate Irritation of eyes and throat; photophobia, conjunctivitis,nausea, dizziness.

Diethylhexylphthalate* Eye, nose and throat irritation; liver damage; testicular damage; central nervous system depression; suspected carcinogen.

Dimethylphthalate Irritation of eyes, mouth, nose, throat; dizziness, abdominal pain, nausea, vomiting, diarrhea; central nervous system depression; reduced respiratory rate; paralysis, coma.

Epichlorohydrin* Skin and eye irritation, conjunctivitis, corneal clouding; nausea, vomiting, fatigue; liver and kidney damage; inflammation of lungs, chronic bronchitis; death by respiratory paralysis; mutagen; fetotoxic.

Ethylbenzene Irritation of eyes, nose and throat; skin irritation, inflammation, blisters and burns; liver and kidney damage; central nervous system disorders; headache, sleepiness, difficulty in breathing; unconsciousness and

coma.

Ethylene dichloride* Nausea, vomiting, diarrhea; damage to liver and kidneys; central nervous system depression; death due to circulatory and respiratory failure.

Isophorone Irritation of skin, nose, throat, respiratory system; lung congestion and degeneration; central nervous system disorders; kidney and liver damage; suspected carcinogen. Methyl bromide* Eye and skin irritation; blurredvision, headache, dizziness, nausea, abdominal cramps; anorexia;

bronchopneumonia, pulmonary edema; brain damage, convulsions, coma; kidney and respiratory failure. -Dichlorobenzene Eye irritation and cataracts; skin irritation and lesions; headache, nausea, vomiting,

drowsiness; respiratory depression; anemia, kidney and liver damage; chromosomal breaks. p-Dichlorobenzene Irritation of skin, eyes, respiratory system; headache, dizziness, hyperactivity, weakness, weight loss; liver and blood disorders; kidney damage; lung congestion, difficulty in breathing; mutagen. Phenol Irritation of eyes, nose, throat; headache, dizziness, fainting, abdominal pain, nausea, vomiting, diarrhea;

damage to liver, kidney and heart; chromosomal aberrations and damage; mutagen.

Propylene dichloride* Eye and skin irritation; dizziness, disorientation, nausea, vomiting; liver and kidney damage; central nervous system damage; coma; hemolytic anemia; suspected carcinogen.

1,1,2-Trichloroethane* Gastrointestinal inflammation and congestion; liver and kidney damage; immune function disorder; central nervous system depression; suspected carcinogen.

Toluene Skin, eye and respiratory irritation; abdominal pain, headache, nausea, dizziness, drowsiness, hallucinations; anemia; liver disorders and enlargement; central nervous system dysfunction; coma and death. Trichloroethylene* Eye irritation, visual distortion; abdominal pain, nausea, diarrhea; anorexia; liver and kidney damage; peripheral nerve damage, numbness and paralysis; blood disorders; cardiac arrhythmia; suspected carcinogen.

*This chemical was identified as an Inert Ingredient by EPA in 1991, but is absent from the most current list of Inert Ingredients released in May, 1995.

Sources: U. S. Environmental Protection Agency, Chemical Profiles, Interim Guidance, Chemical Emergency Preparedness Program, 1985

U. S. Environmental Protection Agency, Office of Health and Environmental Assessment, Health Assessment Documents U. S. Public Health Service, Agency for Toxic Substances and Disease Registry, Toxicological Profiles New York State Department of Health, Chemical Fact Sheets

TABLE 3. A GUIDE TO SELECTED REGULATIONS COVERING CHEMICALS ALSO USED AS INERTS.*

----------------------------------------------------------------------------

Number of _____________________________ _____________________________ REGULATIONS AND

ADVISORIES** _____________________________ _____________________________

Applicable

Regulations/ SDWA TSCA CERCLA/SARA RCRA CWA OSHA NTP ACGIH IARC DOT CAA NIOSH

Chemical Advisories 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26

Chloroform 21 X X X X X X X X X X X X X X X X X X X X X

p-Dichlorobenzene 21 X X X X X X X X X X X X X X X X X X X X X

Ethylene dichloride 20 X X X X X X X X X X X X X X X X X X X X

Carbon tetrachloride 19 X X X X X X X X X X X X X X X X X X X

Chlorobenzene 19 X X X X X X X X X X X X X X X X X X X

o-Dichlorobenzene 19 X X X X X X X X X X X X X X X X X X X

Propylene dichloride 19 X X X X X X X X X X X X X X X X X X X

Trichloroethylene 17 X X X X X X X X X X X X X X X X X

Methyl bromide 16 X X X X X X X X X X X X X X X X

Toluene 16 X X X X X X X X X X X X X X X X

1,1,2-Trichloroethane 15 X X X X X X X X X X X X X X X

Diethylhexylphthalate 15 X X X X X X X X X X X X X X X

Epichlorohydrin 15 X X X X X X X X X X X X X X X

Phenol 15 X X X X X X X X X X X X X X X

Chloroethane 14 X X X X X X X X X X X X X X

Dibutylphthalate 14 X X X X X X X X X X X X X X

Dimethylphthalate 13 X X X X X X X X X X X X X

Ethyl benzene 13 X X X X X X X X X X X X X

Cresols 12 X X X X X X X X X X X X

Isophorone 11 X X X X X X X X X X X

* Adapted from: Suspect Chemicals Sourcebook, K.b. Clansky, Ed., 1989 Edition

(Updated to Jan. 1, 1990) Roytech Publications, Inc.

** See "Explanation of Regulations and Advisories" which follows for specific identification.

--------------------------------------------------------------------------------

Explanation of Regulations and Advisories for Selected Chemicals Used As Inerts

SAFE DRINKING WATER ACT (SDWA)

1. Maximum Contaminant Levels (MCL)

Requires the U. S. Environmental Protection Agency (EPA) to establish primary drinking water regulations which 1) apply to public water systems, 2) specify contaminants which may have adverse health effects, 3) specify Maximum Contaminant Levels (MCL, the maximum permissible level of a contaminant in water) or treatment techniques for each listed contaminant, 4) establish public notification requirements. 2. Maximum Contaminant Level Goals

Establishes non-enforceable Maximum Contaminant Level Goals (MCLG) which are set at a level at which no known or anticipated adverse health effects occur and which provide an adequate margin of safety.

3. Monitoring Requirements

Requires monitoring for contaminants likely to be found in the system's drinking water, including contaminants not regulated under National Primary Drinking Water Regulations. Results must be reported to both the State and EPA and made available to the public.

4. 1986 Amendments/Statutory Contaminants Requires EPA to regulate 83 contaminants by publishing MCLG's and promulgating National Primary Drinking

Water Regulations for each of the 83 listed contaminants. 5. 1986 Amendments/Drinking Water Priority List Requires EPA to establish a priority list of contaminants which may have adverse health effects and are known or participated to occur in public water systems.

TOXIC SUBSTANCE CONTROL ACT (TSCA)

6. Section 4(a), Final Test Rules Requires EPA to test substances which meet certain criteria, such as those which may present an unreasonable risk or injury to health or environment, in order to develop health or environmental data.

7. Section 8(d), Health and Safety Data Rule Requires manufacturers, importers and processors of listed substances to submit to EPA copies and lists of unpublished health and safety studies on the listed substances with which they deal.

8. Section 4(a), Dioxins/Furans Rule Requires manufacturers and importers of certain organic chemicals to test for the presence of halogenated dibenzodioxins (HDD) and halogenated dibenzofurans (HDF) as contaminants. Results and existing test data must

be submitted as well as additional information if HDD and/or HDF concentrations exceed designated levels.

9. Section 12(b), Export Regulations Requires exporters of chemical substances to notify EPA of such exportation if any exported substances are affected by TSCA Sections 4, 5, 6 or 7.

COMPREHENSIVE ENVIRONMENTAL RESPONSE, COMPENSATION AND LIABILITY ACT (CERCLA)/SUPERFUND AMENDMENTS AND REAUTHORIZATION ACT (SARA)

10. CERCLA. Hazardous Substances Establishes a list of substances which must be reported to the National Response Center when released in quantities exceeding a specified reportable quantity.

11. SARA. Title III Section 302 and 304, Extremely Hazardous Substances

Requires facilities handling substances named on the list of extremely hazardous substances to notify the State of the presence of these substances in excess of their Threshold Planning Quantities and must notify local authorities of their release in excess of their Reportable Quantities.

12. SARA. Title III Section 313, Toxic Chemicals Establishes a list of toxic chemicals. Manufacturers, processors and users of these chemicals must submit release

reporting forms.

13. CERCLA Section 104(i), Priority list of CERCLA Hazardous Substances Requires EPA and the Agency of Toxic Substance and Disease Registry to 1) prepare a prioritized list of hazardous substances commonly found at National Priorities List sites which pose the greatest potential health risk, 2) to develop Toxicological Profiles of these substances, 3) establish a research program to fill data gaps.

RESOURCE CONSERVATION AND RECOVERY ACT (RCRA)

14. Requires notification of EPA by anyone who generates, transports, treats, stores or disposes of wastes specified under Section 3001 of RCRA.

15. Hazardous Constituents for Groundwater Monitoring Requires groundwater monitoring at RCRA land-based hazardous waste disposal units for all constituents listed in Appendix IX to 40 Code of Federal Regulations (CFR) 264.

16. Land Disposal Prohibitions - Halogenated Organic Compounds Restricts land disposal of waste containing halogenated organic compounds above specified concentrations.

17. Land Disposal Prohibitions Lists the hazardous wastes identified in 40 Code of Federal Regulations 261 which were scheduled for

restricted/prohibited land disposal after enactment of the Hazardous and Solid Waste Amendments to RCRA in 1984.

CLEAN WATER ACT (CWA)

18. Section 304, Water Quality Criteria; Section 307, Priority Pollutants Requires EPA to publish and periodically update ambient water quality criteria. Criteria are to reflect latest

scientific knowledge on the identifiable effects of substances on public health and welfare, including but not limited to aquatic life, aesthetics and recreation. Establishes a list of toxic pollutants for which EPA is required to publish ambient water quality criteria. Under Section 304, these chemicals shall be subject to effluent limits resulting from

the application of best available technology.

19. Section 311, Hazardous Chemicals Requires EPA to publish a list of substances that are considered hazardous if spilled in navigable waters.

OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION (OSHA)

20. Air Contaminants (29 CFR 1910.1000) Establishes a list of air contaminants and sets exposure limits for the workplace.

NATIONAL TOXICOLOGY PROGRAM

21. Report on Carcinogens Identifies carcinogens and subdivides them into Known and Anticipated. Categorizes 162 substances on this basis.

AMERICAN CONFERENCE OF GOVERNMENTAL AND INDUSTRIAL HYGIENISTS

22. Threshold Limit Value Chemicals Provides various workplace exposure limits (time-weighted average, short-term exposure limits, ceiling limits) for each covered substance.

INTERNATIONAL AGENCY FOR RESEARCH ON CANCER

23. Human Carcinogens (Groups 1, 2A, and 2B) Identifies carcinogens and classifies them as: Group 1 (sufficient evidence of human carcinogenicity); Group 2A

(probable human carcinogen); Group 2B (possible human carcinogen).

DEPARTMENT OF TRANSPORTATION

24. Hazardous Materials Regulates interstate commerce of hazardous materials, including all CERCLA hazardous substances, Specifies Requirements for description, shipping names, class, labeling and packaging, as well as spill notification.

CLEAN AIR ACT

25. Section 111, Potential Human Health Hazards Lists substances published by EPA pursuant to Section 111 of the Clean Air Act, which pose a potential health

hazard and for which specific control techniques are defined.

NATIONAL INSTITUTE OF OCCUPATIONAL HEALTH AND SAFETY (NIOSH)

26. Criteria Documents Specifies a NIOSH Recommended Exposure Limit and appropriate preventive measures to reduce or eliminate adverse health effects.

1. "Inert Ingredients in Pesticides," USEPA, Office of the Inspector General, Audit Report E1EPF1-05-0117-

1100378, Sept. 27, 1991.

2. Memo from Michael Simmons, Associate Assistant Inspector General for Internal and Performance Audits to

Victor J. Kimm, Acting Assistant Administrator for Prevention, Pesticides and Toxic Substances, September 17,

1993. See Foreword for an update on the computer database.

3. FIFRA, Section 10(d)(1)(C), entitled, "Protection of Trade Secrets and Other Information".

4. Based on a market survey conducted during the spring and summer of 1990.

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Comment 107 
This is a long over effort in reconciling the suffering of Vietnam Veterans and their children due to the veteran's exposure to the dioxin Agent Orange. The effects of the exposure will haunt our children for generations to come. We need to do the right thing for the men and women who served our country and to their innocent children.

Comment 108 
http://organicconsumers.org/monsanto/index.cfm 

JOIN MILLIONS AGAINST MONSANTO.

VOTE "I Agree" on "Research on Chemical Sensitivities and Intolerances." We need your organization platform. We are not organized. Many of us are very sick.
LYSOL AND PESTICIDES of many kinds are contaminated with DIOXIN. Don't use them or go near them EVER! Complain about these products to our government.

Learn more each week at WSMCSN@yahoogroups.com, chemicals that are found to cause diseases, travel tips, equipment purchases, food guides and other important issues. Please do not cast any more votes against us. Many of us do not have computers. We were winning. Give us some of our votes back, please.

We need a voice at NIEHS. We can talk about ways to help your children become as healthy as possible. Please help us, help ourselves. Thanks, Susan Jannarone 8172696046

Comment 109 
As a wife of a Vietnam Veteran who was exposed to the Dioxin Agent orange and whom young daughter died of many congenital birth defects I am think this study is past due. Thank you

Comment 110 
The research proposals on this website focus on possible environmental causes of autoimmune diseases, autism, chronic fatigue, chemical sensitivity/intolerance, military veterans' illnesses, as well as individuals who report symptoms associated with oil spills, fracking, hazardous waste sites, various community exposures, dioxin, home remodeling, poor indoor air quality, mold, pesticide use, and myriad other environmental exposures. But, in fact, individuals with these seemingly unrelated exposures and multi-system health problems share a great deal in common: their multi-system symptoms are often triggered by every day, low-level chemical exposures. Many also report adverse reactions to foods, medications, alcoholic beverages and/or caffeine. Dr. Nicholas Ashford of MIT and I first described this phenomenon 15 years ago. Toxicant-Induced Loss of Tolerance (TILT) is the name we gave to the underlying dynamic. It involves a two-step process whereby an initial acute or chronic toxic exposure causes loss of tolerance for everyday exposures. These new-onset intolerances perpetuate the disease process. We described how low-level exposures to common chemicals, foods, and medications may be the driving force behind the increased incidence of many hitherto unexplained medical symptoms and how masking—resulting from overlapping responses to multiple incidents—obscures the fact that everyday exposures can perpetuate illness. These concepts arose from reports by physicians, researchers and patients from more than a dozen industrialized nations. Collectively, their observations provide evidence that toxicant-induced loss of tolerance may be a new theory of disease. Currently, we are at the germ theory stage in terms of our understanding of this phenomenon. Well-founded theories—those based on careful observation, as in the case of the germ theory—are vital for developing shared scientific understanding and igniting future research.

In summary, it appears we are dealing with a two-stage disease process: (1) loss of tolerance resulting from an acute or chronic exposure event, followed by (2) repeated triggering of symptoms by everyday exposures, such as gasoline vapors, engine exhaust, fragrances or cleaning agents—exposures which had not been a problem for the person previously. This phenomenon became increasingly common with the widespread introduction of synthetic organic chemicals following WW II. This, coupled with the fact that 90% of Americans spend 90% of their day inside poorly ventilated structures where unprecedented types and levels of synthetic volatile organic chemicals (VOCs) are present, has led to the epidemic of chronic illnesses we are witnessing today. If we are to understand the extent to which these exposures contribute to the host of chronic illnesses mentioned on this website, doctors and researchers must have access to environmental medical research units— hospital-like research facilities in which people with major illnesses such as autism or autoimmune disorders, can be placed on an elimination diet in a chemically clean environment to see if their symptoms improve. If their symptoms resolve, then everyday exposures and foods can be reintroduced, one at a time. We are all so different and we respond differently to different exposures. NIEHS has an unprecedented opportunity: new approaches for assessing gene and protein expression and new brain imaging techniques can be used both before and after challenges in an EMU. We need to move forward, but not without this essential research tool—the Environmental Medical Unit (EMU). The EMU has been a priority recommendation of several professional and governmental conferences, yet still no research EMU exists in the U.S. It is time for NIEHS/NIH to add the EMU to its portfolio, so that we can all begin to understand the common dynamic shared by so many chronic, costly, and disabling medical conditions. The many excellent comments shared on this website testify to this need.

1. Chemical Exposures: Low Levels and High Stakes by Nicholas A. Ashford and Claudia S. Miller (Wiley). May be downloaded at no charge from www.chemicalexposures.org, along with a published and validated screening questionnaire for chemical intolerance, the Quick Environmental Exposure and Sensitivity Inventory (QEESI).
2. Toxicant-induced loss of tolerance—an emerging theory of disease? Miller CS. Environmental Health Perspectives: vol 105 Supp 2:445-453 (1997).
3. Empirical approaches for the investigation of toxicant-induced loss of tolerance. Miller C, Ashford A, Doty R, Lamielle M, Otto D, Rahill A, Wallace L. Environmental Health Perspectives: vol 105 Supp 2:515-519 (1997).
4. Toxicant-induced loss of tolerance. Miller CS. Addiction 96(1):115-139 (2000).

Comment 111 
Thanks for thinking of the children. The government could care less, they know all of the "Secret" stuff they were pulling off, including Agent Orange. First they said "no spraying", then it was a couple of 10 acre plots. Then we know a fellow by his testimony that he spilled a couple of Agent Orange drums in the motor pool at Korat. Then what about those barrels at the end of the Bangkok run way. They were there for looks, sure. Yes I am disappointed in our Government, darn I almost forgot they sprayed Agent Orange around the perimeters. Well if you surround yourself with the most dangerous poison how can we not be affected. My opinion: They sprayed every base in Thailand, the jungles were to thick and after reading "Lessons Learned", there was a shortage of dependable mechanics and heavy equipment operators and parts. There was also a shortage of personnel. Now the new thing is there was a weaker version "commercial", used everywhere, then there is the "tactical" version. If you believe that we all need to have our heads examined. First of all the Government takes the lowest bid, it was the same crap they used in Vietnam. Now New Zealand Government is apologizing for selling Dioxin to the Americans. That wasn't in the barrel count. Two of my children's hands shake, the doctor says nothing is wrong. Yeah! God Bless all of you

Comment 112 
I have a Marine brother with 2 daughters with birth defects. One has been bedridden her whole life. There is no previous indications of any of their medical conditions on either parents' side of the family. Only one conclusion can be drawn........... DIOXINS !!!!!!!!!! He and his family need all the help this study can generate. Please don't take too long. All of us Vietnam Veterans know what caused these innocent generations to suffer. How do you think we feel about doing this horror to them?
Al Sickle, President, Vietnam Veterans of America
Chapter 391
Sonora, California

Idea 14: Continue NIEHS' climate-health research for vulnerable pop

Research is needed to identify pathogenic interactions and rising disease rates among immunologically naïve populations arising from global climate change. Such studies could include the degree to which aeroallergen production and allergenicity increases in response to rising temperatures and CO2 concentrations; identification of earlier allergic sensitization of individuals to longer aeroallergen seasons, in response to rising temperatures; and increased volatilization of agricultural chemicals as temperature rise, which may potentially lead to increased application by managers, and subsequently increased runoff and pollution by nutrient-enriched waters into ground and surface waterways.


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Idea 15: Dioxin Effects

What has happened in Vietnam and other areas where these have been used. How has the population of these areas been effected. How have the children and grandchildren of those effected been further effected by dioxin exposure to their parents and grandparents.

Comment 1 
Gulfport Mississippi was the CONUS storage in the US for these herbicides before they got shipped to Vietnam. There were major leaks here and have just recently been cleaned up after nearly 40 years. The children who were born and raised in this area where the contamination occurred would make an excellent study group for the effects of dioxin. They have a lot of health problems for their ages. Also, there is a lot of data to support the levels of TCDD in the fish, soil, biota....etc. that would be beneficial to help study levels of exposure.

Comment 2 
I did time in Vietnam from 1968-1969 in I corps, with 1st Tanks, 1st MarDiv. I have 3 kids, oldest daughter born 10 months after I returned, was pregnant, baby was aborted by doctor recommendation, malformed brain, club foot, malformed heart. My son was second no problems, my last daughter, gallbladder removed, kidney stones, has had crippling arthritis since age of 34, dioxins? who knows. My grandson from my last daughter has multiple allergies, terrible psoriasis since birth.

Comment 3 
I am male and did 2 tours in VN and have only one child, tried for more, oh well. My only child is type 1 diabetic and there is no history in either family. Could this be agent orange related? I am 100% disabled from prostate cancer that I didn't catch in time

Comment 4 
I had two infants pass away unexpectedly (one right after the other), within 4 years of my returning from Vietnam. Doctors at the time where unable to give me satisfactory explanations. They gave me the cause of death but were unable to explain the reason they happened. I have always felt it was due to my exposure to Agent Orange.

Idea 16: Disease-first paradigm

Environmental factors, in combination with genetic factors, play a huge role in common disease susceptibility. Associations between environmental factors and health outcomes are, however, complex and poorly characterized. Levels of exposure, for example, are often difficult to ascertain, owing to a lack of detailed monitoring as well as to inevitable variations within any population. New technologies and genomic information, however, promise to meet this long-standing challenge. Common diseases require an understanding of gene–gene, gene–environment, and gene–vector–environment interactions. With the advent of the high-throughput techniques of genomics, proteomics, and metabolomics, biomedical science has been steadily shifting to a more comprehensive focus on understanding the diverse and complex responses underlying the development of disease. Coupled with increases in computational power and sophisticated informatics tools for data integration and modeling, researchers can develop quantitative models to support risk assessment. The current approaches to the exposure arm of exposure–disease relationships, the "traditional approach" and the "hazard-assessment approach," cannot generate the detailed information necessary for a comprehensive appreciation of common multifactorial diseases.

What is needed is a systematic tracking of population health status that will allow us to obtain highly detailed information on combined exposures and provide measurable endpoints. The "disease-first" surveillance uses clinical analyses of population health status as the starting point for research inquiry. The assumption that health status reflects environmental exposures is not novel, as public health practitioners and medical experts have made use of it for centuries. A truly comprehensive health status monitoring system for most common diseases in the US is not yet in place; is unfortunate because consistent and accurate health status data compiled over many decades could be used to reflect changes in environmental conditions. Infectious disease monitoring in the US and health status monitoring in Sweden are good examples of successful programs that illustrate how effective population monitoring can be. A significant component of the disease-first approach aims to obtain a detailed molecular characterization of preclinical and clinical disease, and then to integrate this information with a vast body of information on environmental exposures, broadly defined. The approach starts with a specific common disease and detailed assessments of the molecular, cellular, and tissue changes that underlie pathogenesis in response to candidate environmental stressors. The disease-first approach will rely on the integration of information from the multiple domains and on the blending of information from experimental models of disease and exposure analyses. This integration is the hallmark of the disease-first approach. The disease-first hypothesis is that data amalgamated from these sectors will allow us to do a more sophisticated job of finding molecular signatures of exposures and linking them, through the power of informatics, with pathophysiological changes. Gaining a true understanding of common diseases will require an integrated perspective on the robustness of biological systems. The disease-first paradigm fits squarely within the context of the GEI and the exposome paradigms.

Idea 17: The Effect of High Fructose Corn Syrup on Autoimmunity

Since the late 1970s High Fructose Corn Syrup (HFCS), now also called "corn sugar," has become ubiquitous in the American diet. Those born after 1980 are among the first generation of humans to be continuously fed this genetically engineered, mass marketed food chemical from infancy.

Today, it is a staple of American dietary intake from cradle to grave. It is used in almost everything sold from the supermarket shelf as a cheap replacement for sucrose. It is used as a sweetener, filler, preservative, thickening agent, and humectant. While recently some food manufacturers have yielded to public pressure and removed high fructose corn syrup from their products, the overwhelming majority of food products sold in the United States continue to contain HRFC ("corn syrup") as an ingredient.

Research has yielded mixed results about its possible adverse effects on health and should be rigorously investigated as it relates specifically to effects on autoimmunity and the inflammatory response.

Idea 18: The effects of chronic inflammation on individual susceptibility

This issue parallels the posted idea "Environmental factors in inflammation and associated diseases," which asks if environmental exposures affect the human immune system. We should also ask the question from another perspective: how does inflammation affect a person's susceptibility to environmental exposures? The pathophysiology of inflammation starts with tissue damage (e.g., infection, radiation damage, autoimmune disease) that leads to phagocyte infiltration and generation of cytokines and reactive oxygen and nitrogen species. Host epithelial cells are chronically exposed to these biological and chemical stresses. How do these endogenous stressors affect cellular responses to environmental exposures? Epithelial cells exposed to local inflammation may be more or less susceptible to DNA-damaging environmental toxicants (metals, alkylating agents, radiation, etc.) due to up- or down-regulation of DNA repair mechanisms. How does chronic H. pylori infection of the stomach and the resulting gastritis affect a person's susceptibility to environmental exposures from food-borne toxicants? How does influenza infection of the lungs affect a person's response to airborne toxicants? Colitis and inflammatory bowel disease are well known to affect liver function via the portal circulation, so one might ask how these forms of chronic inflammation could affect hepatic metabolism and activation/detoxification of drugs and environmental chemicals. Further, IBD can disrupt the epithelial barrier in the gut, which can affect the absorption and toxicokinetics of chemicals in food and water. Chronic inflammation may thus have significant influence on individual susceptibility to environmental exposures.

Comment 
Effect of early childhood disease that are influenced by environmental exposures

(asthma, reduced lung function growth) on adult onset cardiorespiratory disease (COPD, heart disease, hypertension) will be very informative to understand how these relates to future burden of disease.

Idea 19: Eliminate breast cancer

Eliminate high output junction boxes and high tension electrical apparatus near homes. The cluster of breast cancer in women is around high output electrical apparatus overhead near homes.

Comment 
In the cities where the high output electrical apparatus is underground, there is a low incidence of breast cancer. In the suburbs where the high output electrical apparatus is overhead, no animals go near it and the grass and weeds grow exceptionally fast and large and the incidence of breast cancer is high. There are clusters of breast cancer around the overhead high output electrical apparatus.

Idea 20: Environmental Health Disparities Research Centers

NIEHS has funded Children's Environmental Health Centers and Superfund Centers. There has been limited focus of NIEHS on environmental health disparities. NIEHS has an opportunity to be more of a leader in this area of research because of the new status of the National Institute for Minority Health and Health Disparities. The goal of health equity should be a major goal of NIEHS and one way to achieve this goal is to fund Environmental Health Disparities Research Centers. This funding initiative could be a partnership between NIEHS, NIMHHD, and the Environmental Protection Agency. Many communities of color have differential burden, exposure, risks, and health outcomes due to their proximity to riskscapes, unhealthy urban, suburban, or rural geographies, and the number of environmental risks that may burden their neighborhoods. By funding these centers, NIEHS can advance the national agenda to eliminate health disparities and achieve health equity.

Idea 21: Environmental Health: Media & Raising Awareness

Funded strategic plan to raise environmental health awareness. Includes series of events to make the case for an "environmental health" beat at media venues to encourage more mainstream media reporting of the issues. Events would be aimed at media venues themselves such as editorial meetings with media staffs, National Press Club, various Journalist Associations, as well as Journalism and Communications programs at universities. Additional funded strategies include training for Environmental Fenceline communities on environmental health information outreach in their own communities and with their own media. Include endowments for journalists focused on environmental health.


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Idea 22: Environment-microbiome interactions in health and disease

There are 10 microbes for every cell in the human body and emerging evidence now points to critical influences of a person's microbial community on disease susceptibility. For example, the drug industry

has recognized that gut microbes have significant effects on drug metabolism, drug uptake and pharmacokinetics. The same should apply to exposure to environmental agents. New tools and animal models are being developed to explore the effects of the environment on the microbiome and the effects of a person's microbiota on his or her susceptibility to environmental exposures.

Idea 23: Focus on human-relevant studies for disease

The National Toxicology Program's (NTP) Host Susceptibility Branch (HSB) was created to study

individual differences in susceptibility to environmental toxicants and disease due to genetic variation –not in humans but among multiple strains of inbred mice, in the hope that identifying mouse genes will indicate orthologous human genes. The use of multiple strains will lead to an exponential increase in the number of animals killed in toxicity testing. The 15 strains initially chosen were selected based on available resources, and the HSB admits that 30-50 strains may be required to obtain sufficient statistical power to identify candidate genes. Even if sufficient statistical power could be achieved, many gene families are so diverse in both gene number and position that it is difficult to determine the human–mouse orthologs even when the actual sequence is examined. In addition, there is little evidence supporting the notion that these genes would actually have the same function in mice and humans. The HSB's approach runs counter to all efforts to move toward human-relevant methods. Further, given the already high cost of animal toxicity testing, it is inconceivable that multiplying that cost 50-fold will result in a comparable benefit. We call upon the NTP to adopt a more relevant and efficient approach, such as that used by the International HapMap Project, which screens the human genome using microchip technologies that can provide information on more than 100,000 different polymorphisms, as well as developing human cellbased approaches that could evaluate the effect of actual human genetic polymorphism.

Idea 24: Giovanni's Legacy Foundation Autism Study

Trying to find children of Vietnam vets to take survey and DNA panel evaluations to corroborate the findings of mutated DNA, we have found from veteran to child and child to grandchild due to exposure to Agent Orange in Vietnam and other military theatres. Please contact us at giovannislegacyfoundation.org. or email rpkopy@yahoo.com; or call 702-742-3398.

Idea 25: Gluten sensitivity and Celiac disease processes

Research how better to find and help those with gluten problems. Investigate theories on how to rid individuals of these diseases.

Idea 26: Health disparity and the environment

What role does the environment play in health disparity of our populations?

This is both from effects of direct toxicity as well as the social/stress/emotional factors that precede and result from these factors.

Comment 1 
I am repeating a comment that I offered on another submission.

I suggest that one important way to help see environmental as well as occupational exposures - let's chip away at what is increasingly a non productive separation between "occupational" and "environmental" exposures - better addressed is to work to mainstream medical awareness of potential exposures, especially among primary care physicians, as well as to ensure that clinical laboratory testing is readily available. Readily available means within the scope of most health plan coverage. It would also be necessary for the results to be medically interpretable. (Just giving levels is a non starter for most physicians and could create anxiety for the patient and confusion for the practitioner.) Many people who would be leery of having this testing done at work, since they fear that it could have some impact on their employment status, would be more comfortable with having it done by their own doctor who would be trusted to maintain their privacy. Within EPA there is a similar interest in reaching "beyond the fence-line". This approach would be supportive of that EPA goal as well. At this time CDC / NCEH is working to develop a surveillance program, limited in scope so far, but grinding ahead, to look at actual chemical uptake in human beings. This could be a huge driver for public health and deserves to be studied in that connection. I am not sure that there is general awareness or appreciation of this important effort. NIEHS would be well placed to take a look at this kind of translational interaction with medicine.
MEO

Comment 2 
I strongly agree that emotional or a high stress atmosphere contributes to the disease state of fibromyalgia. I presented initially with a growth hormone deficiency, then a cortisol deficiency. This clearly indicates a disruption of the HPA( hypothalmic/pituitary/axis). Hypothyroidism was already present which became worse. I was diagnosed with fibromyalgia after the growth hormone deficiency was diagnosed. My job was high stress in the clinical lab on the evening shift of a hospital.

Idea 27: Identify vulnerable lifestages, epigenetic variability

More research to improve our scientific understanding of the biological response to disease progression should be a priority, to help identify vulnerable individuals, populations, life stages, disease states, etc. Identifying genetic and epigenetic differences between individuals can help identify vulnerable individuals, populations, life stages, disease states, etc. Identifying "windows of vulnerability", that is, life stages associated with changes in the biological system that may make it more susceptible to environmental exposures. This research should continue to be a priority for NIEHS as it improves its existing traditional toxicity testing and develops new testing and screening methods.

Idea 28: Illnesses Due To Home Foreclosure, Job Loss & Bad News In Media

ENVIRONMETNAL STRESSORS & ILLNESSES OF LOOSING YOUR HOME, JOB & THE BAD NEWS ON THE TV, RADIO AND THE INTERNET BY MARK RUSSELL 3 29 11


When We think about Environmental Stressors We think about:
1) Loosing your Home due to the Bad Economy
2) Loosing your Job after (25) years and can't Find Employment
3) Bad News in the Newspapers, Radio, Internet and TV

I don't see us curing these Problems within the next (2) years. I don't see any immediate fixes with a person or family that has had their home Foreclosed. I would like to see Solutions and Cure to:

1) 20% of the Problems and Illnesses
2) 40% of the Problems and Illnesses
3) 60% of the Problems and Illnesses
4) 90% of the Problems and Illnesses

I would like to see study done in the following Areas:

HOME FORCLOSURE:

1) Are their more Illnesses linked with families that are loosing their homes?
2) What kind of Illnesses is being reported with People living on the Streets?
3) Is their more Divorce amongst People loosing their homes?
4) Is there more Mental Illnesses amongst these People?
5) Is their more Medical Expense with these People?
6) Is the Crime Rate Higher with People that have lost their home?
7) What are some Solutions to Families that have lost their homes?
8) What Preventative Medicine can we do with Families loosing their homes?
9) Do Support Groups Work?
10) Do Church & Temple Support Groups Work?
11) Does Meditation Help?
12) What Medications Help?

LOOSING YOUR JOB AFTER 25 YEARS

1) What Medical Conditions can we link with Loosing a Job after 25 years of Employment
2) What is the Divorce Rate Amongst these people?
3) What Solutions do we have to stop 20%--40% of the Illnesses due to loosing a Job?
4) Is the Divorce rate higher with People that have lost their Jobs?
5) What Medications can we give these people not to get Sick?
6) Is there Stress Reduction Techniques that can help?
7) Does a Support Group Help?


BAD NEWS IN THE NEWSPAPERS, RADIO, INTERNET, AND TV

1) Can we link Illnesses with people that watch the News 2 hours per day?
2) Can we link Mental Illnesses with People that read 3 Newspapers per day?
3) Can we link Divorce with People that Obsess about the Bad News?
4) Does Exercise help reduce the Stress of Bad News?
5) Does Diet help reduce the Stress of Bad News?
6) Does a Support Group help reduce the Stress of Bad News?
7) What Medications help reduce the Stress of Bad News?
8) Does Religious Involvement help reduce the Stress of Bad News?
9) Do Married people have less Stress then Single People that read and listen to Bad News?

Comment 
Psychology became a Science in 1946 in Bolder Colorado and we had the 1st. Blood Transfusion in 1898. Pavlov in the 1950's--1960's proved that he could Condition Physical Body Responses with Brain Thought. We have an Epidemic of People loosing their Homes and Jobs and they are Traumatized. Great amounts of Stress have been proven to Cause Illnesses. Across the US the Unemployment rate is over 9%. In some Communities the Jobless Rate is as high as 30—50%. Are there Preventive Solutions to this Epidemic? This Idea about is not about creating a New Para Dime of Medicine. This idea is about dealing with the Here and Now and finding out what works for a Community of People that have lost their Homes and their Jobs—A Major Medical Emergency. Charles Darwin did not invent the Theory of Evolution—It was his Grandpa Erasmus Darwin that invented it 72 years Prior. All Charles did was to integrate the 17 theories of the day. We have many solutions to many Trauma and Mental Illnesses with Medication, Cognitive Therapy, Psychology, Psychiatry, Diet, Exercise, Prayer, Meditation, Hope, Values, & Love. We have an Epidemic of "10% of all the American Soldiers are being airlifted out of Afghanistan with Nervous Breakdowns and the Symptoms of ADD". Trauma has its cost to the Complete Medical Community and Everyone in the US. In 1896 Density Became a Science in the US. In 1846 for the 1st. time we used Ether for Dental Surgeries for Pain. Sometimes the Best Ideas are the very simple ideas in front of Everyone's Eyes. We have a Crisis and we have the Best Researches and Doctors in the World to find the Solutions. The Visionary Idea is to Do the "Here and Now".


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Idea 29: Integrated Health Outcomes

We need to think more about biological mechanisms and a "grand unification" of seemingly disparate health outcomes. Environmental exposures stimulate a cascade of responses and considering each respiratory, cardiovascular, neurological, etc. outcome is important but is akin to the proverbial Blind Men and the Elephant. We need to think about how to address multiple outcomes.

Idea 30: Maternal & perinatal disease

Environmental factors cause or influence an array of conditions that lead to illness and death among mothers and children. Worldwide, mothers and children are the populations at greatest risk for premature death and illness. In addition, these populations are also heavily exposed to environmental factors that affect overall health and contribute to a broad spectrum of diseases. Exposures during pregnancy can influence maternal conditions during pregnancy, such as asthma, anemia, and infectious disease susceptibility, and result in adverse pregnancy outcomes, such as miscarriage, intra- uterine growth retardation, prematurity. These exposures can also adversely affect long-term health outcomes for the offspring, such as suboptimal neurobehavioral development, cancer, and other chronic diseases.

Idea 31: Mr..

need much research.. safe , reasonable housing & help needed, helpful/knowledgeable Drs. Safe places to shop, visit, be. Educate public. Safe products, food.

Idea 32: Microbiomes & Stem Cell Research & Treatment

Stem Cell and Microbiomes should be at the top of the List for Treatments and Research for

Environmental Illnesses. Many Environmental Illnesses in the future will be able to cured or Stabilized by Stem Cells Treatments or Mircrobiomes.

Idea 33: Multiple exposures

The impact of multiple environmental exposures on health is unknown.

Communities exposed to multiple exposures are typically underserved, low-income, low education, and other social disparities. The possible compounded effect from social disparity (low education, poor nutrition, low income, etc.) and multiple environmental exposures needs further exploration.

Comment 1 
Dear Erin, I did not create the "Visionary Idea" that would lead to research on Chemical Sensitivities/Intolerances" but I have suffered from what industry calls "Multiple Chemical Sensitivity Syndrome" for 25 years. I first worked in a dry cleaners, printing company, photographic dark room, and then worked as an artist using petroleum-based products such as rubber cements. After college I was married and had my second child when TruGreen ChemLawn sprayed me in an overspray with pesticides. I became completely intolerant of dry cleaning compounds (perchlorethelyne), all printed material, photographs, rubber, oil paints and all pesticides. I also became sensitive to a host of foods. I now weight in at a healthy 145. After my "initiating" exposure I weighted in at 100 lbs because I became sensitive/allergic/hypersensitive to a host of foods and chemicals.

Patients like me come from typically disparately low income homes and have often suffered from some forms of malnutrition.

The reason I am writing is to try to consolidate your very profound topic with the number one Visionary idea on this site, "Research on Chemical Sensitivities/Intolerances." That topic definitely encompasses the one you expressed very well. The topic is usually called "Multiple Chemical Sensitivities" but industry has so harshly attacked us that we no longer use that term.

Contact me at jannarone@aol.com and if you see fit, I will help to refer the votes in the direction of the research topic that encompasses your idea, and the idea of Visionary Mary Lamielle. Thanks very much. SJ

Comment 2 
The research proposals on this website focus on possible environmental causes of autoimmune diseases, autism, chronic fatigue, chemical sensitivity/intolerance, military veterans' illnesses, as well as individuals who report symptoms associated with oil spills, fracking, hazardous waste sites, various community exposures, dioxin, home remodeling, poor indoor air quality, mold, pesticide use, and myriad other environmental exposures. But, in fact, individuals with these seemingly unrelated exposures and multi-system health problems share a great deal in common: their multi-system symptoms are often triggered by every day, low-level chemical exposures. Many also report adverse reactions to foods, medications, alcoholic beverages and/or caffeine. Dr. Nicholas Ashford of MIT and I first described this phenomenon 15 years ago. Toxicant-Induced Loss of Tolerance (TILT) is the name we gave to the underlying dynamic. It involves a two-step process whereby an initial acute or chronic toxic exposure causes loss of tolerance for everyday exposures. These new-onset intolerances perpetuate the disease process.


We described how low-level exposures to common chemicals, foods, and medications may be the driving force behind the increased incidence of many hitherto unexplained medical symptoms and how masking—resulting from overlapping responses to multiple incidents—obscures the fact that everyday exposures can perpetuate illness.


These concepts arose from reports by physicians, researchers and patients from more than a dozen industrialized nations. Collectively, their observations provide evidence that toxicant-induced loss of tolerance may be a new theory of disease. Currently, we are at the germ theory stage in terms of our understanding of this phenomenon.


Well-founded theories—those based on careful observation, as in the case of the germ theory—are vital for developing shared scientific understanding and igniting future research.


In summary, it appears we are dealing with a two-stage disease process: (1) loss of tolerance resulting from an acute or chronic exposure event, followed by (2) repeated triggering of symptoms by everyday exposures, such as gasoline vapors, engine exhaust, fragrances or cleaning agents—exposures which had not been a problem for the person previously. This phenomenon became increasingly common with the widespread introduction of synthetic organic chemicals following WW II. This, coupled with the fact that 90% of Americans spend 90% of their day inside poorly ventilated structures where unprecedented types and levels of synthetic volatile organic chemicals (VOCs) are present, has led to the epidemic of chronic illnesses we are witnessing today. If we are to understand the extent to which these exposures contribute to the host of chronic illnesses mentioned on this website, doctors and researchers must have access to environmental medical research units— hospital-like research facilities in which people with major illnesses such as autism or autoimmune disorders, can be placed on an elimination diet


in a chemically clean environment to see if their symptoms improve. If their symptoms resolve, then everyday exposures and foods can be reintroduced, one at a time. We are all so different and we respond differently to different exposures. NIEHS has an unprecedented opportunity: new approaches for assessing gene and protein expression and new brain imaging techniques can be used both before and after challenges in an EMU. We need to move forward, but not without this essential research tool—the Environmental Medical Unit (EMU). The EMU has been a priority recommendation of several professional and governmental conferences, yet still no research EMU exists in the U.S. It is time for NIEHS/NIH to add the EMU to its portfolio, so that we can all begin to understand the common dynamic shared by so many chronic, costly, and disabling medical conditions. The many excellent comments shared on this website testify to this need.


1. Chemical Exposures: Low Levels and High Stakes by Nicholas A. Ashford and Claudia S. Miller (Wiley). May be downloaded at no charge from www.chemicalexposures.org, along with a published and validated screening questionnaire for chemical intolerance, the Quick Environmental Exposure and Sensitivity Inventory (QEESI).


2. Toxicant-induced loss of tolerance—an emerging theory of disease? Miller CS. Environmental Health Perspectives: vol 105 Supp 2:445-453 (1997).


3. Empirical approaches for the investigation of toxicant-induced loss of tolerance. Miller C, Ashford A, Doty R, Lamielle M, Otto D, Rahill A, Wallace L. Environmental Health Perspectives: vol 105 Supp 2:515-519 (1997).


4. Toxicant-induced loss of tolerance. Miller CS. Addiction 96(1):115-139 (2000).

Idea 34: Neurological Disorders and Glutamate

Glutamate, found naturally in some foods and as an additive in others, can be a potent neurotoxin in individuals in susceptible subgroups as it triggers dysfunction in their body's already fragile glutamatergic balance. Disguised as a food additive under many pseudonyms, susceptible groups are being affected unknowingly every day. NIEHS should determine the degree of toxicity, phenotypes of susceptible sub-groups and consider policy to remove this potent excitotoxin from the U.S. food supply.

Comment 1 
My grandson reacts badly to food additives, including monosodium glutamate and artificial sweeteners. There is presently an 'overload' of these chemicals in many foods and drinks targeted at children.

Comment 2 
I am one who suffers from food additives...MSG included. My remedy is to avoid as many additives as I can, which can be difficult. I would love for NIEHS to bring more visibility to what I see as a real problem.

Comment 3 
This is a huge problem not only for autism but for all of us. Take a look at msgtruth.com It can affect multiple organ systems. Mercury toxicity messes up the metabolic pathway to convert glutamate to glutamine, so it's easy to end up with excessive levels which can kill brain cells. Most of our ASD kids have impaired detoxication pathways. When my son ate a high glutamate processed food (McD's french fries) he was up for days and tormented. I wash more people know about this problem and it got as much attention as trans-fats.

Idea 35: Non-communicable Disease

Chronic non-communicable diseases (NCDs) are steadily increasing around the world, and will soon account for more than 50% of the expenditures for health care and more than 60% of the disability adjusted life years (DALYs). For this reason, the scientific community should address the shifting global burden of disease and disability. Among the leading causes of death are cerebrovascular disease, ischemic heart disease, chronic obstructive pulmonary disease, lung cancer, diabetes, and hypertensive heart disease. Environmental influences, lifestyle factors and diverse socio-economic influences and epigenetic changes interact with the proximal causes (such as genetic susceptibility and infection) of many chronic disorders to influence their trajectory and severity. Increasing evidence for the prenatal and childhood roots of chronic NCDs provide possible avenues for early prevention of and intervention.


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Idea 36: The Northport Project

GOALS OF PROJECT
1) To create a Community Awareness Program for the residents of Northport, WA.

The program will help the residents understand and reduce risks to the toxins they are exposed to, as well as offer free annual health screenings to all Northport residents.

2) For two and a half years we have been mailing out & receiving completed health questionnaires from past and present Northport residents. With the help of the CCC, especially Dr. Mindy Smith, we have published updated summaries on what the questionnaires are showing.

Due to these summaries (on the CCC website as well as our blog northportproject.wordpress.com) we were able to get the attention of a research teams from Massachusetts General Hospital, in collaboration with the Crohn's and Colitis Foundation of America, to conduct an epidemiological study on cases of Crohn's, Colitis and any other IBDs diagnosed in past and present Northport residents (and surrounding communities).

Eventually the results will be published as a Community Health Assessment

3) Our hope is to use the Community Health Assessment to attract more research teams to conduct Epidemiological Research Studies on other health issues found at elevated rates in the community.

The results of these studies help to find better treatments to the illness and possibly even cures. The data can also be used to present a case to the EPA to reevaluate the safety levels for chronic exposure to many of the toxins we are exposed to currently.

4) We would like to offer free annual health screenings and hair element tests to residents. The results of these tests can save your life.


The Hair Element Test gives an accurate read on the amount of heavy metal toxins accumulating in your body. With the results you can learn about the vitamin and mineral deficiencies, (created by certain toxins), you have. Suggested supplements you should be taking will be explained to you by a physician after your results are in. The results will also help the physician doing your annual health screenings by providing important clues' as to which specific diseases and illnesses (known to be linked to the toxins found highest in your hair test) to keep an eye on.

The Health Screenings will assist in early detection of any cancers, diseases, or other health issue found in the area and linked to toxins the community is exposed to. Early detection is what saves lives.

The data collected from both could also lend as data for a decade (or more) long study of the impact of the toxins found in highest concentration (from hair element tests), and the health issues they cause (as your annual health screenings will show). Not to mention these kind of annual tests will save your life!

NORTHPORT – A Beautiful Town, Getting Better Everyday!

Our environment is getting safer every day, in part because of the research and cleanups being done by Teck, EPA and Ecology. As well as the fish studies, that helps to protect the public with health warnings. Also, since Teck began cleaning up their pollution, over a decade ago, by installing the safer kivcet smelter and halting the process of dumping their slag into the river in 1995, levels of toxins have never been lower.

COMMUNITY WORKSHOPS – Informed facts eliminates fear of the unknown

Over time the environment will eventually clean itself of the accumulated slag (toxins) caused by a Century of Teck's pollution – but until that day come, this program can also serve as a way to educate the community through workshops on ways to protect themselves by offering ways to lessen exposure to current toxins found in area.

MAKE AN IMPACT – A Negative to a Positive

There is nothing we can do about the impact the past pollutants, we were unknowingly exposed to for decades, have done to our health. However, by participating in surveys and studies, you can impact the health of future generations for the better.

OUR VISION – Future for Northport and it's Residents

Northport is one of the most beautiful areas in the world. Our family never plans to sell the family farm or leave the area. We also want to see Northport grow through tourism and local businesses. It is not our intention to scare people away from Northport – Visitors are in no danger of visiting our area – as several studies have proven that annual recreational exposure to the area does not pose any health risks.

We want to ensure the residents who are exposed to the toxins, 365 days of the year, are educated and kept safe and healthy, so they can continue living in the town they love so much.

Also, by residents offering to participate in studies and research that will not only protect the health of future generations of Northport, but of the entire world.

NORTHPORT PROJECT — Keep Updated!

To receive updates on all studies and other information via e-mail make sure to register at our

blog (register button on vertical menu, at the top of page.) Go to: Northportproject.wordpress.com

Jamie Paparich — 775.750.6384 — paparichj@live.com

Comment 1 
Please vote for The Northport Project - for more info go to www.northportproject.wordpress.com 

Comment 2 
Northport is a beautiful place with an unhealthy neighbor upstream. Learning to minimize risks of those toxins is very important. I hope that Jamie Paparich's NORTHPORT PROJECT gets funded.

Comment 3 
Northport is my home, a very beautiful place to live. I hope the funding can be obtained to get this project started and that the studies can save a few lives.

Comment 4 
Jamie has spent over two years of her life devoted to nothing but this project - please, give your vote to this extremely important cause!!

Comment 5 
I'm impressed with the research that has gone into this project. Coupling environmental and health studies has resulted in strong scientific support for this project. I'm glad to lend support to this endeavor.

Comment 6 
My great great grandfather and mother pioneered in Northport. I spent summers there since birth. My cousins and their neighbors in the area,(all descendants of pioneers) have high levels of Crohns, MS, cancer, auto-immune and other issues. Our family who visits all have auto-immune, and odd health issues. This project is needed. Education and information is power!

Comment 7 
I remember when Jamie first started asking questions about the smelter and the pollution issues. We each had some information, but not much. She then did something amazing, she started to gather all the information, kept asking questions and soon that unpleasant truth, one we had all suspected--that Cominco has been poisoning us for years--began to emerge. It is undeniable. The truth continues to emerge and enlarge only because Jamie continues to gather and coordinate. She is my hero.

Comment 8 
Thank you Rose! It is you and the other impacted residents courage, dignity and ability to truly forgive that make all of you my heroes. ;)

Idea 37: Radon Mitigation - Slow the Aging Process!

The major and only SCIENTIFICALLY PROVEN concern regarding RDP's from is lung cancer.
The people I talk with everyday are reasonable, scared and don't really understand all the technical information. If the Radon Industry can add a few more Health Benefits besides (Lung Cancer)to the list then why NOT? Any refreshing and REASONABLE additional Health Benefits to add to the MINER stories of the 1950's or the man that set off the radioactive sensors going INTO a Nuclear Power Plant in the 1970's would appeal to a broader base of people and help get the message out.

The population that cares about the impact of FREE Radicals on the body in general, would also

care about radon IF the connection to FREE Radicals is REAL. There are approx. 350 million people living in the United States. From numbers published by the EPA approx. 140,000 (which is .0004%) of the population even suffer from lung cancer per year. EVEN if the number was 10 times larger because of the impact of friends and families of the victims the percentage of the population truly impacted in their everyday lives is still significantly less than even 1% of the population.

The Radon Industry could us additional benefits that MORE people can relate to in their everyday lives. My goodness, the TODAY show yesterday said strawberries help prevent cancer. No one is asking where the strawberries are grown, what is in the soil, is this true of ALL strawberries in any grocery store or are there SPECIAL strawberries? I am sure the STRAWBERRY VARIABLES could be significantly greater in the production process than a Radon Decay Product of Radon that is very exact. Are there differences in one RDP versus another RDP depending on any of those variables except the quantity?
If long term exposure to elevated levels of Ionizing radiation (ALPHA PARTICLES) does increase the production of Free Radicals in the human body, then IT IS ONLY LOGICAL that reducing exposure to RDP's does DECREASE Free Radical Production. There are SCIENTIFIC studies indicating decreasing or protecting the human body from free radical production does slow the aging process or visa versa, exposure to increased free radical production ages us faster.
Right?

Comment 
Lets stop being a stick in the mud and help people understand ALL the possible benefits of Radon Mitigation!

Idea 38: Prevention---Visionary Goals for Environmental Health

VISIONARY GOAL FOR ENVIRONMENTAL HEALTH USING PREVENTION

1) Eliminate 50--90% of all Toxins (Radon, Mold, & Etc) in
Our Homes---Work—Schools---Cars.
2) Eliminate 50—80% of all Toxic Foods in Our Diets.
3) Work with Industry to Find Solutions to Eliminate 50--99%
of all Toxic Pollutants and Facilitate Business to make
Money in the Recycling and Refining of Pollutants.
4) Set up Better Monitoring Systems for Our Food & Air
using Nano Technology
5) The Gas Automobile Engine is 18-24% Energy Efficient—
Lets Make Gas Car Engine 55% Energy Efficient thereby
Reducing Toxic Emissions by 200--300%
6) The Coal/Steam/Electric is only 30% Energy Efficient---
Lets make it 85--95% Energy Efficient thereby reducing
Toxic Emissions by 200--300%
7) Increase Alternative Energy that shows a Profit like Geo
Thermal, Wind, & Solar thereby eliminating the use of
Existing Toxic Pollutants.

The Theory behind this Vision is Prevention without Punishment and everyone profits. If we can Double and Triple our Energy Output in this Country by Recycling the Lost Energy We would have one half to one third less Pollution to Breath. We would have Profits for Businesses and Cities. By Helping Coal/Electric/Steam Consumers Clean up their Sulfur Waste we Benefit in (3) ways.

1) Sulfur is used in Batteries, Matches, Drugs, Rubber, and
Fertilizers rather then putting it in a Land Dump. Last
year we produced over 44,000,000 ton of Sulfur in the
US. Profits will made by Everyone and the Everyone will
have much better health.
2) Sulfur doesn't get into our Air, Water, and Food Systems.
3) Jobs are Created

I would like to see a Contest Amongst Businesses to produce the most Energy Efficient Gas Car Engines and the Prize being $100,000,000. I would like to see a prize for a Company that uses an Existing Gas Engine and makes it 85% Efficient.. I would like to see a Cash Prize for people that come up with ways to make our Steam/ Fossil Fuel Plants and makes them between 85 to 95% Energy Efficient rather then 30% Energy Efficient. The payoff is obvious---1/2 less Pollutants, Profits, Jobs and Better Health

Idea 39: Research related to Environment Justice

This would appear to be a much needed area of research and would be consistent with Dr. Collins' goal of reaching out to disadvantaged communities

Idea 40: Restricted resource access and its effect on indigenous peoples

What happens to an indigenous population when traditional use natural resources are restricted? the health effects as well as mental stability are greatly changed

Idea 41: Research on Chemical Sensitivities/Intolerances

Millions of Americans experience severe and debilitating multi-system reactions and intolerances to a panoply of chemicals, over-the-counter and prescription medications, alcoholic and caffeinated beverages, and numerous other substances and products. Approximately 15-30% of Americans report adverse reactions to particular chemical exposures. Those disabled by chemical sensitivities or chemical intolerances (CS/CI) may be as high as 6% of the population. There is a need for population-based studies among exposed individuals using a validated questionnaire; for research on the mechanism by which people develop these sensitivities or intolerances following chemical exposures; for the creation of an interdisciplinary group to develop and implement research on CS/CI, and for the construction and staffing of an Environmental Medical Unit (EMU), a hospital-based research facility, as recommended by multiple professional and scientific meetings and supported by Congress. The Scientific Understanding Work Group, part of the CDC's National Conversation on Public Health and Chemical Exposures, is the most recent work group report to make detailed research recommendations to investigate individual susceptibility including the use of an Environmental Medical Unit (See Recommendation 7: http://www.resolv.org/site-nationalconversation/files/2011/02/Scientific_Understanding_Final_Report.pdf.) Clinical investigation of chemical intolerance using an EMU would permit examination of populations affected by toxicant-induced intolerances to determine the biomarkers and mechanisms by which to identify individual susceptibility so as to avoid placing such individuals in hazardous situations, detect affected individuals early in their illness, and provide prompt intervention.

Comment 1 
The jury is in and the verdict has been established well that there is a correlation (not just an association) for exposures to certain chemical substances and measurable physiologic (and neurologic)adverse outcomes in humans. The NIEHS needs to bite the bullet and more clearly advertise the extent and consequences of such interactions. The economic impacts to individuals and to industries are significant but so are the adverse outcomes.

Comment 2 
I was able to have genetic testing by a lab that shows that because I have a defect in the cytochrome P450 CYPD2D6 gene, I would be unable to metabolize Dursban, an organophosphate pesticide. I was able to make this connection because a drug containing Dursban, an OP pesticide also referred to as Chlorpyrifos, is used routinely in the treatment of AIDS patients. In addition, the 2D6 defect causes me to be unable to tolerate codeine. Hydrocodone causes a life-threatening illness and hospitalization when it was prescribed for me following a tooth extraction.

I became chemically-sensitive after being sprayed with a pesticide the operator referred to a Temik, a carbamate, and Dursban (Chlorpyrifos). I lost my ability to stand upright and was diagnosed at Johns Hopkins with various brain-heart anomalies such as NMH and CFS. I have had MCS for 25 years. I am unable until the present to withstand exposures to dry-cleaning fluid, perfumes, aftershaves, body washes, laundry detergents/softeners, air fresheners such as "Febreze," alcohol, varnishes or finishes on floors, floor wax, and most items used in a normal hospital setting, such as rubber-coated beds/mattresses, floor wax, antiseptic hand washes, etc. I can withstand only minor exposures to any form of petrochemical exhaust or petrochemical product. Even computers and TV's outgas phenolic resins (petroleum derivative) that cause me to become short of breath, light-headed, dizzy, fatigued, etc. Generally I can feel a sort of pain in the throat where Johns Hopkins reports patients like me develop mast cells.

Currently I am prescribed oxygen for which my insurance carrier pays. I

oxygenate at 88% and no doctor seems to be able to determine why. Last year a cardiologist told me I have cardiomyopathy. I showed him an article regarding the connection between the toxin "Sarin Nerve Gas" an OP, and heart failure. I believe that the OP, Dursban injured my heart muscle and my brain.

I continuously fight low blood volume, low blood pressure, fatigue, urge to lie down, mental fatigue/fog, insomnia and lethargy. I have lost most of my ability to perform activities I would like to have been involved in.

My husband and I have spent years looking for a home where I will not have to be exposed to lawn care products or exhaust.

I currently receive little care because average doctors, including a psychiatrist can find no real illness except the aforementioned issues. I seem to feel much better in cleaner air and suffer from shortness of breath, brain fog, fatigue and insomnia when I am exposed to toxic air.

The economic impact on my and my family is approximately $1,000,000, which would include my lifetime earnings (I have a five year degree in Urban Planning), health-care, oxygen, organic food, modifications to our dwellings, specially equipped cars and childcare required because of the pesticide exposure.

Because I could not medically prove the exposure to Dursban and a carbamate pesticide resulted in my illness I never received SS disability. The Chemical Industry lobby has made it virtually impossible to sue a company such as TruGreen ChemLawn in the event they cause this individuals to develop MCS.

817-269-6046

Comment 3 
I was exposed to many pesticides that, thankfully, are not even available on the market today. I've had fat biopsies that have demonstrated that my chemical load is off the charts. I live in as chemically free house than can be built and I am limited to where I can go because of chemical sensitivities. I do everything else that is recommended for a chemically sensitive person. All this is very restricting and extremely limits the range of my life experiences.

Comment 4 
I was a Registered Respiratory Therapist for over 30 years. In that time I delivered aerosol treatments with Racemic Epinephrine to croup, strider patients. When delivering this medication I would loose my voice, didn't think anything about it. Continued to work (which by the way I loved my job, and would go back if I could)kept loosing my voice and finally lost it for 3 months, was sent to every doctor known to man.(with no help) I went to the Cleveland Clinic went to a voice specialist and had my neck, larynx manipulated to get my voice back! I was told I didn't have Cancer and that I should be thankful--- and many more snide comments to come---- They have decided in their infinite wisdom that I am depressed! Well, of course I am depressed, I have lost my job,(that I truly loved),my voice, my income of over 50,000,and my self-esteem!! And then soon after this it morphed into everything chemical based I am now allergic too! (I have

no other allergies, only chemical) Now when I get around Purell,exhaust,lawn chemicals,perfumes,colognes, deodorants, air fresheners, I lose my voice, then the dizziness,flu-like symptoms,high blood pressure,shortness of breath-(because of my vocal cords spasming)it takes me a few days to bounce back--- I have been told I should be thankful that its not cancer, to the look of disbelief-- its very disheartening because this is not recognized by the medical community--or here go to a voice specialist meaning a speech therapist-- and they will help you --well no that is not the problem the problem is you are not listening and they look at you like you have "3" eyes. Again I am truly thankful that you hopefully, going to investigate this situation. I would be willing to help in anyway I can!
After 5 long years of trying to get someone to understand and occupational health M.D. finally understood my situation and helped me get SS disability, I know I should be thankful, but this does not replace my annual income--- Workers comp disability -- I still have to go to all of their little doctors (psychiatrists)because no matter how much I try to explain my situation to anyone -- they just won't listen and send me down another path“

to yet a different psychiatrist. I would be so ever thankful if chemical sensitivity is looked at with a different light!!! I would be available if need be to help in anyway I could-- Thank You again for hopefully researching this!
phone # 740-965-8342

Comment 5 
My mother has struggled with MCS for many years, and though many doctors/facilities have provided her with remedies and treatments, the information that they/these are based upon is limited in incomplete. There is a large enough portion of the population that is effected both physically and neurologically by exposure to various kinds of chemicals, that additional research need be done to aid those individuals and families who are unsure of what is wrong with them and how to go about getting treatment and carrying on with their lives.

Comment 6 
Dear NIEHS:


I write to the NIEHS because my wife has been chemically sensitive for 25 years. I believe that the primary chemical exposure(s) that brought on her condition were organophosphate and carbamate pesticides, 2,4-D and Milorganite. I believe that other chemical exposures that contributed to her condition were having worked as an artist and photographer. Chemicals that prevent her from

having a normal life include all registered pesticides, perfumes and any forms of volatile petrochemicals.

Her condition has caused her to lose productive potential in her life for 25 years. She has a degree or higher education in the field of Urban Planning but she has been unable to work due to noxious chemicals in the typical workplace.

She has received no/any form of monetary compensation as a consequence of having CI/MCS due to a lawsuit against the offending chemical manufacturer.

She has difficulty buying food because: she has transportation issues during which she is exposed to exhaust fumes. She is able to eat only organically grown food because pesticide-treated food makes her sick. She is unable to eat processed foods, so she is usually unable to eat in a restaurant. In the pursuit of finding food to eat, she is thwarted by the following chemicals on the way to the grocer, in the grocer, or in eating out--car exhaust, road tar, perfumes, pesticides, body washes, cigarette smoke and the odor of the car itself.

She has difficulty in obtaining medical care because the mainstream medical profession and our hospital system do not recognize his condition and therefore make little or no effort to accommodate her special needs. Specifically, in my experience, there is no effort made on the part of physicians' offices or hospitals in this country to minimize or exclude the use of perfumed or petrochemical products for personal or environmental use. Once my wife had to be hospitalized during the time floor wax (a petrochemical) made her very ill.
I believe that doctors who support the diagnosis of MCS are attacked by the AMA. I believe that researchers who seek to prove injury due to pesticides and other toxic chemicals are attacked and often lose their status.
My wife has difficulty engaging in social interaction because of our culture's widespread ' acceptance of the use of synthetic chemical products in gathering places such as offices, restaurants, theaters, places of worship and schools.
I know of people with MCS who live in public housing who are exposed to toxic chemicals. I believe MCS should be recognized in the Americans with Disabilities Act.


My wife has slept in an outgassed car because she could not find a suitable hotel room.


She has slept in a car because the chemical load in my own home became intolerable.


We have used an airstream trailer or other type of motor home that has been retrofitted/abated for MCS as a residence because I could not tolerate a home.
She has been confined to a single room in our own home, using an air filter, organic bed, bedding, clothing, etc. following chemical exposures to pesticides.
She has been forced to eat only a single food per day, two foods per day, or three foods per day in order to stop the onslaught of reactions to various foods she was able to eat prior to the onset of her illness.
 

I have become aware that many chemicals that mimic estrogen are a cause of menstrual problems that occurred in association with chemical exposures.
 

I believe that lawn chemicals contain toxic chemicals that should be disposed of in Superfund Sites. I am aware that four state attorney generals have posted the "inert ingredients" in pesticides on the internet. I know that lawn chemicals used by TruGreen ChemLawn and others contain benzene, xylene, toluene and other carcinogens and sensitizing agents.
 

I know that Gulf War Illness was caused by a combination of a drug PB, that disabled the metabolic pathway so that soldier's whose uniforms were

impregnated with Dursban (Chlorpyrifos) an organophosphate pesticide were rendered seriously ill. I believe that individuals within the population are genetically predisposed to be incapable of metabolizing Dursban and other commonly used pesticides.


I believe that the "Chemical Industry" has employed judges of law to stop the forward momentum of lawsuits due to personal injury caused by nearly all industrial chemicals. I am aware that so-called "class action lawsuits" against chemical producers are no longer allowed in courts of law. I know that if I am exposed to a toxic chemical and wish to sue the company, I would go up against legions of lawyers, and lose due to the miniscule chance of winning such a suit.
 

I believe that the federal government is largely controlled by the same Chemical Industry entities that promote the concept that unsafe chemicals are "safe."
 

I understand that the chemical industry uses the words "inert ingredients" in such a way as to mislead consumers to believe that "inert" means harmless. I know that "inerts" can contain either other toxic pesticides used as main ingredients or such carcinogens as should be disposed of in Superfund sites. I am aware that the lawns in America are being used as "dumps" for toxic chemicals. For this reason I can find nearly no place to live.

Due to improper building practices I believe that some individuals with MCS were exposed to toxic forms of mold either at home or workplace.
I purchase either ionized, spring or other safer waters that have lower levels of xenobiotic, hormone-mimicking chemicals and chlorine.
I have either bought or sold land or a home and subsequently were forced to sell the land or home due to the use of herbicides, pesticides or fungicides by an adjoining neighbor.


I have told neighbors that their use of lawn chemicals made my wife sick and she was continuously exposed to those products at the hands of my neighbors. I understand that it is legal to cause an adjoining neighbor to become ill due to intolerance to pesticides.


I have felt that lawn chemical companies directed an attack on us once they learned that she cannot tolerate lawn sprays by either 1. spraying my lawn against my wishes 2. failing to pre-notify me of potential drift issues 3. using pesticides in such careless ways as to render me unable to leave my own home 4. Using various loopholes so that pesticide drift is undetectable.


I believe it is the manufacturers of Dursban (Chlorpyrifos) owned by or licensed by Dow Chemical Company are responsible for the onset of her illness.
I believe that individuals vary in their tolerance of various toxic chemicals.
I would answer the question, "Why did this happen to me?" with the following 1) Industry controls the EPA 2) Individuals have no way of genetically proving that they are sensitive to certain chemicals and prescription/over-the-counter drugs 3) She was unaware that exposure to certain chemicals can "sensitize" individuals to a vast array of similar chemicals 4) A "chemical-culture" in medicine exists largely due to the chemical industry funding medical schools, research on chemicals, etc. 5) Americans were raised in an American school system that taught that we "need" toxic chemicals by watching "science class" films produced by Dow Chemical Company
 

6) Her condition is not recognized by the proper subsets in medicine 7) At the time of her exposure/onset of illness there were no treatment centers and our health insurance would not pay for the few centers that exist. 7) Doctors who do treat this condition are under attack and subsequently charge a lot of money for treatment so that they can treat patients and pay their concurrent legal bills
She and others we know with chemical injury have been evacuated by ambulance as a result of the inappropriate placement or use of perfumed products in an airport.


She and others we know been unable to travel by plane due to the use of pesticides, perfumes and other chemicals on airplanes.


Post 9-11 she is unable to carry her personal oxygen and outgassed tubing on an airplane, consequently she would be exposed to the plastics in new tygon tubing, should she need oxygen on a plane.


We have been unable to rent or lease a car due to the use of solvent-based products in them such as "Febreze" and other air fresheners.


She has been unable to use public restrooms due to the use of scented air fresheners that are delivered automatically at intervals during which solvents are sprayed into the bathroom.


She has difficulty going anywhere due to outdoor smoking of cigarettes and cigars.


She does not take antidepressants. She is not depressed.

I believe that research on MCS tends to try to promote the concept that MCS is based in psychological disorders. I believe that such research is a waste of money.


I have or my family member has a form of cancer caused by hormone-mimicking chemicals in the environment. For example, there is an increased incidence of

breast cancer among women who use dry-cleaned clothing and concurrently spray their lawns with pesticides.


I believe that chemical sensitivity and chemical injury are one of the most important medical issues of the decade and need immediate research, fully funded by our country.


Many people believe that CFS/ME are highly associated with chemical exposures. Many individuals believe that prenatal exposures to various toxic chemicals may be contributing to Autism Spectrum Disorder.


I support NIEHS research on this important issue.
RTJ
 

Comment 7 
I have been chemically intolerant for 29 years now. It has been any eye opening life experience. What I have found is that I am most intolerant to chemicals that are detoxified through pesticide detoxification pathways. When I become overloaded with formaldehyde, pesticides, or even biocides in food preservatives, my tolerance to my environment becomes severely challenged. Man has created synthetic products which have NEVER existed and have not been a function of adaptation through the evolutionary process. There is a continuum or variability of tolerance of all substances within the human population. This variable has NOT been controlled for by conventional science. LD50 testing for toxicity is meaningless. If one is the first to rat to die because of a low tolerance for a substance, how meaningful is being the average or 50th rat? Time to consider meaningful variables in toxicity research. Many of us have a LOW tolerance to man made toxic chemicals. This fact will NEVER be denied. Time to get our collective heads out of the sand and create alternatives to these products that will engender life and are biocompatible with engendering life. PLEASE do meaningful research! There are too many of us ill because of the toxicity of our modern society. Create new products that are safe alternatives. It will and MUST happen! DRP

Comment 8 
Please fund research to legitimize this condition. Many people suffer from it and conventional physicians are not properly educated to treat persons with this illness. Without proper recognition of this as a debilitating illness, sufferers are forced to take on other labels for their condition. Non-acceptance of this condition and misunderstanding has caused great psychological and emotional harm/hurt for those with this invisible disability.

Comment 9 
Pesticide and herbicide caused "chemical immune system damage" from both short term high level and long term low level exposures and the resulting increases in human sensitivities to the chemicals and resulting adverse medical symptoms must be a primary area of this study. The rationale is the vast number of people who have been exposed to pesticides and herbicides as industry and layman users of pesticide and herbicide industry products and who are, as a consequence of exposure, left permanently incapacitated and/or suffering from the affects of exposure. Those exposed who are negatively

affected often have no clue as to what is causing their illness and are often misdiagnosed by a medical industry unacquainted with chemical poisoning leaving the patients untreated for the cause of their unpleasant and life threatening symptoms and without hope of recovery from something beyond their understanding. Consequently and unfortunately, only those who have connected their symptoms with exposure to pesticides and herbicides report it as such. This can mislead us into thinking the problem is much smaller than statistics indicate. Those negatively affected from both short and long term exposures to pesticides and herbicides come from large segments of the population including but not limited to: pesticide / herbicide industry workers, farmers, farm workers, land developers, those who buy new houses, rent apartments, treat their land and property, work in a facility, work in or go to school, and buy exterminator services for their living environment. Many cases of exposure and illnesses can be found on the internet. I also offer my exposure and consequences for those interested in understanding the problem in greater detail.

Comment 10 
Substances in the environment can and do readily pass into the bloodstream. Just look at all the ways pharmaceuticals can be delivered! However, there is a belief system in the medical community, based on history/legend/etc. and not on science, and reinforced by public relations and lobbying campaigns over the last two generations, that such effects cannot possibly occur, and that anyone reporting them is obviously mentally ill. Ummm...people...the king isn't wearing any clothes here...more and more of the population is unable to function well in the presence of toxins, whether it's formaldehyde in that "Brazilian" hair treatment in the news of late, or the laundry aisle in the grocery store, or some kid wearing 100x too much Axe, or a pesticide.

After my late father's time as Director of Policy at OSHA a few decades ago, we discussed his concern that singular TLVs/PELs really were not the right model. Hard to change the assumption that every person isolates and then metabolizes every poison in exactly the same way, which of course isn't true as discussed above by the person whose P450 Cytochrome pathway is genetically weak. We need a new model, and until we have one we need to stop ridiculing people and denying observations/data which do not fit the previous approximation.

Let's open the doors, get the special interests out of the way, and get to the bottom of this one!

Comment 11 
I strongly urge the staff at NIEHS to read Martin Pall's extensive review of Multiple Chemical Sensitivity (MCS) in the prestigious reference book, General and Applied Toxicology, 3rd Edition (John Wiley & Sons). Pall, a leading researcher of MCS and other "unexplained illnesses," points out that there has been an "extraordinary low level of funding" for MCS. He goes on to estimate that "although MCS has roughly the same prevalence as does diabetes in the USA, the funding available for research on MCS has been approximately 1/1000th of the funding for diabetes." NIEHS needs to finally step up to the plate and start funding research on this growing health problem. Industry, which unfortunately controls so much of medical research today, has intentionally prevented research in this area.

Comment 12 
I have had chemical sensitivities for 27 years and (after a significant exposure to fabric softeners and other man-made scents) would have had to quit working recently without the accommodations that I received at work. Moreover, when diagnosing my MCS in March of this year, my Harvard-trained occupational physician stated that many of her MCS patients are chronically unemployed and suffer from depression.

Multiple Chemical Sensitivities (MCS) is a growing malady around the world (as a simple Internet search shows). We desperately need to create Environmental Medical Units to determine specific biomarkers to better diagnose and treat MCS and related illnesses like Chronic Fatigue Syndrome and Fibromyalgia. Please conduct the requested research.

Comment 13 
Background: Mother in medical field, grew up reading medical books, biochemistry, arts and arts materials and chemistry, minor in City Government (and much more)(environmental policy, pre vet/zoological sciences) and was obtaining my Masters in biochemistry before I "crashed".


This issue is more then just about toxic chemicals which do great harm, but as well to the agencies supposedly designed to provide safety in their use, those

that state they are "safe" to begin with, and policies (again gov run agencies) that have to do with support when those so damaged become to ill to hang on to their jobs. It becomes for most a never ending spiral downward and increasing horror story when they find this system not only does not work but even with certain laws they are not informed or aware of them! (I have had to educate even the legal arm of Mayor Bloomberg's office here in NYC)


I ended up with multi organ failure and near failure, internal bleeding, no red cells being produced, bones breaking down, teeth falling out, and much more horrific symptoms including being "paralyzed" and basically near dead and dysfunctional on all counts due to chemical exposures and eventual poisoning.
I had constant chronic vomiting and the "revenge" (phase two liver had broken down so auto intoxication) that went on for years. These are poisoning symptoms.


This did not happen overnight but was accelerated by a series of events which

eventually did me in.
Not only were their many sources of chemical poisoning over my life time, as with most, because in the past "better living though chemicals" was touted during the 50's forward (mom a nurse and used pesticides in her gardens) bug sprays so on (all told were safe) but having lived in NYC with sealed buildings where industrial chemicals were used, and basic office pollution (more polluted due to closed and sealed windows then the outside air) and second hand smoke.

One back office of a major bank had a count of 5k cigarettes lit in a 20 minute period. I was told by a cardiologist at age 34 (I am 60 now) that I had the lungs, heart, blood and liver of an 80 year old 8 pack a day smoker (it damages all organs).


I minored in city gov and not one agency did it's job, people in the health dept. (the enforcing agency lol lol lol) even smoked under no smoking signs - it took one councilwoman over 8 months to finally get the city to get the bank to put in a smoking room as was required by law) my health began to decline. At first cigarette smoke then "perfumes" and on down the list as my various systems broke down. I was even forced to serve Jury Duty one month before my total collapse even with a medical letter, while the woman in charge was smoking over me stating "if you can work you can serve".


It did not matter that I was put in a private room with giant filters (about 8 and a hepa) and no one with perfumes or colognes (the office smoked even after the no smoking ban was up - president so on). I passed out and had blood coming through my pores and one guy who was in charge of jury selection so on hid me in a closet and let me go early as he saw how very sick I was. I would jump off a building them go through any of these very violent illness reactions ever again.
As many here and living through the worst of this, it is a living nightmare - I can only state it is like chemo therapy (a form of toxic poisoning) that never ends.
(There is copious literature on how chemicals break down enzyme systems, damage molecules, cells, tissues and organs). Because of my background I was able to not only do my own unbiased research but form my own conclusions and create my own therapies. Poisons are poisons and one can have one huge killer exposure or small partials that do damage. (Think cyanide in Little Foxes - where the husband is killed over time by small daily doses - a major component in side stream tobacco smoke btw).


A building fire was the final blow. There was a decade plus of illegal use of floor strippers, 2 part epoxies for the tub and other exposures where their were no proper application of OSHA or NIOSH standers (or even fans at the windows!) Our building was older and what was done on one unit went throughout the building and drifted up into each apt...

No filters or fans helped with this - I had to open the windows and use fans even in the winter months... I was in a vegetative state so my friend did this - no one enforced one single violation (I live near the Waldorf - so address carried no weight in this). When the building was pointed for the first time in decades (and a wall was removed with black fungus under it) no safety measure and oil tar fumes entered right through the cement walls into our apt. Again no enforcement, no obligation to one now on SSD. (which took three years and a court setting before a judge - gave it to me right) and three years for food stamps! My friend went broke taking care of me.


I gave up on workers compensation as the company (Wall Street) had lied and had none but avoided a law suit as the Judge through the case out and even though her action was illegal... I could not fight it anymore - too sick too broke, and horrible lawyers when "free". Come to our state - it's good for business.
I feel grateful however (as I know many are "fighting" to obtain anything), after a life time of having my wages contributing to these "safety nets" (food stamps,

public assistance, SSD and that first check repaid public assistance - but many who cheated the system and when welfare to work was started in NYC they did not have to repay the system) (one of the woman at one of my jobs was collecting cash having babies every three years to keep this going).


Not one single agency which by design was to regulate and enforce the use of these chemicals in my building did a single thing. Not one city "father" either. One staffer wrote a email to another agency (and sent it to my box instead) saying "it's that crazy woman again"... Again having minored in City Government and spent one year as an intern at the health department I know full well the mostly incompetence of these agencies (at least here in NYC).

Obviously I need to move somewhere but as many here have stated where and how on such limited income, always at risk of being taken away (it's all in your head) and although SSD is federal states have the authority to determine if one is still able to continue receiving it. Such as when I was told they needed to do a "lung" test. Mountains of medical documentation with cutting edge tests that this local slop house of a government agency could never do and yet they had the authority to take what little income I had at the time away (started at 6k a year!) I called Washington and that was stopped. (22 page accommodation medical letter)

So the end result and ongoing damage due to chemical exposures is a failure on many counts.

Products and use of and not only setting standards about them being in the market in the first place but enforcing already existing laws that would protect the public. Not to mention company influence over agencies that would consider then "safe" to begin with. On MCS forums I hear the same sad saga (and used to send legal information out to others) re housing and lack of enforcement of laws already on the books to protect the tenants.

The companies that create these products have lobbyist and ties with the very agencies supposed to protect the public (as when the EPA told first responders that the "air was safe" on 9/11)... I suppose the social worker at the emergency room I had to visit once (try to avoid hospitals) would tell them "it's all in their heads" as she did me. It's not her fault, her training was at an institution where many get funding by these very companies... they are educated as what to think.
(I told her to put her head in an oven turn on the gas then tell me how it would feel if someone told her "its' all in your head")

I have had to resort to medical negligence to get a neighbor to stop smoking out of her window (the fumes would enter my apt)even though it is a fire code violation (people's cigg blow in the wind and one even started a fire in our bath long ago) when people toss them out the window.

I have a background in bio sciences and arts materials (and more)(and know full well how highly toxic these chemicals are) and was about to obtain my Masters in the health fields. Due to my background in holistic therapies I recovered to where I can walk and talk and form a thought but have much damage and can not be around any of this and other classes of chemicals and live below the poverty line (ten k a year) in a room with 8 air filters and can barely go out without suffering the consequence of exposures (fake petro based perfumes, cigg smoke so on).
Like many here I had plans, had a life as it were, and now am reduced to living in super poverty, with limited functioning, great pain, and with few places to move to that are chemical "safe" and within my means of living. I know many are living in cars and tents. And many, many have died. I have been selling almost all of my possessions to pay down medical debt (insurance or even medicare do not pay for what greatly assisted me in regaining much so I paid out of pocket)
As many have already stated this issue goes against giant corporations - think

Bayer Aspirin - Bayer Pesticides to get the idea.

We are indeed the canaries in the cave and as I told one of my doctors (who followed what I wanted done and only after a medical freedom act was passed in NYC could I even do that!!!

My therapies did not involve pharmaceuticals - since a child I would use only holistic natural methods - and until this law was passed for example to combat fungus which at a nadir had gone systemic - in blood, and all organs as it does when one is a an end stage, I was not able to use Oxygen therapies ie h2O2 intravenously - had I not done so I would not be here, as that was a major turning point.

Pfizer now has a patent on it for the fish agri business... yet books on it's efficacy are banned and one has to be in a state that has medical freedom laws to utilize this choice! (such as the current effort to ban the use of vitamin c drips - and for those with broken down metabolic/digestive systems this is a crucial treatment for this state).

"The canaries are dropping, flopping and squawking" and we are being kicked aside."

In the end the numbers poisoned (as well as other life forms as these toxins harm all) will be impossible to ignore.

My little story does not cover the years involved but hopefully will give some sort of idea, although I hope this information will not be used against this community. There is already much research done on this topic and it amazed me that a research arm of a NYC hospital would support it yet the clinical side did not. (treating side). Well one only has to follow the money trail to see who funds what.

Have to "run" and close the apt windows now... the hotel has put in a huge laundry machine (and violates laws that state fumes need to be vented vis a vis a system up over and into the air)... and the other spews petro diesel fuels.... (another violation).... like when the crane in NYC fell and it turns out no one was doing their job, so it goes.

Comment 14 
Dear NIEHS:
I'm writing to the NIEHS because I have been chemically sensitive for
10 years and home-bound for over 5 years. I believe that the primary chemical exposures that brought on my condition were living in the Mississippi Delta and working in public schools. I believe that other chemical exposures that contributed to my condition were painting, stripping furniture, multiple surgeries, and remodeling houses. Chemicals that prevent me from having a normal life include all pesticides, cigarette smoke, fragrant personal products and more.

My condition has caused me to lose productive potential in my life
for over 5 years. I have a master's degree in Counselor Education, but I have been unable to work due to cleaning chemicals, fragrant personal products and pesticides in the workplace. I was diagnosed with Immune Deregulation, Autonomic Nervous System Dysfunction, Toxic Encephalopathy, and Chemical Sensitivity. I have food, pollen, and mold sensitivities. I am very reactive to natural gas. I also have Allergic Rhinitis, Rhino sinusitis, Vasculitis, Hypothyroidism, and Allergic Food Gastroenteritis.

I am able to eat only organically grown food because pesticide-treated food makes me sicker. I am unable to eat processed foods and can't tolerate the building, wait staff or customers so I am unable to eat in a restaurant. I am unable to shop and my husband does all of the shopping for our family

I cannot afford to buy the food, prescribed supplements, and other compounded prescriptions and antigens I need. We have had to borrow money from my family and have gone into tremendous debt.

I have difficulty obtaining medical care because the mainstream medical profession and our hospital system do not recognize the condition and therefore make little or no effort to accommodate my special needs. I was denied access to our local hospital in 2006 for shoulder surgery and was in an ongoing battle all of last year trying to have a safe surgical experience there again. I never could work out a safe protocol even after getting all the way to the U.S. Department of Health and Human Services. None of the state agencies were able to help me either. Specifically, in my experience, there is no effort made on the part of physicians' offices or hospitals in this country to minimize or exclude the use of perfumed or petrochemical products for personal or environmental use. I always call ahead and review their situation before keeping an appointment.

I believe that doctors who support the diagnosis of MCS are attacked by the AMA. I believe that researchers who seek to prove injury due to pesticides and other toxic chemicals are attacked and often lose their status. Dr. Rea is a prime example.

I have difficulty engaging in social interaction because of our culture's widespread acceptance of the use of synthetic chemical products in gathering places such as offices, restaurants, theaters, places of worship and schools. I have not been to church in over 5 years. I've tried this past year to attend some functions and even while wearing a mask become ill for at least two days. I don't get out very often.

I believe MCS should be recognized in the Americans with Disabilities Act. When I was seeking help I found no one with an understanding of our illness.

I cannot travel or find a suitable hotel room.

I have been confined to my home where I have air filters, organic bed, bedding, clothing, etc. and cannot have many visitors due to the fragrance they bring into my home that makes me sick and contaminates my environment.

I have been forced to eat only a few foods per day in order to stop the onslaught of reactions to various foods I was able to eat prior to the onset of my illness. I have ongoing gastric problems and I can't find even an environmental doctor that has been able to clear up my Candida and bacteria.

I have become aware that many chemicals that mimic estrogen are a cause of menstrual problems that occurred in association with chemical exposures. I had a very early menopause and have since read research to support that this is brought on by chemicals.

I understand that the chemical industry uses the words "inert ingredients" in such a way as to mislead consumers to believe that "inert" means harmless. I know that "inerts" can contain either other toxic pesticides used as main ingredients or such carcinogens as should be disposed of in Superfund sites. I am aware that the lawns in America are being used as "dumps" for toxic chemicals. I am fortunate to live on over 5 acres and we use no chemicals, but my neighbors use chemicals on their lawns, which of course comes over to my property.

Due to improper building practices I believe that some individuals with MCS were exposed to toxic forms of mold either at home or workplace. I was exposed to many chemicals while my school was being renovated and a new addition was built. My health declined rapidly after moving into the new building.

I only drink safe, home-filtered water.

I have been unable to travel by plane due to the use of pesticides,
perfumes and other chemicals on airplanes. I have been unable to rent or lease a car (or even RIDE in any care but my own) due to the use of solvent-based products in them such as "Febreze" and other air fresheners, and perfumes.

I have been unable to use public restrooms due to the use of scented
air fresheners that are delivered automatically at intervals during
which toxins are sprayed into the bathroom. We stop and go on the side of the road a lot when traveling out of town to doctor appointments. It is just so much easier than having an exposure.

I have difficulty going anywhere due to outdoor smoking of
cigarettes and cigars. I have found NO outdoor gathering that is smoke free.

I believe that research on MCS tends to try to
promote the concept that MCS is based in psychological disorders. I
believe that such research is a waste of money.

I believe that chemical sensitivity and chemical injury are one of
the most important medical issues of the decade and need immediate
research, fully funded by our country. Many more will become ill and doctors do not have the knowledge to recognize this illness as it is progressing. I know my allergy doctor had no idea. He just kept treating me with medications as I became more and more ill.

Many people believe that CFS/ME are highly associated with chemical
exposures. Many individuals believe that prenatal exposures to
various toxic chemicals may be contributing to Autism Spectrum
Disorder. Research into Chemical Intolerance and Chemical
Sensitivities may shed light on many disease associations.

lynnlbarron@yahoo.com

Comment 15 
Dear NIEHS:
I write to the NIEHS because I have been chemically sensitive for 20 years. There is a subset of patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis who are Chemically Sensitive or Chemically Intolerant. I write to the NIEHS because have suffered from Chemical Sensitivities/CI/MCS as a

part of my diagnosis of Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis/ Metabolic Encephalopathy, and my illness has affected my life drastically.
I believe that the primary chemical exposures that brought on my condition were Malathion spraying in Ca. I believe that other chemical exposures that
contributed to my condition were pesticides and herbicides, perfumes, exposure to petrochemicals, ammonia, chlorine, fluoride and art supplies and materials. These chemicals prevent me from having a normal life.

My condition has caused me to lose productive potential in my life for 20 years. I have a BFA in Fine Art and Illustration, but I have been unable to work due to noxious chemicals in the typical workplace for the past 16 years.

I have received no/any form of monetary compensation as a consequence of having CI/MCS due to a lawsuit against the offending chemical manufacturers.

I have difficulty buying food because: I have transportation issues during which I am exposed to exhaust fumes. I am able to eat only organically
grown food because pesticide-treated food makes me sick. I am unable to eat processed foods, so I am unable to eat in most restaurants. In the pursuit of
finding food to eat, I am thwarted by the following chemicals on the way to the grocer, in the grocer, or in eating out- gasoline fumes, perfumes, often pesticide or herbicide spraying at residences or businesses along the way.

I cannot afford to buy the food I need. And am forced to be dependent on my elderly parents.

I have difficulty in obtaining medical care because the mainstream medical profession and our hospital system does not recognize this condition and
therefore makes little or no effort to accommodate my special needs. Specifically, in my experience, there is no effort made on the part of most physicians' offices or hospitals in this country to minimize or exclude the use of perfumed or petrochemical products for personal or environmental use.

I believe that doctors who support the diagnosis of MCS are constantly attacked by the AMA. I believe that researchers who seek to prove injury due to pesticides and other toxic chemicals are attacked and often lose their status.

I have difficulty engaging in social interaction because of our culture's widespread acceptance of the use of synthetic chemical products in gathering places such as offices, restaurants, theaters, places of worship and schools.

I know of people with MCS who live in public housing who are exposed to toxic chemicals. I believe MCS should be recognized in the Americans with Disabilities Act.

I have slept in my car due to exposure to chemicals and because I could not find a suitable hotel room.

I have slept in my car, at friends' or families' houses because the chemical load around my own home became intolerable.

I have been confined to a single room in my own home, using an air filter, organic bedding, clothing, personal products, cleaning products, etc. following use of a chemical either "on my person" or near me.

I have been forced to eat only a single food per day, two foods per day, or three foods per day in order to stop the onslaught of reactions to
various foods I was able to eat prior to the onset of my illness.

I have become aware that many chemicals that mimic estrogen are a cause of menstrual problems that occurred in association with chemical exposures and have both Fibrocystic Breast Disease and Polycystic Ovarian Disease, both as a result of estrogen dominance (high estrogen).

I believe that lawn and garden chemicals contain toxic chemicals that should be disposed of in Superfund Sites. I am aware that four state attorney generals have posted the "inert ingredients" in pesticides on the internet. I know that lawn chemicals used by TruGreen ChemLawn and others contain benzene, xylene, toluene and other carcinogens and sensitizing agents.

I know that Gulf War Illness was caused by a combination of a drug PB, that disabled the metabolic pathway so that soldier's whose uniforms were impregnated with Dursban (Chlorpyrifos) an organophosphate pesticide were rendered seriously ill. I believe that individuals within the population are genetically predisposed to be incapable of metabolizing Dursban and other
commonly used pesticides. In one home I lived in I was constantly exposed to Malathion, Roundup and various other herbicides/ pesticides that rendered me to seek emergency care at the nearest hospital. The chemical load from these exposures caused me to bleed internally; both vomit and diarrhea were bloody. I suffered dizziness, cognitive problems, blackouts, becomes so severely dehydrated, I required IV's on over 20 visits to the ER.

I believe that the "Chemical Industry" has employed judges of law to stop the forward momentum of lawsuits due to personal injury caused by nearly all
industrial chemicals. I am aware that so-called "class action lawsuits" against chemical producers are no longer allowed in courts of law. I know that if I am exposed to a toxic chemical and wish to sue the company, I would go up against legions of lawyers, and lose due to the miniscule chance of winning such a suit.

I believe that the federal government is largely controlled by the same Chemical Industry entities that promote the concept that unsafe chemicals are
"safe."

I understand that the chemical industry uses the words "inert ingredients" in such a way as to mislead consumers to believe that "inert" means
harmless. I know that "inerts" can contain either other toxic pesticides used as main ingredients or such carcinogens as should be disposed of in Superfund sites. I am aware that the lawns and gardens in America are being used as "dumps" for toxic chemicals. For this reason I can find nearly no place to live.

Due to improper building practices I believe that some individuals with MCS were exposed to toxic forms of mold either at home or workplace.

I purchase either ionized, spring or other safer waters that have lower levels of xenobiotic, hormone-mimicking chemicals, fluoride and chlorine.

I have sold land and my home and subsequently was forced to sell the land and home due to the use of herbicides, pesticides or fungicides by the gardener at my former condominium.

I have told family and neighbors that their use of lawn chemicals made me sick and were continuously exposed to those products at the hands of my neighbors, family and friends. I understand that it is legal to cause an adjoining neighbor to become ill due to intolerance to pesticides or difficult to prove, if spraying was done as a result of vandalism or criminal act.

I have felt that the chemical companies directed an attack on me once they learned that I cannot tolerate lawn sprays by either 1. spraying my lawn against my wishes 2. failing to prenotify me of potential drift issues 3. using pesticides in such careless ways as to render me unable to leave my own home 4. Using various loopholes so that pesticide drift is undetectable.

I believe it is the manufacturers of Roundup and Malathion, and those that knowingly used these and other pesticides/ herbicides, who are responsible for my illness.

I believe that individuals vary in their tolerance of various toxic chemicals due to the kindling effect and a lifetime of exposures to toxic chemicals, thus over-exposures can set off CI/ MCS.

I would answer the question, "Why did this happen to me?" with the following 1) Industry controls the EPA 2) Individuals have no way of genetically proving that they are sensitive to certain chemicals and prescription/over-the-counter drugs 3) I was
unaware that exposure to certain chemicals can "sensitize" me to a vast array of
similar chemicals 4) A "chemical-culture" in medicine exists largely due to
the chemical industry funding medical schools, research on chemicals, etc.
5) I was raised in an American school system that taught that we "need" toxic chemicals because I watched films produced by Dow Chemical Company
6) My condition is not recognized by the proper subsets in medicine 7) At the time of my exposure/onset of illness there were no treatment centers and my health insurance would not pay for the few centers that exist. 7) Doctors who do treat this condition are under attack and subsequently charge a lot of money for treatment so that they can treat patients and pay their concurrent legal bills.

I have been unable to travel by plane due to the use of pesticides, perfumes and other chemicals on airplanes.

I have been unable to rent or lease a car due to the use of solvent-based products in them such as "Febreze" and other air fresheners.

I have been unable to use public restrooms due to the use of scented air

fresheners that are delivered automatically at intervals during which toxins
are sprayed into the bathroom.

I do not take antidepressants.
I believe that research on MCS tends to try to promote the concept that MCS is based in psychological disorders. I believe that such research is a waste of money and is a convenient red-herring to blame the patient. If one can render a dismissal of a patient's character and destroy CI/ MCS as a potential research venue, as a result of dismissal through labeling the patient as psychologically weak, which is a practiced technique and usual modus operandi of powerful lobbies.

I have two family members that have a form of cancer caused by hormone-mimicking chemicals in the environment. For example, there is an increased incidence of breast cancer among women who use dry-cleaned clothing and concurrently spray their properties with pesticides they have led to believe is "safe".

I believe that chemical sensitivity and chemical injury are one of the most important medical issues of the century and which needs immediate research, fully funded by our country.

Many people believe that CFS/ME are highly associated with chemical exposures, or at the very least exacerbated by exposures. Many individuals believe that prenatal exposures to various toxic
chemicals may be contributing to Autism Spectrum Disorder.

debalula@yahoo.com

Comment 16 
This issue is not going away; our industry is saturating our air and water with increasing and diversifying chemical loads. We need to understand the impact to human health and productivity of this situation, so that we may weigh the cost, and we need to understand the underlying mechanisms so that we may treat victims and develop effective countermeasures.
ernest.p.webber@boeing.com

Comment 17 
For once, an excellent idea from a federal public health agency!

Comment 18 
For once, an excellent idea from a federal public health agency!

Comment 19 
My husband and I both experience consequences of chemical overload. I have developed such severe food intolerance that I have been forced to eliminate well over half of the food pyramid from my diet. The foods I can eat must be organic and cooked from scratch. Our food bills are astronomical and dining out is a thing of the past. My husband has so many environmental allergies that he has difficulty functioning at home and at work. Formaldehyde is one of his triggers, and it is impossible to eliminate contact. Scented products are the worst, and they are everywhere. His throat spasms when he has too much exposure, and he has stopped breathing on several occasions. We can't go to most public venues anymore because of close contact with people who are wearing scented products. This means theaters, concerts, school events, church, etc. Our lives have become very small and contained because of these issues. It is possible to live without all of these chemicals, we just need to start doing it.

Comment 20 
It is time to acknowledge that Chemical Sensitivity exists and is increasing in the general population world wide. This debilitating condition must be studied and those affected provided proper medical care and treatment, environmentally safe housing and accommodation both in the workplace and in public buildings.
This is a serious illness caused by toxic chemical exposures and one that is affecting millions of people. It is time to recognize this medical condition and begin to remove the toxic chemicals and pollutants from our world.
Sincerely, Patricia Mann RN, MSN University of California Medical Center, San Francisco

Comment 21 
Please help. The chemically injured population has suffered for so long: unrecognized, ridiculed, separated from society, and without resources or understanding. We need access to basic services and accommodations to be able to work and be a part of life. Funding research is an essential first step to helping those already harmed and preventing more chemically induced illnesses.

Comment 22 
I'm just adding my perspective to the excellent comments that have already been submitted. I've been chemically sensitive for nearly 30 years, and my condition has become progressively worse over the years, even though I've done everything I possibly could to avoid exposures.
Lest you think, as so many doctors and psychiatrists do, that people with MCS are inevitably malingerers or hypochondriacs, let me emphasize that I've managed to maintain a very active life as a psychotherapist, magazine editor, book author, husband, and father. But in recent years I've become increasingly limited in the places I can visit or inhabit, to the point that I've purchased three separate houses in the last decade and tried to fix them up to make them tolerable but ultimately failed in each case. In addition, my health has become increasingly compromised. I can no longer see clients in person but must do all my work by phone and computer. Right now I'm unable to tolerate most building materials, including anything with the smallest trace of formaldehyde such as even old carpeting, plywood or particle board.


I know dozens of people who are even worse off than I am, and I'm appalled at how difficult it is for people like myself to find tolerable housing or effective treatment. I urge you to legitimize multiple chemical sensitivities (MCS) as a medical diagnosis, despite the well-funded lobbying of the chemical industry, and do whatever you can to figure out what causes it and how it can best be ameliorated or prevented.
Stephan Bodian, MA, MFT
415-451-7133

Comment 23 
As a nurse and health educator, I was surprised when My body started becoming more sensitive to chemicals some 30 years ago. It was practically unheard of then, yet in 1997 the NMDOH showed @ 16% of New Mexicans claims to have "Unusual sensitivities to common chemicals". Diabetes is at 7% and AIDS at .1%, yet each of these problems are well known and receive a lot of funding for research and education. We need to address this issue now! In my practice, I see the numbers growing in direct proportion to increasing levels of pollution and chemicals that we now routinely use in our homes, foods, and care products for homes, bodies, and businesses. It definitely needs research to understand this new epidemic.

Comment 24 
I have suffered from chemical sensitivities for over 20 years. I lost the better part of my adult life to the effects that chemicals in our environment had on my health. My hopes, dreams, family and career were lost and I have struggled to survive every since. The chemical exposures from being crop dusted during my teens have changed the potential I had to realize a healthy, productive adult life. Further exposures to chemicals have forced me to live behind closed doors, isolated and pretty much alone. I fight a constant battle for housing, food, medical care and my basic needs while I can barely take care of myself on a day I feel the physical effects of some exposure or unknown chemical.
I know there are too many of us who have these same reactions for this to be only "my" issues. Professor Martin Pall has fully shown the physical pathways for chemical sensitivities and has created a protocol that has been shown to work really well for many of us. Still, we need national research.

Please consider that many are suffering and the time is now, in fact, it is long overdue.

Thank you.

Comment 25 
I am a graduate level chemical engineer by training who spent his career in a range of industrial settings. My family's health has been directly and detrimentally affected by exposures to synthetically created pesticides and other chemicals commonly used in everyday life. Nearly all of these pesticides and chemicals are defended by their manufacturers as being safe, even in cases where there is substantial evidence to the contrary. EPA registration is simply that, and does not represent that any sort of a human or animal safety clearance process has even been started for the registered chemical. It is long overdue that the Federal Government (NIEHS being the relevant agency) give priority to funding the study of the widespread negative health effects being suffered by a very large and growing number of people in this country with chemical sensitivities and intolerances.

Comment 26 
I have been an activist since the first months after I was chemically injured in an overspray by my neighbor's "lawn-care" company, TruGreen ChemLawn. An "overspray" is chemical industry jargon for spraying pesticides on a human being. Since this sort of "accidental overspray" has occurred so many times, I comment for the second time.

Many people are unable to vote "I agree" with Research on Chemical Sensitivities and Intolerances because they do not own a computer. These chemically sensitive people cannot afford computers. They cannot be in the room with a computer.

Thousands of individuals across the United States have lost their livelihood and their right to medical diagnosis and treatment because they have been exposed to pesticides. In the next hour I will post information about pesticides that very few people have ever read. No one would ever use pesticides on their food or their lawn if they were told by four state attorney-generals that the "inerts" in pesticides belong in a Superfund Site. The inerts are BENZENE, TOLUENE, NAPTHALENE, XYLENE and DIOXIN.

In a separate posting I will explain how the chemical industry has paid off government officials, gotten themselves into positions of authority in the EPA,

FDA, etc. in order to hide the fact that "inert" does not mean "non-toxic" in the USA.

Many chemically-injured, chemically hypersensitive, chemically sensitive and chemically intolerant people (dubbed as having Multiple Chemical Sensitivities by Industry in order to avoid lawsuits against an individual chemical) live in less-toxic housing, breathing on air filtered air, drinking ozonated water, and eating organic food. THESE ARE THE FORTUNATE FEW!

The truly sick chemically sensitive individual is not able to obtain any of the above types of necessities.

The truly sick chemically sensitive individual is not able to so much as register their opinion. In the past few hours BLOCKS OF MORE THAN 30 VIETNAM VETS have unmercifully voted AGAINST "Research on Chemical Sensitivities/Intolerances." Many of us would feel fortunate to have a diagnosis of cancer, for example. Most cancer patients have a better quality of life than chemically injured/sensitive people. I say with sincerity that cancer patients are better off in every way, unless there is NO TREATMENT for their cancer. I have had two members of my family fall ill to cancer. It is with GREAT DIFFICULTY that I realize, many of us would have been better off had we gotten cancer and treatment.

Do individuals who "vote, I disagree" with our research realize that the same chemicals that they believe made their children develop ADD, ADHD, etc. as a consequence of being in the mother's body who did not even serve in Vietnam, are still used in pesticides? Dioxins contaminate MANY household products such as LYSOL. Once the manufacturers of LYSOL found out that researchers detected DIOXIN IN LYSOL, they elected to generate television commercials every five minutes instead of removing the profitable product from the market. Instead the television commercials depicted MORE infants standing in their cribs "teething" on the edge of the crib. In the commercials, the mothers had just sprayed LYSOL!

As chemically sensitive individuals we realize we need to affect CHANGE. It seems that CHANGE is the most difficult thing of all. It seems that CHANGE is voted DOWN every time.

I realize that pesticides are used on lawns, near children who get sick NOW. Not 30 years ago. Individuals develop immediate symptoms, inability to concentrate, blurry vision, drooling, burning sensations on the body, diarrhea, vomiting, inability to eat, severe and life-threatening weight loss, ADD, ADHD, aching muscles (due to calcium depletion caused by the action of solvents on the calcium pump, and loss of magnesium stores), extreme changes in blood pressure, thickening of the blood (so as to develop hypercoagulable blood), insomnia and many other vascular problems. Some pesticides are now known to cause cardiomyopathy.

The group of people who have chemical sensitivities are the canaries in the coal mines, as they said back in the 80's when the "Daubert Criteria" was being developed by the chemical industry to prevent us from getting medical care. The "Daubert Criteria" decision meant that, if a pesticide made you sick, you could never sue the manufacturer because the proper research did not exist. DOES THIS ISSUE ANNOY/BOTHER ANYONE? To this day, industry works to prevent recognition of MCS/CI/CI, caused by their products. Those of us who have been sick and advocated for this illness witnessed destruction by the AMA of doctors who try to treat us. I have the literature and internal documents to prove that this has been done to our doctors. HAS ANY OTHER MEDICAL DOCTOR LOST THEIR LICENCE BECAUSE THEY TRY TO TREAT SICK PEOPLE?

As MCS'ers, we know which products are safer, and many of us who have gotten better continuously tell each other which chemicals are found in what products.

The question for us is, how to we get from "here" to "there?" How do we live, and how do we INVENT ways to live in the world since our injury.

Chemically sensitive individuals are the most valuable commodity this country has, yet our voices are unheard. Not since Rachel Carson wrote "Silent Spring" has anyone been motivated in the same way as Chemically Sensitive individuals, TO TELL Americans--WE ALL VARY IN OUR GENETIC TOLERANCE of refined petrochemicals. We know that refined petrochemicals in pesticides such as Dursban (Gulf War, researched by Mohammed Abou-Donia at Duke University) and Agent Orange (readily identified by researchers due to Dioxin) do cause "end-organ" damage. Most of these diseases, found on this Visionary Idea website, can be medically treated by still, more petrochemically-based drugs.

Chemically sensitive individuals are not able to tolerate most petro-chemically based drugs. We have been lobbied against for so many years in Washington that many of us have QUIT TRYING. Many of us will die before we ever truly understand the questions we ask ourselves. Was it what our mothers were exposed to? Was it because our parents used alcohol infrequently? Was this caused because of genetics--mine and from both sides/one side of my family? Was this caused by the carpeting that was used while I worked at the EPA? Is it due to my diet? Will my children develop this? Should I have children? Will my grandchildren develop chemical intolerances? When will the research for my disease be done? Who will do it? THE CHEMICAL INDUSTRY?

NO INDIVIDUALS WHO ARE CHEMICALLY SENSITIVE ARE ABLE TO BE NEAR A COMPUTER, unless they have paid for and obtained a computer that does not continuously outgas petrochemicals.

EVERYONE HAS SOMEONE who cares. Many chemically sensitive/intolerant people have no one to care, no one to represent them. I am attempting to do that. Mary Lamielle and a host of other people who either suffer or who have the pain of watching their children suffer, TRY TO GET RESEARCH ON MCS. Now we've tried calling it "Research on Chemical Sensitivities/Intolerances." If the chemical industry wanted to do it, all of the comments posted here would disappear. THAT is the degree of resistance industry has used to keep our chemically injured patients silent.

This situation does not bode well for America.

As I write, there is a liquid oxygen tank in the room, and three air filters. I am very, very fortunate because my family understands me, believes me and recently learned that pesticides caused me to have cardiomyopathy.

Again, I am fortunate.

The issues that really, really bother me are the following. Researchers who try to research our illness do not get funding BECAUSE THE CHEMICAL INDUSTRY CONTROLS FUNDING IN THE USA. The chemical industry has ruined the careers of many scientists who tried to say, these chemicals should not be on the market. The second issue that bothers me is that doctors align against doctors. Any doctor who treats us, eventually gets sued for something totally innocuous, such as a billing error. The AMA attacks our doctors. Even psychologists have this illness. If they treat a patient the patient's insurance carrier WILL NOT PAY (due to work done by industry). DOES ANY OTHER GROUP OF SICK PEOPLE HAVE THESE PROBLEMS? Please speak out if you do.

One of my children developed my condition. The doctors who tried to treat me and my son have been attacked by the AMA (American Medical Association)in order to remove the licenses of medical doctors who do recognize that people who work in various industries or are exposed to certain toxic chemicals do develop immediate symptoms that become disabling without some form of treatment.

Finally Johns Hopkins tried to treat CFS patients with chemical sensitivity. Dr. Peter Rowe, Pediatric Cardiologist sheepishly responded to my complaint that toxic pesticides and other refined petrochemicals were causing illness with a soft, "yes." ALL doctors fear attack from industry.

I have collected the documents from more that 30 years that prove EVERY WORD I write about the Chemical Industry. I have the names, the CEO's names, and the commitment to sell toxic chemicals to the public though various campaign strategies, including the public school system, no matter who gets sick.

The pharmaceutical industry aligns with the chemical industry because once people do get sick, big pharma sells them more petrochemicals in the form of drugs. Since many of these drugs are not used by people with MCS, Chemical

Sensitivities, or Chemical Injury, there are more documents still, the AMA, the PMA, etc. joined the very powerful chemical industry in condemning anyone associated with the illness about which I write.

I, myself, have very good medical care. My cardiologist was able to find two cardiac drugs I can tolerate. Today Mohammed Abou-Donia asked me to send him the research and names of the drugs.

Is this how everyone else on this site gets THEIR MEDICAL CARE?

Those of us who are sick, but well enough to lobby actually ask researchers how to live, and send in research suggestions. Many of us are getting older, and are tired of waiting. I know that is true for me.

We need research now. We are not an organized army. We suffer from no other affliction that having been born in our bodies and been at the wrong place at the wrong times with the wrong petrochemical exposures. Many of us want a singular thing we do not have, somewhere to rest our heads.

I plead that this country will develop the character to begin to care for those with Chemical Sensitivities/Intolerances, otherwise vilified by the name Multiple Chemical Sensitivities. SJ

I will send the info on "inerts" before the voting period ends.

Comment 27 
Dear NIEHS, I have copied and pasted an exasperating example of the "research" individuals with "Chemical Sensitivities/Intolerances" have received over the past 25 years. Because Martin Pall was able to put together Haley's and other's research and develop an idea, someone is able to call it research.

Participating 'scientist,' Grace Ziem once stated "she would work for anybody." She would. She did some very negative work against the concept of MCS, because she was paid by the chemical industry to do so. So--science in this country is recognized as SOUND by a psychologist turned 'scientist' who will go anywhere the WIND BLOWS? GRACE ZEIM worked for industry against us and are we to understand that she is now, a 'scientist' in good standing at NIEHS? Pall cited her research at NIEHS in his "research project."

Is this good research a very well-done high school science type project? Is it mostly comprised of 20 year old notations, too?

Did I try Martin Pall's remedies of shooting glutathione up my nose from a $600.00 non-returnable dispenser, from some pharmacy that overbilled me? Yes, I actually did, and I got very, very sick.

Is ten year too long to wait for ANY research on an illness? How does 30 years feel to NIEHS? Does the country know that the chemical industry controls research in the USA?

Are patients relying on any valid data? From 1997? Or, is the data from 1997 "TAMPER PROOF?"

Does the country realize that industry actually does its own research on its own chemical products or pays a scientist to come up with "THE CORRECT RESEARCH FINDINGS?"

Is NIEHS in league with the Chemical Industry? Try that on for fit.

Enjoy reading the "STUFF THAT DOES NOT WORK FOR MOST PATIENTS!"

**********Note:**********There is no control group and no study group in the research that appears to the be ONLY research on our illness on the internet! My child suffered from this illness! Do something.
OR, go to CIIN.org and read "RESEARCH DONE BY CHEMICALLY INJURED PATIENTS WHO HAVE LITTLE CAPACITY TO THINK, LET ALONE WRITE AND SELL RESEARCH." I propose that someone from NIEHS call and try to talk about two things with the chemically-injured researcher I talked to at CIIN.org. Again, that is our research. We rely on patient research! Does any other illness group have to rely on patient research?

This could be true, or it might be a collection of a bunch of other research ideas from various decades. SJ (sorry and thanks, Martin Pall; at least you tried....)

Neural Sensitization By Dr Martin Pall

Neural Sensitization

Neural sensitization occurs by activation of brain and nerve cell N-methyl-D-aspartate(NMDA), which then increases brain nitric oxide (NO).1,2,3 Several vicious biochemical cycles are then set in motion. Nitric oxide forms a tissue damaging free radical known as peroxynitrite.2,4,5,6 Peroxynitrite depletes energy TP,7,8 which then further increases the sensitization of NMDA. 9,10

Chemical exposure can induce sensitization. Pesticides such as organophosphates inhibit acetylcholine, activating muscarinic receptors, which increase nitric oxide. Formaldehyde activates NMDA.1,11
Petrochemicals (VOC's, solvents) disrupt energy production in the mitochondria, increase super oxide which increases peroxynitrite.12 This can then increase tissue-damaging free radicals in the brain.13 Mitochondrial disruption occurs in chemically injured patients.14 Petrochemicals and many other chemicals are irritants15 that with exposure can cause inflammation. Inflammation of sufficient duration can lead to chronic neurogenic inflammation.16 Inflammation results in increased cytokines, free radicals and elevated nitric oxide.
Neural sensitization is thus associated with self-perpetuating neuroexcitation and excessive response to further chemical exposure.11,17 This NMDA activation with increased nitric oxide and peroxynitrite can cause brain cell death and neurodegenerative disease.2,6,10,18,19,20 Peroxynitrite also weakens the blood-brain barrier, allowing chemicals to enter the brain more readily.21 Nitric oxide also damages the first detoxification step involving the cytochrome p450 system,22 allowing chemicals (and many drugs) to build up more in the body.

This vicious cycle MUST therefore be interrupted to the maximum extent feasible. Because the resulting symptoms of sensitization are warnings that other more silent toxic-induced organ damage of the liver, pancreas, immune system, adrenals, mitochondria and other organs can be also occurring,16,23,24

masking/blocking symptoms of this cycle is not recommended without healing the disturbed biochemical mechanism. (This would be like turning off a battery warning light without fixing the battery.) Cobalamine(B12) is a nitric oxide

scavenger and deficient in the majority of chemically ill patients. The cyano form is not recommended (these patients don't need cyanide and the hydroxy and methyl forms work much better in the brain and nerve cells). Superoxide dismutase is deficient in a significant portion of chemically ill patients and its cofactors, copper, zinc, and manganese must be adequate. These are often reduced in chemically injured patients and should be tested and replaced in well-absorbed and transported forms, for example, picolinates. Antioxidant function is usually inadequate in chemically ill patients,23 and increased lipid peroxides and other free radicals are common.

Intervention to help reduce this vicious biochemical cycle includes: methyl or hydroxycobalamine sublingually or I.M. (not oral due to poor absorption), general antioxidants (C, E, selenium), glutathione by nebulizer due to poor oral absorption, and ample alpha lipoic acid to reactivate the glutathione in the many damaged lipid tissues (cell membranes, mitochondria, lymph, brain, etc,). Trimethyl glycine is recommended as a methyl donor to reduce the effects of peroxynitrite. Magnesium should be ample because deficiency is very common with toxic injury and adequate magnesium decreases NMDA activation. Peroxynitrite scavengers such as a mixture of caretenoids are also recommended. Carotenoids tend to be more organ-specific. An inclusion of gingko (brain), silimarin (liver), bilberry (collagen stabilizing, capillary permeability, vision), cranberry (urinary) and other mixed carotenoids is recommended.

Mineral levels should be measured and followed by intercellular (eg.RBC) or lipid functional (eg. Lymphocyte mutagenesis, a SpectraCell technology). Functional lymphocyte evaluation and follow-up of glutathione, lipoic acid, total antioxidant function, C, E and zinc is also recommended. At this time this technology is only available through Spectra cell laboratory.

None of the above is a substitute for exposure controls at home, work and /or places where the person spends most of their time. Humans are social beings, and these measures above gradually increase the person's ability to enjoy the company of others and use public places. When society is adequately informed and takes public health accommodation measures to reduce irritants and toxins in personal products and public places, this further promotes health and reduces sensitization.

Solvents, Voc's Pesticides (OP,carbamates)
Formaldehyde NMDA Nitric Oxide Inflammation,
Tissue injury Superoxide Neural Peroxynitrite Sensitization
__________________________

1JE Haley etal., "Evidence for spinal N-methyl-D-aspartate receptor involvement in prolonged chemical nociception in a rat". Brain Res518:218-226,1990.
2M Lafon-Cazal etal., "Nitric oxide, superoxide and peroxynitrite: putative mediation of NMDA-induced cell death in cerebellar cells", Neuropharmacology 32:1259-1266,1999.
3IJ Reynolds and TG Hastings, "Glutamate produces production of reactive

oxygen species in cultured forebrain neurons following NMDA receptor activation", J.Neurosci 15:3318-3327,1995.

4JS Beckman, "The double edged role of nitric oxide in brain function and superoxide-mediated injury", J.Dev Physiol15:53-59, 1991.

5M Lafon-Cazal etal., "NMDA-dependent superoxide production and Neurotoxicity", Nature 364:535-537, 1993.

6JT Coyle and P Puttfarken, "Oxidative stress, glutamate and neuro generative disorders", Science262:689-659,1993.

7JS Beckman and JP Crow, "Pathologic implications of nitric oxide,superoxide and peroxynitrite formation", Biochem Soc Trans21:330-333,1993

8WA Pryor and GL Squadrito, "The chemistry of peroxynitirte: a product of the reaction of nitric oxide and superoxide:, Am J.Physiol268:L699-L722,1995.

9A Novelli etal., "Glutamate becomes neurotoxic via the NMDA receptor when intercellular energy levels become reduced", Brain Res451:205-212,1988.

10JB Schultz, etal., "The role of mitochondrial dysfunction and neuronal nitric oxide in animal models of neurodegenative diseases", Mol Cell Biochem 174:171-184,1997.

11SB MaMahon etal., "Central excitability triggered by noxious inputs", Current Opin Neurobiol 3:602-610,1993.

12TR Garbe and H Yukama, "Common solvent toxicity: auto oxidation of respiratory redox-cyclers enforced by membrane derangement", Z Natur forsch 56:483-491,2001.

13CJ Mattia etal., "Toluene-induced oxidative stress in several brain regions and other organs", MolChem Neurophysiol 18:313-328,1993.

14GE Ziem, "Profile of Patients with Chemical Injury and Sensitivity", Env Health Persp105:Supp 2:417-436, 1997.

15RE Lenga, Ed.,Sigma-Aldrich Library of Chemical Safety Data. Sigma-Aldrich Corp,1988.

16GE Ziem, "Evaluation and Treatment of Patients with Chemicals Injury and Sensitivity" presented to a conference sponsored by the National Institute of Environmental Health Sciences, August 2001.

17WD Willis, "Role of neurotransmitters in sensitization of pain responses", Ann

NY Acad Sci 933:175-184,2001.

18A Doble, "NMDA and neurogenative conditions (reviews)", Pharmacol Ther 81:163-221,1999.

19VL Dawson and TM Dawson, "Nitric oxide neruotoxicity", J Chem Neuroanat 10:179-190,1996.

20BC Albenzi, "Models of brain injury and alterations in synaptic neuroplasticity", J Neruosci Res 65:279-283,2001.

21WG Mayhan, "Nitric oxide donor-induced increase in permeability of the blood-brain barrier", Brain Res 866:101-108,2000.

22OG Khatsenko etal., "Nitric oxide is a mediator of the decrease in cytochrome p450-dependent metabolism caused by immunostimulants", Proc Nat Acad Sci USA 90:11147-11151,1993.

23GE Ziem, "Profile of Patients with Chemical Injury and Sensitivity", Int. J Toxicol 18:401-409,1999.

24GE Ziem, Invited presentation: Endocrine changes in Patients with Chronic Illness Following Chemical Overexposure.

Comment 28 
I have a sister who is often totally handicapped by chemical sensitivities. (I have suffered physical symptoms myself when exposed to pesticides and chemicals in the workplace, and in one situation, EVERYONE at our job location would experience the same symptoms. I finally was forced to leave my job for fear of permanent injury.) For those like my sister, who have suffered with chemical sensitivities so long, it is time to do something. Those who do not show these dramatic symptoms are not necessarily going unharmed.

Comment 29 
People with chemical intolerance may be mentally ill because they report illness from synthetic products like pesticides(sarcasm). By the same logic, pests that die from pesticide sprays must be dying from a psychogenic illness. Although humans do not die immediately from BIOCIDES, to assume there is NO effect/affect from synthetics upon humans is equally unrealistic. There is a continuum of tolerance within the human experience. Those of us who are most sensitive (have the least tolerance to these man made poisons) are honestly saying that these poisons are making us sick. We may not die immediately, but there are times we feel like we are. IGNORE US NO MORE! Do the research we deserve, please.

Comment 30 
I have chemical sensitivities (mild compared to most posting here) that I was unaware of until becoming pregnant the first time---I miscarried. With each of my next two pregnancies this chemical intolerance increased significantly. My first child screamed all the time and was in obvious pain, but nothing seemed to help. She had learning challenges and ADD in elementary school and unexplainable depression beginning at age 9 and PCOS and obesity as a teen. She is also chemically sensitive, and much more so than I was at that age. My second child had jaundice when he was born, reacted terribly to every vaccine he's ever had, but he developed normally, though often sick, until he got the MMR shot. He never recovered from that MMR and began a rapid descent into autism. He has very severe chemical sensitivities that seem to get worse every year. He also has extreme food intolerances and is unable to tolerate drugs (which is not necessarily a bad thing).

Both of my children's problems are rooted in chemical exposures. Vaccines are obviously a huge problem for my son, but chemicals in vaccines, food, water, products and even the air a baby breathes could have accumulated so much that his immune system couldn't handle such a challenge. Every autistic person/child that I know has chemical sensitivities and food intolerances.

We are losing our children to neurological disorders by the hundreds of thousands and we cannot afford not do everything we can to protect our babies from further damage. With 1 in 6 children suffering from some kind of neurological or learning disorder, our society depends on it.

Comment 31 
Dear NIEHS, as I read postings here I realize that adams.clan is someone who actually realizes that chemical sensitivities/intolerances are related to autism. I have no research to add to that concept. I have personal, adult onset chemical sensitivity disorder. Since I can afford to do so I have been treated by mainstream, off-stream and alternative doctors. Upon being given EPD (Enzyme Potentiated Desensitization)shots for all foods, all chemicals and all plants at one time, at miniscule doses, I began to suffer the effects that actually mimic what is found in autism. These effects included arm-flapping and bowing, very similar to what one experiences in autistic children. I believe that "timing" is everything when it comes to chemical exposures. Either you are a Gulf War Vet who was just inappropriately given PB, or you are in utero, or you are born and try to live in the world your parents provide for you. The world of-- colored petrochemical food dyes, pesticide/biocide treated food, particle board exuding formaldehyde, the phenomenon of "twice the pollen rate" due to solvents and pollution in the air, mercury in the air and in various products, perfumes and dye in nearly everything we touch and breathe-- is simply not a place where some of us are able to thrive. Do something without industry interference. Do research on the people who get sick immediately upon chemical exposure and learn the most, with the least scientific effort! SJ

Comment 32 
Many people who live in Halifax Nova Scotia have said they no longer suffer from MCS since their city outlawed perfumes and various other fragrances. Since they are no longer being assaulted on a daily basis with ubiquitous perfumes, their bodies have had time to heal. The chemicals in perfumes accumulate in the body, and whether a person has MCS or not, they are still being adversely affected. Take cancer for one example, or asthma, and let's not forget about heart disease. Neurotoxins slowly poison the brain and spine, which consist of your entire Central Nervous System (CNS). I wrote a book, titled Get a Whiff of This, available on amazon.com. It contains peer reviewed scientific journal excerpts and government documentation to prove without a doubt, that these chemicals are deleterious to human health. ~ Connie Pitts, Author

Comment 33 
For most of my 50+ years I was a healthy person who worked hard and enjoyed life. But after two recent chemical exposures at work I no longer have a job and life isn't enjoyable. I have just started my journey down the path of being chemically sensitive; please help by smoothing out some of the bumps in the road and help all who suffer from MCS enjoy life again.

Comment 34 
Last evening, I proposed to publish the information that four state-attorney-generals posted online on the internet. Elliott Spitzer is one of the past SAG's who was involved in posting the information below. To summarize, Steve Tvedten has lost a child due to pesticide poisoning. He has set up a webpage that explains how INDUSTRY IS POISIONING AMERICA. If you or your child suffers from neurologic, autoimmune or cancer-related disease, using PESTICIDE IS TANTAMOUNT to throwing a match on gasoline. Your child cannot THINK due to solvents found in pesticides and all petrochemical products. Your child cannot LEARN due to solvent exposures. Your child cannot ACCOMPLISH goals in life due to the continued use of solvents/pesticides/toxic paints, furniture, perfumes, detergents, shampoos, soaps, dish washing detergent and other related items used near and on your child on a continuous basis. Your child cannot have a HEALTHY GRANDCHILD because of continuous exposure to these toxins in their life.

Can your child live without all those toxins? ABSOLUTELY, YES.
Children with Chemical Sensitivities and Intolerances live without many of the things that they need, such as medical care, research or treatment. Please consider voting in favor of this research next time around, because we know what is making you and your children sick, and we can help. Let's join forces and begin by reading below, what you might be doing wrong near your loved-ones, when you buy or use any form of EPA-registered pesticide, herbicide or fungicide.SJ

The Secret Hazards of Pesticides:
Inert Ingredients
--------------------------------------------------------------------------------
Attorney General of New York
New York State
Office of the Attorney General
Environmental Protection Bureau
February 1996
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Contents
The Secret Hazards of Pesticides: Inert Ingredients
Table 1: Percent Inerts in Some Pesticide Products
Table 2: Some Adverse Health Effects of Certain Inert Pesticide Ingredients
Table 3: Guide to Selected Regulations Covering Chemicals Also Used As Inerts
Explanation of Regulations and Advisories for Selected Chemicals Used As Inerts

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The Secret Hazards of Pesticides: Inert Ingredients

Look at any label on a pesticide product and you will find a list of "active" ingredients, with a few long chemical names, and then typically the phrase "inert ingredients," with only a single percentage figure given and no listing of individual ingredients. The active ingredients are the chemicals used to control the target pest and must be listed on the label. The so-called "inert" ingredients are used as carriers for the active ingredients, to help dissolve them, make them easier to apply or to preserve them.

Unfortunately, many people will conclude from the term "inert" that such ingredients could not possibly have any adverse health or environmental effects. This is not the case at all. The chemicals used as inerts include some of the most dangerous substances known. Some of these chemicals are suspected carcinogens and have been linked to other long-term health problems like central nervous system disorders, liver and kidney damage and birth defects. They can also cause short-term health effects like eye and skin irritation, nausea, dizziness and respiratory difficulty. The U. S. Environmental Protection Agency (EPA), the agency responsible for regulating the use of pesticides, has categorized inert ingredients into four groups: substances known to cause long-term health damage and harm the environment, chemicals suspected of causing such health or environmental damage, chemicals of unknown toxicity, and those of minimal concern. Although EPA has published a list of chemicals used as inerts, this list does not tell consumers which products contain these inerts. Furthermore, pesticide manufacturers are not required to list all inerts on the product label. Thus, people must play blind man's bluff when it comes to which inerts might be in the pesticides they buy or are used where they live, work or play.

Inerts usually make up at least half if not most of consumer pesticide products. For instance, 99.1 percent of Raid's Ant and Roach Killer is inert ingredients and Ortho Diazinon Dust is 96 percent inerts. Of the 85 pesticide products examined by the Attorney General's office, 75 percent contained over 90 percent inert ingredients (see Table 1 on page 7 for a list of these products). Despite the health effects EPA associates with inerts, people do not know to which chemicals they may be exposed since inerts are not identified on the label. Health effects of some inert ingredients are listed in Table 2 on page 9.

Pesticides are widely used throughout the United States in non-agricultural settings--in homes, outside homes, in offices, schools, and recreational areas. Over 70 million pounds of pesticides are applied on lawns alone every year. The use of lawn care pesticides is increasing at about 5 to 8 percent annually. In fact, four times as many pesticides are used on home lawns as are used to grow food crops. Commercial lawn care is now a $1.5 billion industry. In addition, according to a 1985 study, pesticides used on golf courses accounted for nearly 12 million pounds nationwide. And all these pesticide products--whether used in lawn care, household fumigation, pet care or in personal-care products like insect repellents--contain substantial amounts of inert ingredients.

Who knows what the secret inert ingredients are? Obviously, the pesticide manufacturers and formulators know. Under the Federal Insecticide, Fungicide and Rodenticide Act (FIFRA) pesticide registrants (primarily manufacturers and formulators) must report the identity of inert ingredients to EPA. So one might assume that EPA knows the identity of the inert ingredients in every registered pesticide product. Unfortunately, that does not appear to be the case.

In 1987, EPA announced an "Inerts Strategy" designed to eliminate the most toxic inert ingredients from use, require improved label disclosure of inert ingredients, increase disclosure of inert ingredients, and increase the toxicity testing required for inerts. That strategy, if effectively implemented, could have enhanced the level of protection afforded to the public. In 1991, the EPA Inspector General reported on an investigation of EPA's implementation of its own "Inerts Strategy." The Inspector General reported that:

"EPA has not... enforced the 1987 Inert Strategy requirements for inerts with toxic effects... EPA identified 68 inerts as potentially toxic, and assigned them to a high priority for testing... EPA has no specific procedures or timetables for insuring that these inerts are reviewed."
"EPA is not sure how many chemicals registrants are using as inert ingredients because the inerts were not accurately coded into... [the EPA database]... there were about 600 registrations for which ... the chemical name was not available."(1)

How has EPA responded to this criticism of its implementation of the Inerts Strategy? Not very effectively. According to a 1993 internal memo from the EPA Inspector General's office, corrective actions originally scheduled for completion in 1992 or 1993 had been delayed until 1995 or beyond. Attempts to develop a computer database for inert ingredients had failed, and further development of the system was contingent upon further funding.(2)
Thus, the EPA does not necessarily know the identity of the inert ingredients in the pesticide products sold to the general public, and that situation may not be resolved for years to come.

Even when EPA knows the identity of the inerts, FIFRA instructs it to keep that information secret if the manufacturer requests confidentiality unless the agency decides "that disclosure is necessary to protect against an unreasonable risk of injury to health or the environment".(3) Enacted almost half a century ago, the "trade secrecy" section of FIFRA was intended to protect manufacturers from any competitors who might copy the recipe for a successful product. Today, inert pesticide ingredients are still considered confidential under this obsolete regulation even though "trade secrets" are not necessarily secrets within the industry. Companies can now use commonly available "reverse engineering" techniques to find out the inert ingredients in their competitors' products. Now, this information is secret only to the public.

The Attorney General's office went directly to pesticide manufacturers to ask them to name the inert ingredients in some of their products sold in New York State. Many of the companies contacted refused to provide such information. Others agreed to identify inert ingredients only with an expectation of confidentiality. However, a few companies did cooperate without reservation. Thus, the survey shows that inerts information is generally not available to the public; most companies continue to withhold the identity of inert ingredients under a claim of confidentiality.
Ironically, many non-pesticide products containing the same chemicals used as inert ingredients in pesticides are governed by various laws, regulations, standards or guidelines because of their potential toxicity. There are limits for many of these chemicals in air, water and the workplace. There are restrictions on disposal of these chemicals, penalties for spills and special requirements for their transportation. These laws include the Toxic Substances Control Act, the Clean Water Act, the Clean Air Act, the Resource Conservation and Recovery Act (RCRA), and regulations issued by EPA and the Occupational Safety and Health Administration, as well as guidelines from the National Institute for Occupational Safety and Health. (See Table 3 on page 11 for a selected list of regulations, laws, and advisories concerning chemicals used as inerts.)

Even though some laws limit human exposure to these chemicals by restricting their release into air, water or the workplace, there is no way of knowing when the same chemicals are released as inert ingredients in pesticides. As long as pesticide ingredients are kept secret, people cannot even take steps to avoid exposure. And if an individual experiences a health problem in reaction to a pesticide, precious time can be lost while the doctor tries to obtain information concerning the chemicals to which the patient has been exposed.

The Federal Insecticide, Fungicide and Rodenticide Act should be amended to require pesticide manufacturers and formulators to disclose the total composition of pesticide products sold to the public. Product labels should identify each inert ingredient in the formulation. This information is simply too important to keep secret any longer because what the public does not know now about pesticides may very well hurt them some day.

Credits
This report was originally prepared in June 1991 by Michael H. Surgan, Ph.D., Chief Scientist and Assistant Attorneys General Deborah Volberg, Nancy Stearns and James A. Sevinsky, with assistance from other members of the Environmental Protection Bureau.
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Tables
Table 1: Percent Inerts in a Sampling of Pesticide Products(4)
HOUSEHOLD PESTICIDE MANUFACTURER PERCENT INERT
Ant, Roach, and Spider Killer Dexol Industries 99.5
Aphid and Mite Attack Ringer Corp. 97.96
Crawling Insect Attack Ringer Corp. 99.56
Flea Kill Fogger The d-Con Co. Inc. 98.35
Hyponex Bug Spray Hyponex Corp. 99.78
Insecticidal Soap for Indoor Plants Safer, Inc. 98.0
Mite Killer Safer, Inc. 98.0
No-Roach Gaston Johnston Corp. 82.034
Ortho Flea-B-Gon Chevron Chemical Co. 99.17
Ortho Hi-Power Ant, Roach & Spider Killer Chevron Chemical Co. 95.11
Ortho Hornet & Wasp Killer Chevron Chemical Co. 99.50
Raid Ant & Roach Killer S.C.Johnson & Sons Inc. 99.10
Raid Flying Insect Killer S.C.Johnson & Sons Inc. 99.2
Raid Fogger II S.C.Johnson & Sons Inc. 85.0
Raid Fumigator S.C.Johnson & Sons Inc. 87.4
Raid House and Garden Bug Killer S.C.Johnson & Sons Inc. 97.504
Spectracide Garden, Rose & Household Plant Spray Kenco Chem. & Mfg. Corp. 99.5
Spectracide Home Insect Control Kenco Chem. & Mfg. Corp. 99.17
Spectracide Indoor Fogger Kenco Chem. & Mfg. Corp. 99.40
Spectracide Wasp and Hornet Killer Kenco Chem. & Mfg. Corp. 99.3664
Wasp and Hornet Attack Ringer Corp. 99.56

LAWN CARE FUNGICIDE
Lawn and Turf Fungicide Faesy & Besthoff, Inc. 92.0
Lawn Disease Preventer Glorion Corp. 95.0
Lawn Fungicide Lebanon Chemical Corp. 99.945

LAWN CARE HERBICIDE
2-Way Green Power Lebanon Chemical Corp. 96.52
Balan 2, 5G Elanco Products Co. 97.5
Expel Dandelion Killer Lebanon Chemical Corp. 97.92
Longlife Weed and Feed Frank's Nursery & Crafts 99.9845

Preen'n Green Lebanon Chemical Co. 99.26
Spectracide Grass and Weed Killer Kenco Chem. & Mfg. Corp. 99.7
Step 1 Crab Grass Prevention O.M.Scott & Sons Co. 99.85
Step 2 Weed Control O.M.Scott & Sons Co. 97.205
Super Turf Builder Plus 2 O.M.Scott & Sons Co. 97.66
Super Turf Builder Plus Halts O.M.Scott & Sons Co. 98.97
Surety Weed and Feed Plus Howard Johnson Ent. Inc. 99.063
Team 2G Elanco Products Co. 98.0
XL 2G Elanco Products Co. 98.9

LAWN CARE INSECTICIDE
Bugout Lebanon Chemical Corp. 98.86
Chinch Bug & Grub Preventer Glorion Corp. 97.28
Deluxe Weed and Feed Glorion Corp. 97.28
Grub Buster Free Flow Fertilizer 98.5
Insect Control O.M.Scott & Sons Co. 96.40
Lawn Insect Control Glorion Corp. 98.86
Lawn Insect Control O.M.Scott & Sons Co. 94.16
Lawn Insecticide Free Flow Fertilizer 95
Lawn Insecticide Greensweep Household Products 58.5

LAWN CARE INSECTICIDE MANUFACTURER PERCENT INERT
Longlife Lawn & Garden Insecticide Frank's Nursery & Crafts 95.000
Oftanol Glorion Corp. 98.5
Spectracide Lawn & Garden Insect Kenco Chem. & Mfg. Corp. 95
Control (granular)
Spectracide Lawn & Garden Kenco Chem. & Mfg. Corp. 18.7
Insect Control (liquid)
Step 3 Insect Control O.M.Scott & Sons Co. 96.40

GENERAL HERBICIDES
2 in 1 Crabgrass Preventer Glorion Corp. 98.78
AAtrex 4L CIBA-GEIGY Corp. 57.0
Arsenal American Cyanamid Co. 72.4
Chopper American Cyanamid Co. 72.4
Ortho Kleenup Super Edger Chevron Chemical Co. 99.50
Prowl American Cyanamid Co. 57.7

GARDEN FUNGICIDE
Dexol Bordeaux Mixture Dexol Industries 87.35
Garden Fungicide Safer, Inc. 99.6
Pipron L.C. Elanco Products Co. 17.6
Rubigan E.C. Elanco Prodcuts Co. 87.5

GARDEN INSECTICIDE
Liquid Sevin Faesy & Besthoff, Inc. 77.5
Ortho 3-Way Rose & Flower Care Chevron Chemical Co. 98.85
Rose & Flower Spray or Dust Bonide Chemical Co. Inc. 84.5
Spectracide Rose & Garden Insect Killer Kenco Chem. & Mfg. Corp. 99.88

OUTDOOR INSECTICIDE
Abate 1-SG American Cyanamid Co. 99
Amdro American Cyanamid Co. 99.12
Cygon 400 American Cyanamid Co. 56.5
Gypsy Moth Biological Control Acme Burgess Inc. 99.14
Mosquito Attack Ringer Corp. 50
Ortho Diazinon Soil & Foliage Dust Chevron Chemical Co. 96
Ortho Diazinon Plus Insect Spray Chevron Chemical Co. 75
Ortho Home Orchard Spray Chevron Chemical Co. 62.5
Ortho Isotox Insect Killer Chevron Chemical Co. 90.6
Ortho Orthene Systemic Insect Control Chevron Chemical Co. 90.6
Ortho Rose & Flower Insect Killer Chevron Chemical Co. 99.70
Ortho Sevin Chevron Chemical Co. 95
Raid Yard Guard S.C.Johnson & Sons Inc. 99.125
Yard and Garden Insect Attack Ringer Corp. 99.56

PET CARE
Hartz 2 in 1 Flea and Tick The Hartz Mountain Corp. 99.332

INSECT REPELLENT
Cutter Insect Repellent Miles Laboratory 67
Off S.C.Johnson & Sons Inc. 85.00
Ortho Outdoor Insect Fogger Chevron Chemical Co. 91.385

MOLLUSCICIDE
Deadline Pace National Corp. 96
Ortho Slug-geta Chevron Chemical Co. 98

Table 2. Some Adverse Health Effects Of Certain Inert Pesticide Ingredients Chemical Effects

Carbon tetrachloride* Irritation of skin, eyes nose, throat; dizziness, vomiting, abdominal pain; diarrhea; damage to kidneys, liver; central nervous system depression; suspected carcinogen.

Chlorobenzene* Eye and skin irritation, burns and inflammation; chest pain, slow heart rate, ECG irregularities; lung, liver and kidney damage; central nervous system depression; coma.

Chloroform* Irritation to eyes and gastrointestinal tract; damage to liver and kidneys; central nervous system depression; nausea, dizziness, fatigue, respiratory distress; gonadal atrophy; fetal resorption; mutagen; coma and death by cardiac arrest; suspected carcinogen.

Chloroethane Irritation of eyes; abdominal cramps, nausea, vomiting; liver and kidney damage; nervous system dysfunction; blood cell disorders; suspected carcinogen.

Cresols Skin irritation, burns, and inflammation; irritation of eye, permanent damage and blindness; pneumonia; pancreatitis; central nervous system disorders; kidney failure.

Dibutylphthalate Irritation of eyes and throat; photophobia, conjunctivitis,nausea, dizziness.

Diethylhexylphthalate* Eye, nose and throat irritation; liver damage; testicular damage; central nervous system depression; suspected carcinogen.

Dimethylphthalate Irritation of eyes, mouth, nose, throat; dizziness, abdominal pain, nausea, vomiting, diarrhea; central nervous system depression; reduced respiratory rate; paralysis, coma.

Epichlorohydrin* Skin and eye irritation, conjunctivitis, corneal clouding; nausea, vomiting, fatigue; liver and kidney damage; inflammation of lungs, chronic bronchitis; death by respiratory paralysis; mutagen; fetotoxic.

Ethylbenzene Irritation of eyes, nose and throat; skin irritation, inflammation, blisters and burns; liver and kidney damage; central nervous system disorders; headache, sleepiness, difficulty in breathing; unconsciousness and

coma.

Ethylene dichloride* Nausea, vomiting, diarrhea; damage to liver and kidneys; central nervous system depression; death due to circulatory and respiratory failure.

Isophorone Irritation of skin, nose, throat, respiratory system; lung congestion and degeneration; central nervous system disorders; kidney and liver damage; suspected carcinogen.

Methyl bromide* Eye and skin irritation; blurredvision, headache, dizziness, nausea, abdominal cramps; anorexia; bronchopneumonia, pulmonary edema; brain damage, convulsions, coma; kidney and respiratory failure.

o-Dichlorobenzene Eye irritation and cataracts; skin irritation and lesions; headache, nausea, vomiting, drowsiness; respiratory depression; anemia, kidney and liver damage; chromosomal breaks.

p-Dichlorobenzene Irritation of skin, eyes, respiratory system; headache, dizziness, hyperactivity, weakness, weight loss; liver and blood disorders; kidney damage; lung congestion, difficulty in breathing; mutagen.

Phenol Irritation of eyes, nose, throat; headache, dizziness, fainting, abdominal pain, nausea, vomiting, diarrhea; damage to liver, kidney and heart; chromosomal aberrations and damage; mutagen.

Propylene dichloride* Eye and skin irritation; dizziness, disorientation, nausea, vomiting; liver and kidney damage; central nervous system damage; coma; hemolytic anemia; suspected carcinogen.

1,1,2-Trichloroethane* Gastrointestinal inflammation and congestion; liver and kidney damage; immune function disorder; central nervous system depression; suspected carcinogen.

Toluene Skin, eye and respiratory irritation; abdominal pain, headache, nausea, dizziness, drowsiness, hallucinations; anemia; liver disorders and enlargement; central nervous system dysfunction; coma and death.

Trichloroethylene* Eye irritation, visual distortion; abdominal pain, nausea, diarrhea; anorexia; liver and kidney damage; peripheral nerve damage, numbness and paralysis; blood disorders; cardiac arrhythmia; suspected carcinogen.

*This chemical was identified as an Inert Ingredient by EPA in 1991, but is absent from the most current list of Inert Ingredients released in May, 1995.

Sources:

U. S. Environmental Protection Agency, Chemical Profiles, Interim Guidance, Chemical Emergency Preparedness Program, 1985

U. S. Environmental Protection Agency, Office of Health and Environmental Assessment, Health Assessment
 

Documents

U. S. Public Health Service, Agency for Toxic Substances and Disease Registry, Toxicological Profiles

New York State Department of Health, Chemical Fact Sheets

TABLE 3. A GUIDE TO SELECTED REGULATIONS COVERING CHEMICALS ALSO USED AS INERTS.*

----------------------------------------------------------------------------

Number of _____________________________ _____________________________

REGULATIONS AND

ADVISORIES** _____________________________ _____________________________

Applicable

Regulations/ SDWA TSCA CERCLA/SARA RCRA CWA OSHA NTP ACGIH IARC DOT CAA NIOSH

Chemical Advisories 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26

Chloroform 21 X X X X X X X X X X X X X X X X X X X X X

p-Dichlorobenzene 21 X X X X X X X X X X X X X X X X X X X X X

Ethylene dichloride 20 X X X X X X X X X X X X X X X X X X X X

Carbon tetrachloride 19 X X X X X X X X X X X X X X X X X X X

Chlorobenzene 19 X X X X X X X X X X X X X X X X X X X

o-Dichlorobenzene 19 X X X X X X X X X X X X X X X X X X X

Propylene dichloride 19 X X X X X X X X X X X X X X X X X X X

Trichloroethylene 17 X X X X X X X X X X X X X X X X X

Methyl bromide 16 X X X X X X X X X X X X X X X X

Toluene 16 X X X X X X X X X X X X X X X X

1,1,2-Trichloroethane 15 X X X X X X X X X X X X X X X

Diethylhexylphthalate 15 X X X X X X X X X X X X X X X

Epichlorohydrin 15 X X X X X X X X X X X X X X X

Phenol 15 X X X X X X X X X X X X X X X

Chloroethane 14 X X X X X X X X X X X X X X

Dibutylphthalate 14 X X X X X X X X X X X X X X

Dimethylphthalate 13 X X X X X X X X X X X X X

Ethyl benzene 13 X X X X X X X X X X X X X

Cresols 12 X X X X X X X X X X X X

Isophorone 11 X X X X X X X X X X X

* Adapted from: Suspect Chemicals Sourcebook, K.b. Clansky, Ed., 1989 Edition

(Updated to Jan. 1, 1990) Roytech Publications, Inc.

** See "Explanation of Regulations and Advisories" which follows for specific identification.

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Explanation of Regulations and Advisories for Selected Chemicals Used As Inerts

SAFE DRINKING WATER ACT (SDWA)

1. Maximum Contaminant Levels (MCL)

Requires the U. S. Environmental Protection Agency (EPA) to establish primary drinking water regulations which

1) apply to public water systems, 2) specify contaminants which may have adverse health effects, 3) specify Maximum Contaminant Levels (MCL, the maximum permissible level of a contaminant in water) or treatment techniques for each listed contaminant, 4) establish public notification requirements.

2. Maximum Contaminant Level Goals

Establishes non-enforceable Maximum Contaminant Level Goals (MCLG) which are set at a level at which no known or anticipated adverse health effects occur and which provide an adequate margin of safety.

3. Monitoring Requirements

Requires monitoring for contaminants likely to be found in the system's drinking water, including contaminants not regulated under National Primary Drinking Water Regulations. Results must be reported to both the State and EPA and made available to the public.

4. 1986 Amendments/Statutory Contaminants

Requires EPA to regulate 83 contaminants by publishing MCLG's and promulgating National Primary Drinking Water Regulations for each of the 83 listed contaminants.

5. 1986 Amendments/Drinking Water Priority List

Requires EPA to establish a priority list of contaminants which may have adverse health effects and are known or anticipated to occur in public water systems.

TOXIC SUBSTANCE CONTROL ACT (TSCA)

6. Section 4(a), Final Test Rules

Requires EPA to test substances which meet certain criteria, such as those which may present an unreasonable risk or injury to health or environment, in order to develop health or environmental data.

7. Section 8(d), Health and Safety Data Rule

Requires manufacturers, importers and processors of listed substances to submit to EPA copies and lists of unpublished health and safety studies on the listed substances with which they deal.

8. Section 4(a), Dioxins/Furans Rule

Requires manufacturers and importers of certain organic chemicals to test for the presence of halogenated dibenzodioxins (HDD) and halogenated dibenzofurans (HDF) as contaminants. Results and existing test data must

be submitted as well as additional information if HDD and/or HDF concentrations exceed designated levels.

9. Section 12(b), Export Regulations

Requires exporters of chemical substances to notify EPA of such exportation if any exported substances are

affected by TSCA Sections 4, 5, 6 or 7.

COMPREHENSIVE ENVIRONMENTAL RESPONSE, COMPENSATION AND LIABILITY ACT

(CERCLA)/SUPERFUND AMENDMENTS AND REAUTHORIZATION ACT (SARA)

10. CERCLA. Hazardous Substances

Establishes a list of substances which must be reported to the National Response Center when released in quantities exceeding a specified reportable quantity.

11. SARA. Title III Section 302 and 304, Extremely Hazardous Substances

Requires facilities handling substances named on the list of extremely hazardous substances to notify the State of the presence of these substances in excess of their Threshold Planning Quantities and must notify local authorities of their release in excess of their Reportable Quantities.

12. SARA. Title III Section 313, Toxic Chemicals Establishes a list of toxic chemicals. Manufacturers, processors and users of these chemicals must submit release reporting forms.

13. CERCLA Section 104(i), Priority list of CERCLA Hazardous Substances Requires EPA and the Agency of Toxic Substance and Disease Registry to 1) prepare a prioritized list of hazardous substances commonly found at National Priorities List sites which pose the greatest potential health risk, 2) to develop Toxicological Profiles of these substances, 3) establish a research program to fill data gaps.

RESOURCE CONSERVATION AND RECOVERY ACT (RCRA)

14. Requires notification of EPA by anyone who generates, transports, treats, stores or disposes of wastes specified under Section 3001 of RCRA.

15. Hazardous Constituents for Groundwater Monitoring

Requires groundwater monitoring at RCRA land-based hazardous waste disposal units for all constituents listed in Appendix IX to 40 Code of Federal Regulations (CFR) 264.

16. Land Disposal Prohibitions - Halogenated Organic Compounds Restricts land disposal of waste containing halogenated organic compounds above specified concentrations.

17. Land Disposal Prohibitions Lists the hazardous wastes identified in 40 Code of Federal Regulations 261 which were scheduled for restricted/prohibited land disposal after enactment of the Hazardous and Solid Waste Amendments to RCRA in 1984.

CLEAN WATER ACT (CWA)

18. Section 304, Water Quality Criteria; Section 307, Priority Pollutants

Requires EPA to publish and periodically update ambient water quality criteria. Criteria are to reflect latest scientific knowledge on the identifiable effects of substances on public health and welfare, including but not limited to aquatic life, aesthetics and recreation. Establishes a list of toxic pollutants for which EPA is required to publish ambient water quality criteria. Under Section 304, these chemicals shall be subject to effluent limits resulting from the application of best available technology.

19. Section 311, Hazardous Chemicals Requires EPA to publish a list of substances that are considered hazardous if spilled in navigable waters.

OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION (OSHA)

20. Air Contaminants (29 CFR 1910.1000) Establishes a list of air contaminants and sets exposure limits for the workplace.

NATIONAL TOXICOLOGY PROGRAM

21. Report on Carcinogens

Identifies carcinogens and subdivides them into Known and Anticipated. Categorizes 162 substances on this basis.

AMERICAN CONFERENCE OF GOVERNMENTAL AND INDUSTRIAL HYGIENISTS

22. Threshold Limit Value Chemicals Provides various workplace exposure limits (time-weighted average, short-term exposure limits, ceiling limits) for each covered substance.

INTERNATIONAL AGENCY FOR RESEARCH ON CANCER

23. Human Carcinogens (Groups 1, 2A, and 2B) Identifies carcinogens and classifies them as: Group 1 (sufficient evidence of human carcinogenicity); Group 2A (probable human carcinogen); Group 2B (possible human carcinogen).

DEPARTMENT OF TRANSPORTATION

24. Hazardous Materials

Regulates interstate commerce of hazardous materials, including all CERCLA hazardous substances, Specifies requirements for description, shipping names, class, labeling and packaging, as well as spill notification.

CLEAN AIR ACT

25. Section 111, Potential Human Health Hazards

Lists substances published by EPA pursuant to Section 111 of the Clean Air Act, which pose a potential health hazard and for which specific control techniques are defined.

NATIONAL INSTITUTE OF OCCUPATIONAL HEALTH AND SAFETY (NIOSH)

26. Criteria Documents

Specifies a NIOSH Recommended Exposure Limit and appropriate preventive measures to reduce or eliminate adverse health effects.

1. "Inert Ingredients in Pesticides," USEPA, Office of the Inspector General, Audit Report E1EPF1-05-0117-

1100378, Sept. 27, 1991.

2. Memo from Michael Simmons, Associate Assistant Inspector General for Internal and Performance Audits to Victor J. Kimm, Acting Assistant Administrator for Prevention, Pesticides and Toxic Substances, September 17, 1993. See Foreword for an update on the computer database.

3. FIFRA, Section 10(d)(1)(C), entitled, "Protection of Trade Secrets and Other Information".

4. Based on a market survey conducted during the spring and summer of 1990.

-----------------------------------------------------------------------------

Nontoxic Products Recommended by Steve Tvedten

West / Central East

Safe 2 Use Safe Solutions, Inc

Comment 35 
I am a physician who has been disabled with severe chemical sensitivities for over 20 years. To say that research on this illness (and any real help coming from the federal government) is long overdue is the understatement of all time! While the nation's heart pours out to those who have been devastated by

recent tornados - including loss of home, belongings, health and loved ones - I am once again reminded how painful it is for people with chemical sensitivities to receive no such compassion or help even though our devastation is no less. To the contrary, we are often ridiculed and maligned by doctors and government agencies that are supposed to help us. Please make MCS research and the creation of an interagency task force a high priority for NIEHS. At this point, it is unconscionable not to do so.

Comment 36 
I'm so tired of being sick. Please help. The chemically injured population has suffered for so long: unrecognized, ridiculed, separated from society, and without resources or understanding. We need access to basic services and accommodations to be able to work and be a part of life. Funding research is an essential first step to helping those already harmed and preventing more chemically induced illnesses.
Thank you.
Reggi

Comment 37 
I am urging you to read the article :
"MULTIPLE CHEMICAL SENSITIVITY (MCS) IS A WORLDWIDE ENVIRONMENTAL HEALTH CRISIS"
and to visit EXTENSIVELY the award-winning website:
MCS HOMEPAGE/INTERNATIONAL MCS/EMS AWARENESS
http://www.nettally.com/prusty/mcs.htm
as well as reading VERY IMPORTANT RELATED articles in the PRESS:
http://www.americanchronicle.com/authors/view/1766

You will realize the MAGNITUDE of this worldwide epidemic, which is the direct result of global environmental pollution. See all the Multiple Chemical Sensitivity (MCS)and Toxic Injury (TI) proclamations signed by Governors SINCE 1998, for the AWARENESS of this DEVASTATING ENVIRONMENTAL ILLNESS affecting an estimated 47 million people in the U.S. These proclamations have received the FULL APPROVAL from respective States Departments of Health prior to being signed by Governors. MCS is recognized as a disability under the Americans with Disabilities Act(ADA) and by the U.S Access Board ( Federal Agency)which has an extensive guideline of accommodations for people disabled by MCS. This information is on the site mentioned above, MCS/International MCS/EMS Awareness. The governors who signed the MCS/TI Awareness Proclamations have stated that MORE SCIENTIFIC RESEARCH, including GENETICS, must be done.

And it is indeed, a necessity, in order to comprehend ALL the PHYSIOLOGICAL MECHANISMES, responsible for this terrible illness, TRIGGERED by EXPOSURES to toxic chemicals in the environment.

For decades people have been suffering tremendously, due to this devastating environmental illness, and the number of people stricken with MCS in increasing daily at a frightening rate WORLDWIDE.

It is imperative , that Scientific research on Multiple Chemical Sensitivity (MCS)also referred as Chemical Sensitivity, and occasionally as Chemical Intolerance, be done as a PRIORITY due to the ever growing worldwide epidemic of MCS and the MILLIONS of people , including small children, who suffer and even AGONIZE as the illness progresses.

NOW , is the time more than ever, to do what needs to be done for the millions of MCS sufferers, and that is SCIENTIFIC RESEARCH, INCLUDING GENETICS.
This can no longer wait, this environmental Health crisis has reached proportions that are almost beyond point of return.

YOU MUST ACT NOW!

Thank You.

Comment 38 
The direct link to the article :
"MULTIPLE CHEMICAL SENSITIVITY (MCS) IS A WORLDWIDE ENVIRONMENTAL CRISIS" is: http://www.americanchronicle.com/articles/view/89744 

Comment 39 
The research proposals on this website focus on possible environmental causes of autoimmune diseases, autism, chronic fatigue, chemical sensitivity/intolerance, military veterans' illnesses, as well as individuals who report symptoms associated with oil spills, fracking, hazardous waste sites, various community exposures, dioxin, home remodeling, poor indoor air quality, mold, pesticide use, and myriad other environmental exposures. But, in fact, individuals with these seemingly unrelated exposures and multi-system health problems share a great deal in common: their multi-system symptoms are often triggered by every day, low-level chemical exposures. Many also report adverse reactions to foods, medications, alcoholic beverages and/or caffeine. Dr. Nicholas Ashford of MIT and I first described this phenomenon 15 years ago. Toxicant-Induced Loss of Tolerance (TILT) is the name we gave to the underlying dynamic. It involves a two-step process whereby an initial acute or chronic toxic exposure causes loss of tolerance for everyday exposures. These new-onset intolerances perpetuate the disease process. We described how low-level exposures to common chemicals, foods, and medications may be the driving force behind the increased incidence of many hitherto unexplained medical symptoms and how masking—resulting from overlapping responses to multiple incidents—obscures the fact that everyday exposures can perpetuate illness. These concepts arose from reports by physicians, researchers and patients from more than a dozen industrialized nations. Collectively, their observations provide evidence that toxicant-induced loss of tolerance may be a new theory of disease. Currently, we are at the germ theory stage in terms of our understanding of this phenomenon. Well-founded theories—those based on careful observation, as in the case of the germ theory—are vital for developing shared scientific understanding and igniting future research.

In summary, it appears we are dealing with a two-stage disease process: (1) loss of tolerance resulting from an acute or chronic exposure event, followed by (2) repeated triggering of symptoms by everyday exposures, such as gasoline vapors, engine exhaust, fragrances or cleaning agents—exposures which had not been a problem for the person previously. This phenomenon became increasingly common with the widespread introduction of synthetic organic chemicals following WW II. This, coupled with the fact that 90% of Americans spend 90% of their day inside poorly ventilated structures where unprecedented types and levels of synthetic volatile organic chemicals (VOCs) are present, has led to the epidemic of chronic illnesses we are witnessing today. If we are to understand the extent to which these exposures contribute to the host of chronic illnesses mentioned on this website, doctors and researchers must have access to environmental medical research units— hospital-like research facilities in which people with major illnesses such as autism or autoimmune disorders, can be placed on an elimination diet in a chemically clean environment to see if their symptoms improve. If their symptoms resolve, then everyday exposures and foods can be reintroduced, one at a time. We are all so different and we respond differently to different exposures. NIEHS has an unprecedented opportunity: new approaches for assessing gene and protein expression and new brain imaging techniques can be used both before and after challenges in an EMU. We need to move forward, but not without this essential research tool—the Environmental Medical Unit (EMU). The EMU has been a priority recommendation of several professional and governmental conferences, yet still no research EMU exists in the U.S. It is time for NIEHS/NIH to add the EMU to its portfolio, so that we can all begin to understand the common dynamic shared by so many chronic, costly, and disabling medical conditions. The many excellent comments shared on this website testify to this need.

1. Chemical Exposures: Low Levels and High Stakes by Nicholas A. Ashford and Claudia S. Miller (Wiley). May be downloaded at no charge from www.chemicalexposures.org, along with a published and validated screening questionnaire for chemical intolerance, the Quick Environmental Exposure and Sensitivity Inventory (QEESI).

2. Toxicant-induced loss of tolerance—an emerging theory of disease? Miller CS. Environmental Health Perspectives: vol 105 Supp 2:445-453 (1997).

3. Empirical approaches for the investigation of toxicant-induced loss of tolerance. Miller C, Ashford A, Doty R, Lamielle M, Otto D, Rahill A, Wallace L. Environmental Health Perspectives: vol 105 Supp 2:515-519 (1997).

4. Toxicant-induced loss of tolerance. Miller CS. Addiction 96(1):115-139 (2000).

Comment 40 
Dear NIEHS, during the last few moments on Central Time (6:35) I want to make a final comment regarding "Research on Chemical Sensitivities /Intolerances." Many of the people we have asked to vote have found this voting site DOWN with a red triangle at the corner. Many intelligent people who support us have failed to be able to get through the jumps and hoops required to simply elicit a vote. We are very loosely and poorly organized because we are the sickest group on this NIEHS competition.

Those of us who are well enough to use a computer employ the following egroup for updates on world issues regarding all the forms of toxins to which we already adversely react.

Go to WSMCSN@yahoogroups.com to become one of the people who realized 1-30 years ago, that we are polluting the environment, meaning our homes, our yards, our air, soil and water with toxic petrochemicals, drug, and even toxic waste from smoking. OUTDOOR smoking is one of the big issues that keep us in our houses. PESTICIDE SPRAYING causes us unbelievable illness and loss of income.

Please read just this week's research. Do something. We need research on our illness.
----------------------------------------------------
China smoking ban may have little effect. In a country of 300 million smokers, where many don't know of the health risks of tobacco, few expect much from a ban effective Sunday. Previous efforts to ban smoking in public places here have been plagued by false starts and
failed campaigns. Los Angeles Times, California.
http://lat.ms/jOOOfu 

Crude oil chemical linked to heart defect in babies. Babies who are exposed before birth to ethyl benzene, a toxic component in crude oil, may have a higher risk of developing congenital heart disease, US researchers said Saturday. Agence France-Presse
http://bit.ly/mRECSC 

Stillbirths tied to secondhand smoke. Pregnant women who live or work with smokers may be at slightly higher risk of having a stillbirth, suggests a study that adds to evidence that even secondhand smoke can harm unborn babies. Reuters http://reut.rs/mxk4dw 

A new victim of second-hand smoking: Fish. With the world's smokers burning through a breathtaking 5.6 trillion cigarettes per year - 4.5 trillion of which are simply tossed away outside after they're smoked - little things add up fast. That, as it turns out, can be especially
dangerous for one type of nonhuman critter: fish. Time Magazine
 

College students push to restrict bottled water. Bottled water: It's a vending machine's healthy alternative to sugary soda, a convenient way to hydrate on the go and, lately, a total faux pas on many college campuses. Washington Post
http://wapo.st/lQAHw5 

The oil's story, from wellhead to beach. There is no story yet about the ultimate ecological damage last year's spill wrecked on the Gulf of Mexico. Early returns have seemed positive, but more systemic problems could appear. The spike in dolphin deaths could be tied to
oil-derived chemicals. Turtle or crab growth could be stunted. It's too early to know. Greenwire
http://nyti.ms/kSe1IB 

WHO takes on chronic disease. The World Health Organization focused for decades on infectious diseases, but now it's putting non-communicable diseases near the top of its agenda. Washington Post
http://wapo.st/iHAEFn 

Groups call on BLM to act against Wyoming ozone. Environmentalists have asked regulators to consider slowing down the pace of gas drilling and other steps to curb air emissions in western Wyoming following several days of severe ozone pollution last winter.
Associated Press

India has 11 years to ban endosulfan. A UN-backed regime of 173 countries on Friday agreed to globally "phase out" the farm insecticide endosulfan - a decision with significant implications for India, the world's largest manufacturer and user of the chemical. New
Delhi Hindustan Times, India.
http://bit.ly/lixFRS 

Weather chief draws flak over plea not to release radiation forecasts. The chief of the Meteorological Society of Japan has drawn flak from within the academic society over a request for member specialists to refrain from releasing forecasts on the spread of radioactive substances from the troubled Fukushima Daiichi nuclear plant. Mainichi Daily News, Japan.
 

Japan's unhelpful politics: Rebuilding Japan or ruining it. Whether the reconstruction council and nuclear investigation promote deep changes in the way things are done in Japan rests largely on the prime minister's powers of leadership. Economist
http://econ.st/jyy4Gd 

One big obstacle to Japan's recovery? Trash. On the outskirts of the seaside city of Kesennuma, what was once a baseball field and park has been turned into at least two football fields' worth of garbage, piled 15 feet high. This is but a tiny fraction of Japan's tsunami-related debris. All Things Considered, NPR.
http://n.pr/m5w9Fs 

Chubu Electric seeks restart of 'most dangerous' nuke plant. Chubu Electric is proposing to restart a reactor at its Hamaoka nuclear power plant to help alleviate a possible summer power shortage - but local governments and residents are fiercely opposed to restarting
the No. 3 reactor of what is described as "the world's most dangerous" nuclear power plant. Asahi Shimbun, Japan.
 

Climate change could spawn more tornadoes. With this week's tornado outbreak in the South, as with any major weather disaster these days, people ask questions about its relation to the huge elephant that's lurking in the corner - global climate change. USA Today
http://usat.ly/k2Olw0 

Obama appalled by tornado damage in Alabama. President Obama joined thousands of storm victims across the tornado-ravaged South on Friday in making his way past splintered houses along devastated streets, and he promised federal aid to help communities rebuild. Washington Post
http://wapo.st/mSWcf9 

Scientists probe genetic component of climate-hardy species. Forest Service researchers are in the midst of teasing out which genes help Douglas firs and 39 other species of plants, animals and pathogens found in Western forests adapt to climate change. ClimateWire
http://nyti.ms/mOkzcj 

Court rejects challenge to California's clean-car regs. A federal appeals court rejected a legal challenge Friday that sought to bar implementation of a California regulation meant to reduce greenhouse gas emissions by forcing automakers to make and sell less polluting
cars in the state. Associated Press

TVA's Johnsonville plant shutdown fuels counties' job fears. TVA's game-changing plan to shut down parts of its coal-burning power production fleet will mean cleaner air for Middle Tennessee and elsewhere, but it has left at least one community in shock. Nashville
Tennessean, Tennessee. 

EPA revisits rules on streams. The Ohio EPA is planning to change its approach to curbing threats to the state's network of rivers, creeks, wetlands and lakes through tougher pollution limits for sewage-treatment plants and a new process to protect and repair
streams threatened by proposed strip mines, roads and housing subdivisions. Columbus Dispatch, Ohio.
http://bit.ly/mR67x9 

Cancer cluster research continues. Five children in southeastern St. Clair County have been diagnosed with a rare form of kidney cancer in the past four years, and officials are trying to find out why. The answer so far: They're investigating. Port Huron Times Herald,
Michigan.
http://bit.ly/lGkN3Y 

Residents tested for pesticide. Anti-pesticide activists brought more than complaints to a state Board of Forestry meeting. Triangle Lake residents, who for years have been fighting aerial spraying of herbicides on the timbered slopes around their homes, came with data
that showed two herbicides in the urine of 21 community members, including children. Eugene Register Guard, Oregon.
http://bit.ly/inr6zu 

Cairo, Illinois, argues for its life in levee breach plan; others protest. Once the stuff of literary references, blues lyrics and steamboat culture, now Cairo is a dilapidated intersection of two rivers and three states, marked by poverty and decay. Now - as floodwater rises around it - the town has become the center of a debate. Why save a dying town? St. Louis Post-Dispatch, Missouri.
http://bit.ly/iMpeDi 

Anxious eyes on a river as flooding threat looms. Major General Michael J. Walsh is likely to make a lot of people angry over the next few days. But which group of people is not so clear. It will depend on whether he decides to flood farmland in Missouri in order
to save a town in Illinois from the ravages of the rising Mississippi and Ohio Rivers. New York Times
http://nyti.ms/jHYnrk 

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Idea 42: Socioeconomic Public Health

There have been recent findings showing increased rates of certain diseases in low income/minority neighborhoods. I suggest that studies of these neighborhoods include evaluation and monitoring of the electromagnetic environment as other research suggests our power quality is connected with disease development.
See: ScienceDaily (Dec. 9, 2010) — Older people who live in racially segregated neighborhoods

with high crime rates have a much higher chance of developing cancer than do older people with similar health histories and income levels who live in safer, less segregated neighborhoods.
That is one of the key findings of a new study forthcoming in the January 2011 issue of the American Journal of Public Health. The study was conducted by Vicki Freedman, an epidemiologist at the University of Michigan Institute for Social Research and colleagues at the University of Medicine and Dentistry of New Jersey.

Comment 2 
I agree sometimes we forget that we are all suppose to have the same access to care it should not matter where u r from. more research prevention education even outreach need to be done in the low income neighborhoods where we can teach people how to help themselves so what does it show that if u r low income/ minority u do not have the same right and that you don't mean anything

Comment 1 
Kentucky has some of the worst health in the country, lowest incomes, and highest exposures thanks to our coal-based economy. It's not a goal of the NIEHS to understand how economic needs of an impoverished community lead to poor health outcomes, but it would be nice is one of the NIH institutes was interested in moving beyond the pharmaceutical target to understanding the true causes of poor health outcomes in Appalachian America.

Idea 43: "Used Cooking Oil - Fast Foods"

I would like to see a Massive Study on Used Cooking Oil in Fast Foods. According to Dr. Andrew Weil "Australian Studies---Used Cooking Fats Causes Cardiac Infractions". They found within (1) hour after People eat Foods with Used Cooking Oil---They had immediate Arterial Slowdown". I would like to see a study done on When does the Cooking Oil turn bad—In (1) hour---In (10) hours---In (24) hours---In (72) hours. I would like to see if we could come up with some solutions like only using the Cooking Oils for only a Few Hours and then use the Cooking Oil as a Bio Fuel in Diesel Engines.

Dr. Andrew Weil on The Worst Diet
http://www.youtube.com/watch?v=fQDA12ZV2nU 

Idea 44: Vaccination, and consultation by doctor

Doctor should advise on the possibilities of neurological damage after vaccination.

Comment 
Daresay, the majority of physicians do advise on the likelihood of adverse reactions to vaccinations. And, patients are provided with literature and consent forms that advice of such possibilities. The patients need to begin reading such information.

Idea 45: Vapor Intrusion and studies needed on exposed populations

Gas vapor from soils that seeps into ones home like radon gas needs more attention. Currently thousand of homes are affected and very little focus is placed in the literature on those that are being exposed. Common chemicals that are used for degreasing like perchlorethylene and trichloroethylene are still in many household products. With more human studies perhaps these chemicals can be banned to improve home air quality.

Idea 46: Vietnam Era link chloroquine, malthion, dapsone to birth defects

Chloroquine was widely distributed by U.S. medical personnel in tablet form to all American Service Members serving in Vietnam for the prevention of malaria. Dapsone was also widely distributed to American service personnel in the same manner for the prevention of Leprosy. One of the tablets was taken daily and the other medication was to be taken once a week for their entire tour of duty. The list of precautions and known side effects is quite extensive.

On another related subject, I remember being sprayed on as a soldier in Vietnam in my own HHC by low flying C-130 aircraft that were specially equipped with nozzles to try to counter the mosquito problem. I believe the name of the operation was Operation Fly Swatter and my personal research and first hand knowledge of this chemical directs me to Malathion. I worked in my Uncle's greenhouse before entering the service and recognized the odor immediately.

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